Dexamethasone Intracameral Drug-Delivery Suspension for Inflammation Associated with Cataract Surgery
To evaluate the safety and efficacy of an anterior chamber intracameral dexamethasone drug-delivery suspension (IBI-10090; DEXYCU; Icon Bioscience Inc., Newark, CA) that provides medication for up to 21 days with a single application in treating postoperative inflammation in patients undergoing cataract surgery. (Source: Ophthalmology)
Source: Ophthalmology - February 3, 2018 Category: Opthalmology Authors: Eric Donnenfeld, Edward Holland Source Type: research
Choroidal Nevi in the Singapore Epidemiology of Eye Disease Study
Choroidal nevus is a common intraocular tumor. Although choroidal nevus is usually a benign lesion, it has been associated with increased risk of developing uveal melanoma, and when located in the subfoveal region, it may affect vision. Only a few population-based studies have examined choroidal nevi on the basis of retinal photographs using standardized protocols. Such epidemiologic data are even more limited in Asia, with prevalence rates reported to widely range from 0.15% to 2.9% among different Asian populations. (Source: Ophthalmology)
Source: Ophthalmology - February 3, 2018 Category: Opthalmology Authors: Si Rui Ng, Wanting Zhao, Paul Mitchell, Jie Jin Wang, Hui Xian Valencia Foo, Kumari Neelam, Ching-Yu Cheng, Tien Yin Wong, Ning Cheung Tags: Reports Source Type: research
Ranibizumab Plus Panretinal Photocoagulation versus Panretinal Photocoagulation Alone for High-Risk Proliferative Diabetic Retinopathy (PROTEUS Study)
Comparison of the efficacy of ranibizumab (RBZ) 0.5 mg intravitreal injections plus panretinal photocoagulation (PRP) versus PRP alone in the regression of the neovascularization (NV) area in subjects with high-risk proliferative diabetic retinopathy (HR-PDR) over a 12-month period. (Source: Ophthalmology)
Source: Ophthalmology - February 3, 2018 Category: Opthalmology Authors: Jo ão Figueira, Emily Fletcher, Pascale Massin, Rufino Silva, Francesco Bandello, Edoardo Midena, Monica Varano, Sobha Sivaprasad, Haralabos Eleftheriadis, Geeta Menon, Miguel Amaro, Sarah Ayello Scheer, Catherine Creuzot-Garcher, João Nascimento, Dalil Tags: Original Article Source Type: research
Leber Congenital Amaurosis Associated with Mutations in CEP290, Clinical Phenotype, and Natural History in Preparation for Trials of Novel Therapies
To investigate and describe in detail the demographics, functional and anatomic characteristics, and clinical course of Leber congenital amaurosis (LCA) associated with mutations in the CEP290 gene (LCA-CEP290) in a large cohort of adults and children. (Source: Ophthalmology)
Source: Ophthalmology - February 2, 2018 Category: Opthalmology Authors: Leo Sheck, Wayne I.L. Davies, Phillip Moradi, Anthony G. Robson, Neruban Kumaran, Alki C. Liasis, Andrew R. Webster, Anthony T. Moore, Michel Michaelides Tags: Original Article Source Type: research
Conservatively Treated Orbital Blowout Fractures
To determine if conservatively treated blowout fractures of the orbit undergo spontaneous improvement based on radiologic findings. (Source: Ophthalmology)
Source: Ophthalmology - February 2, 2018 Category: Opthalmology Authors: Stephanie Ming Young, Yoon-Duck Kim, Sang Wook Kim, Han Byeol Jo, Stephanie S. Lang, Kyuyeon Cho, Kyung In Woo Source Type: research
Genome-Wide Association Study Reveals Variants in CFH and CFHR4 Associated with Systemic Complement Activation
To identify genetic variants associated with complement activation, which may help to select age-related macular degeneration (AMD) patients for complement-inhibiting therapies. (Source: Ophthalmology)
Source: Ophthalmology - February 1, 2018 Category: Opthalmology Authors: Laura Lor és-Motta, Constantin C. Paun, Jordi Corominas, Marc Pauper, Maartje J. Geerlings, Lebriz Altay, Tina Schick, Mohamed R. Daha, Sascha Fauser, Carel B. Hoyng, Anneke I. den Hollander, Eiko K. de Jong Source Type: research
Characterizing Disease Burden and Progression of Geographic Atrophy Secondary to Age-Related Macular Degeneration
To understand levels of disease burden and progression in a real-world setting among patients from the United Kingdom with bilateral geographic atrophy (GA) secondary to age-related macular degeneration (AMD). (Source: Ophthalmology)
Source: Ophthalmology - January 22, 2018 Category: Opthalmology Authors: Usha Chakravarthy, Clare C. Bailey, Robert L. Johnston, Martin McKibbin, Rehna S. Khan, Sajjad Mahmood, Louise Downey, Narendra Dhingra, Christopher Brand, Christopher J. Brittain, Jeffrey R. Willis, Sarah Rabhi, Anushini Muthutantri, Ronald A. Cantrell Tags: Original Article Source Type: research
Myopia Prevention and Outdoor Light Intensity in a School-Based Cluster Randomized Trial
To investigate the effectiveness of a school-based program promoting outdoor activities in Taiwan for myopia prevention and to identify protective light intensities. (Source: Ophthalmology)
Source: Ophthalmology - January 19, 2018 Category: Opthalmology Authors: Pei-Chang Wu, Chueh-Tan Chen, Ken-Kuo Lin, Chi-Chin Sun, Chien-Neng Kuo, Hsiu-Mei Huang, Yi-Chieh Poon, Meng-Ling Yang, Chau-Yin Chen, Jou-Chen Huang, Pei-Chen Wu, I-Hui Yang, Hun-Ju Yu, Po-Chiung Fang, Chia-Ling Tsai, Shu-Ti Chiou, Yi-Hsin Yang Tags: Original Article Source Type: research
Efficacy and Safety of Ranibizumab 0.5 mg for the Treatment of Macular Edema Resulting from Uncommon Causes
To evaluate the efficacy and safety of ranibizumab 0.5 mg in adult patients with macular edema (ME) resulting from any cause other than diabetes, retinal vein occlusion, or neovascular age-related macular degeneration. (Source: Ophthalmology)
Source: Ophthalmology - January 19, 2018 Category: Opthalmology Authors: Giovanni Staurenghi, Timothy Y.Y. Lai, Paul Mitchell, Sebastian Wolf, Andreas Wenzel, Jun Li, Amitabha Bhaumik, Philip G. Hykin, PROMETHEUS Study Group Tags: Original Article Source Type: research
Genetic Background of Iris Melanomas and Iris Melanocytic Tumors of Uncertain Malignant Potential
Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. Iris melanoma comprises 4% to 10% of all UMs and has a lower mortality rate. The genetic changes in iris melanoma are not as well characterized as ciliary body or choroidal melanoma. The aim of this study was to gain more insight into the genetic background of iris melanoma and iris nevi. (Source: Ophthalmology)
Source: Ophthalmology - January 19, 2018 Category: Opthalmology Authors: Natasha M. van Poppelen, Jolanda Vaarwater, Hardeep S. Mudhar, Karen Sisley, Ian G. Rennie, Paul Rundle, Tom Brands, Quincy C.C. van den Bosch, Hanneke W. Mensink, Annelies de Klein, Emine Kili ç, Robert M. Verdijk Source Type: research
Progression of Myopic Maculopathy during 18-Year Follow-up
To examine the progression pattern of myopic maculopathy. (Source: Ophthalmology)
Source: Ophthalmology - January 19, 2018 Category: Opthalmology Authors: Yuxin Fang, Tae Yokoi, Natsuko Nagaoka, Kosei Shinohara, Yuka Onishi, Tomoka Ishida, Takeshi Yoshida, Xian Xu, Jost B. Jonas, Kyoko Ohno-Matsui Source Type: research
The Discrepancy between Subjective and Objective Measures of Convergence Insufficiency in Whiplash-Associated Disorder versus Control Participants
We examined the incidence of symptoms and findings consistent with CI in a cohort of patients after MVA-related WAD compared with age-matched control participants. (Source: Ophthalmology)
Source: Ophthalmology - January 19, 2018 Category: Opthalmology Authors: Hadas Stiebel-Kalish, Amir Amitai, Michael Mimouni, Michael Bach, Tal Saban, Michelle Cahn, Liat Gantz Source Type: research
Re: Economides et al.: Capturing the moment of fusion loss in intermittent exotropia (Ophthalmology. 2017;124;496-504)
Based on the eye tracker recording data presented, I can agree with the conclusion on page 503 in the discussion section that states “once the ocular axes separate, visual feedback has no impact on the subsequent outward movement of the deviating eye to its final position.”1 However, the abstract conclusion implies something different, stating that the process of fusion loss itself in patients with intermittent exotropia is n ot influenced by visual feedback. Semantics perhaps, but as a clinician who has examined 20 or 30 of these patients weekly for the past 17 years, how else to explain the consistently reported symp...
Source: Ophthalmology - January 18, 2018 Category: Opthalmology Authors: Alex Christoff Tags: Correspondence Source Type: research
Re: Schlenker et al.: Efficacy, safety, and risk factors for failure of standalone ab interno gelatin microstent implantation versus standalone trabeculectomy (Ophthalmology. 2017;124:1579-1588)
The article by Schlenker et al1 retrospectively compares the outcomes of an ab interno gelatin stent to stand alone trabeculectomy in reducing intraocular pressure (IOP) in patients with uncontrolled open angle glaucoma. The article concludes that both procedures demonstrate equal efficacy and risk of failure. “Both proced ures had a 75% survival at approximately 10 months for complete success at an IOP ≤21 mmHg.” In terms of trabeculectomy success rates in this study these data seem to be suboptimal in comparison with recent trabeculectomy outcome data from the UK,2 where Kirwan et al demonstrated a 90% survival ...
Source: Ophthalmology - January 18, 2018 Category: Opthalmology Authors: Imran Masood, Mark Sigona, Mykolas Pajaujis Tags: Correspondence Source Type: research
Reply
We thank Masood et al for their correspondence and interest in our manuscript, and for sharing their results to date. More data are needed on this new microstent, especially comparative studies (ideally prospective and randomized) against trabeculectomy and other filtering surgeries. (Source: Ophthalmology)
Source: Ophthalmology - January 18, 2018 Category: Opthalmology Authors: Matthew B. Schlenker, Husayn Gulamhusein, Ina Conrad-Hengerer, Alix Somers, Markus Lenzhofer, Ingeborg Stalmans, Herbert Reitsamer, Fritz H. Hengerer, Iqbal Ike K. Ahmed Tags: Correspondence Source Type: research
