The citrus flavonoids hesperidin and naringin alleviate alcohol-induced behavioural alterations and developmental defects in zebrafish larvae
In conclusion, this study suggests that the citrus flavonoids hesperidin and naringin could reduce the effects of alcohol damage on embryonic development and neurobehaviour in zebrafish larvae, which would provide useful knowledge for assessing the underlying mechanism of citrus flavonoids and their protective effects.Graphical abstract (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - March 16, 2019 Category: Toxicology Source Type: research
Editorial Board
Publication date: March–April 2019Source: Neurotoxicology and Teratology, Volume 72Author(s): (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - March 6, 2019 Category: Toxicology Source Type: research
Repeated toluene exposure alters the synaptic transmission of layer 5 medial prefrontal cortex
Publication date: Available online 28 February 2019Source: Neurotoxicology and TeratologyAuthor(s): Silvia L. Cruz, Mayra Torres-Flores, Emilio J. GalvánAbstractToluene is an organic solvent commonly misused by inhalation among adolescents to experience psychoactive effects. Repeated toluene exposure produces several cognitive deficits, including working memory impairment in which the medial prefrontal cortex (mPFC) plays a central role. Among other effects, toluene antagonizes NMDA receptors, enhance GABAA receptor-mediated responses and increases dopamine release. We have recently reported that animals repeatedly expose...
Source: Neurotoxicology and Teratology - March 1, 2019 Category: Toxicology Source Type: research
When fish take a bath: Psychopharmacological characterization of the effects of a synthetic cathinone bath salt ‘flakka’ on adult zebrafish
This study also suggests that aquatic models based on zebrafish can help further examine the CNS effects evoked by α-PVP and related synthetic new psychoactive drugs. (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - February 21, 2019 Category: Toxicology Source Type: research
Lead exposure reduces survival, neuronal determination, and differentiation of P19 stem cells
Publication date: Available online 15 February 2019Source: Neurotoxicology and TeratologyAuthor(s): Clayton Mansel, Shaneann Fross, Jesse Rose, Emily Dema, Alexis Mann, Haley Hart, Paul Klawinski, Bhupinder P.S. VohraAbstractLead (Pb) is a teratogen that poses health risks after acute and chronic exposure. Lead is deposited in the bones of adults and is continuously leached into the blood for decades. While this chronic lead exposure can have detrimental effects on adults such as high blood pressure and kidney damage, developing fetuses and young children are particularly vulnerable. During pregnancy, bone-deposited lead i...
Source: Neurotoxicology and Teratology - February 16, 2019 Category: Toxicology Source Type: research
Developmental neurotoxicity of inorganic arsenic exposure in Sprague-Dawley rats
Publication date: Available online 6 February 2019Source: Neurotoxicology and TeratologyAuthor(s): Christopher L. Moore, Timothy J. Flanigan, Charles D. Law, Lucie Loukotková, Kellie A. Woodling, Gonçalo Gamboa da Costa, Suzanne C. Fitzpatrick, Sherry A. FergusonAbstractHigh levels of inorganic arsenic (iAs) exposure are associated with severe health effects. Less clear are effects of lower exposure levels on neurodevelopment. Relative to maternal intake, there is limited lactational transfer of arsenic in humans or rodents, yet there are few rodent studies which directly exposed preweaning animals. To more clearly deter...
Source: Neurotoxicology and Teratology - February 7, 2019 Category: Toxicology Source Type: research
Varying the exposure period and duration of neuroactive pharmaceuticals and their metabolites modulates effects on the visual motor response in zebrafish (Danio rerio) larvae
Publication date: Available online 31 January 2019Source: Neurotoxicology and TeratologyAuthor(s): Irvin J. Huang, Howard I. Sirotkin, Anne E. McElroyAbstractPharmaceuticals and personal care products are emerging contaminants that are increasingly detected in surface waters around the world. Despite the rise in environmental detections, measured concentrations are still typically low, raising the importance of environmental risk assessments that focus on ecologically relevant sublethal endpoints, such as altered behavior. Neuroactive pharmaceuticals, like mental health medications, pain killers, etc., may be particularly ...
Source: Neurotoxicology and Teratology - February 1, 2019 Category: Toxicology Source Type: research
Biocompatibility and toxicity of novel iron chelator Starch-Deferoxamine (S-DFO) compared to zinc oxide nanoparticles to zebrafish embryo: An oxidative stress based apoptosis, physicochemical and neurological study profile
ConclusionOur assays demonstrate that S-DFO does not induce cellular or biochemical stress and has no adverse effect on organ development of zebrafish embryos, suggesting its safe use as an iron chelator.Graphical abstract (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - January 31, 2019 Category: Toxicology Source Type: research
Preclinical modeling of exposure to a global marine bio-contaminant: Effects of in utero Domoic acid exposure on neonatal behavior and infant memory
Publication date: Available online 25 January 2019Source: Neurotoxicology and TeratologyAuthor(s): Kimberly S. Grant, Brenda Crouthamel, Caroline Kenney, Noelle McKain, Rebekah Petroff, Sara Shum, Jing Jing, Nina Isoherranen, Thomas M. BurbacherAbstractDomoic Acid (DA) is a naturally-occurring marine neurotoxin that is increasingly recognized as an important public health issue. Prenatal DA exposure occurs through the maternal consumption of contaminated shellfish/finfish. To better understand the fetal risks associated with DA, we initiated a longitudinal, preclinical study focused on the reproductive and developmental ef...
Source: Neurotoxicology and Teratology - January 26, 2019 Category: Toxicology Source Type: research
Protective effect of 5-HT7 receptor activation against glutamate-induced neurotoxicity in human neuroblastoma SH-SY5Y cells via antioxidative and antiapoptotic pathways
Publication date: Available online 24 January 2019Source: Neurotoxicology and TeratologyAuthor(s): Tugba NurcanYuksel, Muhammed Yayla, Zekai Halici, Elif Cadirci, Beyzagul Polat, Duygu KoseAbstractSerotonin exerts anti-inflammatory, antioxidant and antiapoptotic effects through 5-HT7 receptors. The present study determined the role of 5-HT7 receptors in glutamate-induced neurotoxicity by using human SH-SY5Y neuroblastoma cells. The cells were pretreated with different concentrations of 5-HT7 receptor agonist LP44 and antagonist SB269970 for 60 min, followed by treatment with glutamate. Cell proliferation was measured usi...
Source: Neurotoxicology and Teratology - January 25, 2019 Category: Toxicology Source Type: research
Editorial Board
Publication date: January–February 2019Source: Neurotoxicology and Teratology, Volume 71Author(s): (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - January 10, 2019 Category: Toxicology Source Type: research
Effects of oral domoic acid exposure on maternal reproduction and infant birth characteristics in a preclinical nonhuman primate model
Publication date: Available online 5 January 2019Source: Neurotoxicology and TeratologyAuthor(s): Thomas M. Burbacher, Kimberly S. Grant, Rebekah Petroff, Sara Shum, Brenda Crouthamel, Courtney Stanley, Noelle McKain, Jing Jing, Nina IsoherranenAbstractDomoic Acid (DA) is a naturally-occurring excitotoxin, produced by marine algae, which can bioaccumulate in shellfish and finfish. The consumption of seafood contaminated with DA is associated with gastrointestinal illness that, in the case of high DA exposure, can evolve into a spectrum of responses ranging from agitation to hallucinations, memory loss, seizures and coma. B...
Source: Neurotoxicology and Teratology - January 5, 2019 Category: Toxicology Source Type: research
Teratogenicity and neurotoxicity effects induced by methomyl insecticide on the developmental stages of Bufo arabicus
Publication date: Available online 2 January 2019Source: Neurotoxicology and TeratologyAuthor(s): Amin A. SeleemAbstractMethomyl (MET) is a carbamate insecticide that has been widely used to protect the crop against insects as an alternative for organophosphorus insecticide. Thus the present study aims to evaluate the potential toxic effects of MET on the developmental stages of Bufo arabicus. Tadpoles were classified into three stages (25, 37, 40). Every stage was divided into two groups, control and MET-treated group (10 ppm for two weeks) after LC50 determination in acute toxicity test for 96 h. Control and MET-trea...
Source: Neurotoxicology and Teratology - January 3, 2019 Category: Toxicology Source Type: research
Anxiolytic activity of paraoxon is associated with alterations in rat brain glutamatergic system
Publication date: Available online 19 December 2018Source: Neurotoxicology and TeratologyAuthor(s): Zohreh Zare, Mohsen Tehrani, Noorollah Rezaei, Babak Dana Ghalebarzand, Moslem MohammadiAbstractExposure to organophosphate (OP) compounds leads to behavioral alterations. To determine whether paraoxon has effects on anxiety, anxiety-like behaviors were assessed in paraoxon-exposed rats. Protein expression of glutamate transporters has also been measured in hippocampus and prefrontal cortex. Three doses of paraoxon (0.3, 0.7, or 1 mg/kg) or corn oil (vehicle) were intraperitoneally injected to adult male rats. At 14 or 28â...
Source: Neurotoxicology and Teratology - December 19, 2018 Category: Toxicology Source Type: research
Neurotoxicity of anesthetics: Mechanisms and meaning from mouse intervention studies
Publication date: Available online 22 November 2018Source: Neurotoxicology and TeratologyAuthor(s): Simon C. Johnson, Amanda Pan, Li Li, Margaret Sedensky, Philip MorganAbstractVolatile anesthetics are widely used in human medicine and generally considered to be safe in healthy individuals. In recent years, the safety of volatile anesthesia in pediatric patients has been questioned following reports of anesthetic induced neurotoxicity in pre-clinical studies. These studies in mice, rats, and primates have demonstrated that exposure to anesthetic agents during early post-natal periods can cause acute neurotoxicity, as well ...
Source: Neurotoxicology and Teratology - November 23, 2018 Category: Toxicology Source Type: research
