Perioperative considerations in free flap surgery: A review of pressors and anticoagulation
The head and neck plays a critical role in multiple homeostatic processes. Many of these are noticeable in everyday social interaction. From a physiologic perspective: eating, drinking, articulation, swallowing, and the ability to maintain weight are dependent on intact anatomy and function of the head and neck structures. Any procedure that interferes with the anatomy and thus the physiologic processes will have a debilitating effect on the patient. Whether it is psychological, a cosmetic deformity or a physiological dysfunction, these issues need to be addressed. (Source: Oral Oncology)
Source: Oral Oncology - June 27, 2018 Category: Cancer & Oncology Authors: Mark K. Wax, James Azzi Source Type: research
Oropharyngeal cancer is no longer a disease of younger patients and the prognostic advantage of Human Papillomavirus is attenuated among older patients: Analysis of the National Cancer Database
Human papillomavirus (HPV) is responsible for a unique and growing subset of oropharyngeal cancers (OPCs) in the United States (U.S.) [1]. These HPV-positive OPCs (HPV-OPCs) arise primarily from the immunologically specialized reticulated stratified squamous lymphoepithelium investing the lymphoid tissues of the palatine and lingual tonsils, rather than the continuous stratified squamous epithelium of the soft palate and posterior pharyngeal walls that more often harbors HPV-negative OPCs [2,3]. (Source: Oral Oncology)
Source: Oral Oncology - June 26, 2018 Category: Cancer & Oncology Authors: Eleni M. Rettig, Munfarid Zaidi, Farhoud Faraji, David W. Eisele, Margueritta El Asmar, Nicholas Fung, Gypsyamber D'Souza, Carole Fakhry Source Type: research
Gastro-omental free flap for reconstruction of tongue defects
Surgery is an integral part of the management of oral tongue carcinoma either alone or in combination with adjuvant radiotherapy or chemoradiotherapy [1]. Resection of carcinoma of tongue usually entails a wide resection of the tumor with adequate margins, which can amount to a partial, sub -total or a total glossectomy. Microvascular reconstructive surgery has made a profound impact on improving the outcomes in the management of tongue cancer [2]. Adjuvant radiotherapy in advanced carcinoma of tongue can lead to xerostomia and fibrosis that seriously affects the patient ’s quality of life by directly interfering with sw...
Source: Oral Oncology - June 23, 2018 Category: Cancer & Oncology Authors: Sivakumar Vidhyadharan, Krishnakumar Thankappan, Ramu Janarthanan, Deepak Balasubramanian, Mohit Sharma, Jimmy Mathew, Othiyil Vayoth Sudheer, Subramania Iyer Source Type: research
Validation and assessment of discordance of the 8th edition AJCC (American Joint Committee on Cancer) clinical and pathologic staging systems in patients with p16+ oropharyngeal cancer treated with surgery and adjuvant radiation at a single institution
Major updates have been made in the latest (8th) edition of the American Joint Commission on Cancer (AJCC) manual for staging of oropharynx squamous cell cancer (OPSCC) [1,2] which are based on changes in epidemiology of OPSCC related to the emergence of Human Papilloma Virus (HPV) as the major cause for OPSCC [3,4]. It is now recognized that patients with HPV positive oropharyngeal cancer (HPV+OPSCC) have superior survival compared to patients with HPV negative oropharynx cancer (HPV −OPSCC) [5]. (Source: Oral Oncology)
Source: Oral Oncology - June 23, 2018 Category: Cancer & Oncology Authors: Piyush Gupta, Jocelyn C. Migliacci, Ashley Hay, Matthew Rosenthal, Ximena Mimica, Nancy Lee, Richard J. Wong, Jatin Shah, Snehal Patel, Ian Ganly Source Type: research
Pattern of and survival following loco-regional and distant recurrence in patients with HPV+ and HPV − oropharyngeal squamous cell carcinoma: A population-based study
The incidence of patients diagnosed with human papillomavirus positive (HPV+) oropharyngeal squamous cell carcinoma (OPSCC) is increasing. Nevertheless, this OPSCC group has a markedly better prognosis compared with the tobacco-related (HPV −) OPSCCs [1–3]. Regardless, up to 25% of patients with HPV+ OPSCC encounter disease recurrence within three years of completed treatment [4–6]. The risk of short-term loco-regional failure is reported low for patients with HPV+ or p16+ (a surrogate marker for HPV) tumors compared to patients with HPV or p16 negative tumors. (Source: Oral Oncology)
Source: Oral Oncology - June 22, 2018 Category: Cancer & Oncology Authors: Christian Gr ønhøj, Kathrine Kronberg Jakobsen, David H. Jensen, Jacob Rasmussen, Elo Andersen, Jeppe Friborg, Christian von Buchwald Source Type: research
The course of sexual interest and enjoyment in head and neck cancer patients treated with primary (chemo)radiotherapy
Sexual issues are often reported in patients with cancer [1] and include changes in sexual function (e.g., decreased sexual desire and arousal, vaginal dryness, erectile and orgasm dysfunctions) and changes in sexual activity. Sexual issues can lead to significant distress and have a negative effect on well-being [2,3] and health-related quality of life [4,5] of cancer patients. So far, most research on cancer and sexuality has been performed in patients with breast, prostate, or gynecological cancer, who, given the tumor site, are at high risk for developing sexual issues during and/or after treatment. (Source: Oral Oncology)
Source: Oral Oncology - June 22, 2018 Category: Cancer & Oncology Authors: H.C. Melissant, F. Jansen, L.E.R. Schutte, B.I. Lissenberg-Witte, J. Buter, C.R. Leemans, M.A. Sprangers, M.R. Vergeer, E.T.M. Laan, I.M. Verdonck-de Leeuw Source Type: research
The possible contemporary presence of BRONJ and oral squamous cell carcinoma
Dear Editor, (Source: Oral Oncology)
Source: Oral Oncology - June 22, 2018 Category: Cancer & Oncology Authors: Valentina Terenzi, Andrea Cassoni, Edoardo Coiante, Davide Spadoni, Carlo Della Rocca, Angelina Pernazza, Valentino Valentini Tags: Letter to the editor Source Type: research
Letter to the editor: “Utility of PET-CT in detecting nodal metastasis in cN0 early stage oral cavity squamous cell carcinoma”
To the editor: (Source: Oral Oncology)
Source: Oral Oncology - June 22, 2018 Category: Cancer & Oncology Authors: Yubin Cao, Chunjie Li, Longjiang Li Tags: Letter to the editor Source Type: research
A prospective analysis of prevalence of metastasis in levels IIB and V neck nodes in patients with operable oral squamous cell carcinoma
Oral cavity cancers are one of the leading causes of cancers in India, where chewing of betel, pan and areca is a common habit. The cancers of the oral cavity have highest risk of spread to levels I to III neck nodes. The skip metastasis to level IV or V in the absence of disease in level I to III is exceedingly rare. While surgically managing the neck, the type of neck dissection depends on the clinical status of the neck nodes and consists of selective neck dissection (SND) for clinically node negative patients and modified neck dissection (MND) for clinically involved neck. (Source: Oral Oncology)
Source: Oral Oncology - June 20, 2018 Category: Cancer & Oncology Authors: Sriharsha Haranadh, Rukmangadha Nandyala, Vijayalakshmidevi Bodagala, Narendra Hulikal Source Type: research
Emergency department visits and unplanned hospitalizations in the treatment period for head and neck cancer patients treated with curative intent: A population-based analysis
With the epidemic rise in the incidence of head and neck cancers, particularly HPV-related oropharyngeal squamous cell carcinoma [1,2], and a growing elderly population which is more susceptible to head and neck cancers [2], more patients will require treatment in an already strained healthcare environment. Since the Institute of Medicine ‘Quality Chiasm’ report in 2001 many health care systems are dedicated to a process of ongoing quality improvement and to close the performance gap in areas where current state and ideal care are wide [3–5]. (Source: Oral Oncology)
Source: Oral Oncology - June 19, 2018 Category: Cancer & Oncology Authors: A. Eskander, M.K. Krzyzanowska, H.D. Fischer, N. Liu, P.C. Austin, J.C. Irish, D.J. Enepekides, J. Lee, E. Gutierrez, E. Lockhart, M. Raphael, S. Singh Source Type: research
Prognostic and clinicopathological significance of cyclin D1 expression in oral squamous cell carcinoma: A systematic review and meta-analysis
Oral cancer has a worldwide incidence of 300,400 cases and is responsible for 145,400 deaths a year (GLOBOCAN, IARC, WHO) [1]. Oral squamous cell carcinoma (OSCC) represents around 90% of malignant oral neoplasms [2] and has a 5-year survival rate of 50 –60% [2,3]. Prediction of the prognosis is of major importance and is usually based on the Tumor Node Metastasis (TNM) staging system, with N+ status and the presence of extracapsular spread predicting a worse prognosis [4,5]. The prognostic value of molecular biomarkers has attracted considerable research interest [6,7], and evidence has accumulated on a key role for cyc...
Source: Oral Oncology - June 18, 2018 Category: Cancer & Oncology Authors: Pablo Ramos-Garc ía, Miguel Ángel González-Moles, Lucía González-Ruiz, Isabel Ruiz-Ávila, Ángela Ayén, José Antonio Gil-Montoya Tags: Review Source Type: research
Editorial Board/Aims & Scope
(Source: Oral Oncology)
Source: Oral Oncology - June 15, 2018 Category: Cancer & Oncology Source Type: research
Oncogenic drivers in 11q13 associated with prognosis and response to therapy in advanced oropharyngeal carcinomas
In the last decades, several epidemiological studies have revealed decreased incidence of head and neck squamous cell carcinomas (HNSCC) in oral cavity and larynx as a consequence of lower exposure to the tobacco products. Nevertheless, an increasing incidence of oropharyngeal squamous cell carcinomas (OPSCC) mainly associated with oncogenic human papillomavirus (HPV) has been reported [1 –6]. (Source: Oral Oncology)
Source: Oral Oncology - June 15, 2018 Category: Cancer & Oncology Authors: M.C. Barros-Filho, L.A. Reis-Rosa, M. Hatakeyama, F.A. Marchi, T. Chulam, C. Scapulatempo-Neto, U.R. Nicolau, A.L. Carvalho, C.A.L. Pinto, S.A. Drigo, L.P. Kowalski, S.R. Rogatto Source Type: research
Risk of plate removal in free flap reconstruction of the mandible
Osteocutaneous free flap surgery is the gold standard for mandibular reconstruction following major head and neck oncologic resections [1]. While a variety of flaps exist for reconstruction of the mandible, osteocutaneous free flap reconstruction is most commonly employed given the need for bony reconstruction for both functional and aesthetic purposes [2]. The three most commonly used osteocutaneous flaps are the osteocutaneous radial forearm flap (OCRFF), the fibular flap, and the osteocutaneous scapular flap (OCSF). (Source: Oral Oncology)
Source: Oral Oncology - June 15, 2018 Category: Cancer & Oncology Authors: C. Burton Wood, Justin R. Shinn, Shaunak N. Amin, Sarah L. Rohde, Robert J. Sinard Source Type: research
Nomogram for preoperative prediction of nodal extracapsular extension or positive surgical margins in oropharyngeal squamous cell carcinoma
The management of oropharyngeal squamous cell carcinoma (OPSCC) has undergone a significant transformation over the last two decades, reflecting the increasing incidence of human papillomavirus (HPV) that some experts have called an epidemic [1]. Patients with HPV-associated OPSCC are primarily younger, healthier individuals with little or no tobacco exposure [2]. They tend to have increased response to treatment compared to patients with OPSCC associated with tobacco and alcohol use and thus have much better oncologic outcomes [2,3]. (Source: Oral Oncology)
Source: Oral Oncology - June 13, 2018 Category: Cancer & Oncology Authors: Mohammad K. Hararah, William A. Stokes, Bernard L. Jones, Ayman Oweida, Ding Ding, Jessica McDermott, Julie Goddard, Sana D. Karam Source Type: research
