Otolaryngologic clinics of North America This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Salvage Management of Vestibular Schwannoma
This article is intended to review an approach to the failure of primary interventions for VS, with a focus on the time interval between modalities, rates of tumor control, functional outcomes, and possible complications. (Source: Otolaryngologic clinics of North America)
Source: Otolaryngologic clinics of North America - March 22, 2023 Category: ENT & OMF Authors: Emily Kay-Rivest, John Thomas Roland Source Type: research

Management of Complications in Vestibular Schwannoma Surgery
Microsurgical removal of acoustic neuroma has advanced tremendously; however, complications still occur. Facial nerve injury is the most common detrimental complication and should take precedence over gross tumor removal in cases where there is an unfavorable tumor-facial nerve interface. Cerebrospinal fluid leakage can occur even with meticulous closure techniques and is generally treatable with either lumbar-subarachnoid drainage or revision wound closure. Meningitis is a serious complication that requires a high index of suspicion in the postoperative period. Other less common complications include intraoperative and po...
Source: Otolaryngologic clinics of North America - March 22, 2023 Category: ENT & OMF Authors: Joe Walter Kutz, Donald Tan, Jacob B. Hunter, Samuel Barnett, Brandon Isaacson Source Type: research

Unified Airway Disease: Genetics and Epigenetics
Although unified airway disease (UAD) may have heritable components, genetic changes involving coexistent chronic rhinosinusitis (CRS) are not well understood. Genetic predisposition is stronger in patients with CRS with nasal polyps compared with those without nasal polyps (CRSsNP). Genetic factors account for 25% to 80% of asthma risk and 90% of allergic rhinitis risk but risk contributions are not well described for CRS. Susceptibility genes identified in coexistent CRS-asthma relate to innate and adaptive immunity, cytokine signaling, tissue remodeling, arachidonic acid metabolism, and other proinflammatory pathways. N...
Source: Otolaryngologic clinics of North America - November 19, 2022 Category: ENT & OMF Authors: Tripti Brar, Michael J. Marino, Devyani Lal Source Type: research

Unified Airway Disease
The unified airway is in constant exposure to environmental factors that promote inflammation and disease. Environmental allergens, including house dust mites, pets, pollens, and molds, are strongly linked with development and exacerbation of upper airway disease with nonlinear dose-dependent relationships. Occupational triggers, including combat exposures and construction workers, are associated with the development of both upper and lower airway disease resulting in a “healthy worker effect” where many people leave jobs due to significant morbidity.. (Source: Otolaryngologic clinics of North America)
Source: Otolaryngologic clinics of North America - November 19, 2022 Category: ENT & OMF Authors: Jesse Siegel, Navroop Gill, Murugappan Ramanathan, Monica Patadia Source Type: research

Non-Eosinophilic Granulomatous Disease and the Unified Airway
Granulomatous and vasculitic diseases of the airway may be part of more widespread systemic disease but can occur in isolation. They may present to the ear, nose, and throat (ENT) surgeon initially with vague symptoms that mimic more common chronic inflammatory unified airway conditions, such as rhinitis, chronic rhinosinusitis, and asthma. Early diagnosis is associated with better long-term outcomes, so a high index of suspicion is required. Bloody nasal discharge and crusting are highly suspicious for granulomatous disease, which should also be considered in atypical or recalcitrant disease. A combination of clinical fin...
Source: Otolaryngologic clinics of North America - November 19, 2022 Category: ENT & OMF Authors: Joanne Rimmer, Valerie J. Lund Source Type: research

Unified Airway Disease
Support for the unified airway hypothesis is embedded in similarities in upper and lower airway structure, function, and cellular/extracellular compositions. The impact of endoscopic sinus surgery (ESS) on the unified airway is influenced by multiple factors including the underlying upper and lower airway condition(s) present and severity of pathology. Beyond improvements in subjective and objective CRS outcomes, ESS also improves clinical asthma outcomes and measures of asthma control. Emerging evidence suggests that early ESS may mitigate the risk of developing asthma in CRS patients without asthma. Comprehensive managem...
Source: Otolaryngologic clinics of North America - November 19, 2022 Category: ENT & OMF Authors: Amar Miglani, Tripti K. Brar, Devyani Lal Source Type: research

Unified Airway Disease
Unified airway disease describes the shared epidemiologic and pathophysiologic relationship among the chronic inflammatory diseases of the upper and lower airways including allergic rhinitis, chronic rhinosinusitis, asthma, and chronic otitis media. This concept proposes that these diseases are manifestations of a single inflammatory process and require an integrated diagnostic and therapeutic approach to achieve global disease control. Future directions to further establish this entity should focus on pathophysiology, diagnostic markers, flora microbes with particular emphasis on fungi, the role of type 3 inflammation, an...
Source: Otolaryngologic clinics of North America - November 19, 2022 Category: ENT & OMF Authors: Jumah G. Ahmad, Michael J. Marino, Amber U. Luong Source Type: research

Unified Airway Disease
The concept of a unified airway posits that pathology affects the respiratory tract in a continuum and that disease in one part of the respiratory tract may be associated with or directly or indirectly affect the function of a different part. Transcriptomic analysis has shown 91% homology between the genes expressed in the upper and the lower airway. Approaching inflammatory airway disorders using the unified airway hypothesis allows for a better clarification of disease process and provides a detailed and a high-level overview of dysfunction. There are several tools available to the clinician to use to subtype and diagnos...
Source: Otolaryngologic clinics of North America - November 19, 2022 Category: ENT & OMF Authors: Amar Miglani, Devyani Lal, Rohit D. Divekar Source Type: research

The Unified Airway: From Concept to Practice
While the close relationship between upper- and lower-airway disease has been known for centuries, the concept of the unified airway has come to the forefront in the last few decades. The April 2008 issue of Otolaryngologic Clinics of North America was dedicated to the unified airway and provided for the otolaryngologist a comprehensive review of the knowledge available at that time on this important concept. A common theme of the issue was the frequent co-occurrence of upper- and lower-airway disease and the need to recognize and treat these conditions concurrently. (Source: Otolaryngologic clinics of North America)
Source: Otolaryngologic clinics of North America - November 19, 2022 Category: ENT & OMF Authors: Devyani Lal, Angela M. Donaldson, David W. Jang Tags: Preface Source Type: research

Eliminating Artificial Airway Divisions Enhances Patient Outcomes
In medical school, there are artificial divisions drawn between the upper airway —nose, paranasal sinuses, pharynx, and larynx, and the lower airway—trachea, bronchi, and lungs. Material relating to these organ systems is taught in individual silos of otolaryngology and pulmonology. This separation continues on in the way medicine is practiced. However, patients experience d isease that affects both upper and lower airways, and it behooves the astute clinician to understand the airway as a unified phenomenon. (Source: Otolaryngologic clinics of North America)
Source: Otolaryngologic clinics of North America - November 19, 2022 Category: ENT & OMF Authors: Sujana S. Chandrasekhar Tags: Foreword Source Type: research

Unified Airway Disease
OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA (Source: Otolaryngologic clinics of North America)
Source: Otolaryngologic clinics of North America - November 19, 2022 Category: ENT & OMF Authors: DEVYANI LAL, ANGELA M. DONALDSON, DAVID W. JANG Source Type: research

Copyright
Elsevier (Source: Otolaryngologic clinics of North America)
Source: Otolaryngologic clinics of North America - November 19, 2022 Category: ENT & OMF Source Type: research

Contributors
SUJANA S. CHANDRASEKHAR, MD, FACS, FAAOHNS (Source: Otolaryngologic clinics of North America)
Source: Otolaryngologic clinics of North America - November 19, 2022 Category: ENT & OMF Source Type: research

Contents
Sujana S. Chandrasekhar (Source: Otolaryngologic clinics of North America)
Source: Otolaryngologic clinics of North America - November 19, 2022 Category: ENT & OMF Source Type: research

Forthcoming Issues
Larynx Cancer (Source: Otolaryngologic clinics of North America)
Source: Otolaryngologic clinics of North America - November 19, 2022 Category: ENT & OMF Source Type: research