Suppression of Melatonin Secretion in Totally Visually Blind People by Ocular Exposure to White Light
Although most totally visually blind individuals exhibit nonentrained circadian rhythms due to an inability of light to entrain the circadian pacemaker, a small proportion retain photic circadian entrainment, melatonin suppression, and other nonimage-forming responses to light. It is thought that these responses to light persist because of the survival of melanospin-containing intrinsically photosensitive retinal ganglion cells (ipRGCs), which project primarily to the circadian pacemaker and are functionally distinct from the rod and cone photoreceptors that mediate vision. (Source: Ophthalmology)
Source: Ophthalmology - April 3, 2018 Category: Opthalmology Authors: Joseph T. Hull, Charles A. Czeisler, Steven W. Lockley Source Type: research
Measuring Patient Loyalty in Ophthalmology: A Nationally Representative Study
In 2006, the Hospital Consumer Assessment of Healthcare Providers and Systems survey became the nation ’s “first national, standardized, publicly reported survey of patients’ perspectives of hospital care.”1 The Patient Protection and Affordable Care Act of 2010 tied such surveys directly to hospital reimbursement,2 making understanding what drives patient satisfaction critical for providers to maintain good patient relationships. (Source: Ophthalmology)
Source: Ophthalmology - April 3, 2018 Category: Opthalmology Authors: David J. Ramsey, David L. Lazar, Gregory R. Blaha, Donald L. Malott, Jeffrey L. Marx Tags: Reports Source Type: research
Choroidal and Sub-Retinal Pigment Epithelium Caverns
To survey Friedman lipid globules by high-resolution histologic examination and to compare with multimodal imaging of hyporeflective caverns in eyes with geographic atrophy (GA) secondary to age-related macular (AMD) and other retinal diseases. (Source: Ophthalmology)
Source: Ophthalmology - April 3, 2018 Category: Opthalmology Authors: Rosa Dolz-Marco, Jay P. Glover, Orly Gal-Or, Katie M. Litts, Jeffrey D. Messinger, Yuhua Zhang, Mariano Cozzi, Marco Pellegrini, K. Bailey Freund, Giovanni Staurenghi, Christine A. Curcio Source Type: research
The Globe ’s Eccentric Rotational Axis
Tables typically recommend greater lateral rectus (LR) than medial rectus (MR) surgical doses for horizontal strabismus of any given magnitude, a difference unexplained by mechanical models that assume globe rotation about its center. We tested this assumption during horizontal ductions. (Source: Ophthalmology)
Source: Ophthalmology - March 30, 2018 Category: Opthalmology Authors: Robert A. Clark, Joseph L. Demer Source Type: research
Loss to Follow-Up in Patients with Proliferative Diabetic Retinopathy after Panretinal Photocoagulation or Intravitreal Anti-VEGF Injections
Loss to follow-up (LTFU) may contribute to vision loss in patients with active proliferative diabetic retinopathy (PDR). The aim of this study is to determine and compare the rates of LTFU in patients with PDR receiving panretinal photocoagulation (PRP) or intravitreal injections (IVIs) with anti-vascular endothelial growth factor (VEGF) over approximately 4 years. Moreover, this study evaluates various risk factors for LTFU. (Source: Ophthalmology)
Source: Ophthalmology - March 29, 2018 Category: Opthalmology Authors: Anthony Obeid, Xinxiao Gao, Ferhina S. Ali, Katherine E. Talcott, Christopher M. Aderman, Leslie Hyman, Allen C. Ho, Jason Hsu Source Type: research
Cost Evaluation of Early Vitrectomy versus Panretinal Photocoagulation and Intravitreal Ranibizumab for Proliferative Diabetic Retinopathy
To evaluate costs and cost-utility of early vitrectomy (pars plana vitrectomy [PPV]) compared with panretinal photocoagulation (PRP) and intravitreal ranibizumab (IVR) for proliferative diabetic retinopathy (PDR) without diabetic macular edema. (Source: Ophthalmology)
Source: Ophthalmology - March 29, 2018 Category: Opthalmology Authors: James Lin, Jonathan S. Chang, Nicolas A. Yannuzzi, William E. Smiddy Source Type: research
Determinants of Outcomes of Adenoviral Keratoconjunctivitis
To determine host and pathogen factors predictive of outcomes in a large clinical cohort with keratoconjunctivitis. (Source: Ophthalmology)
Source: Ophthalmology - March 27, 2018 Category: Opthalmology Authors: Cecilia S. Lee, Aaron Y. Lee, Lakshmi Akileswaran, David Stroman, Kathryn Najafi-Tagol, Steve Kleiboeker, James Chodosh, Amalia Magaret, Anna Wald, Russell N. Van Gelder, BAYnovation Study Group Source Type: research
Ten-Year Progression of Myopic Maculopathy
To investigate the progression pattern of myopic maculopathy and associated factors in a population-based study. (Source: Ophthalmology)
Source: Ophthalmology - March 27, 2018 Category: Opthalmology Authors: Yan Ni Yan, Ya Xing Wang, Yan Yang, Liang Xu, Jie Xu, Qian Wang, Jing Yan Yang, Xuan Yang, Wen Jia Zhou, Kyoko Ohno-Matsui, Wen Bin Wei, Jost B. Jonas Source Type: research
Successful Optimization of Adalimumab Therapy in Refractory Uveitis Due to Beh çet's Disease
To assess efficacy, safety, and cost-effectiveness of adalimumab (ADA) therapy optimization in a large series of patients with uveitis due to Beh çet disease (BD) who achieved remission after the use of this biologic agent. (Source: Ophthalmology)
Source: Ophthalmology - March 27, 2018 Category: Opthalmology Authors: Jos é Luis Martín-Varillas, Vanesa Calvo-Río, Emma Beltrán, Juan Sánchez-Bursón, Marina Mesquida, Alfredo Adán, María Victoria Hernandez, Marisa Hernández Garfella, Elia Valls Pascual, Lucía Martínez-Costa, Agustí Sellas-Fernández, Miguel Cor Source Type: research
Evaluation of Ophthalmic Surgical Instrument Sterility Using Short-Cycle Sterilization for Sequential Same-Day Use
This study was undertaken to evaluate the efficacy of short-cycle sterilization processing for consecutive same-day cataract procedures. (Source: Ophthalmology)
Source: Ophthalmology - March 27, 2018 Category: Opthalmology Authors: David F. Chang, Nikki Hurley, Nick Mamalis, Jeffrey Whitman Source Type: research
Retinal Degeneration in Choroideremia follows an Exponential Decay Function
Fundus autofluorescence (AF) arises from lipofuscin, which is derived from retinoid byproducts of the visual cycle and accumulates within retinal pigment epithelial cells. Alterations in AF pattern are seen in a wide range of retinal degenerations. Choroideremia is an X-linked retinal dystrophy caused by loss-of-function mutations within the CHM gene, encoding Rab escort protein-1.1 It is uniquely characterized by a central “island” of residual AF that undergoes gradual shrinkage with disease progression. (Source: Ophthalmology)
Source: Ophthalmology - March 24, 2018 Category: Opthalmology Authors: James W. Aylward, Kanmin Xue, Maria I. Patr ício, Jasleen K. Jolly, Jonathan C. Wood, Jonathan Brett, Kirti M. Jasani, Robert E. MacLaren Tags: Report Source Type: research
Pupillary Responses to Full-Field Chromatic Stimuli Are Reduced in Patients with Early-Stage Primary Open-Angle Glaucoma
To evaluate the ability of chromatic pupillometry to reveal abnormal pupillary responses to light in patients with early-stage primary open-angle glaucoma (POAG) and to test whether the degree of pupillometric impairment correlates with structural hallmarks of optic nerve damage in the disease. (Source: Ophthalmology)
Source: Ophthalmology - March 22, 2018 Category: Opthalmology Authors: Raymond P. Najjar, Sourabh Sharma, Eray Atalay, Annadata V. Rukmini, Christopher Sun, Jing Zhan Lock, Mani Baskaran, Shamira A. Perera, Rahat Husain, Ecosse Lamoureux, Joshua J. Gooley, Tin Aung, Dan Milea Source Type: research
Impact of Incidence and Progression of Diabetic Retinopathy on Vision-Specific Functioning
To investigate the independent impact of the incidence and progression of diabetic retinopathy (DR) on visual functioning (VF). (Source: Ophthalmology)
Source: Ophthalmology - March 20, 2018 Category: Opthalmology Authors: Preeti Gupta, Alfred Tau Liang Gan, Ryan Eyn Kidd Man, Eva K. Fenwick, Neelam Kumari, Gavin Tan, Paul Mitchell, Charumathi Sabanayagam, Tien Yin Wong, Ching-Yu Cheng, Ecosse L. Lamoureux Source Type: research
Clinical Prediction Performance of Glaucoma Progression Using a 2-Dimensional Continuous-Time Hidden Markov Model with Structural and Functional Measurements
Previously, we introduced a state-based 2-dimensional continuous-time hidden Markov model (2D CT HMM) to model the pattern of detected glaucoma changes using structural and functional information simultaneously. The purpose of this study was to evaluate the detected glaucoma change prediction performance of the model in a real clinical setting using a retrospective longitudinal dataset. (Source: Ophthalmology)
Source: Ophthalmology - March 20, 2018 Category: Opthalmology Authors: Youngseok Song, Hiroshi Ishikawa, Mengfei Wu, Yu-Ying Liu, Katie A. Lucy, Fabio Lavinsky, Mengling Liu, Gadi Wollstein, Joel S. Schuman Source Type: research
Cost Evaluation of Laser versus Intravitreal Aflibercept for Proliferative Diabetic Retinopathy
Diabetic retinopathy affects 8 million Americans with diabetes and proliferative diabetic retinopathy (PDR) is associated with severe vision loss. The Diabetic Retinopathy Study (DRS) established panretinal photocoagulation (PRP) as an effective treatment for PDR. Reports including randomized clinical trials1,2 have established intravitreal ranibizumab (IVR) as a noninferior treatment option for PDR. The Diabetic Retinopathy Clinical Research (DRCR) Protocol S showed that eyes treated with IVR had less macular edema, visual field loss, and need for pars plana vitrectomy compared with PRP. (Source: Ophthalmology)
Source: Ophthalmology - March 20, 2018 Category: Opthalmology Authors: Nicolas A. Yannuzzi, Jayanth Sridhar, Jonathan S. Chang, James Lin, Ajay E. Kuriyan, William E. Smiddy Tags: Reports Source Type: research
