Three-dimensional printing of patient-specific surgical plates in head and neck reconstruction: A prospective pilot study
Tumor ablation leads to head and neck defects, which brings about significant aesthetic and functional deficits. Surgical plates have been extensively used in head and neck reconstruction to stabilize bone segments since the twentieth century. Conventionally surgical plates are mass-produced with universal configurations that should be manually bended to match the individual bone anatomy. The plate bending procedure could be time- and energy-consuming, especially for inexperienced surgeons [1]. In order to achieve the desired contour in some complicated cases, surgical plates need to be bended repeatedly, which induces int...
Source: Oral Oncology - January 15, 2018 Category: Cancer & Oncology Authors: Wei-fa Yang, Wing Shan Choi, Yiu Yan Leung, Justin Paul Curtin, Ruxu Du, Chun-yu Zhang, Xian-shuai Chen, Yu-xiong Su Source Type: research
Influence of anemia and BMI on prognosis of laryngeal squamous cell carcinoma: Development of an updated prognostic model
In the Netherlands, over 38% of all head and neck squamous cell carcinoma (HNSCC) originates from the larynx [1]. Also, laryngeal squamous cell carcinoma (LSCC) has a favorable prognosis compared to HNSCC as a whole [1]. Treatment of LSCC can impair speech, swallowing and breathing, which have a profound impact on the quality of life [2,3]. Prognosis and morbidity of LSCC are therefore significant topics in communication between physicians and their patients. (Source: Oral Oncology)
Source: Oral Oncology - January 10, 2018 Category: Cancer & Oncology Authors: R.J.L.M. te Riele, E.A.C. Dronkers, M.H. Wieringa, M.J. De Herdt, A. Sewnaik, J.A. Hardillo, R.J. Baatenburg de Jong Source Type: research
Analysis of images for detection of oral epithelial dysplasia: A review
Cancer of the oral region is single most dominant and lethal health issue faced by humans at present. 575,500 new cases are diagnosed, and 335,000 deaths occur worldwide each year, but the frequency is particularly high in East Asian countries mainly in South and Central domain (India, Indonesia, Thailand, Sri Lanka, Bangladesh, and Pakistan) [1]. Oral cancer accounts for only 2 –4% in western nations but around 30–40% of all malignant neoplasms in the Indian subcontinent [2]. The recurrence of oral benign neoplastic ailment is elevated in India because of addictive oral habits, geographic and ethnic elements. (Source: Oral Oncology)
Source: Oral Oncology - January 10, 2018 Category: Cancer & Oncology Authors: Reetoja Nag, Raunak Kumar Das Tags: Review Source Type: research
Does volumetric measurement serve as an imaging biomarker for tumor aggressiveness of ameloblastomas?
Ameloblastomas are locally aggressive neoplasms of odontogenic epithelial origin [1]. With approximately 40% of all odontogenic tumors, this neoplastic entity constitutes the most frequent subtype, outnumbering keratocystic odontogenic tumors (KCOT) and odontogenic myxomas [2]. The World Health Organization (WHO) distinguishes the solid/multicystic, extraosseous, desmoplastic and unicystic subtype, each one showing differential clinical, radiological and biological characteristics [3]. The mean age at the time of diagnosis is approximately 36 years with a very broad age range (childhood to late adulthood) [4,5]. (Source: Oral Oncology)
Source: Oral Oncology - January 10, 2018 Category: Cancer & Oncology Authors: Ali-Farid Safi, Martin Kauke, Marco Timmer, Andrea Grandoch, Hans-Joachim Nickenig, Elif G ültekin, Reinhard Büttner, Matthias Kreppel, Joachim Zöller Source Type: research
Detecting tumour-positive resection margins after oral cancer surgery by spraying a fluorescent tracer activated by gamma-glutamyltranspeptidase
Surgery remains the treatment of choice for the curative therapy of squamous cell carcinoma (SCC), including oral cancer. A resection requires wide margins to ensure no residual tumour tissue is left behind after surgery. However, such resections often cause functional loss. In the case of oral cancer, inadequate resection margins (i.e. close and positive margins) are reported in up to 85% of these patients [1,2]. These patients more often develop local recurrences and regional neck metastases, resulting in decreased survival rates [3]. (Source: Oral Oncology)
Source: Oral Oncology - January 9, 2018 Category: Cancer & Oncology Authors: Maxime D. Slooter, Henricus J.M. Handgraaf, Martin C. Boonstra, Lily-Ann van der Velden, Shadhvi S. Bhairosingh, Ivo Que, Lorraine M. de Haan, Stijn Keereweer, Pieter B.A.A. van Driel, Alan Chan, Hisataka Kobayashi, Alexander L. Vahrmeijer, Clemens W.G.M. Source Type: research
Viable tumor in salvage neck dissections in head and neck cancer: Relation with initial treatment, change of lymph node size and human papillomavirus
Radiotherapy with or without concomitant systemic treatment is one of the main treatment strategies for patients with locally advanced head and neck squamous cell carcinoma (HNSCC). (Source: Oral Oncology)
Source: Oral Oncology - January 8, 2018 Category: Cancer & Oncology Authors: Karlijn van den Bovenkamp, Bart Dorgelo, Maartje G. Noordhuis, Bernard F.A.M. van der Laan, Bert van der Vegt, Hendrik P. Bijl, Jan L. Roodenburg, Boukje A.C. van Dijk, Sjoukje F. Oosting, Ed M.D. Schuuring, Johannes A. Langendijk, Gyorgy B. Halmos, Boude Source Type: research
Reconnoitre ameloblastic carcinoma: A prognostic update
Odontogenic tumours (OTs) are rare, heterogeneous group of neoplasms, unique to oral cavity, evolving from tissue associated with tooth development or its remnants. These tumours comprise 1% of all jaw tumours and include hamartomatous, benign as well as malignant entities. Most frequent OT is odontoma considered as ‘tooth hamartoma’, followed by ameloblastoma [1]. Ameloblastoma is a slow growing, benign and locally invasive neoplasm which may show malignant characteristics such as metastasis with or without cytological atypia. (Source: Oral Oncology)
Source: Oral Oncology - January 4, 2018 Category: Cancer & Oncology Authors: Tajindra Singh Saluja, Rashmi Hosalkar Tags: Review Source Type: research
Late radiation-associated dysphagia in head and neck cancer patients: evidence, research and management
In the last decades there has been a significant progress in treatment modalities of head and neck cancer (HNC) patients, especially in radiation therapy (RT) field. Globally, RT improved from three-dimensional to intensity modulated RT (IMRT) technique, which showed to be more effective in terms of target volume coverage and organs at risk (OAR) sparing [1]. Since IMRT plus concomitant chemotherapy – the standard treatment in locally advanced disease – improves survival outcomes achieved after RT alone, as well as increases side effects, great interest has been shown in the clinical evaluation of late RT-related toxic...
Source: Oral Oncology - January 4, 2018 Category: Cancer & Oncology Authors: F. De Felice, M. de Vincentiis, V. Luzzi, G. Magliulo, M. Tombolini, G. Ruoppolo, A. Polimeni Tags: Review Source Type: research
Mandibular reconstruction
Since the introduction of free tissue transfer, surgical techniques for mandibular reconstruction have continued to evolve at a rapid pace, leading to improved functional and aesthetic outcomes for patients. Several large series have reported excellent results with a variety of free flap osseous donor sites, establishing microvascular free tissue transfer with bone as the gold standard for reconstruction of the mandible [1 –4]. This review will cover current techniques for the reconstruction of mandibular defects, including the various plating strategies for rigid fixation, the choice of osseous donor site, and the concu...
Source: Oral Oncology - January 3, 2018 Category: Cancer & Oncology Authors: Kiran Kakarala, Yelizaveta Shnayder, Terance T. Tsue, Douglas A. Girod Source Type: research
Suggestions for surveillance and radiation strategy in nasopharyngeal carcinoma treated with IMRT: Based on hazard-rate and patterns of recurrence
Nasopharyngeal carcinoma (NPC) is highly radiochemosensitive and its locoregional control rate, which had been improved by the multidisciplinary approach, has approximated to 85% [1 –3]. Once recurrence, salvage strategy should be administered [4–9] and the location and extent of therecurrentdisease will determine the optimal therapy [10]. Nevertheless, the efficacies of evidence-based re-treatment are yet unsatisfactory for patients suffered recurrent diseases. It may part ly due to the delayed diagnosis of recurrence to advanced stage, which made the re-treatment even harder, so it is essential to discover the recurr...
Source: Oral Oncology - December 29, 2017 Category: Cancer & Oncology Authors: Tingting Xu, Xin Zhou, Chunying Shen, Chaosu Hu Source Type: research
Editorial Board/Aims & Scope
(Source: Oral Oncology)
Source: Oral Oncology - December 29, 2017 Category: Cancer & Oncology Source Type: research
Reader performance in the ultrasonographic evaluation of oropharyngeal carcinoma
Oropharyngeal carcinoma (OPC) is the most common head and neck cancer in North America [1] and is steadily increasing in incidence [2,3]. HPV-related OPC (HPV-OPC) arises primarily from the lymphoid-associated epithelia of the palatine tonsils and base of tongue (BOT) and exhibits a high rate of metastasis to cervical lymph nodes [4,5]. Patients with HPV-OPC often present with a persistently enlarged neck node, unaware of a small primary tumor present in the oropharynx [6]. HPV-OPCs are difficult to assess clinically due to their small size, and the anatomic topology of the oropharynx [6 –11]. (Source: Oral Oncology)
Source: Oral Oncology - December 29, 2017 Category: Cancer & Oncology Authors: Farhoud Faraji, Ericka S. Padilla, Dana Blitz, Meghan B. Wenderoth, Ray G. Blanco, Satomi Kawamoto, Sheila Sheth, Ulrike M. Hamper, Carole Fakhry Source Type: research
Prediction of distant metastasis and survival in adenoid cystic carcinoma using quantitative 18F-FDG PET/CT measurements
Salivary gland cancer is a rare disease that accounts for approximately 5% of all head and neck cancers and 0.3% of all human cancers [1 –3]. Salivary gland carcinoma arises in various regions of the major and minor salivary glands, presenting at least 24 different histological subtypes with different clinical features of metastasis and recurrence [4,5]. Distant metastases are relatively common in salivary gland carcinoma [6], and may be present at initial presentation or may emerge during the post-treatment period. (Source: Oral Oncology)
Source: Oral Oncology - December 28, 2017 Category: Cancer & Oncology Authors: Won Sub Lim, Jungsu S. Oh, Jong-Lyel Roh, Jae Seung Kim, Soo-Jong Kim, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim Source Type: research
HLA class I antigen processing machinery (APM) component expression and PD-1:PD-L1 pathway activation in HIV-infected head and neck cancers
Recent research has found that human immunodeficiency virus (HIV)-infected individuals are at increased risk for developing several non-AIDS related malignancies, with a reported higher incidence of both tobacco-related and virus-related cancers [1 –5]. The higher incidence of tobacco-related cancers among HIV-infected individuals [6,7] has been attributed to the significantly higher prevalence of cigarette smoking among HIV-infected compared with HIV-uninfected individuals (40–60% vs. 17%) [8,9]. (Source: Oral Oncology)
Source: Oral Oncology - December 28, 2017 Category: Cancer & Oncology Authors: Sara I. Pai, J. Jack Lee, Thomas E. Carey, William H. Westra, Soldano Ferrone, Charles Moore, Marina B. Mosunjac, Dong M. Shin, Robert L. Ferris, on behalf of the HNC SPORE HIV supplement consortium Source Type: research
59 years old male with local advanced adenoid cystic carcinoma of the hypopharynx – A case report and a review of the literature
Anatomically, the palate is the commonest site of minor salivary gland tumours, followed by paranasal sinuses, nasal cavity and the larynx [1]. Adenoid cystic carcinoma (AdCC) is the most common subtype of minor salivary gland tumours representing around 10% of all malignant salivary gland tumour [2]. The main cornerstone of treatment is the surgical resection while the role of radiotherapy and chemotherapy are still controversial [3]. Several prognostic factors have been identified such as free resection margin, nodal negativity and negative neural invasion [3]. (Source: Oral Oncology)
Source: Oral Oncology - December 28, 2017 Category: Cancer & Oncology Authors: Amr Muhammed, Ahmed Mohamed, Esraa Elnakib, Amal Omar, Nahawand Elnakib Tags: Review Source Type: research
