The risk of carotid stenosis in head and neck cancer patients after radiation therapy
The role of post-treatment screening for asymptomatic carotid artery stenosis (CAS) in the head and neck cancer (HNC) population is unclear. The United States Preventive Task Force does not recommend CAS screening in the general population due to low CAS prevalence ( (Source: Oral Oncology)
Source: Oral Oncology - March 14, 2018 Category: Cancer & Oncology Authors: David J. Carpenter, Yvonne M. Mowery, Gloria Broadwater, Anna Rodrigues, Amy J. Wisdom, Jennifer A. Dorth, Pretesh R. Patel, Cynthia K. Shortell, Robert Clough, David M. Brizel Source Type: research
Beneficial effects of anti-EGFR agents, Cetuximab or Nimotuzumab, in combination with concurrent chemoradiotherapy in advanced nasopharyngeal carcinoma
Nasopharyngeal carcinoma (NPC) is prevalent in southeast Asia and northern Africa, especially in southern China where the incidence can reach as high as 20/100,000 [1]. When newly diagnosed, most patients present with locoregionally advanced NPC [2]. According to the 2017 National Comprehensive Cancer network (NCCN) guidelines for head and neck cancer, concurrent chemoradiotherapy (CCRT) is recommended as basic treatment for stage II-IVb (AJCC/UICC 7th edition, 2011) NPC patients [3]. Compared to two-dimensional radiation therapy (2D-RT), intensity modulated radiation therapy (IMRT) achieved better local control rate up to...
Source: Oral Oncology - March 13, 2018 Category: Cancer & Oncology Authors: Mei Lin, Rui You, You-Ping Liu, Yi-Nuan Zhang, Hao-Jiong Zhang, Xiong Zou, Qi Yang, Chao-Feng Li, Yi-Jun Hua, Tao Yu, Jing-Yu Cao, Ji-Bin Li, Hao-Yuan Mo, Ling Guo, Ai-Hua Lin, Ying Sun, Chao-Nan Qian, Jun Ma, Hai-Qiang Mai, Ming-Yuan Chen Source Type: research
Cervicofacial actinomycosis can obscure a malignancy: A case report
A 72-year-old male presented with a diffuse growth on his left lower jaw region. The lesion started 1 year back as a small ulcer on his left cheek and gradually progressed to a diffuse growth involving most of his left lower jaw. The patient had a 50-year history of tobacco chewing. Intraoral examination revealed an ulcero-proliferative growth in the left buccal mucosa extending into the gingivob uccal sulcus. Multiple pus discharging sinuses were noted on the surface of the extra-oral lesion. Provisional diagnosis was Cervicofacial Actinomycosis. (Source: Oral Oncology)
Source: Oral Oncology - March 13, 2018 Category: Cancer & Oncology Authors: A. Thirumal Raj, Shankargouda Patil Tags: Letter to the editor Source Type: research
A turning point in therapy for ameloblastomas
Ameloblastoma is a benign but locally aggressive odontogenic neoplasm in the jaw and maxilla [1,2]. If untreated, these lesions can reach enormous sizes and sometimes pose an airway risk. Although most are nonmetastasizing, they frequently recur if not adequately resected [3]. The current standard therapy for ameloblastoma is complete bone resection (radical intervention) with an adequate margin of safety, which is classified as marginal or segmental osteotomy for the mandible, and partial or total maxillectomy for the maxilla [1,4]. (Source: Oral Oncology)
Source: Oral Oncology - March 13, 2018 Category: Cancer & Oncology Authors: Masanobu Abe, Liang Zong, Takahiro Abe, Kazuto Hoshi Tags: Letter to the editor Source Type: research
Cervicofacial actinomycosis can obscure a malignancy: A case report
A 72-year-old male presented with a diffuse growth on his left lower jaw region. The lesion started 1 year back as a small ulcer on his left cheek and gradually progressed to a diffuse growth involving most of his left lower jaw. The patient had a 50-year history of tobacco chewing. Intraoral examination revealed an ulcero-proliferative growth in the left buccal mucosa extending into the gingivob uccal sulcus. Multiple pus discharging sinuses were noted on the surface of the extra-oral lesion. Provisional diagnosis was Cervicofacial Actinomycosis. (Source: Oral Oncology)
Source: Oral Oncology - March 13, 2018 Category: Cancer & Oncology Authors: A. Thirumal Raj, Shankargouda Patil Tags: Letter to the editor Source Type: research
A turning point in therapy for ameloblastomas
Ameloblastoma is a benign but locally aggressive odontogenic neoplasm in the jaw and maxilla [1,2]. If untreated, these lesions can reach enormous sizes and sometimes pose an airway risk. Although most are nonmetastasizing, they frequently recur if not adequately resected [3]. The current standard therapy for ameloblastoma is complete bone resection (radical intervention) with an adequate margin of safety, which is classified as marginal or segmental osteotomy for the mandible, and partial or total maxillectomy for the maxilla [1,4]. (Source: Oral Oncology)
Source: Oral Oncology - March 13, 2018 Category: Cancer & Oncology Authors: Masanobu Abe, Liang Zong, Takahiro Abe, Kazuto Hoshi Tags: Letter to the editor Source Type: research
Myxoma of the mandibular condyle: Report of a rare case and review of the literature
This report describes an extremely rare case of myxoma of the mandibular condyle. The tumor occurred in the left mandibular condyle of a 42-year-old woman, which was identified in a routine radiographic examination. The clinico-radiographic and histopathological features, and histogenesis of the lesion are discussed. A review of the literature and differential diagnosis of radiolucent condylar lesions are also presented. (Source: Oral Oncology)
Source: Oral Oncology - March 9, 2018 Category: Cancer & Oncology Authors: Everaldo Pinheiro de Andrade Lima, Fl ávia Maria de Moraes Ramos-Perez, Rômulo Oliveira de Hollanda Valente, Jorge Esquiche León, Paulo Rogério Ferreti Bonan, Danyel Elias da Cruz Perez Tags: Letter to the editor Source Type: research
Chemoradiotherapy using retrograde superselective intra-arterial infusion for tongue cancer: Analysis of therapeutic results in 118 cases
The tongue is the most common site of oral cavity cancer, the incidence of which has been found to be rapidly increasing. Patients with squamous cell carcinoma (SCC) of the tongue have a significantly worse prognosis than patients with other oral cavity and other head and neck cancers, because of the high rates of local recurrence following definitive treatment [1]. Early stage tongue SCC is treated by glossectomy or definitive radiotherapy including interstitial brachytherapy. For patients with locally advanced oral SCC, including tongue SCC, primary surgery is widely accepted as the standard treatment, and adjuvant concu...
Source: Oral Oncology - March 8, 2018 Category: Cancer & Oncology Authors: Kenji Mitsudo, Yuichiro Hayashi, Shuhei Minamiyama, Nobuhide Ohashi, Masaki Iida, Toshinori Iwai, Senri Oguri, Toshiyuki Koizumi, Mitomu Kioi, Makoto Hirota, Izumi Koike, Masaharu Hata, Iwai Tohnai Source Type: research
Upfront surgery versus definitive chemoradiotherapy in patients with human Papillomavirus-associated oropharyngeal squamous cell cancer
Human papillomavirus-associated oropharyngeal squamous cell cancer (HPV-A OPC) incidence has increased significantly over the past two decades, accounting for over 70% of newly diagnosed OPC and now having an incidence higher than that of uterine cervical cancer [1,2]. HPV-A and HPV-negative OPCs are now considered distinct diseases, as evidenced by different etiologies, natural histories [3,4], biomolecular signatures [5 –7], treatment responsiveness [8], and staging systems [9]. Numerous prospective trials have demonstrated that HPV positivity confers improved prognosis compared to patients with similar stage HPV-negat...
Source: Oral Oncology - March 8, 2018 Category: Cancer & Oncology Authors: Jacqueline R. Kelly, Henry S. Park, Yi An, Wendell G. Yarbrough, Joseph N. Contessa, Roy Decker, Saral Mehra, Benjamin L. Judson, Barbara Burtness, Zain Husain Source Type: research
Chemoradiotherapy using retrograde superselective intra-arterial infusion for tongue cancer: Analysis of therapeutic results in 118 cases
The tongue is the most common site of oral cavity cancer, the incidence of which has been found to be rapidly increasing. Patients with squamous cell carcinoma (SCC) of the tongue have a significantly worse prognosis than patients with other oral cavity and other head and neck cancers, because of the high rates of local recurrence following definitive treatment [1]. Early stage tongue SCC is treated by glossectomy or definitive radiotherapy including interstitial brachytherapy. For patients with locally advanced oral SCC, including tongue SCC, primary surgery is widely accepted as the standard treatment, and adjuvant concu...
Source: Oral Oncology - March 8, 2018 Category: Cancer & Oncology Authors: Kenji Mitsudo, Yuichiro Hayashi, Shuhei Minamiyama, Nobuhide Ohashi, Masaki Iida, Toshinori Iwai, Senri Oguri, Toshiyuki Koizumi, Mitomu Kioi, Makoto Hirota, Izumi Koike, Masaharu Hata, Iwai Tohnai Source Type: research
Upfront surgery versus definitive chemoradiotherapy in patients with human Papillomavirus-associated oropharyngeal squamous cell cancer
Human papillomavirus-associated oropharyngeal squamous cell cancer (HPV-A OPC) incidence has increased significantly over the past two decades, accounting for over 70% of newly diagnosed OPC and now having an incidence higher than that of uterine cervical cancer [1,2]. HPV-A and HPV-negative OPCs are now considered distinct diseases, as evidenced by different etiologies, natural histories [3,4], biomolecular signatures [5 –7], treatment responsiveness [8], and staging systems [9]. Numerous prospective trials have demonstrated that HPV positivity confers improved prognosis compared to patients with similar stage HPV-negat...
Source: Oral Oncology - March 8, 2018 Category: Cancer & Oncology Authors: Jacqueline R. Kelly, Henry S. Park, Yi An, Wendell G. Yarbrough, Joseph N. Contessa, Roy Decker, Saral Mehra, Benjamin L. Judson, Barbara Burtness, Zain Husain Source Type: research
Hypothesizing the potential implications of exposing known carcinogens on normal stem cells
Cancer stem cells (CSCs) have been consistently linked with treatment resistance, cancer recurrence, and metastases [1,2]. Two possible origins for CSCs have been hypothesized [3]. (Source: Oral Oncology)
Source: Oral Oncology - March 5, 2018 Category: Cancer & Oncology Authors: A. Thirumal Raj, Supriya Kheur Tags: Letter to the editor Source Type: research
Overexpression of PIK3CA in head and neck squamous cell carcinoma is associated with poor outcome and activation of the YAP pathway
We have shown that in HNSCC tumors high expression of PIK3CA is a poor prognosis factor. Increased gene expression leads to augmented level of the p110 α protein. This correlates with a decrease in the phosphorylation of the YAP transcription regulator (YAP-P) enabling its translocation to the nucleus and the transcription of YAP-target genes that promote different processes involved in tumorigenesis. The connection between increased PIK3CA expres sion and YAP nuclear translocation has not been established yet at the molecular level (dotted red arrow). (Source: Oral Oncology)
Source: Oral Oncology - March 3, 2018 Category: Cancer & Oncology Authors: Ram ón García-Escudero, Carmen Segrelles, Marta Dueñas, María Pombo, Claudio Ballestín, Marina Alonso-Riaño, Pablo Nenclares, Roberto Álvarez-Rodríguez, Gregorio Sánchez-Aniceto, Ana Ruíz-Alonso, José Luis López-Cedrún, Jesús M. Paramio, Cor Source Type: research
