Biomarkers and Gene Polymorphisms in Members of Long- and Short-lived Families: A Longevity Study.
Authors: Kolovou V, Diakoumakou O, Papazafiropoulou AK, Katsiki N, Fragopoulou E, Vasiliadis I, Degiannis D, Duntas L, Antonopoulou S, Kolovou G Abstract Background: The influence of biomarkers in human lifespan has been investigated but with no clear results yet. Materials and methods: Lipids, Uric Acid (UA), Adiponectin (ADIPOQ), Insulin-like Growth Factor (IGF-1), cholesteryl ester transfer protein (CETP) and angiotensin-converting enzyme (ACE) proteins, as well as CETP, ADIPOQ, insulin-like growth factor binding protein-3 (IGFBP3) and ACE-gene polymorphisms were evaluated in 149 Greek individuals. The Long-...
Source: Open Cardiovascular Medicine Journal - September 1, 2018 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Trends of Cardiovascular Disease Mortality in Relation to Population Aging in Greece (1956 - 2015).
Conclusion: Population aging is a historically unprecedented event that cannot be avoided, deterred or alleviated. Its negative effects act cumulatively with the recent increases in cardiovascular mortality, especially in the light of the ongoing economic crisis which is expected to further exacerbate the existing contrasts. A possible way to successfully cope with the new demographic realities is to unlock an, up till now largely overlooked, opportunity named "healthy aging". PMID: 30159093 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - September 1, 2018 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

False Positive Troponin I Rendering Two Admissions for "Recurrent Acute Myopericarditis".
Conclusion: Troponin I was found to be a false positive and alkaline phosphatase interference was proved to have been the responsible for this. PMID: 30069255 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - August 3, 2018 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

A Very Rare Cause of Lower Limb Ischemia in Young People: Popliteal Artery Entrapment.
Conclusions: PAES can result in lower limb ischemia due to chronic vascular trauma in young healthy patients. The use of diagnostic tools such as US, a non-invasive method, and MRA are effective diagnostic tools for early diagnosis. With their combined approach, exact and early diagnosis can be achieved. PA release, alone or with arterial bypass using RA, is a viable treatment option when intervention is necessary to prevent limb loss in the early stages of the disease. PMID: 29785211 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - May 24, 2018 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Reduction of Vascular Inflammation, LDL-C, or Both for the Protection from Cardiovascular Events?
Conclusion: Both LDL-C and inflammation reduction are beneficial to the reduction of CVD risk. However, canakinumab is a very expensive drug that only induced a 15% reduction in CVD events, thus drastically reducing the possibility for it to be used in clinical practice. Besides, canakinumab is associated with increased infections, some fatal. A potent statin with anti-inflammatory effects is probably the best choice for the majority of those needing hypolipidaemic drug therapy. PMID: 29785212 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - May 24, 2018 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Cardiovascular Disease Risk Factors: Hypertension, Diabetes Mellitus and Obesity among Tabuk Citizens in Saudi Arabia.
Authors: Gutierrez J, Alloubani A, Mari M, Alzaatreh M Abstract Background: Cardiovascular Disease (CVD) is considered as the main cause of death worldwide. Identifying the links among CVDs risk factors can help decrease CVD-related deaths. Aim: To assess the prevalence of risk factors for CVD and their relationships among the Tabuk City population in Saudi Arabia. Methods: A cross-sectional design was used; 432 participants in the Tabuk region were included in this study. Results: The prevalence of diabetes mellitus (DM) was 5.6%, the prevalence of hypertension (HTN) was 11.1% and obesity and overweigh...
Source: Open Cardiovascular Medicine Journal - May 15, 2018 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

A Practical Approach to the Percutaneous Treatment of Iatrogenic Aorto-coronary Dissection.
Authors: Kassimis G, Raina T Abstract Catheter-induced aortic dissection during coronary angiography and Percutaneous Coronary Intervention (PCI) is a relatively infrequent, but potentially life-threatening complication. Patients who suffer this complication may require emergency aortic surgery. More recently, reports of treating the ostium of the dissected coronary artery have emerged as an alternative therapeutic option. In this article we describe two cases of extensive guide catheter induced dissection and their successful treatment using PCI and provide a concise overview of the available literature. PMID:...
Source: Open Cardiovascular Medicine Journal - May 15, 2018 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Electrocardiogram Changes with Acute Alcohol Intoxication: A Systematic Review.
Conclusion: The most common ECG changes associated with acute alcohol intoxication are (in decreasing order of frequency) P-wave and QTc prolongation, followed by T-wave abnormalities and QRS complex prolongation. Mostly, these changes are completely reversible. PMID: 29541259 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - March 16, 2018 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Risk Stratification and in Hospital Morality in Patients Presenting with Acute Coronary Syndrome (ACS) in Bahrain.
Conclusion: Patients with STEMI compared with NSTEMI and UA were of younger age. There was higher in-hospital mortality in STEMI compared with NSTEMI and UA patients. The most significant predictors of death or cardiac events on admission in ACS were DM, GRACE Score>170, systolic hypertension>180 mmHg, positive serum troponin and HR>90 bpm. PMID: 29541260 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - March 16, 2018 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Insulin Sensitivity and Insulin Resistance in Non-Diabetic Middle-Aged Patients with Obstructive Sleep Apnoea Syndrome.
Authors: Archontogeorgis K, Papanas N, Nena E, Tzouvelekis A, Tsigalou C, Voulgaris A, Xanthoudaki M, Mouemin T, Froudarakis M, Steiropoulos P Abstract Background: Obstructive sleep apnoea syndrome (OSAS) has been linked with abnormal glucose metabolism, insulin resistance (IR) and development of diabetes mellitus. Methods: Non-diabetic patients (n=69) with OSAS, diagnosed by polysomnography, were prospectively recruited. To evaluate IR among OSAS patients, the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) and Insulin sensitivity by Quantitative Insulin sensitivity Check Index (QUICKI) were used....
Source: Open Cardiovascular Medicine Journal - February 7, 2018 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

The Role of Echocardiography in the Optimization of Cardiac Resynchronization Therapy: Current Evidence and Future Perspectives.
Conclusion: LV ejection fraction along with specific electrocardiographic criteria remains the cornerstone of CRT patient selection. Echocardiography is a non-invasive, cost-effective, highly reproducible method with certain limitations and accuracy that is affected by measurement errors. Echocardiography can assist with the identification of the appropriate electromechanical substrate of CRT response and LV lead placement. The targeted approach can improve the haemodynamic response, as also the patient-specific parameters estimation. PMID: 29387277 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - February 3, 2018 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Khat (Catha Edulis) as a Risk Factor for Cardiovascular Disorders: Systematic Review and Meta-Analysis.
Conclusion: We showed that khat chewing could significantly affect the cardiovascular system through its effect on heart rate and blood pressure. Therefore, health promotion should be aimed to encourage quitting khat chewing. PMID: 29387278 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - February 3, 2018 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Pulmonary Artery Hypertension and Related Complications Associated to Left Atrial Myxoma.
Authors: Centurión OA, García LB PMID: 29387279 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - February 3, 2018 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Prognostic Assessment of Diabetics Using Myocardial Perfusion Imaging: Diabetes Mellitus is Still a Coronary Artery Disease Equivalent.
Conclusions: In diabetic patients without known CAD, the rate of death was not significantly different from patients with prior CAD and without DM. Abnormal MPS increased risk similarly in diabetic patients and in those with CAD. These findings suggest that DM may still be considered a high-risk condition, comparable to known CAD, and effectively stratified by MPS. PMID: 29290832 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - January 3, 2018 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Trends in Stroke-Related Mortality in the ABC Region, S ão Paulo, Brazil: An Ecological Study Between 1997 and 2012.
Conclusion: The ABC region showed greater mortality due to stroke in males, the age group above 49 years, and non-specified stroke between 1997 and 2012. PMID: 29290833 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - January 3, 2018 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Barnidipine Real-Life Efficacy and Tolerability in Arterial Hypertension: Results from Younger and Older Patients in the BASIC-HT Study.
Authors: Lins R, De Vries C Abstract Objective: The aim of this study was to compare the efficacy and tolerability of barnidipine, a strong lipophilic calcium channel blocker, in younger (≤55 for efficacy or 55 or ≥65 years) patients with uncomplicated hypertension. Methods: 20,275 patients received barnidipine, 10 or 20 mg/day, as monotherapy or in combination with other antihypertensive drug(s) in the observational BArnidipine real-life Safety and tolerability In Chronic HyperTension (BASIC-HT) study. Efficacy and tolerability were assessed over a 3-month period. The present paper describes results from...
Source: Open Cardiovascular Medicine Journal - January 3, 2018 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Interpreting the Mechanism of APOE (p.Leu167del) Mutation in the Incidence of Familial Hypercholesterolemia; An In-silico Approach.
Conclusion: This in-silico study suggests that p.Leu167del is causing the protein APOE to associate strongly with its receptor, LDLR. This gain-of-function is likely hindering the ability of LDLR to be effectively recycled back to the surface of the hepatocytes to clear cholesterol from the circulation therefore leading to FH. PMID: 29204218 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - December 6, 2017 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Validation of the EuroSCORE II in a Greek Cardiac Surgical Population: A Prospective Study.
Conclusion: The findings of the present work suggest that EuroSCORE II is a very good predictor of in-hospital mortality after cardiac surgery, in our population and, therefore can safely be used for quality assurance and risk assessment. PMID: 29204219 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - December 6, 2017 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Impact of Post-Exodontia Bleeding in Cardiovascular Patients: A New Classification Proposal.
Conclusion: In order to overcome the aforementioned issues, this article presents an overview of post-extraction bleeding and proposes a classification, based on the well-recognized Bleeding Academic Research Consortium (BARC) bleeding definition, aiming at reducing heterogeneity in this field. PMID: 29204220 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - December 6, 2017 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

The Spectrum of Familial Hypercholesterolemia (FH) in Saudi Arabia: Prime Time for Patient FH Registry.
CONCLUSION: The establishment of FH registry and genetic testing should raise awareness not only among healthcare professionals, but the general population as well. It also helps to provide the best treatment regimen in a cost effective manner to this under-recognised population of FH patients. PMID: 28868092 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - September 6, 2017 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Coronary Perforation of Distal Diagonal Branch Followed by Prolonged Recurrent Cardiac Tamponade Finally Resolved with Pericardiotomy - the Potential Risk of Hydrophilic Guide-Wires.
CONCLUSION: This case depicts that in some cases, more aggressive endovascular treatment of CAP during the acute phase could decrease the probability of future radical surgical treatment. Although, in other cases, avoiding radical endovascular treatment of CAP and secondary necrosis along the distribution of the artery culminates in a higher risk for conversion to a surgical cardiac procedure. Accurate primary assessment of CAP seriousness and careful observation after PCI could improve results and lead to avoiding severe complications. PMID: 28761561 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - August 3, 2017 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Electrocardiographic Changes After Suicidal Digoxin Intoxication in a Healthy Woman.
We describe a case of suicidal attempt after massive digoxin intake that was satisfactory managed with conservative management strategy that involved a close clinical surveillance of the evolving electrocardiographic changes and digoxin serum levels. PMID: 28572865 [PubMed - in process] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - June 4, 2017 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

The Predictive Value of the Syntax Score in Patients With Chronic Coronary Artery Disease Undergoing Percutaneous Coronary Intervention or Coronary Artery Bypass Grafting: A Pilot Study.
CONCLUSION: In this patient population, the SS predicted angina in the year following revascularization but was not predictive of MI, death or repeat revascularization. PMID: 28567131 [PubMed - in process] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - June 3, 2017 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Nitric Oxide and Related Aspects Underlying Angina.
Authors: Restini CBA, Gonçalves L Abstract Increased number of patients affected by metabolic syndrome (MS) has prompted the necessity of better understanding what is involved in such syndrome. Nevertheless, the establishment of promising therapies depends on the knowledge about the interaction of molecules within MS. In such context, Nitric Oxide (NO) emerges from a bulk of works relating its roles on aspects of MS, including cardiovascular diseases, their symptoms and comorbidities, which are thought to be triggered by similar sources. NO, nitric oxide synthase and enzymatic chains are keys for those disea...
Source: Open Cardiovascular Medicine Journal - June 3, 2017 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Socioeconomic Factors and Severity of Coronary Artery Disease in Patients Undergoing Coronary Angiography: A Multicentre Study of Arabian Gulf States.
CONCLUSION: Communal and socioeconomic factors are associated with higher odds of significant CAD and MVD in the group of patients referred for CAG. The underpinnings of these associations (e.g. pathophysiologic factors, access to care, and system-wide determinants of quality) require further study. PMID: 28553410 [PubMed - in process] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - May 31, 2017 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Revision of Echocardiographic Indications and Findings in Neurologically Ill Patients.
Authors: Stöllberger C, Wegner C, Finsterer J Abstract BACKGROUND AND OBJECTIVE: Little is known about the general indications for echocardiography and the prevalence of abnormalities detected by echocardiography in patients who are referred from a neurological department. Left ventricular hypertrabeculation/noncompaction (LVHT) is associated with neuromuscular disorders and embolism. The aim of the study was to assess the indications for echocardiography in patients from a neurological department and to review the cine-loops of the examinations in order to assess the frequency of abnormal echocardiographic fi...
Source: Open Cardiovascular Medicine Journal - April 13, 2017 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

An Audit of Clinical Practice in a Single Centre in Kuwait: Management of Children on Continuous Subcutaneous Insulin Infusion and Cardiovascular Risk Factors Screening.
CONCLUSION: There was no significant change in HbA1c values at the end of 12 months follow up. However, HbA1c values in poorly controlled children improved. CSII requires care by skilled health professionals as well as education and selection of motivated parents and children. PMID: 28400862 [PubMed - in process] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - April 13, 2017 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Does Body Mass Index Affect Mortality in Coronary Surgery?
DISCUSSION: Patients with extreme BMI's undergoing CABG (underweight ones more than morbidly obese) suffer increased crude mortality. This simple observation indicates that under nutrition and morbid obesity need be further explored as risk factors for coronary surgery. PMID: 28217179 [PubMed - in process] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - February 23, 2017 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Hypoxic Pulmonary Vasoconstriction in Humans: Tale or Myth.
Authors: Hussain A, Suleiman MS, George SJ, Loubani M, Morice A Abstract Hypoxic Pulmonary vasoconstriction (HPV) describes the physiological adaptive process of lungs to preserves systemic oxygenation. It has clinical implications in the development of pulmonary hypertension which impacts on outcomes of patients undergoing cardiothoracic surgery. This review examines both acute and chronic hypoxic vasoconstriction focusing on the distinct clinical implications and highlights the role of calcium and mitochondria in acute versus the role of reactive oxygen species and Rho GTPases in chronic HPV. Furthermore it ident...
Source: Open Cardiovascular Medicine Journal - February 23, 2017 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Risk of Cerebral Embolization with Caseous Calcification of the Mitral Annulus: Review Article.
CONCLUSION: Based on our review, it would be reasonable to consider elective surgical resection of CCMA in asymptomatic patients who are good surgical candidates, because patients with CCMA may be at increased risk of embolic strokes, which are unrelated to AF. PMID: 27990181 [PubMed - in process] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - December 21, 2016 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Effect of ATP-binding Cassette Transporter A1 (ABCA1) Gene Polymorphisms on Plasma Lipid Variables and Common Demographic Parameters in Greek Nurses.
CONCLUSION: Findings suggested that only R1587K polymorphism of ABCA1 gene was associated with lipid variables, age, and gender of Greek nurses. These findings may be helpful in assessing the risk factors for premature coronary heart disease and distinct individuals with lower/higher atherosclerotic burden. PMID: 27990182 [PubMed - in process] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - December 21, 2016 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Correlation between Diastolic Function and Endothelial Function in Patients with Type 2 Diabetes and Hypertension.
CONCLUSION: The endothelial function assessed by FMD was worse in hypertensive diabetic patients with diastolic dysfunction. There were correlations between the diastolic function indexes and the endothelial function indexes in our sample. PMID: 27867429 [PubMed - in process] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - November 22, 2016 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Insights in Hypothesis Testing and Making Decisions in Biomedical Research.
Authors: Sacha V, Panagiotakos DB Abstract It is a fact that p values are commonly used for inference in biomedical and other social fields of research. Unfortunately, the role of p value is very often misused and misinterpreted; that is why it has been recommended the use of resampling methods, like the bootstrap method, to calculate the confidence interval, which provides more robust results for inference than does p value. In this review a discussion is made about the use of p values through hypothesis testing and its alternatives using resampling methods to develop confidence intervals of the tested statistic o...
Source: Open Cardiovascular Medicine Journal - October 14, 2016 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Life-threatening Rupture of a Femoral Pseudoaneurysm after Cardiac Catheterization.
Authors: Petrou E, Malakos I, Kampanarou S, Doulas N, Voudris V Abstract A pseudoaneurysm refers to a defect in the arterial wall, allowing communication of arterial blood with the adjacent extra-luminal space. Pseudoaneurysms result from traumatic arterial injury. With the increasing utilization of percutaneous arterial interventions, iatrogenic arterial injury has become the predominant cause of pseudoaneurysm formation. Rupture of the pseudoaneurysm comprises a vascular emergency. Clinical suspicion and imaging techniques are the cornerstones of timely diagnosis and appropriate management of the condition. Herei...
Source: Open Cardiovascular Medicine Journal - October 14, 2016 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Chest Pain of Uncertain Aetiology: Role of Contrast Enhanced Computed Tomography in the Emergency Department.
We report a case where non ECG gated contrast enhanced CT in the emergency department for rule-out of pulmonary embolus guided to the actual diagnosis, which was, acute coronary event, as evidenced by the presence of perfusion defect. PMID: 27733870 [PubMed - in process] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - October 14, 2016 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

The Current Indication for Pacemaker in Patients with Cardioinhibitory Vasovagal Syncope.
Authors: da Silva RM Abstract The most frequent cause of syncope is vasovagal reflex. It is associated with worse quality of life, depression, fatigue and physical injury. Recurrence of vasovagal syncope is an aggravating, reaching the rate of 69%. Initial step and pharmacological treatment may not work, especially in patients with recurrent syncope without prodrome. These patients can present cardioinhibitory response with asystole. Studies were designed to analyses the effectiveness of pacemaker for prevention of syncope. In this review, nonrandomized clinical trials, open-label randomized, double-blind randomize...
Source: Open Cardiovascular Medicine Journal - September 22, 2016 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Pulse Wave Analysis by Applanation Tonometry for the Measurement of Arterial Stiffness.
Authors: Doupis J, Papanas N, Cohen A, McFarlan L, Horton E Abstract The aim of our study was to investigate the association between pulse wave velocity (PWV) and pulse wave analysis (PWA)-derived measurements for the evaluation of arterial stiffness. A total of 20 (7 male and 13 female) healthy, non-smoking individuals, with mean age 31 ± 12years were included. PWV and PWA measurements were performed using a SphygmoCor apparatus (Atcor Medical Blood Pressure Analysis System, Sydney Australia). PWV significantly correlated with all central aortic haemodynamic parameters, especially with pulse pressure (PP) (p
Source: Open Cardiovascular Medicine Journal - September 22, 2016 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Heparin Versus Bivalirudin in Acute Myocardial Infarction: Unfractionated Heparin Monotherapy Elevated to Primary Treatment in Contemporary Percutaneous Coronary Intervention.
Authors: Centurión OA Abstract Bivalirudin, a direct thrombin inhibitor, was developed as an antithrombin agent for patients undergoing percutaneous coronary interventions (PCI) with the hypothesis that it would reduce bleeding complications without compromising the rate of ischemic events compared to heparin plus GP IIb/IIIa inhibitors. Although the cumulative evidence makes a strong argument for the use of bivalirudin rather than heparin plus systematic GP IIb/IIIa inhibitors for the great majority of patients with acute myocardial infarction (AMI) undergoing PCI, the benefit observed with bivalirudin was ...
Source: Open Cardiovascular Medicine Journal - September 3, 2016 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

The Effects of Levosimendan and Sodium Nitroprusside Combination on Left Ventricular Functions After Surgical Ventricular Reconstruction in Coronary Artery Bypass Grafting Patients.
Authors: Temizturk Z, Azboy D, Atalay A, Atalay H, Dogan OF Abstract OBJECTIVE: The aim of our study was to research the effects of levosimendan (LS) and sodium nitroprusside (SNP) combination on systolic and diastolic ventricular function after coronary artery bypass grafting (CABG) who required endoventricular patch repair (EVPR). PATIENTS AND METHODS: We studied 70 patients with ischemic dilated cardiomyopathy. LS and SNP combination was administered in 35 patients (study group, SG). In the remaining patients, normal saline solution was given (placebo group, PG). Levosimendan (10µgr/kg) started 4 h pri...
Source: Open Cardiovascular Medicine Journal - September 3, 2016 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Impaired Myocardial Bioenergetics in HFpEF and the Role of Antioxidants.
This article is a summative review of the recent relevant literature that addresses cardiac bioenergetics, deficiency in myocardial bioenergetics, and increased reactive oxygen species associated with HFpEF and the promising potential use of antioxidants in managing this condition. PMID: 27583040 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - September 3, 2016 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Initial Experience with Renal Denervation for the Treatment of Resistant Hypertension - The Utility of Novel Anesthetics and Metaiodobenzylguanidine Scintigraphy (MIBG).
CONCLUSION: Patients with resistant hypertension who underwent RDN in our department had a significant reduction in BP 6 months after the intervention. (123)I-MIBG was not useful in predicting RDN response. Dexmedetomidine and remifentanil provided sufficient patient comfort during the procedure, allowing an adequate number of ablations per renal artery to be performed, and this could probably lead to improved RDN results. PMID: 27583041 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - September 3, 2016 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Comparison of the Effects of Dialysis Methods (Haemodialysis vs Peritoneal Dialysis) on Diastolic Left Ventricular Function Dialysis Methods and Diastolic Function.
CONCLUSION: The method of dialysis seems to influence LV diastolic function. We observed a higher prevalence of diastolic LV dysfunction in the PD group. Echocardiographic follow up is essential as this could improve the management of cardiovascular complications in dialysis patients. PMID: 27583042 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - September 3, 2016 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Cardiac Dual-source Computed Tomography for the Detection of Left Main Compression Syndrome in Patients with Pulmonary Hyper-tension.
CONCLUSION: DSCT may represent the initial testing modality in PH patients with dilated PA trunk to exclude LMCS. A periodical rule-out of this rare entity, as assessed by DSCT, in patients with a severely dilated PA seems to be mandatory for PH patients contributing to survival improvement. PMID: 27499817 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - August 9, 2016 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Allogeneic Blood Product Usage in Coronary Artery Bypass Grafting (CABG) with minimalized Extracorporeal Circulation System (MECC) Versus Standard On-Pump Coronary Artery Bypass Grafting.
The objective of this study was to evaluate the ABPTs in minimalized extracorporeal cardiopulmonary (MECC(TM)) compared with standard open system on-pump coronary revascularization. METHODS: Data of 156 patients undergoing myocardial revascularization between September 2008 and September 2010 were reviewed. 83 patients were operated by the MECC technique and 73 were treated by standard extracorporeal circulation (sECC). ABPT and overall early postoperative complications were analyzed. RESULTS: Operative mortality and morbidity were similar in both groups. ABPT in the MECC group was significantly lower than in the s...
Source: Open Cardiovascular Medicine Journal - August 9, 2016 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Prevalence of Major Cardiovascular Risk Factors and Coronary Heart Disease in a Sample of Greek Adults: The Saronikos Study.
CONCLUSION: Classic risk factors are highly prevalent and frequently clustered, especially in adults aged 50 years and older. These findings raise concerns about future trends of already increased rates of CHD. Multifactorial and integrated population-based interventions need to be applied to reduce the burden of cardiovascular conditions. PMID: 27429668 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - July 20, 2016 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Aortic Wall Extracellular Matrix Proteins Correlate with Syntax Score in Patients Undergoing Coronary Artery Bypass Surgery.
Authors: Chiong T, Cheow ES, Woo CC, Lin XY, Khin LW, Lee CN, Hartman M, Sze SK, Sorokin VA Abstract AIMS: The SYNTAX score correlate with major cardiovascular events post-revascularization, although the histopathological basis is unclear. We aim to evaluate the association between syntax score and extracellular matrix histological characteristics of aortic punch tissue obtained during coronary artery bypass surgery (CABG). This analysis compares coronary artery bypass surgery patients with High and Low syntax score which were followed up for one year period. METHODS AND RESULTS: Patients with High (score ≥ ...
Source: Open Cardiovascular Medicine Journal - June 29, 2016 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Does Stroke Volume Increase During an Incremental Exercise? A Systematic Review.
CONCLUSION: The stroke volume are unclear, include contradictory evidence. Additional studies with standardized reporting for subjects (e.g., age, gender, physical fitness, and body position), exercise test protocols, and left ventricular function are required to clarify the characteristics of stroke volume during incremental maximal-exercise load. PMID: 27347221 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - June 29, 2016 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Is There an Association Between Carotid-Femoral Pulse Wave Velocity and Coronary Heart Disease in Patients with Coronary Artery Disease: A Pilot Study.
Authors: Katsiki N, Kollari E, Dardas S, Dardas P, Haidich AB, Athyros VG, Karagiannis A Abstract Arterial stiffness has been shown to predict cardiovascular morbidity and mortality. Carotid-femoral pulse wave velocity (cfPWV) is regarded the gold standard marker of arterial stiffness. In previous studies, cfPWV was associated with the presence of coronary heart disease (CHD). However, with regard to CHD severity as assessed by the Syntax Score, only brachial-ankle PWV was reported to correlate with Syntax Score; no data exist for cfPWV. In this pilot study, we evaluated the possible associations between cfPWV, CHD...
Source: Open Cardiovascular Medicine Journal - June 29, 2016 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

Neurocardiology.
Authors: Khan M PMID: 27347223 [PubMed] (Source: Open Cardiovascular Medicine Journal)
Source: Open Cardiovascular Medicine Journal - June 29, 2016 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research

An Overview of Cardiac Management in Neuromuscular Disease.
Authors: Hickey RM, Cullen JD, Sachs GM Abstract Muscular dystrophy and myasthenia gravis are two neuromuscular disorders that can involve significant cardiovascular complications. The frequency and severity of cardiac pathology varies widely among the muscular dystrophies. In some, it is nearly inevitable and requires regular evaluation. In others, assessment of cardiac function can be more symptom-driven. On-ly a minority of myasthenic patients manifest disease-related cardiovascular complications; however, their presentation can be rapidly progressive and life-threatening.. PMID: 27347224 [PubMed] (Source: ...
Source: Open Cardiovascular Medicine Journal - June 29, 2016 Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research