Cause-specific mortality in patients with head and neck cancer: Long-term follow-up of a population-based cohort from 1986 to 2012 accounting for competing risks
Head and neck squamous cell carcinoma (HNSCC) is a common malignancy with approximately 630,000 annual cases diagnosed worldwide [1]. Despite the declining prevalence of smoking, the incidence of HNSCC is increasing [2], although the 5-year relative survival rate has improved somewhat through a changing etiology coupled with a rise in human papillomavirus (HPV)-associated disease and advances in treatment [3,4]. (Source: Oral Oncology)
Source: Oral Oncology - February 20, 2018 Category: Cancer & Oncology Authors: Janne A. V äisänen, Olli-Pekka Alho, Petri T. Koivunen, Esa Läärä Source Type: research
Optimizing the induction chemotherapy regimen for patients with locoregionally advanced nasopharyngeal Carcinoma: A big-data intelligence platform-based analysis
This study aimed at identifying the optimal induction chemotherapy regimen for patients with locoregionally advanced nasopharyngeal carcinoma (NPC) treated by intensity-modulated radiotherapy. (Source: Oral Oncology)
Source: Oral Oncology - February 20, 2018 Category: Cancer & Oncology Authors: Hao Peng, Ling-Long Tang, Bin-Bin Chen, Lei Chen, Wen-Fei Li, Yan-Ping Mao, Xu Liu, Yuan Zhang, Li-Zhi Liu, Li Tian, Ying Guo, Ying Sun, Jun Ma Source Type: research
The impact of HPV status on weight loss and feeding tube use in oropharyngeal carcinoma
Patients with oropharyngeal carcinoma (OPC) are at nutritional risk due to the effects of the tumour itself and the toxicities of the treatment modalities used [1 –3]. It has been well established that malnutrition and weight loss is common in head and neck cancer (HNC), and critical weight loss (CWL) (defined as ≥5% loss in one month [4,5]), has been shown to affect outcomes and survival [6–8]. The epidemiology of OPC has changed in the last decade wit h the increasing incidence of human papillomavirus (HPV)-associated disease [9]. (Source: Oral Oncology)
Source: Oral Oncology - February 20, 2018 Category: Cancer & Oncology Authors: Belinda Vangelov, Damian P. Kotevski, Janet R. Williams, Robert I. Smee Source Type: research
Tumor volume as a predictor of survival in T3 glottic carcinoma: A novel approach to patient selection
Advanced laryngeal cancer will affect over 4000 Americans this year [1]. Critical functions of breathing, swallowing and speech may be decimated by the disease if not by our treatments for the disease. Thus, modern head and neck cancer care strives to achieve a delicate balance between maximizing survival, functional outcomes and quality of life. (Source: Oral Oncology)
Source: Oral Oncology - February 20, 2018 Category: Cancer & Oncology Authors: Peter T. Dziegielewski, William J. Reschly, Chris G. Morris, Reordan Danny DeJesus, Natalie Silver, Brian J. Boyce, Inocente Santiago, Robert J. Amdur, William M. Mendenhall Source Type: research
Oculosympathetic paresis after selective neck dissection: A ‘distant’ complication
A 76 year old Caucasian lady underwent left sided selective neck dissection as part of her ablative surgery for poorly differentiated squamous cell carcinoma (SCC) of the left lingual mucosa. Postoperatively, the patient had no immediate surgical complications except that she complained of drooping of the left eyelid in the immediate aftermath (see Figs. 1 and 2). (Source: Oral Oncology)
Source: Oral Oncology - February 16, 2018 Category: Cancer & Oncology Authors: S. Mumtaz, J. Parrish, M. Singh Tags: Letter to the editor Source Type: research
Hyperglycemia and risk of adverse outcomes following microvascular reconstruction of oncologic head and neck defects
Ample evidence of the deleterious effects of poor glycemic control on clinical outcomes following major surgical procedures have emerged over the past two decades [1]. Increased post-operative complications have been reliably associated with hyperglycemia in patients undergoing mastectomy [2], colon resection [3], vascular surgery [4], hernia repair [5] and cardiac surgery [6]. The literature is particularly robust with respect to the link between tight glycemic control and a decreased incidence of post-operative infections following cardiac surgery [7,8]. (Source: Oral Oncology)
Source: Oral Oncology - February 13, 2018 Category: Cancer & Oncology Authors: Anaeze C. Offodile, Hsuan-Yu Chou, Jennifer An-Jou Lin, Charles Yuen Yung Loh, Kai-Ping Chang, Mario A. Aycart, Huang-Kai Kao Source Type: research
Clinical outcomes and prognostic factors in cisplatin versus cetuximab chemoradiation for locally advanced p16 positive oropharyngeal carcinoma
Definitive chemoradiation (CRT) is an effective organ-preserving treatment for locally advanced oropharyngeal cancer (OPC) [1,2]. As median survival times increase, reducing the often debilitating short and long-term morbidities associated with the standard concurrent cisplatin-based approach has become the focus of multiple clinical trials. This is especially true in patients with p16 positive (p16+) disease who are generally younger, healthier, and have higher treatment response rates [3]. One approach to toxicity reduction has been replacing cisplatin with the targeted systemic agent cetuximab, which is an epidermal gro...
Source: Oral Oncology - February 12, 2018 Category: Cancer & Oncology Authors: Christian L. Barney, Steve Walston, Pedro Zamora, Erin H. Healy, Nicole Nolan, Virginia M. Diavolitsis, Anterpreet Neki, Robert Rupert, Panos Savvides, Amit Agrawal, Matthew Old, Enver Ozer, Ricardo Carrau, Stephen Kang, James Rocco, Theodoros Teknos, Joh Source Type: research
Three-dimensional imaging assessment of anatomic invasion and volumetric considerations for chemo/radiotherapy-based laryngeal preservation in T3 larynx cancer
The concept of nonsurgical laryngeal preservation was demonstrated as an alternative to total laryngectomy (TL) for patients with locally advanced laryngeal cancer in the landmark “Department of Veterans Affairs (VA) Laryngeal Cancer Study“ (VALCS) in 1991 [1]. While advocating a general role for nonsurgical therapy for advanced laryngeal cancer, the VA study did suggest that this approach was less successful for patients with the most advanced (but resectable) disease, s ince 56% of patients with T4 disease required salvage laryngectomy compared with 29% with smaller tumors. (Source: Oral Oncology)
Source: Oral Oncology - February 11, 2018 Category: Cancer & Oncology Authors: Mona Kamal, Sweet Ping Ng, Salman A. Eraj, Crosby D. Rock, Brian Pham, Jay A. Messer, Adam S. Garden, William H. Morrison, Jack Phan, Steven J. Frank, Adel K. El-Naggar, Jason M. Johnson, Lawrence E. Ginsberg, Renata Ferrarotto, Jan S. Lewin, Katherine A. Source Type: research
Real time indocyanin green near infrared lymphangiography for the reduction of drainage volume after neck dissection
Neck dissection is an integral part of the surgical treatment for cancers in the head and neck region. The presence of lymph node metastasis, especially those with extra-capsular spread, is shown to have a negative impact on the survival outcome after treatment, warranting aggressive therapeutic neck dissection followed by adjuvant chemoradiation. On the other hand, in patients with clinically N0 necks, elective selective neck dissections are frequently performed for better staging of the cervical nodal status [1]. (Source: Oral Oncology)
Source: Oral Oncology - February 11, 2018 Category: Cancer & Oncology Authors: Jimmy Yu Wai Chan, Stanley Thian Sze Wong, William Ignace Wei Source Type: research
Phosphorylation of PI3K regulatory subunit p85 contributes to resistance against PI3K inhibitors in radioresistant head and neck cancer
Phosphatidylinositol 3 –kinase (PI3K)/AkT/mTOR axis regulates essential cellular functions, including cell metabolism, growth, migration, survival, and angiogenesis [1,2]. PI3K pathway activation is commonly observed in different cancers and is correlated with tumor development, progression, poor prognosis, and resistan ce to cancer therapies, including radiotherapy and chemotherapy [3–5]. Class IA PI3K is a heterodimeric protein containing a catalytic subunit (p110) and a regulatory subunit (p85). (Source: Oral Oncology)
Source: Oral Oncology - February 11, 2018 Category: Cancer & Oncology Authors: Myung Woul Han, In Sun Ryu, Jong Cheol Lee, Song Hee Kim, Hyo Won Chang, Yoon Sun Lee, Seulkina Lee, Seong Who Kim, Sang Yoon Kim Source Type: research
Neck recurrence in clinically node-negative oral cancer: 27-year experience at a single institution
The incidence of oral squamous cell carcinoma (OSCC) has gradually increased during the last 4 decades [1]. Despite advances in surgical techniques, radiation therapy (RT), and systemic agents, 5-year overall survival (OS) has plateaued at 65% [2]. With the exception of prevention measures and early-detection educational initiatives, there have been no major changes in the management of patients with OSCC, which is primarily surgical [3,4]. Disease-specific survival (DSS) and OS, are, in large part, dependent on achieving local and regional control [5]. (Source: Oral Oncology)
Source: Oral Oncology - February 11, 2018 Category: Cancer & Oncology Authors: Aviram Mizrachi, Jocelyn C. Migliacci, Pablo H. Montero, Sean McBride, Jatin P. Shah, Snehal G. Patel, Ian Ganly Source Type: research
