Re: Keel et al.: The prevalence of diabetic retinopathy in Australian adults with self-reported diabetes: The National Eye Health Survey (Ophthalmology. 2017;124:977-984)
We congratulate Keel et al1 for their interesting paper on estimating the prevalence of diabetic retinopathy (DR) in non-Indigenous Australians and Indigenous Australians with self-reported diabetes. Collectively, these findings will be greatly useful in the future planning of healthcare resource allocation. (Source: Ophthalmology)
Source: Ophthalmology - January 18, 2018 Category: Opthalmology Authors: Lei Liu, Yih-Chung Tham Tags: Correspondence Source Type: research
Re: Guy et al.: Gene therapy for Leber hereditary optic neuropathy: low-and medium-dose visual results (Ophthalmology. 2017;124:1621-1634)
We read with interest the article by Guy et al1 about gene therapy by intravitreous, monocular injection of the AAV2-P1ND4v2 vector carrying the wild-type ND4 gene in 14 patients with Leber hereditary optic neuropathy (LHON) owing to the variant m.11778G>A in the ND4 gene. We have the following comments and concerns. (Source: Ophthalmology)
Source: Ophthalmology - January 18, 2018 Category: Opthalmology Authors: Josef Finsterer, Sinda Zarrouk-Mahjoub Tags: Correspondence Source Type: research
Reply
The primary objective of our manuscript was to report the prevalence of any diabetic retinopathy (DR) and vision-threatening DR among Indigenous (aged ≥40 years) and non-Indigenous (aged ≥50 years) Australians with known diabetes.1 Given the substantial burden of diabetes in Australia, coupled with a paucity of recent national population-based prevalence data on DR, this study was clearly warranted to assist planning for eye health care delive ry in Australia. (Source: Ophthalmology)
Source: Ophthalmology - January 18, 2018 Category: Opthalmology Authors: Stuart Keel, Joshua Foreman, Mohamed Dirani Tags: Correspondence Source Type: research
Reply
In the abstract conclusion, we are referring to the eye movement occurring after loss of fusion. Of course, maintenance of fusion in intermittent exotropia relies on visual feedback. (Source: Ophthalmology)
Source: Ophthalmology - January 18, 2018 Category: Opthalmology Authors: John R. Economides, Daniel L. Adams, Jonathan C. Horton Tags: Correspondence Source Type: research
Reply
Patients entered into our gene therapy study underwent complete physical and neurologic examinations before and after treatment, in addition to the visual studies. They also underwent many laboratory studies, which included hematology, coagulation, renal, and liver profiles. We did not detect any abnormalities other than visual loss. We had replied to this same query previously.1 Newman et al2 described normal electrocardiographs, lumbar punctures, computed tomography scans, and magnetic resonance imaging in all 72 of their 11 778 patients. (Source: Ophthalmology)
Source: Ophthalmology - January 18, 2018 Category: Opthalmology Authors: John Guy, William J. Feuer, Janet L. Davis, Vittorio Porciatti, Phillip J. Gonzalez, Rajeshwari D. Koilkonda, Huijun Yuan, William W. Hauswirth, Byron L. Lam Tags: Correspondence Source Type: research
Pediatric Keratoprosthesis: A Promise Unfulfilled
My foray into pediatric keratoprosthesis began in 2003. I was managing a challenging patient, a young boy aged 4 years with severe herpes simplex keratitis. After 3 penetrating keratoplasties, each one plagued by nonhealing epithelial defects with subsequent corneal melting, I discussed the possibility of a Boston Keratoprosthesis (KPro) with Claes Dohlman. Cornea aficionados will need no introduction to Dr. Dohlman, who has spent decades developing and improving the Boston KPro. Claes was skeptical about placing a KPro in a child. (Source: Ophthalmology)
Source: Ophthalmology - January 18, 2018 Category: Opthalmology Authors: Kathryn Colby Tags: Editorial Source Type: research
Open Search or Rotating Leadership: Thoughts Concerning Selecting Chairs for an Academic Ophthalmology Department
Frederick “Fritz” Redlich, an outstanding psychiatrist and Dean of Yale Medical School in the 1960s and 1970s, enjoyed recounting the evolution of department chairs in American medical schools. Originally it was the great clinician who was appointed chair, then the great clinician-teacher; after that, the great scientist was added to the mix, followed by the great financial manager. “And now,” Dean Redlich would conclude, “only a psychopath can believe himself to have all the qualifications for the job.”1 By the 1980s and 1990s, when Donna Shalala, Chancellor of the University of Wisconsin, interviewed candidat...
Source: Ophthalmology - January 18, 2018 Category: Opthalmology Authors: Daniel M. Albert, George B. Bartley Tags: Editorial Source Type: research
XEN Implant-Related Endophthalmitis
A 71-year-old woman presented with pain and hand movements vision in her left eye, following a failed XEN45 implant (Allergan, Dublin, Ireland) 11 months previously. She had a 1-mm hypopyon (Fig 1A) and an exposed XEN45 implant (Fig 1B, arrow) that stained with fluorescein (Fig 1C, arrow). She improved with intravitreal and topical antibiotics. Erosion of XEN implants through the conjunctiva can lead to severe infections such as endophthalmitis. Patients with flat blebs may have a higher risk due to direct contact of the implant and the overlying conjunctiva causing erosion, as in our case. (Source: Ophthalmology)
Source: Ophthalmology - January 18, 2018 Category: Opthalmology Authors: Rongxuan Lim, Kin Sheng Lim Tags: Pictures & Perspectives Source Type: research
Solitary Retinal Capillary Hemangioma with Nonlipid Exudative Retinal Detachment
A 42-year-old myopic woman with best-corrected visual acuity of 20/25 complained of vitreous floaters in her right eye for 6 months. Examination revealed vitreous opacity and inferonasal retinal detachment without hard exudates or retinal tears (Fig 1A). Within the area of retinal detachment, there was a mid-peripheral fibrotic retinal capillary hemangioma with feeding and draining vessels. Fundus autofluorescence image demonstrated more obvious retinal capillary hemangioma with prominent dilated and tortuous feeding artery and draining vein (Fig 1B). (Source: Ophthalmology)
Source: Ophthalmology - January 18, 2018 Category: Opthalmology Authors: Kuan-Jen Chen, Nan-Kai Wang, An-Ning Chao Tags: Pictures & Perspectives Source Type: research
OCT of Anterior Capsular Opacification in the Visual Axis
An 89-year-old woman with history of unremarkable cataract surgery 20 years ago and nonexudative age-related macular degeneration presented with decreased vision. Slit lamp showed an opacity on retroillumination (Fig 1A). Anterior segment (AS) OCT demonstrated fibrotic material with translucent and opacified cystic spaces of varying sizes overlying the anterior surface of the lens (Fig 1B). Visual acuity improved from 20/200 to 20/80 after removal of the fibrosis by anterior vitrectomy. Postoperative AS-OCT confirmed the source of fibrosis as capsular material extending from the posterior iris onto the lens (Fig 1C). (Source: Ophthalmology)
Source: Ophthalmology - January 18, 2018 Category: Opthalmology Authors: Aaron Z. Priluck, Joshua C. Priluck, Jarred Holweger Tags: Pictures & Perspectives Source Type: research
Imaging of Neovascular Membrane Over a Choroidal Osteoma by OCT Angiography
A 26-year-old man presented with a 5-month history of blurry vision, photopsia, and metamorphopsia of the right eye. Retinal examination showed a geographic orange-yellow calcified macular lesion, with retinal pigment epithelium (RPE) mottling and subtle hemorrhage (Fig 1A), suggesting a choroidal neovascular membrane (CNVM). An OCT angiography (OCTA) showed an increased capillary density (Fig 1B and C, white arrows), identifying a juxtafoveal CNVM along the edge of the tumor, at the level of the choroid capillary plexus (Fig 1B) and the external plexiform layer (Fig 1C). (Source: Ophthalmology)
Source: Ophthalmology - January 18, 2018 Category: Opthalmology Authors: Ana Beatriz D. Grisolia, Maira de Fran ça Martins, Hakan Demirci Tags: Pictures & Perspectives Source Type: research
Epidermal Growth Factor Receptor Inhibitor Induced Trichomegaly and Poliosis
A 50-year-old man diagnosed with colon cancer and liver metastasis, underwent extensive chemotherapy with m-FOLFOX6 combined with avastin, hemicolectomy, segmental liver resection followed by addition of multiple cycles of Panitumumab (epidermal growth factor inhibitor [EGFR]). A baseline eye examination before initiation of another drug revealed hyperemia of face with papulopustular lesions (black arrow) similar to rosacea lesions. The eyebrows were found to be thick and rigid (blue arrow). Slit lamp examination revealed elongated and thickened eyelashes (trichomegaly) with curled terminal ends (red arrow). (Source: Ophthalmology)
Source: Ophthalmology - January 18, 2018 Category: Opthalmology Authors: Sunali Goyal, Sami H. Uwaydat Tags: Pictures & Perspectives Source Type: research
Editorial Board
(Source: Ophthalmology)
Source: Ophthalmology - January 18, 2018 Category: Opthalmology Source Type: research
Contents
(Source: Ophthalmology)
Source: Ophthalmology - January 18, 2018 Category: Opthalmology Source Type: research
Abstracts
Sara Forsell, MD, Eva M önestam, MD, PhD (Source: Ophthalmology)
Source: Ophthalmology - January 18, 2018 Category: Opthalmology Tags: Ophthalmology retina abstracts Source Type: research
