The Pathophysiology of Dry Eye Disease
Clinical and laboratory studies performed over the past few decades have discovered that dry eye is a chronic inflammatory disease that can be initiated by numerous extrinsic or intrinsic factors that promote an unstable and hyperosmolar tear film. These changes in tear composition, in some cases combined with systemic factors, lead to an inflammatory cycle that causes ocular surface epithelial disease and neural stimulation. Acute desiccation activates stress signaling pathways in the ocular surface epithelium and resident immune cells. (Source: Ophthalmology)
Source: Ophthalmology - October 18, 2017 Category: Opthalmology Authors: Stephen C. Pflugfelder, Cintia S. de Paiva Tags: Original article Source Type: research
Neuropathic Corneal Pain
The objectives of this review are to provide guidelines for diagnosis and treatment of patients with NCP and to summarize current evidence-based literature in this area. (Source: Ophthalmology)
Source: Ophthalmology - October 18, 2017 Category: Opthalmology Authors: Gabriela Dieckmann, Sunali Goyal, Pedram Hamrah Tags: Original article Source Type: research
Meibomian Gland Disease
To discuss the pathology, causes, and ocular surface impact of meibomian gland disease (MGD), as well as its relationship to dry eye. (Source: Ophthalmology)
Source: Ophthalmology - October 18, 2017 Category: Opthalmology Authors: Priyanka Chhadva, Raquel Goldhardt, Anat Galor Tags: Original article Source Type: research
Update in Current Diagnostics and Therapeutics of Dry Eye Disease
Dry eye disease (DED) represents a heterogeneous group of conditions with tear film insufficiency and signs and/or symptoms of ocular surface irritation. The clinical manifestations of DED can be highly variable; hence the diagnosis is often based on a combination of symptoms, signs, and clinical tests, given that any one of these alone would miss a significant number of patients. Similarly, the treatment must often be tailored to each patient by targeting the specific mechanisms involved in his or her disease. (Source: Ophthalmology)
Source: Ophthalmology - October 18, 2017 Category: Opthalmology Authors: Praneetha Thulasi, Ali Reza Djalilian Tags: Original article Source Type: research
Inflammation in Dry Eye Disease
This article reviews the literature and summarizes the role of inflammation in dry eye disease. A PubMed search was performed using the keywords inflammatory cycle and dry eye. All searches were limited to articles published in or translated into the English language, dating from 1973 through March 2017. There were no restrictions on the study design. Advances in understanding the pathogenesis of dry eye disease has revealed that inflammation is a core driver: the so-called “vicious circle” of inflammation. (Source: Ophthalmology)
Source: Ophthalmology - October 18, 2017 Category: Opthalmology Authors: Michelle K. Rhee, Francis S. Mah Tags: Original article Source Type: research
Dry Eye Disease: Let's Start Thinking Outside of the Artificial Tear Box
“Why do I have dry eyes, Doctor? How can they be dry if I just put in an eye drop? And how can I cure it?” (Source: Ophthalmology)
Source: Ophthalmology - October 18, 2017 Category: Opthalmology Authors: Marjan Farid Tags: Foreword Source Type: research
Editorial Board
(Source: Ophthalmology)
Source: Ophthalmology - October 18, 2017 Category: Opthalmology Source Type: research
Contents
(Source: Ophthalmology)
Source: Ophthalmology - October 18, 2017 Category: Opthalmology Source Type: research
Screening Children at Risk for Retinoblastoma
To provide a set of surveillance guidelines for children at risk for development of retinoblastoma. (Source: Ophthalmology)
Source: Ophthalmology - October 18, 2017 Category: Opthalmology Authors: Alison H. Skalet, Dan S. Gombos, Brenda L. Gallie, Jonathan W. Kim, Carol L. Shields, Brian P. Marr, Sharon E. Plon, Patricia Ch évez-Barrios Source Type: research
Cellular Characterization of OCT and Outer Retinal Bands Using Specific Immunohistochemistry Markers and Clinical Implications
OCT has been a technological breakthrough in the diagnosis, treatment, and follow-up of many ocular diseases, especially retinal and neuro-ophthalmologic pathologic conditions. Until now, several controversies have arisen over the specific cell types that the bands observed in the OCT represent, especially over the 4 outer retinal bands. (Source: Ophthalmology)
Source: Ophthalmology - October 13, 2017 Category: Opthalmology Authors: Nicol ás Cuenca, Isabel Ortuño-Lizarán, Isabel Pinilla Tags: Original article Source Type: research
Cellular Characterization of Optical Coherence Tomography and Outer Retinal Bands Using Specific Immunohistochemistry Markers and Clinical Implications
Optical coherence tomography has been a technological breakthrough in the diagnosis, treatment, and follow-up of many ocular diseases, especially retinal and neuro-ophthalmologic pathologic conditions. Until now, several controversies have arisen over the specific cell types that the bands observed in the OCT represent, especially over the 4 outer retinal bands. (Source: Ophthalmology)
Source: Ophthalmology - October 13, 2017 Category: Opthalmology Authors: Nicol ás Cuenca, Isabel Ortuño-Lizarán, Isabel Pinilla Source Type: research
Genetic Polymorphisms of CFH and ARMS2 Do Not Predict Response to Antioxidants and Zinc in Patients with Age-Related Macular Degeneration
Considerable controversy has erupted in recent years regarding whether genotyping should be part of standard care for patients with age-related macular degeneration (AMD) who are being considered for treatment with antioxidants and zinc. We aimed to determine whether genotype predicts response to supplements in AMD. (Source: Ophthalmology)
Source: Ophthalmology - October 9, 2017 Category: Opthalmology Authors: Melissa J. Assel, Fan Li, Ying Wang, Andrew S. Allen, Keith A. Baggerly, Andrew J. Vickers Source Type: research
Risk Factors for Developing Choroidal Neovascular Membrane and Visual Loss in Punctate Inner Choroidopathy
To examine a large cohort of subjects with punctate inner choroidopathy (PIC) looking at risk factors for development of choroidal neovascular membrane (CNVM) and visual loss. (Source: Ophthalmology)
Source: Ophthalmology - October 6, 2017 Category: Opthalmology Authors: Rachael L. Niederer, Rose Gilbert, Sue L. Lightman, Oren Tomkins-Netzer Source Type: research
Early and Late Retinal Pigment Epithelium Tears after Anti –Vascular Endothelial Growth Factor Therapy for Neovascular Age-Related Macular Degeneration
To investigate when retinal pigment epithelium (RPE) tears occur and their associated treatment patterns and long-term visual outcomes in patients with neovascular age-related macular degeneration (nAMD) during anti –vascular endothelial growth factor (VEGF) treatment. (Source: Ophthalmology)
Source: Ophthalmology - October 6, 2017 Category: Opthalmology Authors: Alessandro Invernizzi, Vuong Nguyen, Jennifer Arnold, Stephanie Young, Daniel Barthelmes, Mark C. Gillies Tags: Original Article Source Type: research
Assessment of Confocal Microscopy for the Diagnosis of Polymerase Chain Reaction –Positive Acanthamoeba Keratitis
To determine in vivo confocal microscopy diagnostic criteria to diagnose Acanthamoeba keratitis (AK) using polymerase chain reaction (PCR) as the reference diagnostic technique. (Source: Ophthalmology)
Source: Ophthalmology - September 28, 2017 Category: Opthalmology Authors: Sophie De Craene, Juliette Knoeri, Cristina Georgeon, Philippe Kestelyn, Vincent M. Borderie Source Type: research
