The common truncation variant p.W358X of the PNLIPRP2 lipase is not associated with chronic pancreatitis
Objectives Pancreatic Lipase-Related Protein 2 (PNLIPRP2) is a lesser lipase isoform which can digest long chain triglycerides, diglycerides and monoglycerides. In vitro experiments showed that the common nonsense variant c.1074G>A (p.W358X) causes the formation of a shorter misfolded protein that is not secreted well but induces endoplasmic reticulum (ER) stress. ER stress is a known susceptibility factor for chronic pancreatitis, suggesting that the p.W358X mutation of the PNLIPRP2 gene might contribute the development of pancreatitis. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Zsofia Gabriella Pesei, Balazs Csaba Nemeth, Eszter Hegyi, Andrea Szentesi, Aron Vince, Dezso Kelemen, Peter Hegyi, Miklos Sahin-Toth Tags: 4. Genetics in pancreatic diseases Source Type: research
Genetic variability of the ABCC2 gene and overall survival in pancreatic cancer
Objectives Context: The critical role of the ATP binding cassette subfamily C member 2 (ABCC2) protein in the response to various drugs has been documented in several reports. It is more recent knowledge that the ABCC2 gene is differently expressed in gemcitabine sensitive and resistant cells. Moreover, Single Nucleotide Polymorphisms (SNPs) in the gene have been associated with differential outcomes and prognosis in several tumour types. Objective: The aim of this study was to investigate the possible association between SNPs in the ABCC2 gene and overall survival in PDAC patients. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Manuel Gentiluomo, Alice Galeotti, Raffaele Pezzilli, Ugo Boggi, Gabriele Capurso, Ewa Ma łecka-Panas, Juozas Kupcinskas, Markus Büchler, Angelo Andriulli, William Greenhalf, John P. Neoptolemos, Andrea Mambrini, Aldo Scarpa, Pavel Soucek, Martin Lovece Tags: 4. Genetics in pancreatic diseases Source Type: research
Prevalence of Pancreatic Secretory Trypsin Inhibitor (SPINK1) gene mutation in patients with acute alcohol pancreatitis (AAP) compared to alcoholics and healthy controls
Objectives Approximately 10% of heavy alcohol users develop acute pancreatitis (AP). This suggests that additional triggers are required to initiate the inflammatory process. Genetic susceptibility contributes to the development of AP and for example SPINK1 mutation is a documented risk factor for the disease. However, only few genetic studies comparing AP patients and heavy alcohol users without pancreatitis exist. Our aim was to study the prevalence of SPINK1 (N34S) mutation in patients with acute alcohol pancreatitis (AAP) compared to heavy alcohol users who had never suffered an episode of pancreatitis. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Anssi Nikkola, Karl-Heinz Herzig, Kari M äkelä, Shivaprakash Jagalur Mutt, Terho Lehtimäki, Mika Kähönen, Olli Raitakari, Ilkka Seppälä, Pihla Paakkanen, Hanna Seppänen, Isto Nordback, Juhani Sand, Johanna Laukkarinen Tags: 4. Genetics in pancreatic diseases Source Type: research
DPC4, P53 and MTAP expression in patients with locally advanced and metastastic pancreatic cancer
Objectives Whole-genome sequencing studies have given extensive insight in the genetic landscape of resectable pancreatic cancer. However, little is known about the molecular features of locally advanced (LAPC) and metastatic pancreatic cancer, which represents 80% of the patients at time of diagnosis. P53 and DPC4 are frequently mutated genes in pancreatic cancer and are also suggested to have clinical implications. Moreover, a homozygous deletion of the gene coding for methylthiadenosine phosphorylase (MTAP) has become a subject of interest because of its potential for therapeutic targeted therapy. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Marieke S. Walma, Livia E. de Guerre, Hjalmar C. van Santvoort, Johan A. Offerhaus, I.Q. Molenaar, Lodewijk A. Brosens Tags: 4. Genetics in pancreatic diseases Source Type: research
Novel chymotrypsin C (CTRC) variant c.173C > T (p.T58M) in a case of late onset recurrent acute pancreatitis
Objectives Chymotrypsin C (CTRC) is a digestive enzyme produced by the pancreatic acini. Active CTRC inhibits early, intrapancreatic activation of trypsinogen and protects against the development of pancreatitis. Loss of function mutations that reduce secretion or impair catalytic activity of CTRC are associated with chronic pancreatitis. Some mutations of the CTRC gene induce endoplasmic reticulum (ER) stress that is a trypsin-independent pathway leading to pancreatitis. The Hungarian Pancreatic Study Group (HPSG) recruits patients with acute and chronic pancreatitis. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Balazs Csaba Nemeth, Tamas Takacs, Peter Hegyi, Miklos Sahin-Toth Tags: 4. Genetics in pancreatic diseases Source Type: research
Pre-existing diabetes elevates risk of local and systemic complications in acute pancreatitis
Objectives Acute pancreatitis (AP) is an inflammatory condition which commonly requires hospitalization and shows increased incidence. The prevalence of diabetes mellitus (DM) has duplicated in the last 35 years. Acute pancreatitis may result in pancreatic exocrine insufficiency and DM, but nowadays the influence of pre-existing DM in AP patients represents a hot research topic. The aim of our meta-analyses is to understand the influence of DM on the outcomes of AP including mortality, length of hospitalization, incidence of organ failures and intensive care unit admission. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Alexandra Mik ó, Nelli Farkas, Hungarian Pancreatic Study Group Hegyi, László Czakó Tags: 5. Diabetes and the pancreas Source Type: research
Diagnostic criteria for acute pancreatitis should be reconsidered in patients with diabetes mellitus
Objectives The incidence of both acute pancreatitis (AP) and diabetes mellitus (DM) have been increasing, therefore, more and more AP patients have also been suffering from DM. Basic research revealed that the pancreatic enzyme synthesis is non-parallel in acinar cells. A strong reduction in amylase and elevation of trypsin synthesis are observed in diabetic animals. Our aim was to i) analyze the amylase level on-admission in AP and ii) to understand the effect of DM on the course and outcome of AP in prospectively collected, large, multicentre cohort. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Klaudia K árász, Bálint Erőss, Mária Papp, Péter Mátrai, Katalin Márta, Dániel Pécsi, Dóra Illés, Czimmer József, Eszter Fehér, Erika Darvasi, Zoltán Szepes, Tamás Takács, Patrícia Sarlós, József Hamvas, László Gajdán, Ferenc Izbék Tags: 5. Diabetes and the pancreas Source Type: research
Development of antidiabetic poly herbal sustained release formulation composed of traditional Indian plant extract with their protective effect on antioxidant enzyme
Objectives Multifactorial metabolic diseases, for instance diabetes develop several complications like hyperlipidemia, hepatic toxicity, immunodeficiency etc., Hence, instead of mono-drug therapy the management of the disease requires the combination of herbs. In present study Floating tablets of hydro alcoholic extracts of Triticum aestivum, Embelia ribes and Cedrus deodara were developed with an aim to prolong its gastric residence time and increase the bioavailability of drug. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Aakanchha Jain, Saurabh Bhargav, Sourabh Jain Tags: 5. Diabetes and the pancreas Source Type: research
Mechanisms and possible treatment strategies for pancreatogenic (type 3c) diabetes
Objectives To assess possible mechanisms for the development of pancreatogenic (type 3c) diabetes mellitus (T3cDM), and to identify possible treatment strategies. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Dana Andersen, Philip Hardt, Nils Ewald Tags: 5. Diabetes and the pancreas Source Type: research
Formulation and evaluation of embelin loaded pectin nanoparticles for the treatment of diabetes
Objectives Embelin exhibited insulin sensitizing effect through adipose tissue specific partial agonist of PPAR γ and activated glucose transport through translocation and activation of GLUT4 mediated by insulin dependent PI3k/p-Akt pathway in epidermal adipose tissue. It also protected β-cells by scavenging free radicals and alleviated dyslipidemia in insulin resistant animal model. So in present study we developed embelin loaded controlled release nanoparticles using pectin. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Sourabh Jain, Aakanchha Jain, Saurabh Bhargav Tags: 5. Diabetes and the pancreas Source Type: research
Pancreatogenic Diabetes: Peculiarities in Diagnosis and Treatment
Objectives To give an overview about special implications for diagnosis and treatment of pancreatogenic diabetes (DM) (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Nils Ewald, Philip Hardt, Dana Andersen Tags: 5. Diabetes and the pancreas Source Type: research
Preparation And Evaluation Of Eudragit Coated Chitosan Microparticles For Oral Insulin Delivery
Objectives Diabetes mellitus was known in relic and vestiges at present a global and ascalating health problem with millions of cases being diagnosed daily. Diabetes can affect numerous parts of the body and is associated with solemn complications, such as heart disease and stroke, blindness, kidney failure, and lower-limb amputation. Some complications, particularly micro vascular (e.g., eye, kidney, and nerve) disease, can be reduced with good glucose control. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Aakanchha Jain, S.A.U.R.A.B.H. Bhargav, S.O.U.R.A.B.H. JAIN Tags: 5. Diabetes and the pancreas Source Type: research
Pancreatogenic diabetes mellitus – Prevalence and risk factors
Objectives Pancreatogenic or pancreoprivic (type 3c) diabetes mellitus (DM) represents the diabetes that occurs secondary to diseases of the exocrine pancreas – chronic pancreatitis (CP), post-necrotizing acute pancreatitis (NAP), pancreatic resections (PR), and pancreatic tumors (PT). Although it’s a relative common finding in gastroenterology wards, it’s often underdiagnosed or mislabeled as type 2 DM, although their clinical and laboratory charac teristics are different. Our aim was to evaluate the prevalence and risk factors associated with pancreatogenic DM. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Daniel Vasile Balaban, Andreea Zoican, Marina Ciochina, Georgiana Robu, Ionel Petrut Nuta, Raluca Simona Costache, Florentina Ionita-Radu, Mariana Jinga Tags: 5. Diabetes and the pancreas Source Type: research
Evaluation of antidiabetic and hypolipidemic activity of cedrus deodara and embelia ribes with their synergistic effects
Objectives Herbal medicines are getting more importance in the treatment of diabetes, cancer and hepatic disorders because of the side effects of the current allopathic therapy. The medicinal plants Cedrus deodara and Embelia ribes are rich with antidiabetic active contstituents like flavonoids, tannins and embelin. Former studies showed that both pants are potential for the treatment of diabetes. The present study was undertaken to study combined synergistic effect of hydro-alcoholic extract of heart wood of Cedrus deodara with Seeds of Embelia ribes on blood glucose, insulin, and cholesterol and triglyceride level in nor...
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Sourabh Jain, Aakanchha Jain, Saurabh Bhargav Tags: 5. Diabetes and the pancreas Source Type: research
Risk of acute pancreatitis after sitagliptin, a dipeptidyl peptidase - 4 inhibitors
The objective of this study was to assess the risk of acute pancreatitis in patients with type 2 diabetes treated with sitagliptin, a DPP-4 inhibitors. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Adriana Gherbon, Romulus Timar Tags: 5. Diabetes and the pancreas Source Type: research
