Prognostic Assessment of Diabetics Using Myocardial Perfusion Imaging: Diabetes Mellitus is Still a Coronary Artery Disease Equivalent.
Conclusions: In diabetic patients without known CAD, the rate of death was not significantly different from patients with prior CAD and without DM. Abnormal MPS increased risk similarly in diabetic patients and in those with CAD. These findings suggest that DM may still be considered a high-risk condition, comparable to known CAD, and effectively stratified by MPS. PMID: 29290832 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - January 3, 2018 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Trends in Stroke-Related Mortality in the ABC Region, S ão Paulo, Brazil: An Ecological Study Between 1997 and 2012.
Conclusion: The ABC region showed greater mortality due to stroke in males, the age group above 49 years, and non-specified stroke between 1997 and 2012. PMID: 29290833 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - January 3, 2018 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Barnidipine Real-Life Efficacy and Tolerability in Arterial Hypertension: Results from Younger and Older Patients in the BASIC-HT Study.
Conclusion: The efficacy and tolerability profiles of barnidipine as monotherapy or in combination with other antihypertensive drugs were shown to be favorable in both younger and older patients in a real-life practice setting. Randomized double-blind controlled studies are needed to confirm these results. PMID: 29290834 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - January 3, 2018 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Interpreting the Mechanism of APOE (p.Leu167del) Mutation in the Incidence of Familial Hypercholesterolemia; An In-silico Approach.
Conclusion: This in-silico study suggests that p.Leu167del is causing the protein APOE to associate strongly with its receptor, LDLR. This gain-of-function is likely hindering the ability of LDLR to be effectively recycled back to the surface of the hepatocytes to clear cholesterol from the circulation therefore leading to FH. PMID: 29204218 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - December 6, 2017 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Validation of the EuroSCORE II in a Greek Cardiac Surgical Population: A Prospective Study.
Conclusion: The findings of the present work suggest that EuroSCORE II is a very good predictor of in-hospital mortality after cardiac surgery, in our population and, therefore can safely be used for quality assurance and risk assessment. PMID: 29204219 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - December 6, 2017 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Impact of Post-Exodontia Bleeding in Cardiovascular Patients: A New Classification Proposal.
Conclusion: In order to overcome the aforementioned issues, this article presents an overview of post-extraction bleeding and proposes a classification, based on the well-recognized Bleeding Academic Research Consortium (BARC) bleeding definition, aiming at reducing heterogeneity in this field. PMID: 29204220 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - December 6, 2017 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

The Spectrum of Familial Hypercholesterolemia (FH) in Saudi Arabia: Prime Time for Patient FH Registry.
CONCLUSION: The establishment of FH registry and genetic testing should raise awareness not only among healthcare professionals, but the general population as well. It also helps to provide the best treatment regimen in a cost effective manner to this under-recognised population of FH patients. PMID: 28868092 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - September 6, 2017 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Coronary Perforation of Distal Diagonal Branch Followed by Prolonged Recurrent Cardiac Tamponade Finally Resolved with Pericardiotomy - the Potential Risk of Hydrophilic Guide-Wires.
CONCLUSION: This case depicts that in some cases, more aggressive endovascular treatment of CAP during the acute phase could decrease the probability of future radical surgical treatment. Although, in other cases, avoiding radical endovascular treatment of CAP and secondary necrosis along the distribution of the artery culminates in a higher risk for conversion to a surgical cardiac procedure. Accurate primary assessment of CAP seriousness and careful observation after PCI could improve results and lead to avoiding severe complications. PMID: 28761561 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - August 3, 2017 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Electrocardiographic Changes After Suicidal Digoxin Intoxication in a Healthy Woman.
We describe a case of suicidal attempt after massive digoxin intake that was satisfactory managed with conservative management strategy that involved a close clinical surveillance of the evolving electrocardiographic changes and digoxin serum levels. PMID: 28572865 [PubMed - in process] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - June 4, 2017 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

The Predictive Value of the Syntax Score in Patients With Chronic Coronary Artery Disease Undergoing Percutaneous Coronary Intervention or Coronary Artery Bypass Grafting: A Pilot Study.
CONCLUSION: In this patient population, the SS predicted angina in the year following revascularization but was not predictive of MI, death or repeat revascularization. PMID: 28567131 [PubMed - in process] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - June 3, 2017 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Nitric Oxide and Related Aspects Underlying Angina.
Authors: Restini CBA, Gonçalves L Abstract Increased number of patients affected by metabolic syndrome (MS) has prompted the necessity of better understanding what is involved in such syndrome. Nevertheless, the establishment of promising therapies depends on the knowledge about the interaction of molecules within MS. In such context, Nitric Oxide (NO) emerges from a bulk of works relating its roles on aspects of MS, including cardiovascular diseases, their symptoms and comorbidities, which are thought to be triggered by similar sources. NO, nitric oxide synthase and enzymatic chains are keys for those di...
Source: Open Cardiovascular Medicine Journal - June 3, 2017 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Socioeconomic Factors and Severity of Coronary Artery Disease in Patients Undergoing Coronary Angiography: A Multicentre Study of Arabian Gulf States.
CONCLUSION: Communal and socioeconomic factors are associated with higher odds of significant CAD and MVD in the group of patients referred for CAG. The underpinnings of these associations (e.g. pathophysiologic factors, access to care, and system-wide determinants of quality) require further study. PMID: 28553410 [PubMed - in process] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - May 31, 2017 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Revision of Echocardiographic Indications and Findings in Neurologically Ill Patients.
CONCLUSION: Care should be taken to visualize the left ventricular apical regions when investigating patients referred from a neurologic department in order not to overlook LVHT and thrombi within the left ventricular apex. PMID: 28400861 [PubMed - in process] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - April 13, 2017 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

An Audit of Clinical Practice in a Single Centre in Kuwait: Management of Children on Continuous Subcutaneous Insulin Infusion and Cardiovascular Risk Factors Screening.
CONCLUSION: There was no significant change in HbA1c values at the end of 12 months follow up. However, HbA1c values in poorly controlled children improved. CSII requires care by skilled health professionals as well as education and selection of motivated parents and children. PMID: 28400862 [PubMed - in process] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - April 13, 2017 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Does Body Mass Index Affect Mortality in Coronary Surgery?
DISCUSSION: Patients with extreme BMI's undergoing CABG (underweight ones more than morbidly obese) suffer increased crude mortality. This simple observation indicates that under nutrition and morbid obesity need be further explored as risk factors for coronary surgery. PMID: 28217179 [PubMed - in process] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - February 23, 2017 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research