The clinical use of mechanical insufflation-exsufflation in children with neuromuscular disorders in Europe
Mechanical insufflation-exsufflation (MI-E) is a strategy to treat pulmonary exacerbations in neuromuscular disorders (NMDs). Pediatric guidelines for optimal setting titration of MI-E are lacking and the settings used in studies vary. Our objective was to assess the actual MI-E settings being used in current clinical treatment of children with NMDs and a survey was sent in July 2016 to European expertise centers. Ten centers from seven countries gave information on MI-E settings for 240 children aged 4 months to 17.8 years (mean 10.5). (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - November 3, 2017 Category: Respiratory Medicine Authors: Brit Hov, Tiina Andersen, Vegard Hovland, Michel Toussaint Tags: Review Source Type: research
The clinical use of mechanical insufflation-exsufflation in children with neuromuscular disorders in Europe
Mechanical insufflation-exsufflation (MI-E) is a strategy to treat pulmonary exacerbations in neuromuscular disorders (NMDs). Pediatric guidelines for optimal setting titration of MI-E are lacking and the settings used in studies vary. Our objective was to assess the actual MI-E settings being used in current clinical treatment of children with NMDs and a survey was sent in July 2016 to European expertise centers. Ten centers from seven countries gave information on MI-E settings for 240 children aged 4 months to 17.8 years (mean 10.5). (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - November 3, 2017 Category: Respiratory Medicine Authors: Brit Hov, Tiina Andersen, Vegard Hovland, Michel Toussaint Source Type: research
Does vitamin E prevent asthma or wheeze in children: A systematic review and meta-analysis
Asthma is a heterogeneous disease with multiple phenotypes. Epidemiologic studies suggest a close relationship between vitamin E and the occurrence of asthma, wheezing and atopic conditions during childhood. Previous results on its effects have been conflicting. The aim of this meta-analysis was to critically examine the current evidence on the association of vitamin E with childhood asthma and wheezing. We searched electronic databases for observational studies in English-language journals published from 2000 to 2016. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - October 14, 2017 Category: Respiratory Medicine Authors: Hui Wu, Chunwei Zhang, Yongqing Wang, Yanlin Li Tags: Review Source Type: research
Does vitamin E prevent asthma or wheeze in children: a systematic review and meta-analysis
Asthma is a heterogeneous disease with multiple phenotypes. Epidemiologic studies suggest a close relationship between vitamin E and the occurrence of asthma, wheezing and atopic conditions during childhood. Previous results on its effects have been conflicting. The aim of this meta-analysis was to critically examine the current evidence on the association of vitamin E with childhood asthma and wheezing. We searched electronic databases for observational studies in English-language journals published from 2000 to 2016. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - October 14, 2017 Category: Respiratory Medicine Authors: Wu Hui, Chunwei Zhang, Yongqing Wang, Yanlin Li Tags: Review Source Type: research
Medicolegal issues for the respiratory paediatrician
This article draws on 20 years of experience in medicolegal work relating to paediatric respiratory medicine. It highlights some of the legal principles that lie behind an expert opinion and what constitutes clinical negligence. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - October 13, 2017 Category: Respiratory Medicine Authors: Ian M. Balfour-Lynn Tags: Mini-symposium: The court and the clinician Source Type: research
Tracheobronchial stenting for airway malacia
Tracheobronchomalacia is a rare but clinically troublesome condition in paediatrics. The softening of the major airways – which can include some or all of the tracheobronchial tree can lead to symptoms ranging from the minor (harsh barking cough, recurrent chest infections) to severe respiratory difficulties including prolonged ventilator support and ‘near death attacks’. The causes are broadly divided into int rinsic softening of the airway wall which is considered a primary defect (e.g. syndromes; post tracheo-oesophageal fistula repair; extreme prematurity) or secondary malacia due to external compression from vas...
Source: Paediatric Respiratory Reviews - October 13, 2017 Category: Respiratory Medicine Authors: Colin Wallis, Clare A. McLaren Tags: Review Source Type: research
Medicolegal issues for the respiratory paediatrician
This article draws on 20 years of experience in medicolegal work relating to paediatric respiratory medicine. It highlights some of the legal principles that lie behind an expert opinion and what constitutes clinical negligence. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - October 13, 2017 Category: Respiratory Medicine Authors: Ian M Balfour Lynn Tags: Mini-symposium Source Type: research
Tracheobronchial stenting for airway malacia
Tracheobronchomalacia is a rare but clinically troublesome condition in paediatrics. The softening of the major airways – which can include some or all of the tracheobronchial tree can lead to symptoms ranging from the minor (harsh barking cough, recurrent chest infections) to severe respiratory difficulties including prolonged ventilator support and ‘near death attacks’. The causes are broadly divided into int rinsic softening of the airway wall which is considered a primary defect (e.g. syndromes; post tracheo-oesophageal fistula repair; extreme prematurity) or secondary malacia due to external compression from vas...
Source: Paediatric Respiratory Reviews - October 13, 2017 Category: Respiratory Medicine Authors: Colin Wallis, Clare A. McLaren Source Type: research
Treating resistant Pseudomonas aeruginosa lung disease in young children with cystic fibrosis
Pseudomonas aeruginosa is a common bacterial pathogen in the evolution of bronchiectasis in cystic fibrosis. The appearance of resistant strains of pseudomonas is increasing with the earlier and more liberal use of a range of anti-pseudomonal antibiotics for the treatment of bacterial chest infections. The rationale for treatment and potential benefits of aggressive treatment of resistant strains of Pseudomonas aeruginosa from early in life are discussed. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - September 1, 2017 Category: Respiratory Medicine Authors: Sandy Z.P. Lim, Dominic A. Fitzgerald Tags: Clinical usefulness Source Type: research
Pulmonary sequelae and functional limitations in children and adults with bronchopulmonary dysplasia
Preterm infants with bronchopulmonary dysplasia (BPD) often suffer from life-long pulmonary impairments in pulmonary physical function. This review summarizes our current understanding of the chronic pulmonary impairments and physical functional limitations associated with BPD from preterm birth to adulthood. It also identifies opportunities for intervention in children and adults living with chronic lung disease (CLD) after preterm birth. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - August 23, 2017 Category: Respiratory Medicine Authors: Daniel T. Malleske, Olena Chorna, Nathalie L. Maitre Tags: Review Source Type: research
The evaluation and management of respiratory disease in children with Down syndrome (DS)
Children with Down syndrome (DS) have wide range of respiratory problems. Although underlying abnormalities in the respiratory system are important causes of morbidity and mortality in children with DS, particularly in the young, abnormalities in other organ systems may also impact respiratory function. A comprehensive evaluation of the child with DS and respiratory disease may prevent short-term morbidity and mortality, and reduce the incidence of complications in the long term. This review provides an overview of the various causes of respiratory disease, and insight into some of the newer therapies available to treat ob...
Source: Paediatric Respiratory Reviews - August 23, 2017 Category: Respiratory Medicine Authors: Haya S. Alsubie, Dennis Rosen Tags: Review Source Type: research
Pulmonary sequelae and functional limitations in children and adults with bronchopulmonary dysplasia
Preterm infants with bronchopulmonary dysplasia (BPD) often suffer from life-long pulmonary impairments in pulmonary physical function. This review summarizes our current understanding of the chronic pulmonary impairments and physical functional limitations associated with BPD from preterm birth to adulthood. It also identifies opportunities for intervention in children and adults living with chronic lung disease (CLD) after preterm birth. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - August 23, 2017 Category: Respiratory Medicine Authors: Daniel T. Malleske, Olena Chorna, Nathalie L. Maitre Tags: Review Source Type: research
The evaluation and management of respiratory disease in children with Down syndrome (DS)
Children with Down syndrome (DS) have wide range of respiratory problems. Although underlying abnormalities in the respiratory system are important causes of morbidity and mortality in children with DS, particularly in the young, abnormalities in other organ systems may also impact respiratory function. A comprehensive evaluation of the child with DS and respiratory disease may prevent short-term morbidity and mortality, and reduce the incidence of complications in the long term. This review provides an overview of the various causes of respiratory disease, and insight into some of the newer therapies available to treat ob...
Source: Paediatric Respiratory Reviews - August 23, 2017 Category: Respiratory Medicine Authors: Haya S. Alsubie, Dennis Rosen Tags: Review Source Type: research
Childhood community-acquired pneumonia: A review of etiology- and antimicrobial treatment studies
Community acquired pneumonia (CAP) is a leading cause of childhood morbidity worldwide. Because of the rising antimicrobial resistance rates and adverse effects of childhood antibiotic use on the developing microbiome, rational prescribing of antibiotics for CAP is important. This review summarizes and critically reflects on the available evidence for the epidemiology, etiology and antimicrobial management of childhood CAP. Larger prospective studies on antimicrobial management derive mostly from low- or middle-income countries as they have the highest burden of CAP. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - July 14, 2017 Category: Respiratory Medicine Authors: Gerdien A. Tramper-Stranders Tags: Review Source Type: research
