Acute Annular Outer Retinopathy
A 26-year-old Chinese woman presented with a rapid onset temporal visual field defect in her left eye. She denied photopsia. Her visual acuity was 20/20 in both eyes. Fundus examination of her left eye showed a well-demarcated annular band of yellowish-white deep retinal opacification that surrounded the optic disc (Fig 1A). Spectral-domain OCT showed an absence of photoreceptors (Fig 1C-D) in the zone of retina encompassed by this ring and corresponded to her absolute visual field defect. Autofluorescence imaging showed hyper-autofluorescence in general and scattered granular hypo-autofluorescence within the affected area...
Source: Ophthalmology - December 18, 2017 Category: Opthalmology Authors: Renpan Zeng, Xiaoqiong Liang, Lixia Du Tags: Pictures & Perspectives Source Type: research
Rhegmatogenous Retinal Detachment after Pediatric Cataract Surgery
Rhegmatogenous retinal detachment is a well-known late complication of pediatric cataract surgery, historically reported to occur 20 years or more after the primary surgery, with only a third of cases occurring in the first 10 years.1 –4 Previous studies have not fully elucidated the risk factors for postoperative retinal detachment in the modern era of pediatric cataract surgery; thus, it is not known which patients require close long-term follow-up. Similarly, there have been limited data on the surgical outcomes of rhegmatog enous retinal detachment related to pediatric cataract surgery. (Source: Ophthalmology)
Source: Ophthalmology - December 18, 2017 Category: Opthalmology Authors: Irina De la Huerta, George A. Williams Tags: Editorial Source Type: research
Splitting the Lumps: The Importance of Phenotyping Drusen
Age-related macular degeneration, (AMD) is currently defined by the presence of drusen, and as such, many retinal drusen phenotypes are lumped in the catch-all disease AMD. There is no doubt AMD is a heterogenous disease, and to date as many as 34 different gene loci have been identified as contributing to the AMD phenotype.1,2 However, now more than ever, we need to be “splitters” rather than “lumpers,” as we enter an era where there will be specific treatments to slow progression of early stages of AMD toward vision-threatening complications. (Source: Ophthalmology)
Source: Ophthalmology - December 18, 2017 Category: Opthalmology Authors: Robyn H. Guymer Tags: Editorial Source Type: research
Conjunctival Stromal Tumor
A 66-year-old woman developed a 4 ×8-mm slow-growing, buff-colored mass of her left conjunctiva over 5 years. The lesion was firm, fixed to underlying tissue, and straddled the limbus eccentrically (Fig 1A). Biopsy showed the substantia propria replaced with a pauci-cellular tumor, consisting of delicate spindle cells separated by bundles of collagen and scattered blood vessels (Fig 1B). The spindle cells expressed CD34 (Fig 1C) and vimentin. The diagnosis of conjunctival stromal tumor describes a CD34-positive benign mesenchymal tumor with matrix varying from purely myxoid to purely collagenous. (Source: Ophthalmology)
Source: Ophthalmology - December 18, 2017 Category: Opthalmology Authors: Erin L. Greenberg, Edgar M. Espana, Curtis E. Margo Tags: Pictures & Perspectives Source Type: research
Large Area of Myelinated Retinal Nerve Fibers
A 28-year-old man presented with left eye trauma. During the examination, the ophthalmologist found the right retina had a large area myelinated retinal nerve fibers (MRNF), reaching to the equator but without coverage of the area of macula lutea. His best corrected visual acuity was 1/20 in the right eye. He had a history of high myopia and amblyopia for 10 years. Extensive MRNF are known to be associated with ipsilateral myopia and amblyopia (Fig 1A shows the fundus, Fig1B shows the OCT). MRNF are seen as grey-white patches well-demarcated along the retinal nerve fiber layer. (Source: Ophthalmology)
Source: Ophthalmology - December 18, 2017 Category: Opthalmology Authors: Jieling Chen, Nailei Chen, Suilian Zheng Tags: Pictures & Perspectives Source Type: research
Editorial Board
(Source: Ophthalmology)
Source: Ophthalmology - December 18, 2017 Category: Opthalmology Source Type: research
Contents
(Source: Ophthalmology)
Source: Ophthalmology - December 18, 2017 Category: Opthalmology Source Type: research
The Temin Effect
Many years ago, one of us (M.G.) interviewed the biologist Howard Temin. Temin had just won the Nobel Prize for his work on the discovery of reverse transcriptase —the class of enzymes capable of creating DNA from a RNA template—and he was an unforgettable figure. He had a wiry shock of hair and a wry smile. He was raised by activist parents in Philadelphia. His bar mitzvah money was donated to a refugee camp. His valedictory address in high school was ab out the hydrogen bomb. He had read deeply about philosophy and literature, and during the interview he spent as much time, brilliantly, in the larger world of ideas a...
Source: Ophthalmology - December 18, 2017 Category: Opthalmology Authors: David Epstein, Malcolm Gladwell Tags: Editorial Source Type: research
This Issue at a Glance
Silva et al (p. 57) evaluated the efficacy and safety of a treat and extend (T&E) regimen versus a monthly regimen of ranibizumab 0.5 mg in patients with neovascular age-related macular degeneration (nAMD). They conducted a 12-month, Phase IIIb, multicenter randomized interventional study of 650 patients with newly diagnosed nAMD enrolled between December 2013 and November 2015 at 90 centers across 18 countries. The researchers found that patients made similar rapid gains in best-corrected visual acuity under both the T&E and monthly regimens. (Source: Ophthalmology)
Source: Ophthalmology - December 18, 2017 Category: Opthalmology Authors: Sandeep Ravindran Tags: This issue at a glance Source Type: research
A Simple Vista en Este N úmero
Silva y otros (p. 57) evaluaron la eficacia y seguridad de un r égimen de tratamiento y extensión (T&E) comparado con un r égimen mensual de ranibizumab al 0,5 mg en pacientes con degeneración macular neovascular relacionada con la edad (nAMD). Realizaron un estudio multicentro intervencional aleatorio de 12 meses, Fase IIIb, de 650 pacientes con diagnóstico reciente de nAMD aceptados para estudio de diciembre de 201 3 a noviembre de 2015 en 90 centros de 18 países. Los investigadores encontraron que los pacientes lograban mejorías en la agudeza visual mejor corregida tanto con el régimen de T&E como con el r égim...
Source: Ophthalmology - December 18, 2017 Category: Opthalmology Authors: Sandeep Ravindran Tags: This issue at a glance Source Type: research
期刊一览
Silva (p. 57) 等对新生血管性年龄相关性黄斑变性(neovascular age-related macular degeneration [nAMD])患者进行雷珠单抗0.5 mg核心治疗及延长治疗(treat and extend [T&E]) 疗法和每月疗法的有效性和安全性进行评估。研究者进行了为期12个月的IIIb期多中心随机干预试验,共纳入650名新诊断nAMD患者;受试者来自18个国家的90所研究中心,于2013年12月至2015年11月入选试验。研究者发现T&E 疗法及每月疗法下,受试者最佳矫正视力均得到快速改善且效果相当。另外,两组改善均主要集中在前6个月治疗期内,且疗...
Source: Ophthalmology - December 18, 2017 Category: Opthalmology Authors: Sandeep Ravindran Tags: This issue at a glance Source Type: research
Topical Cidofovir for Treatment-Refractory Ocular Surface Squamous Neoplasia
Ocular surface squamous neoplasia (OSSN) is defined as a group of dysplastic, preinvasive, and malignant squamous lesions involving the cornea and conjunctiva. Management of OSSN varies, and typically is governed by lesion size, distribution, and pathologic severity. Treatment incorporates surgical excision with adjuvant cryotherapy to margins, topical chemotherapy, or both, the latter commonly with mitomycin C and 5-fluorouracil.1 More recently, the application of topical interferon alfa-2b has been used successfully for treating OSSN. (Source: Ophthalmology)
Source: Ophthalmology - December 15, 2017 Category: Opthalmology Authors: Matthew H. Ip, C.R. Robert George, Zin Naing, Elliot M. Perlman, William Rawlinson, Minas T. Coroneo Tags: Reports Source Type: research
The Primary Tube Versus Trabeculectomy Study
To describe the methodology of the Primary Tube Versus Trabeculectomy (PTVT) Study. (Source: Ophthalmology)
Source: Ophthalmology - December 14, 2017 Category: Opthalmology Authors: Steven J. Gedde, Philip P. Chen, Dale K. Heuer, Kuldev Singh, Martha M. Wright, William J. Feuer, Joyce C. Schiffman, Wei Shi, Primary Tube Versus Trabeculectomy Study Group Source Type: research
Glaucoma after Lens-Sparing Vitrectomy for Advanced Retinopathy of Prematurity
To report the incidence of, and factors related to, glaucoma after lens-sparing vitrectomy (LSV) surgery in advanced retinopathy of prematurity (ROP). (Source: Ophthalmology)
Source: Ophthalmology - December 11, 2017 Category: Opthalmology Authors: Eric Nudleman, Ilkay Kilic Muftuoglu, Raouf Gaber, Joshua Robinson, Kimberly Drenser, Antonio Capone, Michael T. Trese Source Type: research
Fragility of Results in Ophthalmology Randomized Controlled Trials
Evidence-based medicine is guided by our interpretation of randomized controlled trials (RCTs) that address important clinical questions. Evaluation of the robustness of statistically significant outcomes adds a crucial element to the global assessment of trial findings. The purpose of this systematic review was to determine the robustness of ophthalmology RCTs through application of the Fragility Index (FI), a novel metric of the robustness of statistically significant outcomes. (Source: Ophthalmology)
Source: Ophthalmology - December 11, 2017 Category: Opthalmology Authors: Carl Shen, Isabel Shamsudeen, Forough Farrokhyar, Kourosh Sabri Source Type: research
