Fully Automated Detection and Quantification of Macular Fluid in OCT Using Deep Learning
Development and validation of a fully automated method to detect and quantify macular fluid in conventional OCT images. (Source: Ophthalmology)
Source: Ophthalmology - December 8, 2017 Category: Opthalmology Authors: Thomas Schlegl, Sebastian M. Waldstein, Hrvoje Bogunovic, Franz Endstra ßer, Amir Sadeghipour, Ana-Maria Philip, Dominika Podkowinski, Bianca S. Gerendas, Georg Langs, Ursula Schmidt-Erfurth Source Type: research
Central Visual Field Damage and Parapapillary Choroidal Microvasculature Dropout in Primary Open-Angle Glaucoma
To determine whether microvasculature dropout (MvD) in the parapapillary choroid is related to the presence of central visual field defects in primary open-angle glaucoma (POAG). (Source: Ophthalmology)
Source: Ophthalmology - December 7, 2017 Category: Opthalmology Authors: Eun Ji Lee, Tae-Woo Kim, Ji-Ah Kim, Jeong-Ah Kim Source Type: research
Association of Rare Predicted Loss-of-Function Variants in Cellular Pathways with Sub-Phenotypes in Age-Related Macular Degeneration
To investigate the association of rare predicted loss-of-function (pLoF) variants within age-related macular degeneration (AMD) risk loci and AMD sub-phenotypes. (Source: Ophthalmology)
Source: Ophthalmology - December 7, 2017 Category: Opthalmology Authors: Alexandra Pietraszkiewicz, Freekje van Asten, Alan Kwong, Rinki Ratnapriya, Goncalo Abecasis, Anand Swaroop, Emily Y. Chew Source Type: research
Mucous Membrane Pemphigoid with Ocular Involvement
This study explored the validity of the First International Consensus on Mucous Membrane Pemphigoid (MMP) guidance, which recommends that clinically indistinguishable patients, who have direct immunofluorescence (DIF)-negative biopsies, be excluded from a diagnosis of MMP. Misdiagnosis, or delayed diagnosis, of MMP with ocular involvement leads to the inappropriate use of topical therapy, the standard of care for causes of cicatrising conjunctivitis other than MMP, rather than systemic immunomodulatory therapy, resulting in irreversible clinical deterioration in patients with MMP. (Source: Ophthalmology)
Source: Ophthalmology - December 5, 2017 Category: Opthalmology Authors: Hon Shing Ong, Jane F. Setterfield, Darwin C. Minassian, John K. Dart, Mucous Membrane Pemphigoid Study Group 2009 –2014 Tags: Original article Source Type: research
A Study of the Natural History of Vitreomacular Traction Syndrome by OCT
To examine the natural history of vitreomacular traction syndrome (VMTS) in the absence of other ocular comorbidities. (Source: Ophthalmology)
Source: Ophthalmology - December 5, 2017 Category: Opthalmology Authors: Marie-H élène Errera, Sidath E. Liyanage, Petros Petrou, Pearse A. Keane, Rene Moya, Eric Ezra, David G. Charteris, Louisa Wickham Source Type: research
Ethnic Differences in the Prevalence and Risk Factors of Diabetic Retinopathy
To evaluate the prevalence and risk factors for diabetic retinopathy (DR) in the Singapore Epidemiology of Eye Diseases (SEED) Study. (Source: Ophthalmology)
Source: Ophthalmology - December 5, 2017 Category: Opthalmology Authors: Gavin S. Tan, Alfred Gan, Charumathi Sabanayagam, Yih Chung Tham, Kumari Neelam, Paul Mitchell, Jie Jin Wang, Ecosse L. Lamoureux, Ching-Yu Cheng, Tien Y. Wong Source Type: research
Mucous Membrane Pemphigoid with Ocular Involvement: The Clinical Phenotype and Its Relationship to Direct Immunofluorescence Findings
This study explored the validity of the First International Consensus on Mucous Membrane Pemphigoid (MMP) guidance, which recommends that clinically indistinguishable patients, who have direct immunofluorescence (DIF)-negative biopsies, be excluded from a diagnosis of MMP. Misdiagnosis, or delayed diagnosis, of MMP with ocular involvement leads to the inappropriate use of topical therapy, the standard of care for causes of cicatrising conjunctivitis other than MMP, rather than systemic immunomodulatory therapy, resulting in irreversible clinical deterioration in patients with MMP. (Source: Ophthalmology)
Source: Ophthalmology - December 5, 2017 Category: Opthalmology Authors: Hon Shing Ong, Jane F. Setterfield, Darwin C. Minassian, John K. Dart, Mucous Membrane Pemphigoid Study Group 2009 –2014 Source Type: research
Intracameral Chemotherapy for Globe Salvage in Retinoblastoma with Secondary Anterior Chamber Invasion
The presence of anterior chamber seeding (ACS), whether primary (1%) or secondary, is commonly treated by enucleation. Considering the new frontiers of conservative management of very advanced retinoblastoma, the reported incidence of secondary ACS leading to conservative failure has progressed from 6% after chemoreduction to 67% after intra-arterial chemotherapy (IAC).1 (Source: Ophthalmology)
Source: Ophthalmology - December 2, 2017 Category: Opthalmology Authors: Francis L. Munier, Alexandre Moulin, Marie-Claire Gaillard, Massimo Bongiovanni, Sarah Decembrini, Susan Houghton, Maja Beck-Popovic, Christina Stathopoulos Tags: Reports Source Type: research
Personalized Prediction of Glaucoma Progression Under Different Target Intraocular Pressure Levels Using Filtered Forecasting Methods
To generate personalized forecasts of how patients with open-angle glaucoma (OAG) experience disease progression at different intraocular pressure (IOP) levels to aid clinicians with setting personalized target IOPs. (Source: Ophthalmology)
Source: Ophthalmology - December 1, 2017 Category: Opthalmology Authors: Pooyan Kazemian, Mariel S. Lavieri, Mark P. Van Oyen, Chris Andrews, Joshua D. Stein Source Type: research
Prospective Randomized Trial of Corneal Cross-linking Riboflavin Dosing Frequencies for Treatment of Keratoconus and Corneal Ectasia
To investigate whether the riboflavin dosing frequency affects corneal cross-linking efficacy or safety, given that isotonic riboflavin solution is viscous and each installation coats the corneal surface with a film that absorbs some of the incident ultraviolet A light. (Source: Ophthalmology)
Source: Ophthalmology - December 1, 2017 Category: Opthalmology Authors: Marianne O. Price, Kelly Fairchild, Matthew T. Feng, Francis W. Price Source Type: research
Evaluation of Medical Students' Perception of an Ophthalmology Career
The Association of American Medical Colleges projects an overall shortage of ophthalmologists by the year 2025.1 In addition, there exists a shortage of ophthalmologists of racial and ethnic minority groups considered to be underrepresented in medicine (URM).2 Targeted recruitment of URM individuals serves to meet overall demands for ophthalmologists in the coming decades and to address eye healthcare inequalities among minority populations. Physician workforce diversity positively influences key health outcomes. (Source: Ophthalmology)
Source: Ophthalmology - November 28, 2017 Category: Opthalmology Authors: Marguerite O. Linz, Albert S. Jun, Sarah L. Clever, Shari M. Lawson, Abanti Sanyal, Adrienne W. Scott Tags: Reports Source Type: research
Peripapillary and Macular Vessel Density in Patients with Primary Open-Angle Glaucoma and Unilateral Visual Field Loss
To characterize OCT angiography (OCT-A) vessel density of patients with primary open-angle glaucoma (POAG) with unilateral visual field (VF) loss. (Source: Ophthalmology)
Source: Ophthalmology - November 21, 2017 Category: Opthalmology Authors: Adeleh Yarmohammadi, Linda M. Zangwill, Patricia Isabel C. Manalastas, Nathanael J. Fuller, Alberto Diniz-Filho, Luke J. Saunders, Min Hee Suh, Kyle Hasenstab, Robert N. Weinreb Tags: Original Article Source Type: research
Detecting Visual Field Progression
Timely detection of glaucomatous progression is crucial in the delivery of glaucoma care. Clinical judgment may be used to make this assessment, but relatively modest agreement among practitioners supports the use of complementary methods. Event-based analyses take into account expected localized test –retest variabilities in sensitivity, and trend-based analyses are helpful for determining and predicting overall visual function. Landmark clinical trials have used various visual field progression criteria as end points with variable performances. (Source: Ophthalmology)
Source: Ophthalmology - November 17, 2017 Category: Opthalmology Authors: Ahmad A. Aref, Donald L. Budenz Tags: Original article Source Type: research
The Evolving Role of the Relationship between Optic Nerve Structure and Function in Glaucoma
The relationship between functional vision loss and structural changes of the optic nerve head and retinal ganglion cells is the hallmark of glaucoma diagnosis. Understanding and measuring this relationship has been the focus of numerous studies, the goal of which have been to improve glaucoma diagnosis and detection of glaucoma worsening. In this review, a historical perspective is used to understand structure –function relationships in glaucoma and their application to improve glaucoma diagnosis and monitoring. (Source: Ophthalmology)
Source: Ophthalmology - November 17, 2017 Category: Opthalmology Authors: Jithin Yohannan, Michael V. Boland Tags: Original article Source Type: research
Detecting Structural Progression in Glaucoma with Optical Coherence Tomography
Optical coherence tomography (OCT) is increasingly used to obtain objective measurements of the retinal nerve fiber layer (RNFL), optic nerve head, and macula for assessing glaucoma progression. Although OCT has been adopted widely in clinical practice, uncertainty remains concerning its optimal role. Questions include: What is the best structure to measure? What quantity of change is significant? Are structural changes relevant to the patient? How are longitudinal measurements affected by aging? How can changes resulting from aging be differentiated from true progression? How best should OCT be used alongside visual field...
Source: Ophthalmology - November 17, 2017 Category: Opthalmology Authors: Andrew J. Tatham, Felipe A. Medeiros Tags: Original article Source Type: research
