Effects of a novel weight-loss combination product containing orlistat and acarbose on obesity: A randomized, placebo-controlled trial
CONCLUSIONS: This trial indicates that orlistat and acarbose can be successfully combined in a modified-release formulation to provide efficacious weight loss with no unexpected safety issues. EMP16 may be a promising candidate among other medications for improved weight management.PMID:36123783 | DOI:10.1002/oby.23557 (Source: Obesity)
Source: Obesity - September 20, 2022 Category: Eating Disorders & Weight Management Authors: Ulf Holmb äck Stefan Grud én Helena Litorp Daniel Willhems Sandra Kuusk G öran Alderborn Arvid S öderhäll Anders Forslund Source Type: research

Effects of a novel weight-loss combination product containing orlistat and acarbose on obesity: A randomized, placebo-controlled trial
CONCLUSIONS: This trial indicates that orlistat and acarbose can be successfully combined in a modified-release formulation to provide efficacious weight loss with no unexpected safety issues. EMP16 may be a promising candidate among other medications for improved weight management.PMID:36123783 | DOI:10.1002/oby.23557 (Source: Obesity)
Source: Obesity - September 20, 2022 Category: Eating Disorders & Weight Management Authors: Ulf Holmb äck Stefan Grud én Helena Litorp Daniel Willhems Sandra Kuusk G öran Alderborn Arvid S öderhäll Anders Forslund Source Type: research

Effects of a novel weight-loss combination product containing orlistat and acarbose on obesity: A randomized, placebo-controlled trial
CONCLUSIONS: This trial indicates that orlistat and acarbose can be successfully combined in a modified-release formulation to provide efficacious weight loss with no unexpected safety issues. EMP16 may be a promising candidate among other medications for improved weight management.PMID:36123783 | DOI:10.1002/oby.23557 (Source: Obesity)
Source: Obesity - September 20, 2022 Category: Eating Disorders & Weight Management Authors: Ulf Holmb äck Stefan Grud én Helena Litorp Daniel Willhems Sandra Kuusk G öran Alderborn Arvid S öderhäll Anders Forslund Source Type: research

T cells dominate peripheral inflammation in a cross-sectional analysis of obesity-associated diabetes
CONCLUSIONS: T cells dominate peripheral inflammation in obesity; therefore, targeting T cells may be an effective approach for prevention/management of metaflammation.PMID:36069294 | DOI:10.1002/oby.23528 (Source: Obesity)
Source: Obesity - September 7, 2022 Category: Eating Disorders & Weight Management Authors: Gabriella H Pugh Sajjad Fouladvand Sara SantaCruz-Calvo Madhur Agrawal Xiaohua Douglas Zhang Jin Chen Philip A Kern Barbara S Nikolajczyk Source Type: research

T cells dominate peripheral inflammation in a cross-sectional analysis of obesity-associated diabetes
CONCLUSIONS: T cells dominate peripheral inflammation in obesity; therefore, targeting T cells may be an effective approach for prevention/management of metaflammation.PMID:36069294 | DOI:10.1002/oby.23528 (Source: Obesity)
Source: Obesity - September 7, 2022 Category: Eating Disorders & Weight Management Authors: Gabriella H Pugh Sajjad Fouladvand Sara SantaCruz-Calvo Madhur Agrawal Xiaohua Douglas Zhang Jin Chen Philip A Kern Barbara S Nikolajczyk Source Type: research

T cells dominate peripheral inflammation in a cross-sectional analysis of obesity-associated diabetes
CONCLUSIONS: T cells dominate peripheral inflammation in obesity; therefore, targeting T cells may be an effective approach for prevention/management of metaflammation.PMID:36069294 | DOI:10.1002/oby.23528 (Source: Obesity)
Source: Obesity - September 7, 2022 Category: Eating Disorders & Weight Management Authors: Gabriella H Pugh Sajjad Fouladvand Sara SantaCruz-Calvo Madhur Agrawal Xiaohua Douglas Zhang Jin Chen Philip A Kern Barbara S Nikolajczyk Source Type: research

T cells dominate peripheral inflammation in a cross-sectional analysis of obesity-associated diabetes
CONCLUSIONS: T cells dominate peripheral inflammation in obesity; therefore, targeting T cells may be an effective approach for prevention/management of metaflammation.PMID:36069294 | DOI:10.1002/oby.23528 (Source: Obesity)
Source: Obesity - September 7, 2022 Category: Eating Disorders & Weight Management Authors: Gabriella H Pugh Sajjad Fouladvand Sara SantaCruz-Calvo Madhur Agrawal Xiaohua Douglas Zhang Jin Chen Philip A Kern Barbara S Nikolajczyk Source Type: research

T cells dominate peripheral inflammation in a cross-sectional analysis of obesity-associated diabetes
CONCLUSIONS: T cells dominate peripheral inflammation in obesity; therefore, targeting T cells may be an effective approach for prevention/management of metaflammation.PMID:36069294 | DOI:10.1002/oby.23528 (Source: Obesity)
Source: Obesity - September 7, 2022 Category: Eating Disorders & Weight Management Authors: Gabriella H Pugh Sajjad Fouladvand Sara SantaCruz-Calvo Madhur Agrawal Xiaohua Douglas Zhang Jin Chen Philip A Kern Barbara S Nikolajczyk Source Type: research

T cells dominate peripheral inflammation in a cross-sectional analysis of obesity-associated diabetes
CONCLUSIONS: T cells dominate peripheral inflammation in obesity; therefore, targeting T cells may be an effective approach for prevention/management of metaflammation.PMID:36069294 | DOI:10.1002/oby.23528 (Source: Obesity)
Source: Obesity - September 7, 2022 Category: Eating Disorders & Weight Management Authors: Gabriella H Pugh Sajjad Fouladvand Sara SantaCruz-Calvo Madhur Agrawal Xiaohua Douglas Zhang Jin Chen Philip A Kern Barbara S Nikolajczyk Source Type: research

T cells dominate peripheral inflammation in a cross-sectional analysis of obesity-associated diabetes
CONCLUSIONS: T cells dominate peripheral inflammation in obesity; therefore, targeting T cells may be an effective approach for prevention/management of metaflammation.PMID:36069294 | DOI:10.1002/oby.23528 (Source: Obesity)
Source: Obesity - September 7, 2022 Category: Eating Disorders & Weight Management Authors: Gabriella H Pugh Sajjad Fouladvand Sara SantaCruz-Calvo Madhur Agrawal Xiaohua Douglas Zhang Jin Chen Philip A Kern Barbara S Nikolajczyk Source Type: research

The impact of social rhythm and sleep disruptions on waist circumference after job loss: A prospective 18-month study
CONCLUSIONS: The frequency and consistency of social rhythms after job loss play a key role in WC loss. These findings support the implementation of social rhythm interventions after job loss, a potentially sensitive time for the establishment of new daily routines that have an impact on metabolic health.PMID:36062849 | DOI:10.1002/oby.23513 (Source: Obesity)
Source: Obesity - September 5, 2022 Category: Eating Disorders & Weight Management Authors: Patricia L Haynes George W Howe Graciela E Silva Stuart F Quan Cynthia A Thomson David A Glickenstein Duane Sherrill Devan N Gengler April Yingst Candace Mayer Darlynn M Rojo-Wissar Ume Kobayashi Matthew Hoang Source Type: research

Effect of low skeletal muscle mass and sarcopenic obesity on chronic kidney disease in patients with type 2 diabetes
CONCLUSIONS: Sarcopenic obesity, but not low muscle mass alone, may increase the risk of CKD in patients with T2DM.PMID:36062861 | DOI:10.1002/oby.23512 (Source: Obesity)
Source: Obesity - September 5, 2022 Category: Eating Disorders & Weight Management Authors: Da Hea Seo Young Ju Suh Yongin Cho Seong Hee Ahn Seongha Seo Seongbin Hong Yong-Ho Lee Young Ju Choi Eunjig Lee So Hun Kim Source Type: research

High-fat diet decreases H3K27ac in mice adipose-derived stromal cells
CONCLUSIONS: These results show that an HFD significantly reduces acetylation of H3K27 in ASCs and the expression of ATP-citrate lyase in subcutaneous ASCs, suggesting that, in this fat depot, the H3K27ac reduction could be partly due to lower acetyl-coenzyme A availability. H3K27ac is an epigenetic mark responsible for increasing the transcription rate and its reduction can have an important impact on ASC proliferation and differentiation potential.PMID:36062886 | DOI:10.1002/oby.23537 (Source: Obesity)
Source: Obesity - September 5, 2022 Category: Eating Disorders & Weight Management Authors: Viviane S da Silva Jussara J Sim ão Victor Plata Andressa Fran ça de Sousa Roberta D C da Cunha de S á Cleiton Fagundes Machado Taiza Stumpp Maria Isabel C Alonso-Vale Lucia Armelin-Correa Source Type: research

The impact of social rhythm and sleep disruptions on waist circumference after job loss: A prospective 18-month study
CONCLUSIONS: The frequency and consistency of social rhythms after job loss play a key role in WC loss. These findings support the implementation of social rhythm interventions after job loss, a potentially sensitive time for the establishment of new daily routines that have an impact on metabolic health.PMID:36062849 | DOI:10.1002/oby.23513 (Source: Obesity)
Source: Obesity - September 5, 2022 Category: Eating Disorders & Weight Management Authors: Patricia L Haynes George W Howe Graciela E Silva Stuart F Quan Cynthia A Thomson David A Glickenstein Duane Sherrill Devan N Gengler April Yingst Candace Mayer Darlynn M Rojo-Wissar Ume Kobayashi Matthew Hoang Source Type: research

Effect of low skeletal muscle mass and sarcopenic obesity on chronic kidney disease in patients with type 2 diabetes
CONCLUSIONS: Sarcopenic obesity, but not low muscle mass alone, may increase the risk of CKD in patients with T2DM.PMID:36062861 | DOI:10.1002/oby.23512 (Source: Obesity)
Source: Obesity - September 5, 2022 Category: Eating Disorders & Weight Management Authors: Da Hea Seo Young Ju Suh Yongin Cho Seong Hee Ahn Seongha Seo Seongbin Hong Yong-Ho Lee Young Ju Choi Eunjig Lee So Hun Kim Source Type: research