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Abstracts: 5th Annual Congress of the European Society for Translational Medicine (EUSTM-2017), 20-22 October 2017, Berlin, Germany
Publication date: Available online 8 November 2017 Source:New Horizons in Translational Medicine (Source: New Horizons in Translational Medicine)
Source: New Horizons in Translational Medicine - November 24, 2017 Category: Research Source Type: research

Abstracts: 5th Annual Congress of the European Society for Translational Medicine (EUSTM-2017), 20 –22 October 2017, Berlin, Germany
Publication date: Available online 8 November 2017 Source:New Horizons in Translational Medicine Author(s): Aamir Shahzad, Randall J. Cohrs (Source: New Horizons in Translational Medicine)
Source: New Horizons in Translational Medicine - November 8, 2017 Category: Research Source Type: research

Safety Study of Autologous Adult Bone Marrow Derived Mesenchymal Stromal Cells in Idiopathic Pulmonary Fibrosis - Pilot Data
Conclusions BMSC central line infusion in “no option” IPF cases provided an insight into the strategies in improving the quality of life for patient and thereby increasing the therapeutic window period for lung transplantation. (Source: New Horizons in Translational Medicine)
Source: New Horizons in Translational Medicine - October 13, 2017 Category: Research Source Type: research

PSO-ANN based Diagnostic Model for the Early Detection of Dengue Disease
The objective of this work is to develop a diagnostic model for earlier diagnosis of dengue disease. Dengue fever is spread through the bite of the female mosquito (Aedes aegypti). The symptoms of this fever are similar to other fever such as that of Viral influenza, Chikungunya, Zika fever, and so on. However, in this fever, human life can be at risk due to severe depletion of blood platelets. Therefore, early diagnosis of dengue disease can help in protecting human lives by making a preventive move before it turns into an infectious disease. In this work, an effort is made to develop a PSO-ANN based diagnostic model for ...
Source: New Horizons in Translational Medicine - October 11, 2017 Category: Research Source Type: research

Synthesis of a series of new 6-Nitrobenzofuran-2-carbohydrazide derivatives with cytotoxic and antioxidant activity
This study will be useful to develop potential lead molecules with cytotoxic and antioxidant potential. (Source: New Horizons in Translational Medicine)
Source: New Horizons in Translational Medicine - August 27, 2017 Category: Research Source Type: research

Pros, Cons and Future of Antibiotics
Publication date: Available online 22 August 2017 Source:New Horizons in Translational Medicine Author(s): Elroy P. Weledji, Elizabeth K Weledji, Jules C. Assob, Dickson S. Nsagha The advantages of antibiotics have been most clearly seen in those acute bacterial infections which had a high mortality before the introduction of antibiotics. The reality of the potential harmful effects of antibiotics, both short term in individual patients and long term in favoring emergent resistance and opportunistic pathogens are discussed. Bacterial resistance makes the standard treatments ineffective, and increases the risk of infe...
Source: New Horizons in Translational Medicine - August 23, 2017 Category: Research Source Type: research

Improving disease diagnosis by a new hybrid model
Publication date: Available online 14 July 2017 Source:New Horizons in Translational Medicine Author(s): Bikash Kanti Sarkar Knowledge extraction is an important part of e-Health system. However, datasets in health domain are highly imbalanced, voluminous, conflicting and complex in nature, and these can lead to erroneous diagnosis of diseases. So, designing accurate and robust clinical diagnosis models for such datasets is a challenging task in data mining. In literature, numerous standard intelligent models have been proposed for this purpose but they usually suffer from several drawbacks like lack of understandabilit...
Source: New Horizons in Translational Medicine - July 14, 2017 Category: Research Source Type: research

A new horizon for sepsis: Personalised medicine: Hype or hope?
Publication date: Available online 15 June 2017 Source:New Horizons in Translational Medicine Author(s): R.J. McGalliard, E.D. Carrol (Source: New Horizons in Translational Medicine)
Source: New Horizons in Translational Medicine - June 16, 2017 Category: Research Source Type: research

Nicotine mediated activation of Pak1/NFkB cascade in Pancreatic cancer cells – A pilot study
Conclusion Our findings suggest probable mechanism of action of nicotine through Pak1 signalling on PC pathogenesis and this could be targeted using Pak1 inhibitors for PC treatment. (Source: New Horizons in Translational Medicine)
Source: New Horizons in Translational Medicine - June 16, 2017 Category: Research Source Type: research

Metabolomics for the masses: the future of metabolomics in a personalized world
Publication date: Available online 7 June 2017 Source:New Horizons in Translational Medicine Author(s): Drupad K. Trivedi, Katherine A. Hollywood, Royston Goodacre Current clinical practices, which focus on a small number of biochemicals directly relevant to the pathophysiology within patients, only describe a very limited metabolome of the patient, and do not generally consider the interactions of these small molecules. This lack of information may prevent clinicians from making the best possible therapeutic interventions in time to improve patient care. Various post-genomics (’omics) approaches have been used for ...
Source: New Horizons in Translational Medicine - June 8, 2017 Category: Research Source Type: research

Analysis of Osteoporosis Gene Interactome to Identify Heterogenic Genes and Pathways
Publication date: Available online 6 April 2017 Source:New Horizons in Translational Medicine Author(s): Bharat Singh, Yasha Hasija Latest advances in genetics have prompted swift progress towards the efficient identification of genes tangled in complex diseases. Still, the comprehensive understanding of the relation between the physiological and molecular mechanism of genes and how they affect disease phenotypes remains a challenge for researchers and clinicians. Here, we wish to identify the osteoporosis disease module, i.e. the indigenous neighborhood of the interactome whose agitation is associated with osteoporosi...
Source: New Horizons in Translational Medicine - April 10, 2017 Category: Research Source Type: research

Association of Bone Morphogenic Protein 4 Gene Polymorphism and Left Ventricle Hypertrophy in Diabetic Chronic Kidney Disease Patients: A Pilot Study
Conclusion BMP4 gene polymorphism has been confirmed in patients having LVH regardless of the presence or absence of diabetic CKD along with it. Focal Points • Benchside: Left ventricular (LV) hypertrophy is a strong autonomous predictor of increased cardiovascular morbidity and mortality in clinical and population-based samples. Thus understanding the correlation of LVH with BMP4 gene is necessitated to provide alternate therapeutics strategy at genome level. Eventually, genetic investigations provide high assurance for future prevention, early intervention and treatment of this major public health issue. • Bedsi...
Source: New Horizons in Translational Medicine - February 16, 2017 Category: Research Source Type: research

Drug Delivery Through Nails: Present And Future
Publication date: Available online 25 January 2017 Source:New Horizons in Translational Medicine Author(s): Pradnya Palekar Shanbhag, Urvi Jani (Source: New Horizons in Translational Medicine)
Source: New Horizons in Translational Medicine - January 24, 2017 Category: Research Source Type: research

BioMicroelectromechanical Systems: A Novel Approach for Drug Targeting In Chronic Diseases
Publication date: Available online 22 January 2017 Source:New Horizons in Translational Medicine Author(s): Pradnya Palekar Shanbhag, Ninadha S. Patil Despite of decades of research in conventional drug delivery systems many challenges are unconfronted in treatment of chronic diseases at a personalized medicine level. So there is a need for development of targeted and efficient drug delivery systems at such levels of treatment. Microelectromechanical systems have some unique characteristics like analyte sensitivity, electrical responsiveness, temporal control and sizes similar to cells and organelles that has led to en...
Source: New Horizons in Translational Medicine - January 21, 2017 Category: Research Source Type: research

Vegf mimic peptides: potential applications in central nervous system therapeutics
Publication date: Available online 22 December 2016 Source:New Horizons in Translational Medicine Author(s): Luca Domenico D'Andrea, Lucia De Rosa, Chiara Vigliotti, Mauro Cataldi VEGF is expressed in central nervous system and its expression increases in hypoxia and in inflammatory brain disorders. A wealth of data suggests that VEGF may exert neuroprotective activities and promote neuroregeneration in disease status. Moreover, the risk of developing certain neurological disorders may be dependent on dysfunction in the VEGF system. Therefore, a strong rationale does exist to suggest that VEGF-based therapeutics coul...
Source: New Horizons in Translational Medicine - December 21, 2016 Category: Research Source Type: research