S-Nitrosoglutathione exhibits greater stability than S-nitroso-N-acetylpenicillamine under common laboratory conditions: A comparative stability study
Publication date: Available online 6 August 2019Source: Nitric OxideAuthor(s): Alyssa C. Melvin, W. Matthew Jones, Alec Lutzke, Christopher L. Allison, Melissa M. ReynoldsAbstractS-Nitrosothiols (RSNOs) such as S-nitrosoglutathione (GSNO) and S-nitroso-N-acetylpenicillamine (SNAP) are susceptible to decomposition by stimuli including heat, light, and trace metal ions. Using stepwise isothermal thermogravimetric analysis (TGA), we observed that NO-forming homolytic cleavage of the S–N bond occurs at 134.7 ± 0.8 °C in GSNO and 132.8 ± 0.9 °C in SNAP, contrasting with the value of 150 °C that has been pre...
Source: Nitric Oxide - August 7, 2019 Category: Chemistry Source Type: research
DDAH1 and DDAH2 polymorphisms associate with asymmetrical dimethylarginine plasma levels in erectile dysfunction patients but not in healthy controls
In this study were included 98 healthy controls and 130 ED patients. ADMA levels were measured by ELISA and nitrite levels by Chemiluminescence. DDAH1 and DDAH2 polymorphisms were assessed by Taqman assays. We found that ED had increased nitrite levels and lower ADMA levels than Control group (P < 0.05). We found a significant correlation of ADMA with Nitrite levels only in ED (B = -0.57, P < 0.001). Genotypes and haplotypes of DDAH1 were associated with ADMA levels in ED (P < 0.05), while haplotypes of DDAH2 were associated with levels of nitrite in ED (P < 0.05). Erectile dysfunction p...
Source: Nitric Oxide - August 6, 2019 Category: Chemistry Source Type: research
Visible light-controlled NO generation for photoreceptor-mediated plant root growth regulation
Publication date: Available online 1 August 2019Source: Nitric OxideAuthor(s): Suprakash Biswas, Neha Upadhyay, Debojyoti Kar, Sourav Datta, Apurba Lal KonerAbstractNitric oxide (NO) is an essential redox-signaling molecule, contributes a significant role in a diverse range of physiological processes. However, photo-triggered NO donors have significant potential compared to other NO donors because it releases NO in the presence of light. Hence, an efficient visible light-triggered NO donor is designed and synthesized by coupling 2,6-dimethyl nitrobenzene moiety at the peri-position of 1, 8-naphthalimide. The NO-releasing a...
Source: Nitric Oxide - August 3, 2019 Category: Chemistry Source Type: research
‘Differential effects of resveratrol on the dilator responses of femoral arteries, ex vivo’
Publication date: Available online 29 July 2019Source: Nitric OxideAuthor(s): Miguel Diaz, Vijay Parikh, Saira Ismail, Raja Maxamed, Emily Tye, Clare Austin, Tristan Dew, Brigitte A. Graf, Luc Vanhees, Hans Degens, May AzzawiAbstractResveratrol is a plant-derived phytoalexin with antioxidant, anti-inflammatory and cardio-protective properties and may be a promising therapeutic intervention strategy in cardiovascular disease. Here, we investigated the acute direct effects of trans-resveratrol (RV), on acetylcholine (ACh)-induced and flow-mediated dilation (FMD) of isolated pressurized femoral arteries of young (4-month-old)...
Source: Nitric Oxide - July 30, 2019 Category: Chemistry Source Type: research
Amyloid-β induced neuropathological actions are suppressed by Padina gymnospora (Phaeophyceae) and its active constituent α-bisabolol in Neuro2a cells and transgenic Caenorhabditis elegans Alzheimer's model
Publication date: Available online 27 July 2019Source: Nitric OxideAuthor(s): Balakrishnan Shanmuganathan, Sethuraman Sathya, Boopathi Balasubramaniam, Krishnaswamy Balamurugan, Kasi Pandima DeviAbstractThe inhibition of Aβ peptide development and aggregation is a hopeful curative approach for the discovery of disease modifying drugs for Alzheimer's disease (AD) treatment. Recent research mainly focuses on the discovery of drugs from marine setting due to their immense therapeutic potential. The present study aims to evaluate the brown macroalga Padina gymnospora and its active constituent α-bisabolol against Aβ25-35 in...
Source: Nitric Oxide - July 28, 2019 Category: Chemistry Source Type: research
Structure effect of water-soluble iron porphyrins on catalyzing protein tyrosine nitration in the presence of nitrite and hydrogen peroxide
Publication date: Available online 24 July 2019Source: Nitric OxideAuthor(s): Jiayu Lia, Zhen Yang, Hailing Li, Zhonghong GaoAbstractWater-soluble iron porphyrins, such as FeTPPS (5,10,15,20-tetrakis (4-sulfonatophenyl) porphyrinato iron (III)), FeTMPyP (5,10,15,20-tetrakis (N-methyl-4′-pyridyl) porphyrinato iron (III) chloride) and FeTBAP (5,10,15,20-tetrakis (4-benzoic acid) porphyrinato iron (III)), are highly active catalysts for peroxynitrite decomposition and thereby have been suggested as therapeutic agent for inflammatory diseases that implicate the involvement of nitrotyrosine formation. Here, we systemically in...
Source: Nitric Oxide - July 25, 2019 Category: Chemistry Source Type: research
Nitric oxide might be an inducing factor in cognitive impairment in Alzheimer's disease via downregulating the monocarboxylate transporter 1
Publication date: Available online 18 July 2019Source: Nitric OxideAuthor(s): Xiaoyi Tang, Zhuang Li, Weiwei Zhang, Zhongxiang YaoAbstractAlzheimer's disease (AD) is a typical neurodegenerative disease in central nervous system (CNS). Generally speaking, patients with severe AD are often accompanied with cognitive impairment. Oligodendrocytes (OLs) are myelin-forming cells in CNS, and myelin injury potentially has something to do with the cognitive impairment in AD. Based on the previous experimental studies, it has been recognized that nitric oxide (NO), as a signaling molecule, might have an influence on the axon and mye...
Source: Nitric Oxide - July 19, 2019 Category: Chemistry Source Type: research
Electroacupuncture ameliorates neuronal injury by Pink1/Parkin-mediated mitophagy clearance in cerebral ischemia-reperfusion
In this study, rats were treated with mitochondrial permeability transition pore (mPTP) opening inhibitor, peroxynitrite (ONOO−) scavenger, or selective inhibitor of mitophagy activation during 2-h middle cerebral artery occlusion (MCAO) followed by 24 h of reperfusion in combination with EA treatment. RNA-Seq analysis showed that EA treatment in cerebral I/R was linked to the autophagosome, the PI3K/Akt signaling pathway and metabolic pathways. We found that I/R resulted in significantly mitochondrial function impairments including decreased mitochondrial membrane potential (MMP) and ATP levels, aggregation of damaged...
Source: Nitric Oxide - July 17, 2019 Category: Chemistry Source Type: research
Upregulation of the nitrosylome in bipolar disorder type 1 (BP1) and major depression, but not BP2: Increased IgM antibodies to nitrosylated conjugates are associated with indicants of leaky gut
ConclusionsBP1 and MDD are characterized by an upregulation of the nitrosylome (the proteome of nitrosylated proteins) and increased IgM responses to nitrosylated conjugates. Increased nitrosylation may be driven by increased bacterial translocation and is associated with lipid peroxidation processes. Innate-like (B1 and marginal zone) B cells and increased nitrosylation may play a key role in the major affective disorders through activation of immune-inflammatory and oxidative pathways, cardiovascular comorbidity and impairments in antioxidant defenses, neuro-glial interactions, synaptic plasticity, neuroprotection, neuro...
Source: Nitric Oxide - July 17, 2019 Category: Chemistry Source Type: research
Editorial Board
Publication date: 1 September 2019Source: Nitric Oxide, Volume 90Author(s): (Source: Nitric Oxide)
Source: Nitric Oxide - July 13, 2019 Category: Chemistry Source Type: research
Inhaled nebulized nitrite and nitrate therapy in a canine model of hypoxia-induced pulmonary hypertension
Publication date: Available online 9 July 2019Source: Nitric OxideAuthor(s): Irene Cortés-Puch, Junfeng Sun, Alan N. Schecter, Steven B. Solomon, Ji Won Park, Jing Feng, Cameron Gilliard, Charles Natanson, Barbora PiknovaAbstractDysfunction in the nitric oxide (NO) signaling pathway can lead to the development of pulmonary hypertension (PH) in mammals. Discovery of an alternative pathway to NO generation involving reduction from nitrate to nitrite and to NO has motivated the evaluation of nitrite as an alternative to inhaled NO for PH. In contrast, inhaled nitrate has not been evaluated to date, and potential benefits inc...
Source: Nitric Oxide - July 10, 2019 Category: Chemistry Source Type: research
Validity and reliability of test strips for the measurement of salivary nitrite concentration with and without the use of mouthwash in healthy adults
This study suggests that commercially available salivary NO2− test strips provide a reasonable surrogate marker for monitoring changes in salivary NO2− concentrations in humans. However, the strips do not provide accurate estimates of absolute NO2− concentrations. (Source: Nitric Oxide)
Source: Nitric Oxide - July 9, 2019 Category: Chemistry Source Type: research
Zinc-induced root architectural changes of rhizotron-grown B. napus correlate with a differential nitro-oxidative response
In this study the effect of a low, growth-inducing, and a high, growth inhibiting Zn concentrations on the early development of Brassica napus (L.) root architecture and the underlying nitro-oxidative mechanisms were studied in a soil-filled rhizotron system.The growth-inhibiting Zn treatment resulted in elevated protein tyrosine nitration due to the imbalance in ROS and RNS homeostasis, however its pattern was not changed compared to the control. This nitro-oxidative stress was accompanied by serious changes in the cell wall composition and decrease in the cell proliferation and viability, due to the high Zn uptake and di...
Source: Nitric Oxide - July 1, 2019 Category: Chemistry Source Type: research
Effect of nitrite on the electroencephalographic activity in the healthy brain
ConclusionOur study shows that exogenous sodium nitrite does not alter the electrical activity in the healthy brain. This might be because the sodium nitrite is converted to vasoactive nitric oxide in areas of hypoxia, and in the healthy brain there is no significant amount of conversion due to lack of hypoxia. However, this lack of change in the power spectrum density in healthy people emphasises the specificity of the brain's response to nitrite in disease. (Source: Nitric Oxide)
Source: Nitric Oxide - June 27, 2019 Category: Chemistry Source Type: research
Editorial Board
Publication date: 1 August 2019Source: Nitric Oxide, Volume 89Author(s): (Source: Nitric Oxide)
Source: Nitric Oxide - June 13, 2019 Category: Chemistry Source Type: research
