Pediatric Donation after Circulatory Determination of Death (pDCD): A narrative review
Pediatric donation after circulatory death (pDCD) is an established pathway for organ donation. It remains, however, a relatively rare event worldwide, and most clinicians outside of the pediatric intensive care unit (PICU) are unfamiliar with it. The goal of this review is to introduce the processes and concepts of pDCD. While most children die in circumstances that would not allow pDCD, many children that die after withdrawal of life sustaining therapy (WLST) may be eligible for donation of some organs. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - April 13, 2018 Category: Respiratory Medicine Authors: Matthew J. Weiss, Wendy Sherry, Laura Hornby Tags: Mini-symposium: Ethics and Palliative Care Source Type: research
Persistent and progressive long-term lung disease in survivors of preterm birth
Preterm birth accounts for approximately 11% of births globally, with rates increasing across many countries. Concurrent advances in neonatal care have led to increased survival of infants of lower gestational age (GA). However, infants born (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - April 13, 2018 Category: Respiratory Medicine Authors: Rhea Urs, Sailesh Kotecha, Graham L. Hall, Shannon J Simpson Tags: Review Source Type: research
Outdoor Air Pollution and Cystic Fibrosis
Outdoor air pollution is increasingly identified as a contributor to respiratory and cardiovascular disease. Pro-inflammatory particles and gases are inhaled deep into the lungs, and are associated with impaired lung growth and exacerbations of chronic respiratory diseases. The magnitude of these effects are of interest to patients and families, and have been assessed in studies specific to CF. Using systematic review methodology, we sought to collate these studies in order to summarise the known effects of air pollution in cystic fibrosis, and to present information on decreasing personal air pollution exposures. (Source:...
Source: Paediatric Respiratory Reviews - April 10, 2018 Category: Respiratory Medicine Authors: Rossa Brugha, Claire Edmondson, Jane C. Davies Tags: Review Source Type: research
Hypersensitivity reactions to intravenous antibiotics in cystic fibrosis
Hypersensitivity reactions to intravenous antibiotics are common in cystic fibrosis (CF). As well as causing immediate morbidity, the need for future avoidance of the causative antibiotic can have a long-term negative impact on CF management. This paper reviews the epidemiology and clinical presentation of hypersensitivity reactions in CF patients, and using an illustrative case describes a rare but severe form of delayed drug reaction for which a high index of suspicion is required. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - April 4, 2018 Category: Respiratory Medicine Authors: Marie F.A. Wright, Andrew Bush, Siobhan B Carr Tags: The 2017 Royal Society Of Medicine Cystic Fibrosis Symposium Source Type: research
New and developing therapies in spinal muscular atrophy
Great progress has been made in the clinical translation of several therapeutic strategies for spinal muscular atrophy (SMA), including measures to selectively address Survival Motor Neuron (SMN) protein deficiency with SMN1 gene replacement or modulation of SMN2 encoded protein levels, as well as neuroprotective approaches and supporting muscle strength and function. This review highlights these novel therapies. This is particularly vital with the advent of the first disease modifying therapy, which has brought to the fore an array of questions surrounding who, how and when to treat, and stimulated challenges in resource ...
Source: Paediatric Respiratory Reviews - April 4, 2018 Category: Respiratory Medicine Authors: Didu Kariyawasam, Kate A. Carey, Kristi J. Jones, Michelle A. Farrar Tags: Mini-Symposium: Spinal Muscular Atrophy Source Type: research
Hypersensitivity reactions to intravenous antibiotics in Cystic Fibrosis
Hypersensitivity reactions to intravenous antibiotics are common in cystic fibrosis (CF). As well as causing immediate morbidity, the need for future avoidance of the causative antibiotic can have a long-term negative impact on CF management. This paper reviews the epidemiology and clinical presentation of hypersensitivity reactions in CF patients, and using an illustrative case describes a rare but severe form of delayed drug reaction for which a high index of suspicion is required. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - April 4, 2018 Category: Respiratory Medicine Authors: Marie F.A. Wright, Siobhan B Carr, Andrew Bush Source Type: research
New and developing therapies in spinal muscular atrophy
Great progress has been made in the clinical translation of several therapeutic strategies for spinal muscular atrophy (SMA), including measures to selectively address Survival Motor Neuron (SMN) protein deficiency with SMN1 gene replacement or modulation of SMN2 encoded protein levels, as well as neuroprotective approaches and supporting muscle strength and function. This review highlights these novel therapies. This is particularly vital with the advent of the first disease modifying therapy, which has brought to the fore an array of questions surrounding who, how and when to treat, and stimulated challenges in resource ...
Source: Paediatric Respiratory Reviews - April 4, 2018 Category: Respiratory Medicine Authors: Didu Kariyawasam, Kate Carey, Kristi J Jones, Michelle A Farrar Tags: Mini-Symposium: Spinal Muscular atrophy: polysomnoagraphy and role of non-invasive support Source Type: research
Interventions for autumn exacerbations of asthma in children
Asthma exacerbations in school-aged children peak in autumn [1]. The peak follows shortly after the summer school holiday; occurring in September in the Northern Hemisphere [2] and February in the Southern Hemisphere [3]. This likely reflects a combination of risk factors, including poor treatment adherence, increased allergen and viral exposure, and altered immune tolerance [4]. Asthma admissions during the month when children return to school account for approaching a quarter of the annual total [5]. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - April 3, 2018 Category: Respiratory Medicine Authors: Katharine C. Pike, Melika Akhbari, Dylan Kneale, Katherine M. Harris Tags: Cochrane Corner in Paediatric Respiratory reviews Source Type: research
Interventions for autumn exacerbations of asthma in children
Asthma exacerbations in school-aged children peak in autumn [2]. The peak follows shortly after the summer school holiday; occurring in September in the Northern Hemisphere [3] and February in the Southern Hemisphere [4]. This likely reflects a combination of risk factors, including poor treatment adherence, increased allergen and viral exposure, and altered immune tolerance [5]. Asthma admissions during the month when children return to school account for approaching a quarter of the annual total [6]. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - April 3, 2018 Category: Respiratory Medicine Authors: Katharine C Pike, Melika Akhbari, Dylan Kneale, Katherine M Harris Source Type: research
Side effects of medications used to treat childhood interstitial lung disease
Interstitial lung disease in children (chILD) comprises a range of different rare diseases. There is limited evidence for the treatment of chILD and no randomised clinical trials of treatment have been undertaken. Most treatments are therefore prescribed off-label based on expert opinion. The off-label nature of prescription of drugs for chILD highlights the importance of a solid understanding of the side effects to facilitate risk-benefit assessment. The European Respiratory Society chILD guidelines recommend the use of systemic glucocorticosteroids, hydroxychloroquine and azithromycin. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - March 17, 2018 Category: Respiratory Medicine Authors: Oded Breuer, Andr é Schultz Tags: Review Source Type: research
Cystic fibrosis papers of the year 2017
The number of published articles on Cystic Fibrosis (CF) continues to increase year on year. The evidence base for small molecule therapies in CF has continued to expand, with evidence for lumacaftor/ivacaftor in younger patients and longer-term evidence in adults, and pivotal studies on tezacaftor/ivacaftor. There were reports on emerging CFTR mutation agnostic therapies, and new evidence for long standing therapies. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - March 15, 2018 Category: Respiratory Medicine Authors: Iolo Doull Tags: Royal Society of Medicine 2017 Cystic Fibrosis Mini-symposium Review Source Type: research
Cystic Fibrosis Papers of the Year 2017
The number of published articles on Cystic Fibrosis (CF) continues to increase year on year. The evidence base for small molecule therapies in CF has continued to expand, with evidence for lumacaftor/ivacaftor in younger patients and longer-term evidence in adults, and pivotal studies on tezacaftor/ivacaftor. There were reports on emerging CFTR mutation agnostic therapies, and new evidence for long standing therapies. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - March 15, 2018 Category: Respiratory Medicine Authors: Iolo Doull Tags: Review Source Type: research
Question 1: Why do children still die from asthma?
Asthma is one of the commonest chronic conditions in children and can occasionally be fatal. Little has changed regarding the risk factors for children dying from asthma in the last 30 years. The majority of deaths from asthma occur in children from socio-economically disadvantaged backgrounds. These should be preventable with better education of families, oversight of medication adherence and improved communication between health care professionals and families. More needs to be done to deliver basic messages more effectively about asthma management to the most vulnerable in communities around the world. (Source: Paedi...
Source: Paediatric Respiratory Reviews - February 17, 2018 Category: Respiratory Medicine Authors: Ana Maria Herrera Gana, Dominic A. Fitzgerald Tags: Asthma Frequently Asked Questions Source Type: research
