Maternal disease and gasotransmitters
Publication date: Available online 3 January 2020Source: Nitric OxideAuthor(s): Aishwarya Rengarajan, Amanda K. Mauro, Derek S. BoeldtAbstractThe three known gasotransmitters, nitric oxide, carbon monoxide, and hydrogen sulfide are involved in key processes throughout pregnancy. Gasotransmitters are known to impact on smooth muscle tone, regulation of immune responses, and oxidative state of cells and their component molecules. Failure of the systems that tightly regulate gasotransmitter production and downstream effects are thought to contribute to common maternal diseases such as preeclampsia and preterm birth. Normal pr...
Source: Nitric Oxide - January 5, 2020 Category: Chemistry Source Type: research
Cellular microdomains for nitric oxide signaling in endothelium and red blood cells
Publication date: Available online 3 January 2020Source: Nitric OxideAuthor(s): Francesca Leo, Beate Hutzler, Claire A. Ruddiman, Brant E. Isakson, Miriam M. Cortese-KrottAbstractThere is accumulating evidence that biological membranes are not just homogenous lipid structures, but are highly organized in microdomains, i.e. compartmentalized areas of protein and lipid complexes, which facilitate necessary interactions for various signaling pathways. Each microdomain exhibits unique composition, membrane location, and dynamics that ultimately shape their functional characteristics. In the vasculature, microdomains are crucia...
Source: Nitric Oxide - January 5, 2020 Category: Chemistry Source Type: research
The role of gasotransmitters in neonatal physiology
Publication date: Available online 20 December 2019Source: Nitric OxideAuthor(s): Taiming Liu, George T. Mukosera, Arlin B. BloodAbstractThe gasotransmitters, nitric oxide (NO), hydrogen sulfide (H2S), and carbon monoxide (CO), are endogenously-produced volatile molecules that perform signaling functions throughout the body. In biological tissues, these small, lipid-permeable molecules exist in free gaseous form for only seconds or less, and thus they are ideal for paracrine signaling that can be controlled rapidly by changes in their rates of production or consumption. In addition, tissue concentrations of the gasotransmi...
Source: Nitric Oxide - December 21, 2019 Category: Chemistry Source Type: research
DDAH-1 via HIF-1 target genes improves cerebral ischemic tolerance after hypoxic preconditioning and middle cerebral artery occlusion-reperfusion
Publication date: Available online 20 December 2019Source: Nitric OxideAuthor(s): Yichen Zhao, Yuchen Zhou, Xiaoye Ma, Xiaohui Liu, Yanxin Zhao, Xueyuan LiuAbstractDimethylarginine dimethylamino hydrolase-1 (DDAH-1) as an indirect regulator of nitric oxide (NO) metabolism, its role in hypoxic preconditioning (HPC) and ischemic tolerance (IT) of ischemic stroke has still been unknown and needs to be elucidated. Herein, DDAH-1 knock-out (KO) and wild-type (WT) rats underwent HPC and middle cerebral artery occlusion/reperfusion (MCAO/R) model. After 24 h, neurological severity scores, TTC staining and TUNEL assay were used ...
Source: Nitric Oxide - December 21, 2019 Category: Chemistry Source Type: research
Therapies that enhance pulmonary vascular NO-signaling in the neonate
Publication date: Available online 20 December 2019Source: Nitric OxideAuthor(s): Julie Dillard, Marta Perez, Bernadette ChenAbstractThere are several pulmonary hypertensive diseases that affect the neonatal population, including persistent pulmonary hypertension of the newborn (PPHN) and bronchopulmonary dysplasia (BPD)-associated pulmonary hypertension (PH). While the indication for inhaled nitric oxide (iNO) use is for late-preterm and term neonates with PPHN, there is a suboptimal response to this pulmonary vasodilator in ∼40% of patients. Additionally, there are no FDA-approved treatments for BPD-associated PH or fo...
Source: Nitric Oxide - December 21, 2019 Category: Chemistry Source Type: research
Inhaled nitric oxide use in neonates: Balancing what is evidence-based and what is physiologically sound
This article reviews the off-label uses of iNO in infants. Rationale is discussed for a selective application of iNO based on physiologically guided principles, and new research avenues are considered. (Source: Nitric Oxide)
Source: Nitric Oxide - December 20, 2019 Category: Chemistry Source Type: research
Nitric oxide signaling in pregnancy and preeclampsia
Publication date: Available online 15 December 2019Source: Nitric OxideAuthor(s): Elizabeth F. Sutton, Mary Gemmel, Robert W. PowersAbstractWhile the etiology of preeclampsia continues to be elucidated, it is clear that preeclampsia is a complex obstetrical syndrome associated with maternal vascular dysfunction within which impairments in nitric oxide (NO) signaling likely play a key role in driving disease progression and severity. The goal of this review is to present the available evidence for maladaptations in NO and NO signaling in pregnancies complicated by preeclampsia. After a brief overview of preeclampsia, a revi...
Source: Nitric Oxide - December 17, 2019 Category: Chemistry Source Type: research
Editorial Board
Publication date: 1 January 2020Source: Nitric Oxide, Volume 94Author(s): (Source: Nitric Oxide)
Source: Nitric Oxide - December 11, 2019 Category: Chemistry Source Type: research
Saliva panel of protein candidates: A comprehensive study for assessing high altitude acclimatization
In this study, we employed iTRAQ based LC-MS/MS for comparing saliva samples from humans exposed to hypobaric hypoxia from 7 to 120 days with normoxic controls followed by analysis using Ingenuity Pathway Analysis software and validation by immunoassays. Nearly 67 proteins were found to be differentially expressed in the exposed groups as compared to normoxia indicating modulated canonical pathways as lipid metabolism; acute phase response signalling and proteins as carbonic anhydrase 6, alpha-enolase, albumin, and prolactin inducible protein. Collectively, this study provides the proof of concept for the non-invasive asse...
Source: Nitric Oxide - November 26, 2019 Category: Chemistry Source Type: research
Nitric oxide signaling inhibits microglia proliferation by activation of protein kinase-G
Publication date: Available online 21 November 2019Source: Nitric OxideAuthor(s): Matthew J.E. Maksoud, Vasiliki Tellios, Yun-Yan Xiang, Wei-Yang LuAbstractMicroglia population is primarily determined by a finely-regulated proliferation process during early development of the central nervous system (CNS). Nitric oxide (NO) is known to inhibit proliferation of numerous types of cells. However, how NO signaling regulates microglia proliferation remains elusive. Using wildtype (WT) and inducible nitric oxide synthase knockout (iNOS−/-) mice, this study investigated the role and underlying mechanisms of iNOS/NO signaling in ...
Source: Nitric Oxide - November 22, 2019 Category: Chemistry Source Type: research
Delivering nitric oxide into human skin from encapsulated S-nitrosoglutathione under UV light: An in vitro and ex vivo study
Publication date: Available online 21 November 2019Source: Nitric OxideAuthor(s): Milena T. Pelegrino, Richard B. Weller, André Paganotti, Amedea B. SeabraAbstractNitric oxide (NO) is a crucial molecule in the human body. The encapsulation of exogenous NO donors into chitosan nanoparticles (CS NPs) has been widely used to overcome NO drawbacks in pharmacological applications, such as, its short half-life. The NO donor, S-nitrosoglutathione (GSNO), was encapsulated into CS NPs (GSNO-CS NPs) and characterized by AFM and DLS measurements. The nanoparticles presented a hydrodynamic size of 123.3 ± 1.5 nm and a polydisp...
Source: Nitric Oxide - November 21, 2019 Category: Chemistry Source Type: research
Role of hippocampal nitrergic neurotransmission in behavioral and cardiovascular dysfunctions evoked by chronic social stress
Publication date: Available online 21 November 2019Source: Nitric OxideAuthor(s): Jeferson Almeida, Leandro A. Oliveira, Ricardo Benini, Carlos C. CrestaniAbstractIncreased nitric oxide (NO) levels have been identified in the hippocampus of animals subjected to social isolation. However, a role of this change in behavioral and physiological changes evoked by isolation has never been evaluated. Thus, this study investigated the involvement of nitrergic neurotransmission acting via the neuronal isoform of nitric oxide synthase (nNOS) within the dorsal hippocampus in behavioral and cardiovascular changes in isolated reared ra...
Source: Nitric Oxide - November 21, 2019 Category: Chemistry Source Type: research
Exogenous nitric oxide alleviates sulfur deficiency-induced oxidative damage in tomato seedlings
Publication date: Available online 7 November 2019Source: Nitric OxideAuthor(s): Manzer H. Siddiqui, Saud Alamri, Qasi D. Alsubaie, Hayssam M. Ali, M. Nasir Khan, Abdullah Al-Ghamdi, Abdullah A. Ibrahim, Abdullah AlsadonAbstractDespite numerous reports on the role of nitric oxide (NO) in regulating plants growth and mitigating different environmental stresses, its participation in sulfur (S) -metabolism remains largely unknown. Therefore, we studied the role of NO in S acquisition and S-assimilation in tomato seedlings under low S-stress conditions by supplying NO to the leaves of S-sufficient and S-deficient seedlings. S-...
Source: Nitric Oxide - November 9, 2019 Category: Chemistry Source Type: research
Past, current and future perspectives of the use of inhaled NO as a primary therapeutic for the newborn
Publication date: Available online 6 November 2019Source: Nitric OxideAuthor(s): Joseph B. Philips (Source: Nitric Oxide)
Source: Nitric Oxide - November 7, 2019 Category: Chemistry Source Type: research
Editorial Board
Publication date: 1 December 2019Source: Nitric Oxide, Volume 93Author(s): (Source: Nitric Oxide)
Source: Nitric Oxide - November 6, 2019 Category: Chemistry Source Type: research
