Nitroxides affect neurological deficits and lesion size induced by a rat model of traumatic brain injury
In conclusion, DCTEIO significantly improved tissue repair and preserved neurological function in rats with TBI possibly via a mitophagy mechanism. This study provides evidence for DCTEIO as a promising new option to alleviate lesion severity after moderate TBI, which is not actively treated. (Source: Nitric Oxide)
Source: Nitric Oxide - February 14, 2020 Category: Chemistry Source Type: research
Interactive role of exogenous 24 Epibrassinolide and endogenous NO in Brassica juncea L. under salinity stress: Evidence for NR-dependent NO biosynthesis
Publication date: Available online 8 February 2020Source: Nitric OxideAuthor(s): Praveen Gupta, Chandra Shekhar SethAbstractThe present study unravels origin of nitric oxide (NO) and the interaction between 24-Epibrassinolide (EBL) and nitrate reductase (NR) for NO production in Indian mustard (Brassica juncea L.) under salinity stress. Two independent experiments were performed to check whether (i) Nitrate reductase or Nitric oxide synthase takes part in the biosynthesis of endogenous NO and (ii) EBL has any regulatory effect on NR-dependent NO biosynthesis in the alleviation of salinity stress. Results revealed that NR-i...
Source: Nitric Oxide - February 9, 2020 Category: Chemistry Source Type: research
Head-to-head comparison of inorganic nitrate and metformin in a mouse model of cardiometabolic disease
Conclusion/ImplicationsNitrate and metformin had equipotent metabolic effects, while nitrate was superior regarding protection against cardiovascular dysfunction and liver steatosis. If reproduced in future clinical trials, these findings may have implications for novel nutrition-based strategies against metabolic syndrome, T2D and associated complications.Graphical abstract (Source: Nitric Oxide)
Source: Nitric Oxide - February 5, 2020 Category: Chemistry Source Type: research
Neonatal comorbidities and gasotransmitters
Publication date: Available online 31 January 2020Source: Nitric OxideAuthor(s): Samuel J. Gentle, Trent E. Tipple, Rakesh PatelAbstractHydrogen sulfide, nitric oxide, and carbon monoxide are endogenously produced gases that regulate various signaling pathways. The role of these transmitters is complex as constitutive production of these molecules may have anti-inflammatory, anti-microbial, and/or vasodilatory effects whereas induced production or formation of secondary metabolites may lead to cellular death. Given this fine line between friend and foe, therapeutic attenuation of these molecules’ production has involved ...
Source: Nitric Oxide - February 1, 2020 Category: Chemistry Source Type: research
Renal nitrate clearance in chronic kidney disease
ConclusionsWe have observed a strong positive association between renal nitrate clearance and renal function such that plasma nitrate rises as renal function falls. Fractional excretion of nitrate appears to decline as renal function falls. As such, urinary nitrate excretion is unlikely to be a reliable marker of endogenous NO synthesis in settings where renal function is altered. (Source: Nitric Oxide)
Source: Nitric Oxide - January 31, 2020 Category: Chemistry Source Type: research
A comparison of multifunctional donors of carbon monoxide: Their anticoagulant, antioxidant, anti-aggregatory and cytotoxicity activities in an in vitro model
Publication date: Available online 30 January 2020Source: Nitric OxideAuthor(s): Weronika Adach, Beata OlasAbstractThe study examines the effect of two water-soluble carbon monoxide (CO) donors, CORM-3 and CORM-A1, on selected parameters of oxidative stress and hemostasis in human plasma and blood platelets in vitro. It also compares their activity with that of the lipid-soluble CORM-2. The oxidation of amino acid residues in plasma proteins was evaluated by measuring the amounts of thiol and carbonyl groups. Plasma lipid peroxidation was measured as thiobarbituric acid reactive substance (TBARS) concentration. In addition...
Source: Nitric Oxide - January 30, 2020 Category: Chemistry Source Type: research
Editorial Board
Publication date: 1 March 2020Source: Nitric Oxide, Volume 96Author(s): (Source: Nitric Oxide)
Source: Nitric Oxide - January 29, 2020 Category: Chemistry Source Type: research
Intratracheal injection of nitric oxide, generated from air by pulsed electrical discharge, for the treatment of pulmonary hypertension in awake ambulatory lambs
ConclusionsContinuously delivering electrically generated NO through a Scoop catheter produces vasodilation of the pulmonary vasculature of awake lambs with pulmonary hypertension. Transtracheal NO delivery may provide a long-term treatment for patients with chronic pulmonary hypertension as an outpatient without requiring a mask or tracheal intubation. (Source: Nitric Oxide)
Source: Nitric Oxide - January 24, 2020 Category: Chemistry Source Type: research
Poor glycemic control impairs the cardioprotective effects of red blood cells on myocardial ischemia/reperfusion injury
Publication date: Available online 22 January 2020Source: Nitric OxideAuthor(s): Johanna M. Muessig, Luise Moellhoff, Johanna Noelle, Sema Kaya, Leonie Hidalgo Pareja, Maryna Masyuk, Michael Roden, Malte Kelm, Christian JungAbstractRed blood cells (RBCs) play an important role in the cardiac ischemia/reperfusion (I/R) injury. Cardiovascular risk factors impair the RBC function in an endothelial nitric oxide synthase (eNOS) dependent manner. However, it is unclear whether the protective role of RBCs can be rescued by modifying cardiovascular risk factors or by pharmacologic intervention. RBCs obtained from elderly patients ...
Source: Nitric Oxide - January 23, 2020 Category: Chemistry Source Type: research
Supplementation of dietary nitrate attenuated oxidative stress and endothelial dysfunction in diabetic vasculature through inhibition of NADPH oxidase
Publication date: Available online 21 January 2020Source: Nitric OxideAuthor(s): Rong Tian, Rou Peng, Ziyi Yang, Yi-Yuan Peng, Naihao LuAbstractThe metabolic disorders in diabetes, which are usually accompanied by oxidative stress and impaired nitric oxide (NO) bioavailability, increase the risk of detrimental cardiovascular complications. Herein, we investigated the therapeutic potential of dietary nitrate, which is found in high content in green leafy vegetables, on vascular oxidative stress and endothelial dysfunction in diabetic mice induced by high-fat diet and streptozotocin injection. Dietary nitrate in drinking wat...
Source: Nitric Oxide - January 21, 2020 Category: Chemistry Source Type: research
Mechanisms of the protective effects of nitrate and nitrite in cardiovascular and metabolic diseases
Publication date: Available online 16 January 2020Source: Nitric OxideAuthor(s): Yang Liu, Kevin D. Croft, Jonathan M. Hodgson, Trevor Mori, Natalie C. WardAbstractWithin the body, NO is produced by nitric oxide synthases via converting l-arginine to citrulline. Additionally, NO is also produced via the NOS-independent nitrate-nitrite-NO pathway. Unlike the classical pathway, the nitrate-nitrite-NO pathway is oxygen independent and viewed as a back-up function to ensure NO generation during ischaemia/hypoxia. Dietary nitrate and nitrite have emerged as substrates for endogenous NO generation and other bioactive nitrogen ox...
Source: Nitric Oxide - January 17, 2020 Category: Chemistry Source Type: research
Real-time redox monitoring of a nitrosyl ruthenium complex acting as NO-donor agent in a single A549 cancer cell with multiplex Fourier-transform infrared microscopy
Publication date: Available online 14 January 2020Source: Nitric OxideAuthor(s): Fernando Postalli Rodrigues, Lucyano J.A. Macedo, Leandro N.C. Máximo, Fernanda C.P.F. Sales, Roberto Santana da Silva, Frank N. CrespilhoAbstractMultiplex Fourier-transform infrared microscopy (μFT-IR) helped to monitor trans-[Ru(NO) (NH3)4 (isn)]3+ (I), uptake by A549 lung carcinoma cell, as well as the generation of its product, nitric oxide (NO), inside the cell. Chronoamperometry with NO-sensor and μFT-IR showed that exogenous NADH and the A549 cell induced the NO release redox mechanism. Chemical imaging confirmed that (I) was taken...
Source: Nitric Oxide - January 15, 2020 Category: Chemistry Source Type: research
Inhaled nitric oxide to control platelet hyper-reactivity in patients with acute submassive pulmonary embolism
ConclusionsIn patients with acute submassive PE, despite evidence of adequate drug delivery, inhaled NO had no major effect on platelet O2 consumption or agonist-stimulated parameters on TEG. Pharmacological activation, but not stimulation, of sGC effectively decreased platelet cytosolic [Ca++], and platelet sGC activity was increased with PE, confirming the viability of sGC as a therapeutic target.Graphical abstract (Source: Nitric Oxide)
Source: Nitric Oxide - January 12, 2020 Category: Chemistry Source Type: research
Nitric oxide synthase inhibitor L-NG-nitroarginine methyl ester (L-NAME) attenuates remobilization-induced joint inflammation
This study aimed to investigate whether: 1) administration of the NOS inhibitor L-NG-nitroarginine methyl ester (l-NAME) can attenuate remobilization-induced joint inflammation; and 2) hypoxia/reoxygenation is induced by joint immobilization and followed by remobilization. Unilateral knee joints of rats were immobilized using external fixators for three weeks. After removal of the fixation device, knees were allowed to move freely for one day (remobilization) with or without l-NAME administration. Without L-NAME administration, inflammatory reactions including joint swelling and inflammatory cell infiltration, edema, and u...
Source: Nitric Oxide - January 9, 2020 Category: Chemistry Source Type: research
Editorial Board
Publication date: 1 February 2020Source: Nitric Oxide, Volume 95Author(s): (Source: Nitric Oxide)
Source: Nitric Oxide - January 8, 2020 Category: Chemistry Source Type: research
