Re: Zweifel et  al.: Clinical and histopathologic findings in disseminated Mycobacterium chimera infection after cardiothoracic surgery (Ophthalmology. 2017;124:178-188)
The report by Zweifel et al1 is an important paper. The findings of such nontuberculous mycobacteria in lung granulomas of a patient with choroidal lesions so similar to those seen in active multifocal choroiditis (MFC) buttresses previous speculation that such agents are a cause of MFC, particularly in areas where histoplasmosis is not endemic.2 In fact, given the recognized unreliability of skin test evaluation and the ubiquitous environmental presence of nontuberculous mycobacteria, they could also be causative in histoplasmosis endemic areas. (Source: Ophthalmology)
Source: Ophthalmology - April 19, 2018 Category: Opthalmology Authors: Robert Watzke Tags: Correspondence Source Type: research

Public Health Burden and Potential Interventions for Myopia
Myopia is the most common ocular abnormality in the world.1,2 Its growing prevalence has resulted in it reaching near ubiquitous status in many East Asian communities, affecting 80% to 90% of young adults in many communities.3 –5 Approximately one third of adult Americans and Europeans are myopic.6,7 A limitation of both of these estimates is that they used noncycloplegic refractions, which may have overestimated myopia in younger patients because of accommodation.6,7 The estimated prevalence of myopia (≤−0.75 diopt ers [D]) among Europeans aged 50 to 54 years is 33.6%, with 2.6% of those in this age group b...
Source: Ophthalmology - April 19, 2018 Category: Opthalmology Authors: Bobeck S. Modjtahedi, Frederick L. Ferris, David G. Hunter, Donald S. Fong Tags: Editorial Source Type: research

Reply
We would like to thank Dr Watzke for his interest in our article.1 (Source: Ophthalmology)
Source: Ophthalmology - April 19, 2018 Category: Opthalmology Authors: Sandrine A. Zweifel, Peter M. Keller, Barbara Hasse, Daniel Barthelmes, Christian B öni Tags: Correspondence Source Type: research

Re: Assel et al.: Genetic polymorphisms of CFH and ARMS2 do not predict response to antioxidants and zinc in patients with age-related macular degeneration (Ophthalmology. 2018;125:391-397)
We requested that the National Institutes of Health Agency of Intramural Research Integrity investigate the use of the National Eye Institute's position of authority to advance its commercial interest in the Age-Related Eye Disease Study (AREDS) formulation. A statistical review was commissioned and is reported, in part, in the publication by Assel et  al.1 As part of the review process genotypes from 535 AREDS cases that were not analyzed in the publications that first highlighted potential genotype-specific harm and previously unavailable were provided. (Source: Ophthalmology)
Source: Ophthalmology - April 19, 2018 Category: Opthalmology Authors: Brent Zanke Tags: Correspondence Source Type: research

Reply
In response to Dr Zanke's letter, we would first note that he raises no objection to the substantive content of our paper. Zanke's comments seem to us to be an effort in moving the goalposts: yes, we are right that genotyping does not predict whether supplements reduce the risk of age-related macular degeneration (AMD) in general, but apparently that is not the point; genotyping predicts response with respect to only 1 type of AMD progression. (Source: Ophthalmology)
Source: Ophthalmology - April 19, 2018 Category: Opthalmology Authors: Andrew J. Vickers Tags: Correspondence Source Type: research

Re: Srinivasan et  al.: Comparison of new visual disturbances after superior versus nasal/temporal laser peripheral iridotomy: a prospective randomized trial (Ophthalmology. 2018;125:345-351)
We applaud Srinivasan et  al1 for their well-powered study examining dysphotopsia's post-laser peripheral iridotomy (LPI) in a South Indian population. Their findings do contrast other reported studies with more diverse ethnic groups.2,3 Their study was designed to ensure that the LPI was covered by the eyelid superiorly a nd not covered in the temporal/nasal region. However, they failed to comment on the location of the LPI relative to the eyelid after the procedure. In addition, the short follow-up period of 2 weeks, is likely too short to adequately differentiate between a temporary and long-term dysphotopsia. (Source: Ophthalmology)
Source: Ophthalmology - April 19, 2018 Category: Opthalmology Authors: Graham W. Belovay, Vanessa Vera, Devesh K. Varma, Iqbal Ike K. Ahmed Tags: Correspondence Source Type: research

Von Hippel-Lindau Incidentally Diagnosed in Evaluation of Sporadic Aniridia
A 15-year-old girl with history of unilateral sporadic aniridia presented with decreased vision and eye pain in the left eye (Fig 1A). Fundus examination of right eye revealed a capillary hemangioma inferonasally with circumferential exudation consistent with Von Hippel-Lindau Syndrome (VHL) (Fig 1B). Examination of the left eye revealed complete chronic exudative retinal detachment and neovascular glaucoma presumed to be due to capillary hemangioma (Fig 1C). Genetic testing and a systemic work-up were performed. (Source: Ophthalmology)
Source: Ophthalmology - April 19, 2018 Category: Opthalmology Authors: Ian C. Holmen, Zackery Oakey, Michael M. Altaweel Tags: Pictures & Perspectives Source Type: research

Reply
We thank Belovay et  al for their comments on our paper regarding how iridotomy location affects the likelihood of post-laser peripheral iridotomy (LPI) symptoms.1 We also congratulate them on their prior randomized trial on the same topic,2 and welcome an open discussion regarding why their trial noted significantly more new post-LPI linear dysphotopsias with superiorly placed iridotomies as compared with nasal/temporal LPIs (P = 0.002), whereas our trial showed no such difference (P = 0.6). Neither study showed group differences with regard to overall rates of dysphotopsia or other types of dysphotopsia. (...
Source: Ophthalmology - April 19, 2018 Category: Opthalmology Authors: Kavitha Srinivasan, Nazlee Zebardast, Rengaraj Venkatesh, Pradeep Y. Ramulu Tags: Correspondence Source Type: research

Subconjunctival Mascara Deposition
A 50-year-old woman presented with chronic foreign body sensation in both eyes. She admitted to more than 25 years of heavy mascara use on her lashes with inadequate removal. Eversion of the upper lids revealed multiple darkly pigmented subconjunctival concretions, some eroding through the conjunctival surface (Fig 1A). This was associated with a patchy follicular conjunctivitis and punctate corneal erosions. Histopathological examination of a conjunctival biopsy revealed a chronic inflammatory infiltrate with pigmented macrophages, in keeping with foreign body deposition (Fig 1B). (Source: Ophthalmology)
Source: Ophthalmology - April 19, 2018 Category: Opthalmology Authors: Dana Robaei Tags: Pictures & Perspectives Source Type: research

Deep Lamellar Endothelial Keratoplasty for Epithelial Ingrowth
A 9-year-old child presented with left eye corneal opacity for 5 months followed by trauma with plastic stick. There was greyish white opacity (Fig 1A), which seemed to be a fluid collection with in the well-defined anterior and posterior wall (yellow arrow), confirmed with anterior segment OCT (Fig 1B). The diagnosis of posttraumatic intracorneal epithelial cyst was made. We performed deep lamellar endothelial keratoplasty. The patient showed well attached lenticule along with clear visual axis 2 months postoperatively (Fig 1C). (Source: Ophthalmology)
Source: Ophthalmology - April 19, 2018 Category: Opthalmology Authors: Bhupesh Bagga, Sridhar Rao Tags: Pictures & Perspectives Source Type: research

Direct View of the Angle Structures in Bilateral Congenital Megalocornea
A 3-year-old boy presented to the pediatric ophthalmology department with a diagnosis of bilateral congenital megalocornea. On observation, he had extremely large corneal diameters with minimal sclera show (Fig 1A), and the appearance of large palpebral apertures. There was a corneal optical aberration when viewed from the side (left eye; Fig  1B) and when magnified, it is possible to view the angle structures (right eye; Fig 1C) without the aid of a gonioscopy lens. Apart from the corneas, all anterior segment structures appeared to be normal, with no evidence of glaucoma. (Source: Ophthalmology)
Source: Ophthalmology - April 19, 2018 Category: Opthalmology Authors: Damien C.M. Yeo, Stephanie Figg, William Moore Tags: Pictures & Perspectives Source Type: research

Predicting Choroidal Melanoma Regression after Brachytherapy
After brachytherapy, some choroidal melanomas regress faster than others. Several studies suggest that these tumors are more likely to metastasize than those that regress slowly. Not all authors support this view, some reporting no correlation between tumor regression and monosomy 3, which is highly lethal.1 More research is needed to determine whether tumor regression rate after brachytherapy predicts metastasis. (Source: Ophthalmology)
Source: Ophthalmology - April 19, 2018 Category: Opthalmology Authors: Bertil Damato Tags: Commentary Source Type: research

Leukemic Optic Nerve Infiltration Responds to Radiation and Blinatumomab
A 52-year-old man with a history of Philadelphia chromosome negative B-cell acute lymphoblastic leukemia in remission presented with decreased vision in the right eye (OD) and headache. His visual acuity was count fingers OD and 20/20 left eye (OS). Fundoscopic examination revealed bilateral optic disc edema (Fig 1A and B). He was diagnosed with leukemic infiltration of the optic nerves. Treatment consisted of urgent radiotherapy and Blinatumomab, an anti-CD19 antibody that redirects T cells to enhance lysis of tumor cells. (Source: Ophthalmology)
Source: Ophthalmology - April 19, 2018 Category: Opthalmology Authors: Erol Verter, Alina Yang, Renelle P. Lim Tags: Pictures & Perspectives Source Type: research

Retinal Imaging of an Optic Tract Lesion: OCT Angiography of Structural and Functional Defects
A 44-year-old man presented with a 10-month history of right-sided vision loss. Humphrey visual fields showed a right, incomplete homonymous hemianopia (Fig 1A) secondary to a left optic tract metastasis from melanoma (Fig  1C). Homonymous macular ganglion cell complex loss and “bow-tie” retinal nerve fiber loss were demonstrated with OCT (Fig 1B). OCT-angiography showed dropout of capillaries in the retinal superficial vascular plexus centered on the optic discs in the areas of “bow-tie” atrophy (Fig 1D). (Source: Ophthalmology)
Source: Ophthalmology - April 19, 2018 Category: Opthalmology Authors: Jonathan A. Micieli, Nancy J. Newman, Val érie Biousse Tags: Pictures & Perspectives Source Type: research

Editorial Board
(Source: Ophthalmology)
Source: Ophthalmology - April 19, 2018 Category: Opthalmology Source Type: research

Contents
(Source: Ophthalmology)
Source: Ophthalmology - April 19, 2018 Category: Opthalmology Source Type: research

Corrigendum
The authors of “XEN Implant-Related Endophthalmitis” (Ophthalmology. 2018;125(2):209) would like to issue a correction to their Pictures& Perspectives. The author Saurabh Goyal should have appeared as the second author. The authors should have appeared as follows: (Source: Ophthalmology)
Source: Ophthalmology - April 19, 2018 Category: Opthalmology Tags: Corrigendum Source Type: research

Corrigendum
The authors of “Ultrastructural integrity of human capsulotomies created by a thermal device” (Ophthalmology. 2018;125:340–344) would like to issue the following correction to the magnification (in boldface) in Fig 3A. The figure legend should have appeared as follows: “Figure 3. A, Irregularly rolled edg e of the precision pulse capsulotomy (PPC) at low magnification (original magnification, ×500). B, Subtle PPC margin irregularities at high magnification (arrow indicates the width of the capsulotomy margin; original magnification, ×4000). (Source: Ophthalmology)
Source: Ophthalmology - April 19, 2018 Category: Opthalmology Tags: Corrigendum Source Type: research

Corrigendum
The authors of “Foveal hypoplasia in patients with Stickler syndrome” (Ophthalmology. 2017;124:896–902) would like to issue the following correction to their article. The mutation description in the second paragraph of the Methods section is incorrect. The corrected description appears in boldface: “These 4 patients had known mutations: c.1693C>T (p.Arg565Cys) for patients 22 and 23, c.1957C>T (p.R653*) for patient 24, and c.3624delT (p.P1208fs) for patient 25. ” (Source: Ophthalmology)
Source: Ophthalmology - April 19, 2018 Category: Opthalmology Tags: Corrigendum Source Type: research

A Fragility Index: Handle with Care
Criticizing P values never goes out of style. A person looking for examples of misinterpretation and miscalculation will not search long.1 More damning, the P value answers a question the reader may not have even asked, unless of course they like to frame their questions conditioned on a null hypothesis. The fragility index points out yet another flaw in relying on a dichotomous threshold for significance. The index highlights how conclusions based on P values close to the threshold could be dependent on a few cases going the right way. (Source: Ophthalmology)
Source: Ophthalmology - April 19, 2018 Category: Opthalmology Authors: Travis C. Porco, Thomas M. Lietman Tags: Commentary Source Type: research

Abstracts
Justis P. Ehlers, MD, Mehnaz Khan, MD, Daniel Petkovsek, MD, Laura Stiegel, Peter K. Kaiser, MD, Rishi P. Singh, MD, Jamie L. Reese, BSN, Sunil K. Srivastava, MD (Source: Ophthalmology)
Source: Ophthalmology - April 19, 2018 Category: Opthalmology Source Type: research

This Issue at a Glance
Atchison et  al (p. 676) set out to identify the sustained effects of anti-vascular endothelial growth factor (VEGF) drug injections on intraocular pressure (IOP). They analyzed 23 873 patients from the AAO IRIS Registry who received an intravitreous injection with aflibercept, bevacizumab, or ranibizumab in their right eyes between January 1, 2013 and December 31, 2015, and they used fellow, untreated eyes for comparison. Patients showed a statistically significant decrease in IOP, with a mean of 0.9 mmHg in treated eyes compared with an average decrease of 0.2 mmHg in fellow, untreated eyes. (Source: Ophthalmology)
Source: Ophthalmology - April 19, 2018 Category: Opthalmology Authors: Sandeep Ravindran Tags: This issue at a glance Source Type: research

A Simple Vista en Este N úmero
Atchison y otros (p. 676) se propusieron identificar los efectos sostenidos de las inyecciones de antifactor de crecimiento endotelial vascular (VEGF) en la presi ón intraocular (IOP). Analizaron 23.873 pacientes del Registro AAO IRIS que recibieron una inyección intravítrea de aflibercept, bevacizumab o ranibizumab en el ojo derecho entre el 1 de enero de 2013 y el 31 de diciembre de 2015, utilizando los ojos contralaterales no tratados como comparación. Los pacientes mostraron una reducción estadísticamente significativa de la IOP con una media de 0,9 mmHg en los ojos tratados co...
Source: Ophthalmology - April 19, 2018 Category: Opthalmology Authors: Sandeep Ravindran Tags: This issue at a glance Source Type: research

期刊一览
Atchison (p. 676) 等就抗血管内皮生长因子 (anti-vascular endothelial growth factor [VEGF]) 药物注射对眼压 (intraocular pressure [IOP]) 的持续性影响进行研究。他们共分析了来自AAO IRIS登记的23873名右眼接受玻璃体腔注射患者, 于2013年1月1日至2015年12月31日期间分 别接受阿柏西普、贝伐单抗或雷珠单抗治疗; 并与未治疗的对侧眼进行比较。患者IOP显著降低, 具有统计学差异; 在治疗眼平均下降0.9 mmHg, 对侧未治疗眼平均下降0.2 mmHg。多数亚组中, 贝伐单抗治疗较阿柏西普和雷珠单抗治疗IOP下降 程度...
Source: Ophthalmology - April 19, 2018 Category: Opthalmology Authors: Sandeep Ravindran Tags: This issue at a glance Source Type: research

Phase 2 Randomized, Double-Masked, Vehicle-Controlled Trial of Recombinant Human Nerve Growth Factor for Neurotrophic Keratitis
To evaluate the safety and efficacy of topical recombinant human nerve growth factor (rhNGF) for treating moderate-to-severe neurotrophic keratitis (NK), a rare degenerative corneal disease resulting from impaired corneal innervation. (Source: Ophthalmology)
Source: Ophthalmology - April 10, 2018 Category: Opthalmology Authors: Stefano Bonini, Alessandro Lambiase, Paolo Rama, Francesco Sinigaglia, Marcello Allegretti, Wendy Chao, Flavio Mantelli, REPARO Study Group Source Type: research

A Deep Learning Algorithm for Prediction of Age-Related Eye Disease Study Severity Scale for Age-Related Macular Degeneration from Color Fundus Photography
Age-related macular degeneration (AMD) is a common threat to vision. While classification of disease stages is critical to understanding disease risk and progression, several systems based on color fundus photographs are known. Most of these require in-depth and time-consuming analysis of fundus images. Herein, we present an automated computer-based classification algorithm. (Source: Ophthalmology)
Source: Ophthalmology - April 10, 2018 Category: Opthalmology Authors: Felix Grassmann, Judith Mengelkamp, Caroline Brandl, Sebastian Harsch, Martina E. Zimmermann, Birgit Linkohr, Annette Peters, Iris M. Heid, Christoph Palm, Bernhard H.F. Weber Source Type: research

Phase I Trial of Recombinant Human Nerve Growth Factor for Neurotrophic Keratitis
Neurotrophic keratitis/keratopathy (NK), a rare degenerative corneal disease, lacks effective pharmacologic therapies.1 Because NK pathology involves trigeminal nerve damage and loss of corneal innervation, nerve growth factor (NGF) is surmised to promote healing of NK.2 Preliminary studies with murine NGF demonstrated efficacy for treating corneal neurotrophic ulcers;3 however, the complex tertiary structure of NGF has complicated the production of recombinant human NGF (rhNGF) suitable for clinical development. (Source: Ophthalmology)
Source: Ophthalmology - April 10, 2018 Category: Opthalmology Authors: Stefano Bonini, Alessandro Lambiase, Paolo Rama, Isabella Filatori, Marcello Allegretti, Wendy Chao, Flavio Mantelli, REPARO Study Group Tags: Reports Source Type: research

Chemodenervation for the Treatment of Facial Dystonia
To review the medical literature on the outcomes and complications of various Food and Drug Administration-approved botulinum toxins for benign essential blepharospasm (BEB) and hemifacial spasm (HFS). (Source: Ophthalmology)
Source: Ophthalmology - April 10, 2018 Category: Opthalmology Authors: Jurij R. Bilyk, Michael T. Yen, Elizabeth A. Bradley, Edward J. Wladis, Louise A. Mawn Tags: Ophthalmic Technology Assessment Source Type: research

Posterior Vitreous Detachment as Observed by Wide-Angle OCT Imaging
Posterior vitreous detachment (PVD) plays an important role in vitreoretinal interface disorders. Historically, observations of PVD using OCT have been limited to the macular region. The purpose of this study is to image the wide-angle vitreoretinal interface after PVD in normal subjects using montaged OCT images. (Source: Ophthalmology)
Source: Ophthalmology - April 6, 2018 Category: Opthalmology Authors: Mayuka Tsukahara, Keiko Mori, Peter L. Gehlbach, Keisuke Mori Source Type: research

Contact Lens Correction of Aphakia in Children
To review the published literature to assess the visual outcomes and adverse events associated with the 2 most commonly used contact lenses for treating aphakia in children: silicone elastomer (SE) and rigid gas permeable (RGP). (Source: Ophthalmology)
Source: Ophthalmology - April 6, 2018 Category: Opthalmology Authors: Scott R. Lambert, Raymond T. Kraker, Stacy L. Pineles, Amy K. Hutchinson, Lorri B. Wilson, Jennifer A. Galvin, Deborah K. VanderVeen Tags: Ophthalmic Technology Assessment Source Type: research

Suppression of Melatonin Secretion in Totally Visually Blind People by Ocular Exposure to White Light
Although most totally visually blind individuals exhibit nonentrained circadian rhythms due to an inability of light to entrain the circadian pacemaker, a small proportion retain photic circadian entrainment, melatonin suppression, and other nonimage-forming responses to light. It is thought that these responses to light persist because of the survival of melanospin-containing intrinsically photosensitive retinal ganglion cells (ipRGCs), which project primarily to the circadian pacemaker and are functionally distinct from the rod and cone photoreceptors that mediate vision. (Source: Ophthalmology)
Source: Ophthalmology - April 3, 2018 Category: Opthalmology Authors: Joseph T. Hull, Charles A. Czeisler, Steven W. Lockley Source Type: research

Measuring Patient Loyalty in Ophthalmology: A Nationally Representative Study
In 2006, the Hospital Consumer Assessment of Healthcare Providers and Systems survey became the nation ’s “first national, standardized, publicly reported survey of patients’ perspectives of hospital care.”1 The Patient Protection and Affordable Care Act of 2010 tied such surveys directly to hospital reimbursement,2 making understanding what drives patient satisfaction critical for providers to maintain good patient relationships. (Source: Ophthalmology)
Source: Ophthalmology - April 3, 2018 Category: Opthalmology Authors: David J. Ramsey, David L. Lazar, Gregory R. Blaha, Donald L. Malott, Jeffrey L. Marx Tags: Reports Source Type: research

Choroidal and Sub-Retinal Pigment Epithelium Caverns
To survey Friedman lipid globules by high-resolution histologic examination and to compare with multimodal imaging of hyporeflective caverns in eyes with geographic atrophy (GA) secondary to age-related macular (AMD) and other retinal diseases. (Source: Ophthalmology)
Source: Ophthalmology - April 3, 2018 Category: Opthalmology Authors: Rosa Dolz-Marco, Jay P. Glover, Orly Gal-Or, Katie M. Litts, Jeffrey D. Messinger, Yuhua Zhang, Mariano Cozzi, Marco Pellegrini, K. Bailey Freund, Giovanni Staurenghi, Christine A. Curcio Source Type: research

The Globe ’s Eccentric Rotational Axis
Tables  typically recommend greater lateral rectus (LR) than medial rectus (MR) surgical doses for horizontal strabismus of any given magnitude, a difference unexplained by mechanical models that assume globe rotation about its center. We tested this assumption during horizontal ductions. (Source: Ophthalmology)
Source: Ophthalmology - March 30, 2018 Category: Opthalmology Authors: Robert A. Clark, Joseph L. Demer Source Type: research

Loss to Follow-Up in Patients with Proliferative Diabetic Retinopathy after Panretinal Photocoagulation or Intravitreal Anti-VEGF Injections
Loss to follow-up (LTFU) may contribute to vision loss in patients with active proliferative diabetic retinopathy (PDR). The aim of this study is to determine and compare the rates of LTFU in patients with PDR receiving panretinal photocoagulation (PRP) or intravitreal injections (IVIs) with anti-vascular endothelial growth factor (VEGF) over approximately 4 years. Moreover, this study evaluates various risk factors for LTFU. (Source: Ophthalmology)
Source: Ophthalmology - March 29, 2018 Category: Opthalmology Authors: Anthony Obeid, Xinxiao Gao, Ferhina S. Ali, Katherine E. Talcott, Christopher M. Aderman, Leslie Hyman, Allen C. Ho, Jason Hsu Source Type: research

Cost Evaluation of Early Vitrectomy versus Panretinal Photocoagulation and Intravitreal Ranibizumab for Proliferative Diabetic Retinopathy
To evaluate costs and cost-utility of early vitrectomy (pars plana vitrectomy [PPV]) compared with panretinal photocoagulation (PRP) and intravitreal ranibizumab (IVR) for proliferative diabetic retinopathy (PDR) without diabetic macular edema. (Source: Ophthalmology)
Source: Ophthalmology - March 29, 2018 Category: Opthalmology Authors: James Lin, Jonathan S. Chang, Nicolas A. Yannuzzi, William E. Smiddy Source Type: research

Determinants of Outcomes of Adenoviral Keratoconjunctivitis
To determine host and pathogen factors predictive of outcomes in a large clinical cohort with keratoconjunctivitis. (Source: Ophthalmology)
Source: Ophthalmology - March 27, 2018 Category: Opthalmology Authors: Cecilia S. Lee, Aaron Y. Lee, Lakshmi Akileswaran, David Stroman, Kathryn Najafi-Tagol, Steve Kleiboeker, James Chodosh, Amalia Magaret, Anna Wald, Russell N. Van Gelder, BAYnovation Study Group Source Type: research

Ten-Year Progression of Myopic Maculopathy
To investigate the progression pattern of myopic maculopathy and associated factors in a population-based study. (Source: Ophthalmology)
Source: Ophthalmology - March 27, 2018 Category: Opthalmology Authors: Yan Ni Yan, Ya Xing Wang, Yan Yang, Liang Xu, Jie Xu, Qian Wang, Jing Yan Yang, Xuan Yang, Wen Jia Zhou, Kyoko Ohno-Matsui, Wen Bin Wei, Jost B. Jonas Source Type: research

Successful Optimization of Adalimumab Therapy in Refractory Uveitis Due to Beh çet's Disease
To assess efficacy, safety, and cost-effectiveness of adalimumab (ADA) therapy optimization in a large series of patients with uveitis due to Beh çet disease (BD) who achieved remission after the use of this biologic agent. (Source: Ophthalmology)
Source: Ophthalmology - March 27, 2018 Category: Opthalmology Authors: Jos é Luis Martín-Varillas, Vanesa Calvo-Río, Emma Beltrán, Juan Sánchez-Bursón, Marina Mesquida, Alfredo Adán, María Victoria Hernandez, Marisa Hernández Garfella, Elia Valls Pascual, Lucía Martínez-Costa, Agustí Sellas-Fernández, Miguel Cor Source Type: research

Evaluation of Ophthalmic Surgical Instrument Sterility Using Short-Cycle Sterilization for Sequential Same-Day Use
This study was undertaken to evaluate the efficacy of short-cycle sterilization processing for consecutive same-day cataract procedures. (Source: Ophthalmology)
Source: Ophthalmology - March 27, 2018 Category: Opthalmology Authors: David F. Chang, Nikki Hurley, Nick Mamalis, Jeffrey Whitman Source Type: research

Retinal Degeneration in Choroideremia follows an Exponential Decay Function
Fundus autofluorescence (AF) arises from lipofuscin, which is derived from retinoid byproducts of the visual cycle and accumulates within retinal pigment epithelial cells. Alterations in AF pattern are seen in a wide range of retinal degenerations. Choroideremia is an X-linked retinal dystrophy caused by loss-of-function mutations within the CHM gene, encoding Rab escort protein-1.1 It is uniquely characterized by a central “island” of residual AF that undergoes gradual shrinkage with disease progression. (Source: Ophthalmology)
Source: Ophthalmology - March 24, 2018 Category: Opthalmology Authors: James W. Aylward, Kanmin Xue, Maria I. Patr ício, Jasleen K. Jolly, Jonathan C. Wood, Jonathan Brett, Kirti M. Jasani, Robert E. MacLaren Tags: Report Source Type: research

Pupillary Responses to Full-Field Chromatic Stimuli Are Reduced in Patients with Early-Stage Primary Open-Angle Glaucoma
To evaluate the ability of chromatic pupillometry to reveal abnormal pupillary responses to light in patients with early-stage primary open-angle glaucoma (POAG) and to test whether the degree of pupillometric impairment correlates with structural hallmarks of optic nerve damage in the disease. (Source: Ophthalmology)
Source: Ophthalmology - March 22, 2018 Category: Opthalmology Authors: Raymond P. Najjar, Sourabh Sharma, Eray Atalay, Annadata V. Rukmini, Christopher Sun, Jing Zhan Lock, Mani Baskaran, Shamira A. Perera, Rahat Husain, Ecosse Lamoureux, Joshua J. Gooley, Tin Aung, Dan Milea Source Type: research

Impact of Incidence and Progression of Diabetic Retinopathy on Vision-Specific Functioning
To investigate the independent impact of the incidence and progression of diabetic retinopathy (DR) on visual functioning (VF). (Source: Ophthalmology)
Source: Ophthalmology - March 20, 2018 Category: Opthalmology Authors: Preeti Gupta, Alfred Tau Liang Gan, Ryan Eyn Kidd Man, Eva K. Fenwick, Neelam Kumari, Gavin Tan, Paul Mitchell, Charumathi Sabanayagam, Tien Yin Wong, Ching-Yu Cheng, Ecosse L. Lamoureux Source Type: research

Clinical Prediction Performance of Glaucoma Progression Using a 2-Dimensional Continuous-Time Hidden Markov Model with Structural and Functional Measurements
Previously, we introduced a state-based 2-dimensional continuous-time hidden Markov model (2D CT HMM) to model the pattern of detected glaucoma changes using structural and functional information simultaneously. The purpose of this study was to evaluate the detected glaucoma change prediction performance of the model in a real clinical setting using a retrospective longitudinal dataset. (Source: Ophthalmology)
Source: Ophthalmology - March 20, 2018 Category: Opthalmology Authors: Youngseok Song, Hiroshi Ishikawa, Mengfei Wu, Yu-Ying Liu, Katie A. Lucy, Fabio Lavinsky, Mengling Liu, Gadi Wollstein, Joel S. Schuman Source Type: research

Cost Evaluation of Laser versus Intravitreal Aflibercept for Proliferative Diabetic Retinopathy
Diabetic retinopathy affects 8 million Americans with diabetes and proliferative diabetic retinopathy (PDR) is associated with severe vision loss. The Diabetic Retinopathy Study (DRS) established panretinal photocoagulation (PRP) as an effective treatment for PDR. Reports including randomized clinical trials1,2 have established intravitreal ranibizumab (IVR) as a noninferior treatment option for PDR. The Diabetic Retinopathy Clinical Research (DRCR) Protocol S showed that eyes treated with IVR had less macular edema, visual field loss, and need for pars plana vitrectomy compared with PRP. (Source: Ophthalmology)
Source: Ophthalmology - March 20, 2018 Category: Opthalmology Authors: Nicolas A. Yannuzzi, Jayanth Sridhar, Jonathan S. Chang, James Lin, Ajay E. Kuriyan, William E. Smiddy Tags: Reports Source Type: research

Re: Schlenker et  al.: Efficacy, safety, and risk factors for failure of standalone ab interno gelatin microstent implantation versus standalone trabeculectomy. (Ophthalmology. 2017;124:1579-1588)
We read with interest the paper by Schlenker et  al.1 The authors state that the results with the Xen implant (Allergan, Parsippany-Troy Hills, NJ) with mitomycin C (MMC) are very similar to those of trabeculectomy with MMC in terms of both safety and efficacy. Based on these data, they suggest that the Xen implant is a reasonable alternative to trabeculectomy. When comparing the 2 groups in this paper, this finding does indeed seem to be the case. However, we think it is reasonable to point out that results from the trabeculectomy group are considerably worse than those from other real-world studies. (Source: Ophthalmology)
Source: Ophthalmology - March 19, 2018 Category: Opthalmology Authors: James Kirwan, Alastair Lockwood, Peter Shah, David Broadway, Andrew McNaught, Anthony King Tags: Correspondence Source Type: research

Establishing a Vision and Eye Health Surveillance System for the Nation: A Status Update on the Vision and Eye Health Surveillance System
Vision loss and eye disorders cost the US health care system $65.1 billion in 2013, the fifth leading cause of medical expenditures.1 Americans fear losing vision as much as or more than memory, hearing, or speech, and consider blindness among the top 4 worst things that could happen to them.2 It is estimated that as much as 98% of visual impairment and blindness, much of it consisting of uncorrected refractive error and untreated cataracts, in the United States can be prevented through timely diagnosis and early treatment. (Source: Ophthalmology)
Source: Ophthalmology - March 19, 2018 Category: Opthalmology Authors: David B. Rein, John S. Wittenborn, Emily A. Phillips, Jinan B. Saaddine, Vision and Eye Health Surveillance System Study Group Tags: Editorial Source Type: research

Reply
We thank Dr Kirwan for his interest and comments on our article. Dr Kirwan asserts that an ab interno gelatin microstent is a reasonable alternative to trabeculectomy “where the trabeculectomy results are suboptimal.” In our earlier correspondence, we have shown that our trabeculectomy results are very much in keeping with the modern trabeculectomy literature, and elaborated on the “difficulties” Dr Kirwan alludes to but does not address in comparing resu lts across studies. For instance, the retrospective 2015 study by Kirwan et al compared with this one has differences in baseline characteris...
Source: Ophthalmology - March 19, 2018 Category: Opthalmology Authors: Matthew B. Schlenker, Husayn Gulamhusein, Ina Conrad-Hengerer, Alix Somers, Markus Lenzhofer, Ingeborg Stalmans, Herbert Reitsamer, Fritz H. Hengerer, Iqbal Ike K. Ahmed Tags: Correspondence Source Type: research

Re: Francis et  al.: Clinical and morphologic characteristics of MEK inhibitor-associated retinopathy: differences from central serous chorioretinopathy (Ophthalmology. 2017;124:1788-1798)
We read with interest the work by Francis et  al,1 describing the clinical characteristics and OCT findings of a novel pathologic condition named mitogen-activated protein kinase (MEK) inhibitor-associated retinopathy (MEKAR). They explained that the toxicity profile of a novel class of chemotherapeutics that specifically blocks the mitogen-a ctivated protein kinase pathway includes the acute accumulation (within approximately 2 weeks from the first intake) of focal or multifocal, self-limited (approximately 32 days), nongravitational, subretinal fluid (SRF) pockets, distributed through the entire macula in one or bot...
Source: Ophthalmology - March 19, 2018 Category: Opthalmology Authors: Raul Velez-Montoya, Daniel Rangel-O ’Shea, Scott C. Oliver Tags: Correspondence Source Type: research

Re: Reddy et  al.: Vitrectomy and vitrector port needle biopsy of choroidal melanoma for gene expression profile testing immediately before brachytherapy. (Ophthalmology. 2017;124:1377-1382)
We read with interest the article by Reddy et  al,1 which advocates combined 25-gauge pars plana vitrectomy, transvitrectomy port fine-needle aspiration biopsy of choroidal melanoma with subsequent endolaser photocoagulation and suturing of the sclerotomies to prevent scleral tumor seeding. (Source: Ophthalmology)
Source: Ophthalmology - March 19, 2018 Category: Opthalmology Authors: Armin R. Afshar, Bertil E. Damato, Jay M. Stewart, Heinrich Heimann, Sarah E. Coupland Tags: Correspondence Source Type: research