Cuticular Drusen
To define the range and life cycles of cuticular drusen phenotypes using multimodal imaging and to review the histologic characteristics of cuticular drusen. (Source: Ophthalmology)
Source: Ophthalmology - September 27, 2017 Category: Opthalmology Authors: Chandrakumar Balaratnasingam, Svetlana Cherepanoff, Rosa Dolz-Marco, Murray Killingsworth, Fred K. Chen, Randev Mendis, Sarah Mrejen, Lay Khoon Too, Orly Gal-Or, Christine A. Curcio, K. Bailey Freund, Lawrence A. Yannuzzi Source Type: research
Natural History of Subclinical Neovascularization in Nonexudative Age-Related Macular Degeneration Using Swept-Source OCT Angiography
Swept-source (SS) OCT angiography (OCTA) was used to determine the prevalence, incidence, and natural history of subclinical macular neovascularization (MNV) in eyes with nonexudative age-related macular degeneration (AMD). (Source: Ophthalmology)
Source: Ophthalmology - September 27, 2017 Category: Opthalmology Authors: Jo ão R. de Oliveira Dias, Qinqin Zhang, José M.B. Garcia, Fang Zheng, Elie H. Motulsky, Luiz Roisman, Andrew Miller, Chieh-Li Chen, Sophie Kubach, Luis de Sisternes, Mary K. Durbin, William Feuer, Ruikang K. Wang, Giovanni Gregori, Philip J. Rosenfeld Source Type: research
Clinicopathologic Correlation of Anti –Vascular Endothelial Growth Factor–Treated Type 3 Neovascularization in Age-Related Macular Degeneration
To correlate histologic results with previously recorded multimodal imaging results from a patient with type 3 neovascularization secondary to age-related macular degeneration (AMD). (Source: Ophthalmology)
Source: Ophthalmology - September 27, 2017 Category: Opthalmology Authors: Miaoling Li, Rosa Dolz-Marco, Jeffrey D. Messinger, Lan Wang, Richard M. Feist, Christopher A. Girkin, Sarra Gattoussi, Daniela Ferrara, Christine A. Curcio, K. Bailey Freund Source Type: research
Accuracy of Intraocular Lens Calculation Formulas
To compare the accuracy of intraocular lens (IOL) calculation formulas (Barrett Universal II, Haigis, Hoffer Q, Holladay 1, Holladay 2, Olsen, and SRK/T) in the prediction of postoperative refraction using a single optical biometry device. (Source: Ophthalmology)
Source: Ophthalmology - September 23, 2017 Category: Opthalmology Authors: Ronald B. Melles, Jack T. Holladay, William J. Chang Source Type: research
The Rapid-Onset Chorioretinopathy Phenotype of ABCA4 Disease
To characterize patients affected by a uniquely severe, rapid-onset chorioretinopathy (ROC) phenotype of ABCA4 disease. (Source: Ophthalmology)
Source: Ophthalmology - September 22, 2017 Category: Opthalmology Authors: Koji Tanaka, Winston Lee, Jana Zernant, Kaspar Schuerch, Lyam Ciccone, Stephen H. Tsang, Janet R. Sparrow, Rando Allikmets Source Type: research
Update on the Management of Infectious Keratitis
Infectious keratitis is a major global cause of visual impairment and blindness, often affecting marginalized populations. Proper diagnosis of the causative organism is critical, and although culture remains the prevailing diagnostic tool, newer techniques such as in vivo confocal microscopy are helpful for diagnosing fungus and Acanthamoeba. Next-generation sequencing holds the potential for early and accurate diagnosis even for organisms that are difficult to culture by conventional methods. Topical antibiotics remain the best treatment for bacterial keratit is, and a recent review found all commonly prescribed topical...
Source: Ophthalmology - September 20, 2017 Category: Opthalmology Authors: Ariana Austin, Tom Lietman, Jennifer Rose-Nussbaumer Source Type: research
Immunosuppression for the Uveitides
The uveitides are a collection of more than 30 diseases characterized by intraocular inflammation. Many cases of juvenile idiopathic arthritis –associated uveitis, many cases of intermediate uveitis, and most cases of posterior and panuveitides requiring treatment are treated with corticosteroids and immunosuppression. Disease-specific, time-updated modeling of clinical data for several uveitides suggests superior prevention of ocular co mplications and visual outcomes with immunosuppression. These studies also suggest that oral corticosteroids at doses low enough for safe long-term therapy (i.e., (Source: Ophthalmology)
Source: Ophthalmology - September 20, 2017 Category: Opthalmology Authors: Douglas A. Jabs Source Type: research
Massive Extraocular Extension of Choroidal Melanoma after Brachytherapy
A 63-year-old woman presented with a pigmented choroidal tumor (Fig 1A), which progressively enlarged in thickness, from 2.3 to 3.6 mm in 6 months. Systemic work-up showed multiple lung nodules, which biopsy demonstrated adenocarcinoma. (Source: Ophthalmology)
Source: Ophthalmology - September 19, 2017 Category: Opthalmology Authors: Bernadete Ayres, Victor Elner, Hakan Demirci Tags: Pictures & Perspectives Source Type: research
Cilioretinal Artery Imaged with Optical Coherence Tomography Angiography
A 48-year-old woman presented with peripapillary chorioretinal atrophy and cilioretinal artery in the left eye without other findings (Fig 1A). Optical coherence tomography angiography (OCTA) through full-thickness retinal segmentation (Fig 1B) showed intact retinal perfusion. The cilioretinal artery arose from the temporal margin of the optic nerve and coursed into the retina, resembling a hook. On OCT B-scan with angio-overlay (Fig 1C), the cilioretinal artery was visualized at 2 levels, with the point of the hook (arrow) at the level of the retinal pigment epithelium and the shank of the hook (arrowhead) at the level of...
Source: Ophthalmology - September 19, 2017 Category: Opthalmology Authors: Margaret V. Shields, R. Joel Welch, Emil A.T. Say Tags: Pictures & Perspectives Source Type: research
Demodex Clusters
A 66-year-old woman with a 2-year history of recurrent infections presented with foreign body sensation, itching, and red eye. Eye examination revealed meibomian gland dysfunction, cylindrical dandruff, and lid margin telangiectasia (Fig 1A). A clinical diagnosis of demodecosis was confirmed by eyelash epilation and fluorescein 0.25% dye. Massive infestation was found (Fig 1B, eyelash follicle [arrow], adult mite s [asterisks]), and cluster formations detected (Fig 1C and D, mouth [red arrow], legs [black arrows]). (Source: Ophthalmology)
Source: Ophthalmology - September 19, 2017 Category: Opthalmology Authors: Chantal Favier Tags: Pictures & Perspectives Source Type: research
Re: Good: Bevacizumab for retinopathy of prematurity: treatment when pathology is embedded in a normally developing vascular system (Ophthalmology. 2016;123:1843-1844)
We commend Dr Good's editorial1 for its maintenance of equipoise on the use of intravitreal bevacizumab (IVB) in retinopathy of prematurity (ROP). We would like to expand on his discussion regarding the potential neurodevelopmental consequences of vascular endothelial growth factor inhibition, over which there has been much concern.2 The strong opinions expressed in other editorials and positions taken in public meetings raise the suspicion that confirmation bias may lead to widespread acceptance of retrospective studies whose interpretations qualify as hypothesis generators. (Source: Ophthalmology)
Source: Ophthalmology - September 19, 2017 Category: Opthalmology Authors: Michael P. Blair, Michael J. Shapiro, Ad Hoc Group Concerning Neurodevelopment and antiVEGF Tags: Correspondence Source Type: research
Re: Haripriya et al.: Endophthalmitis reduction with intracameral moxifloxacin prophylaxis: an analysis of 600 000 surgeries (Ophthalmology. 2017;124:768-775)
This study had no standardized protocol and included 10 different hospitals. Although the sample size is impressive, the study is necessarily limited by its retrospective design. Clearly, the highest level of evidence comes from prospectiv e randomized clinical trials.2 (Source: Ophthalmology)
Source: Ophthalmology - September 19, 2017 Category: Opthalmology Authors: Nidhi Relhan, Stephen G. Schwartz, Andrzej Grzybowski, Harry W. Flynn Tags: Correspondence Source Type: research
Intraoperative Optical Coherence Tomography of Internal Limiting Membrane Flap
A 66-year-old woman with a 450- μm diameter macular hole (MH) in her right eye underwent vitrectomy, internal limiting membrane (ILM) peel with inverted ILM flap, and perfluoropropane (C3F8) gas tamponade. Inverted ILM flaps may improve outcomes for holes larger than 400 μm; however, confirming proper ILM placement is difficult after air-fluid exchange. Intraoperative optical coherence tomography (OCT; Zeiss, Oberkochen, Germany) was used to visualize the MH before ILM peel (Fig 1A) and confirm positioning of the inverted ILM flap (Fig 1B, arrow) following complete air-fluid exchange. (Source: Ophthalmology)
Source: Ophthalmology - September 19, 2017 Category: Opthalmology Authors: Thomas L. Jenkins, Murtaza K. Adam, Jason Hsu Tags: Pictures & Perspectives Source Type: research
En face Optical Coherence Tomography Imaging of Baylisascaris Procyonis
A 7-year-old boy presented with decreased vision in the right eye to 20/300. He had longstanding 20/400 vision in the left eye due to a congenital scar. His examinations revealed right anterior chamber and vitreous inflammation, as well as optic disc and macular edema with diffuse irregular retinal pigmentation. An intraretinal nematode was identified on fundus photography and subsequently imaged with a Heidelberg spectral-domain optical coherence tomography (Spectralis; Heidelberg Engineering, Germany). (Source: Ophthalmology)
Source: Ophthalmology - September 19, 2017 Category: Opthalmology Authors: David L. Nash, Jaime Tesmar, Brian G. Mohney Tags: Pictures & Perspectives Source Type: research
Growth Hormone Deficiency, Basal Encephalocele, and Morning Glory Anomaly
A 3-year-old girl with short-stature ( (Source: Ophthalmology)
Source: Ophthalmology - September 19, 2017 Category: Opthalmology Authors: Rajesh C. Rao, Scott A. Larson, Brian J. Dlouhy Tags: Pictures & Perspectives Source Type: research
