Otolaryngologic clinics of North America This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The Future of Vestibular Schwannoma Management
The future of the management of both sporadic and neurofibromatosis type 2-asscoiated vestibular schwannomas (VSs) will be shaped by cutting-edge technologic and biomedical advances to enable personalized, precision medicine. This scoping review envisions the future by highlighting the most promising developments published, ongoing, planned, or potential that are relevant for VS, including integrated omics approaches, artificial intelligence algorithms, biomarkers, liquid biopsy of the inner ear, digital medicine, inner ear endomicroscopy, targeted molecular imaging, patient-specific stem cell-derived models, ultra-high do...
Source: Otolaryngologic clinics of North America - April 4, 2023 Category: ENT & OMF Authors: Lindsay Scott Moore, Konstantina M. Stankovic Source Type: research

Management of Subglottic Cancer
Primary subglottic carcinoma is a rare subgroup of laryngeal malignancy with exact incidence unknown due to the lack of a standard definition of its anatomic boundaries. Early-stage subglottic carcinoma can be treated with either primary radiation or surgery with similar overall survival rates. Most patients present at an advanced stage due to a paucity of symptoms, and these patients are treated in a multidisciplinary fashion. Particular attention should be paid to the prelaryngeal and pretracheal nodal basins, as well as the stoma region, when managing these patients. (Source: Otolaryngologic clinics of North America)
Source: Otolaryngologic clinics of North America - April 1, 2023 Category: ENT & OMF Authors: Hayley Mann, Kristen Seligman, Nicholas Colwell, Adam Burr, Tiffany A. Glazer Source Type: research

Larynx Cancer
Reconstruction for laryngeal cancer will depend on the defect left by surgical resection and patient-related factors such as medical comorbidities and history of previous radiation treatment. The goals of reconstruction are to preserve and/or restore the primary functions of the larynx (breathing, swallowing, voicing). Options include primary closure, locoregional flaps, and microvascular free tissue each with their advantages and disadvantages, which should be considered when planning reconstruction. (Source: Otolaryngologic clinics of North America)
Source: Otolaryngologic clinics of North America - April 1, 2023 Category: ENT & OMF Authors: Russel Kahmke, Mirabelle Sajisevi Source Type: research

Voice Restoration and Quality of Life in Larynx Cancer
Voice restoration following laryngectomy has a significant influence on quality of life (QOL). Three main techniques exist to provide voice: esophageal speech (ES), artificial larynx (electrolarynx [EL]), and tracheoesophageal puncture (TEP). Although the EL was historically the most used technique, TEP has quickly become the gold standard. ES remains the least frequently used technique in developed countries. Technique selection must be made on an individual basis, considering the patient ’s cancer history and comorbidities. Ultimately, the choice in voice-restoration technique requires joint decision making with the su...
Source: Otolaryngologic clinics of North America - April 1, 2023 Category: ENT & OMF Authors: Jessica A. Tang, Liane McCarroll, Cecelia E. Schmalbach Source Type: research

Swallowing Function After Treatment of Laryngeal Cancer
Dysphagia is a common functional outcome following treatment of laryngeal cancer. Despite curative advances in both nonsurgical and surgical approaches, preserving and optimizing swallowing function is critical. Understanding the nature and severity of dysphagia depending on initial tumor staging and treatment modality and intensity is crucial. This chapter explores current evidence on the acute and chronic impacts of treatments for laryngeal cancer on swallow function, as well as the medical and nonmedical management of dysphagia in this population. (Source: Otolaryngologic clinics of North America)
Source: Otolaryngologic clinics of North America - April 1, 2023 Category: ENT & OMF Authors: Maude Brisson-McKenna, Gina D. Jefferson, Sana H. Siddiqui, Sarah Adams, Sofia Afanasieva (Sonia), A ïda Chérid, Jesse Burns, Carla Di Gironimo, Leila J. Mady Source Type: research

Laryngeal Cancer and the End of Life (As We Know It)
This article characterizes the suffering experienced by patients with laryngeal cancer, including societal shame, poor mental health, and inequitable outcomes. For patients with advanced laryngeal cancer, surgical palliative care provides a necessary and helpful paradigm for caregiver support, goals-of-care conversations, and treatment counseling. (Source: Otolaryngologic clinics of North America)
Source: Otolaryngologic clinics of North America - April 1, 2023 Category: ENT & OMF Authors: Monica H. Bodd, Susan D. McCammon Source Type: research

Laryngeal Anatomy, Molecular Biology, Cause, and Risk Factors for Laryngeal Cancer
This article reviews the relevant anatomy and lymphatic drainage pathways of the larynx because they pertain to cancer spread. The molecular and immune landscapes of laryngeal cancer, which are tightly linked to smoking, are also discussed. (Source: Otolaryngologic clinics of North America)
Source: Otolaryngologic clinics of North America - April 1, 2023 Category: ENT & OMF Authors: Anthony B. Law, Nicole C. Schmitt Source Type: research

Salvage Surgery
The Department of Veterans Affairs Laryngeal Cancer Study propelled the combination of chemotherapy and radiation therapy to the forefront of strategies used for the management of locally advanced laryngeal cancer. The organ preservation rate was 84%. However, over the past 30  years that these approaches have been in place, there have been concerns regarding long-term survival and high failure rates requiring salvage. Furthermore, salvage laryngectomy, if feasible when considering increased morbidity after CRT, is fraught with a higher risk of wound complications includ ing fistula, longer hospitalization, and reduced qu...
Source: Otolaryngologic clinics of North America - April 1, 2023 Category: ENT & OMF Authors: Somtochi Okafor, Oluwaseyi O. Awaonusi, Tammara L. Watts, Trinitia Y. Cannon Source Type: research

Perioperative Assessment/Prehabilitation in Larynx Cancer
Head and neck cancer (HNC) survivorship is increasing, and with it, a shift in treatment practices has occurred. Radical surgical resections for the treatment of HNC have decreased, and organ preservation treatments have increased. Although effective in treating HNC, chemoradiation therapy toxicities can be detrimental to a patient ’s overall health, nutrition status, and quality of life (QOL). Considering that dysphagia is typically a driving element of dysfunction, speech–language pathologists are vital to the prehabilitation phase. Prehabilitation programs include a variety of components, with the primary goal being...
Source: Otolaryngologic clinics of North America - April 1, 2023 Category: ENT & OMF Authors: Mary Caroline Murray, Anne Kane Source Type: research

Chemoradiation for Locoregionally Advanced Laryngeal Cancer
This article provides an overview of the current therapeutic approaches used to treat locoregionally advanced laryngeal cancer and outlines other currently investigated therapies. (Source: Otolaryngologic clinics of North America)
Source: Otolaryngologic clinics of North America - April 1, 2023 Category: ENT & OMF Authors: Andr éanne Leblanc, Toms Vengaloor Thomas, Nathaniel Bouganim Source Type: research

Prognosis
is defined as the likely outcome or course of a disease and is the result of a complex interplay between patient and tumor factors. Unfortunately, the prognosis of patients with laryngeal cancer has not changed significantly over the past several decades. However, as our understanding of these patient and tumor factors becomes more nuanced and the resulting treatment options become more precise, there is the potential to improve the prognosis for these patients. (Source: Otolaryngologic clinics of North America)
Source: Otolaryngologic clinics of North America - April 1, 2023 Category: ENT & OMF Authors: Chihun Han, Nayel I. Khan, Leila J. Mady Source Type: research

Diagnostic Assessment (Imaging) and Staging of Laryngeal Cancer
Diagnosis of larynx cancer relies on a detailed history and physical and objective assessment with endoscopy and imaging. Endoscopy is needed to assess for vocal fold function that directly affects staging. Computed tomography and MRI can be used to assess for tumor extent in relation to intra- and extra-laryngeal structures, especially paraglottic and pre-epiglottic space involvement as well as cartilage invasion. Accurate staging is critical for subsequent treatment decision-making regarding larynx preservation. (Source: Otolaryngologic clinics of North America)
Source: Otolaryngologic clinics of North America - April 1, 2023 Category: ENT & OMF Authors: Kyohei Itamura, Victor B. Hsue, Anca M. Barbu, Michelle M. Chen Source Type: research

Surgical Management of Advanced Glottic Cancer
In advanced glottic cancer, it is widely known that definitive chemoradiation can result in comparable survival outcomes to primary surgery. This deserves consideration given the immense effects total laryngectomy (TL) has on patients. It is important to consider that not all advanced glottic tumors should be treated in the same way, and surgical management remains a critical consideration for optimization of local control and survival outcomes. Advances in organ preservation surgery and the more developed understanding of the survival benefits of TL in extensive T4 disease further support the importance of surgery in the ...
Source: Otolaryngologic clinics of North America - April 1, 2023 Category: ENT & OMF Authors: Seerat K. Poonia, Elizabeth Nicolli Source Type: research

Radiation for Early Glottic Cancer
Multidisciplinary evaluation of early-stage glottic cancer facilitates optimal treatment with either surgery or radiation therapy. Standard of care radiation treatment of early-stage glottic cancer continues to be three-dimensional opposed lateral fields to include the whole larynx. Modern radiation treatment techniques are allowing studies to examine the efficacy and toxicity of altered doses and treatment volumes. Advanced techniques, such as stereotactic body radiation therapy or single-vocal cord irradiation, are not yet considered standard of care for early-stage glottic cancer and should be performed at institutions ...
Source: Otolaryngologic clinics of North America - April 1, 2023 Category: ENT & OMF Authors: Caitlin A. Schonewolf, Jennifer L. Shah Source Type: research

Surgical Treatment of Early Glottic Cancer
This article focuses on various approaches to the surgical treatment of early glottic cancer. Details include the clinical and radiological evaluation of laryngeal cancer, the goals of treatment, current surgical options for early disease, approach to surgical resection margins and management of nodal disease, and complications associated with each treatment modality. (Source: Otolaryngologic clinics of North America)
Source: Otolaryngologic clinics of North America - April 1, 2023 Category: ENT & OMF Authors: Jennifer A. Silver, Sena Turkdogan, Catherine F. Roy, Karen M. Kost Source Type: research