Litter effects: Comments on Golub and Sobin's “Statistical modeling of litter as a random effect in mixed models to manage “intralitter likeness””
Publication date: Available online 11 December 2019Source: Neurotoxicology and TeratologyAuthor(s): Charles V. Vorhees, Michael T. WilliamsAbstractThe importance of litter effects (clustering of variance among offspring in rodents) has been known for decades. The standard approach was to treat the entire litter a unit or to select one male and one female from each litter to prevent oversampling. These methods work but are imperfect. Treating the litter as a whole fails to use valuable interindividual differences among offspring, and selecting representative pups fails to use all the data available. Golub and Sobin [Ref] ad...
Source: Neurotoxicology and Teratology - December 11, 2019 Category: Toxicology Source Type: research
Association of prenatal maternal perceived stress with a sexually dimorphic measure of cognition in 4.5-month-old infants
Publication date: Available online 6 December 2019Source: Neurotoxicology and TeratologyAuthor(s): F.M. Merced-Nieves, A. Aguiar, K.L.C. Dzwilewski, S. Musaad, S.A. Korrick, S.L. SchantzAbstractMaternal prenatal stress can adversely impact subsequent child neurodevelopment, but little is known about its effect on cognitive development in infancy. This analysis of 107 infants from a prospective birth cohort assessed whether prenatal stress disrupts sexually dimorphic performance typically observed on a physical reasoning task. Maternal stress was assessed at 8–14 and 33–37 gestational weeks using the Perceived Stress Sc...
Source: Neurotoxicology and Teratology - December 7, 2019 Category: Toxicology Source Type: research
Neuron-specific toxicity of chronic acrylamide exposure in C. elegans
Publication date: Available online 20 November 2019Source: Neurotoxicology and TeratologyAuthor(s): Sydney M. Murray, Brandon M. Waddell, Cheng-Wei WuAbstractAcrylamide is a food-borne chemical with well-known neurotoxic properties. To date, the toxicity mechanisms of chronic acrylamide exposure are not fully understood. Using the genetic model Caenorhabditis elegans, we found that chronic acrylamide exposure induces a locomotor defect that is characterized by severe uncoordination of muscle movement that is distinct from an overall reduction in activity. C. elegans exhibiting chronic acrylamide-induced locomotor defects s...
Source: Neurotoxicology and Teratology - November 20, 2019 Category: Toxicology Source Type: research
Editorial Board
Publication date: November–December 2019Source: Neurotoxicology and Teratology, Volume 76Author(s): (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - November 13, 2019 Category: Toxicology Source Type: research
Sex-specific effects of perinatal FireMaster® 550 (FM 550) exposure on socioemotional behavior in prairie voles
Publication date: Available online 12 November 2019Source: Neurotoxicology and TeratologyAuthor(s): Sagi Enicole A. Gillera, William P. Marinello, Brian M. Horman, Allison L. Phillips, Matthew T. Ruis, Heather M. Stapleton, David Reif, Heather B. PatisaulAbstractThe rapidly rising incidence of neurodevelopmental disorders with social deficits is raising concern that developmental exposure to environmental contaminants may be contributory. Firemaster 550 (FM 550) is one of the most prevalent flame-retardant (FR) mixtures used in foam-based furniture and baby products and contains both brominated and organophosphate componen...
Source: Neurotoxicology and Teratology - November 12, 2019 Category: Toxicology Source Type: research
Paternal valproic acid exposure in mice triggers behavioral alterations in offspring
This study seeks to investigate whether paternal VPA exposure in rodents triggers behavioral and epigenetic alterations in offspring. The results show that paternal VPA exposure impairs object cognitive memory, suppresses the hyperactivity evoked by an NMDA receptor antagonist in male and female offspring, and disturbs sensorimotor gating in only females. In addition, since VPA is well known as an inhibitor of histone deacetylases, we examined the levels of acetylated histone H3 in the frontal cortex and hippocampus in the offspring of VPA-exposed sires. Interestingly, paternal VPA exposure down-regulates the levels of ace...
Source: Neurotoxicology and Teratology - October 23, 2019 Category: Toxicology Source Type: research
Protective effects of syringic acid on neurobehavioral deficits and hippocampal tissue damages induced by sub-chronic deltamethrin exposure
In conclusion, SA (25 mg/kg/day) had potential neuroprotective and therapeutic impacts against sub-chronic DTM exposure via its antioxidant and antiapoptotic efficacy. Therefore, it can be used as a neuroprotective natural plant-derived agent against DTM-induced neurotoxicity. (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - October 22, 2019 Category: Toxicology Source Type: research
Gestational exposure to paracetamol in rats induces neurofunctional alterations in the progeny
Publication date: Available online 20 October 2019Source: Neurotoxicology and TeratologyAuthor(s): Rodrigo Moreno Klein, Camila Rigobello, Camila Borecki Vidigal, Kawane Fabrício Moura, Décio Sabbatini Barbosa, Daniela Cristina Ceccatto Gerardin, Graziela Scalianti Ceravolo, Estefânia Gastaldello MoreiraAbstractParacetamol (PAR) is an over-the-counter medicine used as analgesic or antipyretic by 40–50% of the pregnant women in different countries. Epidemiologic studies have been associating maternal use of PAR with neurodevelopmental disruption and special attention has been given to its potential to increase the odds...
Source: Neurotoxicology and Teratology - October 22, 2019 Category: Toxicology Source Type: research
A combination insecticide at sub-lethal dose debilitated the expression pattern of crucial signalling molecules that facilitate craniofacial patterning in domestic chick Gallus domesticus
Publication date: Available online 5 October 2019Source: Neurotoxicology and TeratologyAuthor(s): Shashikant Sharma, Gowri K. Uggini, Isha Desai, Suresh BalakrishnanAbstractPesticides despite being agents that protect the plants and humans from noxious pests, are infamous for their potential to cause detrimental health issues in nontargeted species. In order to ascertain the latter, a set of experiments were conducted by exposing early chick embryos to a widely used combination insecticide (Ci, 50% chlorpyrifos and 5% cypermethrin). The results revealed a myriad of congenital defects pertaining to craniofacial development ...
Source: Neurotoxicology and Teratology - October 7, 2019 Category: Toxicology Source Type: research
Venlafaxine plus melatonin ameliorate reserpine-induced depression-like behavior in zebrafish
Publication date: Available online 10 September 2019Source: Neurotoxicology and TeratologyAuthor(s): Ya-Qiu Tang, Zhuo-Ran Li, Shao-Zhi Zhang, Ping Mi, Dong-Yan Chen, Xi-Zeng FengAbstractVenlafaxine (VEN) is one of the first clinical drugs for the treatment of depression. Long-term use may cause a potentially life-threatening serotonin syndrome. Melatonin (MT) could ameliorate depression behavior. Therefore, the aim of this study was to investigate the antidepressant effects of venlafaxine in combination with melatonin on zebrafish. Reserpine was used to induce depression-like behavioral zebrafish. To explore the effects o...
Source: Neurotoxicology and Teratology - September 11, 2019 Category: Toxicology Source Type: research
Experience during adolescence shapes brain development: From synapses and networks to normal and pathological behavior
This report will summarize some examples of adaptation which occur during adolescence and some evidence that the adolescent brain responds differently to stimuli compared to adults and children.This symposium, “Experience during adolescence shapes brain development: from synapses and networks to normal and pathological behavior” occurred during the Developmental Neurotoxicology Society/Teratology Society Annual Meeting in Clearwater Florida, June 2018. The sections will describe the maturation of the brain during adolescence as studied using imaging technologies, illustrate how plasticity shapes the structure of the br...
Source: Neurotoxicology and Teratology - September 8, 2019 Category: Toxicology Source Type: research
Editorial Board
Publication date: September–October 2019Source: Neurotoxicology and Teratology, Volume 75Author(s): (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - September 4, 2019 Category: Toxicology Source Type: research
Weekly ethanol exposure alters dopaminergic parameters in zebrafish brain
Publication date: Available online 14 August 2019Source: Neurotoxicology and TeratologyAuthor(s): Maria Cecilia Manenti Alexandre, Niuany Viel Mendes, Carolina Antunes Torres, Samira Leila Baldin, Henrique Teza Bernardo, Rahisa Scussel, Suelen Baggio, Ben Hur Marins Mussulini, Kamila Cagliari Zenki, Maria Inês da Rosa, Eduardo Pacheco RicoAbstractBinge drinking is defined as the infrequent consumption of excessive doses of alcohol in a short period of time. Zebrafish is a reliable model to investigate ethanol consumption impact on the CNS, including reward signaling like dopaminergic neurotransmission system. The aim of t...
Source: Neurotoxicology and Teratology - August 15, 2019 Category: Toxicology Source Type: research
ROS-mediated JNK pathway critically contributes to PFOS-triggered apoptosis in SH-SY5Y cells
Publication date: Available online 8 August 2019Source: Neurotoxicology and TeratologyAuthor(s): Pingping Sun, Lingqi Gu, Jiashan Luo, Yi Qin, Lingli Sun, Shengyang JiangAbstractRecent studies have indicated that perfluorooctane sulfonate (PFOS) and its derivatives can lead to neurotoxicity. In the present study, we showed that PFOS may trigger neuronal apoptosis through a c-Jun N-terminal kinase (JNK)-related mechanism. We revealed that c-Jun N-terminal kinase (JNK) was robustly activated in PFOS-exposed neuronal cells. The doses of PFOS that initiates JNK activation coincides with that inducing neuronal apoptosis, as con...
Source: Neurotoxicology and Teratology - August 10, 2019 Category: Toxicology Source Type: research
Editorial Board
Publication date: July–August 2019Source: Neurotoxicology and Teratology, Volume 74Author(s): (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - July 18, 2019 Category: Toxicology Source Type: research
