On the studies of time periods in head and neck cancer diagnosis and treatment
We have read with great interest the valuable paper by Polesel et al. [1] published early this year, where their authors conclude that HNSCC treated within 45 days from diagnosis have increased survival probabilities and also that early-stage patients suffered the most from diagnostic delay. (Source: Oral Oncology)
Source: Oral Oncology - December 27, 2017 Category: Cancer & Oncology Authors: Pablo Varela-Centelles, Jos é M. García-Martín, Juan Seoane-Romero Tags: Letter to the editor Source Type: research
Proportion of CD4 and CD8 tumor infiltrating lymphocytes predicts survival in persistent/recurrent laryngeal squamous cell carcinoma
Recurrent and persistent head and neck squamous cell carcinoma is becoming an increasingly important cohort for head and neck cancer providers. While curative treatment is achieved in many instances, approximately 25 –50% of patients with head and neck squamous cell carcinoma will experience recurrence, and the overall median survival for those with recurrent disease who undergo treatment is less than 22 months [1]. Treatment for recurrence tends to be difficult, as these tumors are often resistant to standa rd therapy, complication rates are higher, and prognosis is guarded [2]. (Source: Oral Oncology)
Source: Oral Oncology - December 25, 2017 Category: Cancer & Oncology Authors: Rebecca Hoesli, Andrew C. Birkeland, Andrew J. Rosko, Mohamad Issa, Kelsey L. Chow, Nicole L. Michmerhuizen, Jacqueline E. Mann, Steven B. Chinn, Andrew G. Shuman, Mark E. Prince, Gregory T. Wolf, Carol R. Bradford, Jonathan B. McHugh, J. Chad Brenner, Ma Source Type: research
Assessing miRNAs profile expression as a risk stratification biomarker in oral potentially malignant disorders: A systematic review
Lip, oral cavity and oropharyngeal cancer (OCC-OPC) continues to be a significant worldwide health problem. The global estimated incidence of OCC-OPC is projected to rise by 66.4% by 2030; it specifically will increase from 442,760 in 2012 to 666,432 in 2030 [1]. It is also estimated that OCC-OPC will be responsible for 368,684 deaths in 2030 from that estimated of 241,458 in 2012 [1]. Oral squamous cell carcinoma (OSCC) is the most common form and accounts 95% of all oral malignancies [2]. The prevalence of OSCC is highly related to the consumption of tobacco, smoking, alcohol drinking, betel quid chewing, the presence of...
Source: Oral Oncology - December 22, 2017 Category: Cancer & Oncology Authors: Haytham El-Sakka, Omar Kujan, Camile S. Farah Tags: Review Source Type: research
Sensitivity and specificity of oral HPV detection for HPV-positive head and neck cancer
Human papillomavirus (HPV) is a sexually transmitted infection that causes most oropharyngeal cancer cases in the United States [1,2]. While there are over 100 types of HPV, only 13 are considered carcinogenic, most notably HPV16 [3]. The proportion of oropharyngeal cancers in the U.S. that are caused by HPV has increased from approximately 20% in 1990 to more than 70%, and the incidence of HPV-related oropharyngeal squamous cell carcinoma (HPV-OPSCC) has increased 225% over the past 20 years [2]. (Source: Oral Oncology)
Source: Oral Oncology - December 22, 2017 Category: Cancer & Oncology Authors: Brooke J. Gipson, Hilary A. Robbins, Carole Fakhry, Gypsyamber D'Souza Source Type: research
A squamous odontogenic tumor following an orthodontic micro-screw: A rare case report and review of the literature
We reported a very rare case of squamous odontogenic tumor(SOT) in a 23-year-old female. The tumor arose after an implanting operation of an orthodontic micro-screw, and was definitely diagnosed by the histopathological examination. Based on the case report and a review of the literature, we discussed about the general features, differential diagnosis and pathogenesis of SOT. (Source: Oral Oncology)
Source: Oral Oncology - December 21, 2017 Category: Cancer & Oncology Authors: Jingqiu Tu, Ping Yin, Yunyi Yuan, Jie Chen, Yongxiang Yuan, Yonghua Lei Tags: Letter to the editor Source Type: research
Head and neck squamous cell carcinoma of unknown primary: Outcomes of a pre-defined institutional treatment policy in a region with a high prevalence of skin cancer
Head and neck squamous cell carcinoma of unknown primary (UKP HNSCC) comprises up to 7% of all HNSCC metastatic to regional lymph nodes in the absence of distant metastatic disease [1]. (Source: Oral Oncology)
Source: Oral Oncology - December 20, 2017 Category: Cancer & Oncology Authors: Michael Huo, Benedict Panizza, Anne Bernard, Sandro V. Porceddu Source Type: research
Intraoral ultrasonography to measure tumor thickness of oral cancer: A systematic review and meta-analysis
Head and neck cancer is the sixth most common malignancy worldwide of which approximately one third consists of oral squamous cell carcinoma (OSCC) [1,2]. For early OSCC (Stage I-II), surgery is the preferred treatment choice. Its complete removal is essential for locoregional control and disease-free survival [3]. Most authors agree that adequate histopathological resection margins are crucial, although it is debated how wide surgical margins should be [4 –9]. For all T-stages, free margins of at least 5 mm to the tumor invasive front are accepted as “negative” resection margins. (Source: Oral Oncology)
Source: Oral Oncology - December 18, 2017 Category: Cancer & Oncology Authors: Thomas J.W. Klein Nulent, Rob Noorlag, Ellen M. Van Cann, Frank A. Pameijer, Stefan M. Willems, Adrian Yesuratnam, Antoine J.W.P. Rosenberg, Remco de Bree, Robert J.J. van Es Tags: Review Source Type: research
Postoperative staging of the neck dissection using extracapsular spread and lymph node ratio as prognostic factors in HPV-negative head and neck squamous cell carcinoma patients
Lymph node status is one of the most important clinical predictors of survival for head and neck squamous cell carcinoma (HNSCC) patients. The standard pathological nodal staging (pN) of a neck dissection considers the number, size and location of positive lymph nodes. (Source: Oral Oncology)
Source: Oral Oncology - December 18, 2017 Category: Cancer & Oncology Authors: Katarina Majercakova, Cristina Valero, Montserrat L ópez, Jacinto García, Nuria Farré, Miquel Quer, Xavier León Source Type: research
Venous thromboembolism incidence in head and neck surgery patients: Analysis of the Veterans Affairs Surgical Quality Improvement Program (VASQIP) database
Venous thromboembolism (VTE), which consists of deep vein thrombosis (DVT) and pulmonary embolism (PE), is the most common preventable cause of mortality in hospitalized patients, accounting for approximately 10% of annual hospital deaths [1,2]. VTE is particularly common post-operatively, as surgery can increase the risk 20-fold [3]. Without prophylaxis, VTE incidence in many surgical patients is estimated to be 15 –40% [2]. Certain subsets of surgical patients are known to have an even greater risk of VTE – for example, oncology patients undergoing surgical resection experience an estimated 2 times higher incidence o...
Source: Oral Oncology - December 15, 2017 Category: Cancer & Oncology Authors: Alia Mowery, Tyler Light, Daniel Clayburgh Source Type: research
Influence of tumor and microenvironment characteristics on diffusion-weighted imaging in oropharyngeal carcinoma: A pilot study
In head and neck squamous cell carcinomas (HNSCC) imaging plays a major role in staging, response evaluation and early detection of recurrent disease. Magnetic resonance imaging (MRI) is a modality which is increasingly used, since it provides excellent soft-tissue contrast. Besides conventional anatomical images, additional functional MRI sequences are applied, such as diffusion weighted MRI (DWI). DWI quantifies the restriction of random motion of water molecules in tissues as the apparent diffusion coefficient (ADC) [1,2]. (Source: Oral Oncology)
Source: Oral Oncology - December 12, 2017 Category: Cancer & Oncology Authors: Justin E. Swartz, Juliette P. Driessen, Pauline M.W. van Kempen, Remco de Bree, Luuk M. Janssen, Frank A. Pameijer, Chris H.J. Terhaard, Marielle E.P. Philippens, Stefan Willems Source Type: research
Treatment outcomes of nasopharyngeal carcinoma in modern era after intensity modulated radiotherapy (IMRT) in Hong Kong: A report of 3328 patients (HKNPCSG 1301 study)
Nasopharyngeal carcinoma (NPC) is an endemic malignancy in Southern China and South-East Asia. The mainstay treatment is radiotherapy (RT) with or without concurrent chemotherapy (CRT). Lee et al. reported the results of NPC treated in Hong Kong (HK) from 1996 to 2000 [1]. Since then, the standard care of NPC has undergone major changes in the decades that followed, which included adopting the 7th edition of the American Joint Committee on Cancer and International Union Against Cancer (AJCC/UICC) [2,3] staging system, employing magnetic resonance imaging (MRI) as standard radiological staging of loco-regional disease, addi...
Source: Oral Oncology - December 12, 2017 Category: Cancer & Oncology Authors: K.H. Au, Roger K.C. Ngan, Alice W.Y. Ng, Darren M.C. Poon, W.T. Ng, K.T. Yuen, Victor H.F. Lee, Stewart Y. Tung, Anthony T.C. Chan, Henry C.K. Sze, Ashley C.K. Cheng, Anne W.M. Lee, Dora L.W. Kwong, Anthony H.P. Tam Source Type: research
Compositional and functional variations of oral microbiota associated with the mutational changes in oral cancer
Oral cancer is a prevalent malignancy globally, with a huge majority ( ∼90%) of cases being oral squamous cell carcinoma (OSCC) [1]. In spite of advances in etiological studies and therapeutic options, the mortality of OSCC has not improved substantially over the past decades [2]. It is known that OSCC is a multifactorial neoplasm in which genetic variants interact w ith environmental triggers in the predisposition to this disease [3]. Various genetic alterations that influence cell cycle, apoptosis, and DNA repair [4] alone or in combination with external risks, including human papillomavirus (HPV) infection and habitua...
Source: Oral Oncology - December 11, 2017 Category: Cancer & Oncology Authors: Shun-Fa Yang, Hsien-Da Huang, Wen-Lang Fan, Yuh-Jyh Jong, Mu-Kuan Chen, Chien-Ning Huang, Chun-Yi Chuang, Yu-Lun Kuo, Wen-Hung Chung, Shih-Chi Su Source Type: research
Altered fractionation radiotherapy combined with concurrent low-dose or high-dose cisplatin in head and neck cancer: A systematic review of literature and meta-analysis
Improving patient outcomes, as the ultimate goal in oncology, greatly depends on concentrated efforts to promote public health programs, overcome challenges in diagnosis and disease management, and expand health care availability. In squamous cell carcinoma of the head and neck (SCCHN), the Surveillance, Epidemiology, and End Results (SEER) database revealed a substantial enhancement of the 5-year overall survival rate from 54.7% in 1990s to 65.9% in 2000s, particularly in patients with tongue (including base of tongue) and tonsil cancers, in whom the proportion of prognostically favourable human papillomavirus (HPV)-posit...
Source: Oral Oncology - December 8, 2017 Category: Cancer & Oncology Authors: Petr Szturz, Kristien Wouters, Naomi Kiyota, Makoto Tahara, Kumar Prabhash, Vanita Noronha, David Adelstein, Jan B. Vermorken Tags: Review Source Type: research
Pre-Radiation dental considerations and management for head and neck cancer patients
In 2016, there were over 48,000 new cases of head and neck cancer (HNC) resulting in over 9,500 deaths in the United States alone [1]. Approximately 90% of HNC are squamous cell carcinomas [2]. It is widely known that major risk factors such as smoking, alcohol, and use of smokeless tobacco products are associated with head and neck squamous cell carcinoma (HNSCC) [3,4]. HNSCC has been known to have a high incidence of lymph node metastasis, with over two-thirds of patients presenting with regional lymph node involvement, and 10% presenting with distant metastases [5,6]. (Source: Oral Oncology)
Source: Oral Oncology - December 5, 2017 Category: Cancer & Oncology Authors: Kenneth Kufta, Michael Forman, Samuel Swisher-McClure, Thomas P. Sollecito, Neeraj Panchal Tags: Review Source Type: research
Oral cancer-derived exosomal NAP1 enhances cytotoxicity of natural killer cells via the IRF-3 pathway
Oral cancer (OC) is one of the most common cancers in the world, four-fifths of what occurred in developing countries [1,2]. The major treatments for OC are still primarily conventional therapies, i.e., surgery, radiotherapy and chemotherapy. Many patients with OC are diagnosed at locally advanced stages, and OC cases with distant metastasis or recurrence lack effective therapies. Immunotherapy has recently proved effective for several malignant tumor types, including OC. However, a systematic increase in median progression-free survival has not been observed [3,4]. (Source: Oral Oncology)
Source: Oral Oncology - December 1, 2017 Category: Cancer & Oncology Authors: Yingnan Wang, Xing Qin, Xueqin Zhu, Wanjun Chen, Jianjun Zhang, Wantao Chen Source Type: research
