Neuroplasticity in Cerebral Visual Impairment (CVI): Assessing Functional Vision and the Neurophysiological Correlates of Dorsal Stream Dysfunction
Publication date: Available online 23 October 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Christopher R. Bennett, Corinna M. Bauer, Emma S. Bailin, Lotfi B. MerabetAbstractCerebral visual impairment (CVI) results from perinatal injury to visual processing structures and pathways and is the most common individual cause of pediatric visual impairment and blindness in developed countries. While there is mounting evidence demonstrating extensive neuroplastic reorganization in early onset, profound ocular blindness, how the brain reorganizes in the setting of congenital damage to cerebral (i.e. retro-genicula...
Source: Neuroscience and Biobehavioral Reviews - October 24, 2019 Category: Neuroscience Source Type: research

Chronic oxytocin administration as a tool for investigation and treatment: A cross-disciplinary systematic review
Publication date: Available online 21 October 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Marilyn Horta, Kathryn Kaylor, David Feifel, Natalie C. EbnerAbstractOxytocin (OT) subserves various physiological, behavioral, and cognitive processes. This paired with the ability to administer OT with minimal and inconsistent side effects has spurred research to explore its therapeutic potential. Findings from single-dose studies indicate that OT administration may be beneficial, at least under certain circumstances. The state of the field, however, is less clear regarding effects from chronic OT administration, ...
Source: Neuroscience and Biobehavioral Reviews - October 22, 2019 Category: Neuroscience Source Type: research

Revealing the optimal thresholds for movement performance: A systematic review and meta-analysis to benchmark pathological walking behaviour
Publication date: Available online 19 October 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Deepak K. Ravi, Michelle Gwerder, Niklas König Ignasiak, Christian R. Baumann, Mechtild Uhl, Jaap H. van Dieën, William R. Taylor, Navrag B. SinghAbstractIn order to address whether increased levels of movement output variability indicate pathological performance, we systematically reviewed and synthesized meta-analysis data on healthy and pathological motor behavior. After screening up to 24’000 reports from four databases, 85 studies were included containing 2409 patients and 2523 healthy asymptoma...
Source: Neuroscience and Biobehavioral Reviews - October 21, 2019 Category: Neuroscience Source Type: research

Can we ‘seize’ the gut microbiota to treat epilepsy?
Publication date: Available online 15 October 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Carmen De Caro, Luigi Francesco Iannone, Rita Citraro, Pasquale Striano, Giovambattista De Sarro, Andrew Constanti, John F. Cryan, Emilio RussoAbstractThe gut-microbiota, the complex intestinal microbial ecosystem essential to health, is an emerging concept in medicine. Several studies demonstrate a microbiota-gut-brain bidirectional connection via neural, endocrine, metabolic and immune pathways. Accordingly, the gut microbiota has a crucial role in modulating intestinal permeability, to alter local/peripheral immu...
Source: Neuroscience and Biobehavioral Reviews - October 16, 2019 Category: Neuroscience Source Type: research

Structural and functional brain reorganisation due to blindness: the special case of bilateral congenital anophthalmia
We describe the functional reorganisation and associated structural and connectivity changes that occur in the brain of those affected by the condition. By considering animal models of this condition, we investigate the changes that may be occurring on a scale that is not captured by human in vivo imaging techniques. Finally, we lay out a model pathway for taking auditory information to the occipital cortex that may be specific to anophthalmia. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - October 16, 2019 Category: Neuroscience Source Type: research

The interaction between stress and chronic pain through the lens of threat learning
Publication date: Available online 14 October 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Inge Timmers, Conny W.E.M. Quaedflieg, Connie Hsu, Lauren C. Heathcote, Cynthia R. Rovnaghi, Laura E. SimonsAbstractStress and pain are interleaved at multiple levels - interacting and influencing each other. Both are modulated by psychosocial factors including fears, beliefs, and goals, and are served by overlapping neural substrates. One major contributing factor in the development and maintenance of chronic pain is threat learning, with pain as an emotionally-salient threat – or stressor. Here, we argue tha...
Source: Neuroscience and Biobehavioral Reviews - October 15, 2019 Category: Neuroscience Source Type: research

The Sensitivity to Threat and Affiliative Reward (STAR) Model and the Development of Callous-Unemotional Traits
Publication date: Available online 13 October 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Rebecca Waller, Nicholas WagnerAbstractResearch implicates callous-unemotional (CU) traits (i.e., lack of empathy, prosociality, and guilt, and reduced sensitivity to others’ emotions) in the development of severe and persistent antisocial behavior. To improve etiological models of antisocial behavior and develop more effective treatments, we need a better understanding of the origins of CU traits. In this review, we discuss the role of two psychobiological and mechanistic precursors to CU traits: low affiliat...
Source: Neuroscience and Biobehavioral Reviews - October 15, 2019 Category: Neuroscience Source Type: research

Eye tracking correlates of acute alcohol consumption: A systematic and critical review
Publication date: Available online 12 October 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Pierre Maurage, Nicolas Masson, Zoé Bollen, Fabien D’HondtAbstractEye tracking has emerged as a reliable neuroscience tool indexing the eye movements’ correlates of impairments resulting from alcohol-use disorders, ranging from perceptive abilities to high-level cognitive functions. This systematic review, following PRISMA guidelines, encompasses all human studies using eye tracking in participants presenting acute alcohol consumption. A literature search was conducted in PsycINFO, PubMed and Scop...
Source: Neuroscience and Biobehavioral Reviews - October 13, 2019 Category: Neuroscience Source Type: research

Affective Touch: a Meta-Analysis on Sex Differences
Publication date: Available online 12 October 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Valentina Russo, Cristina Ottaviani, Grazia Fernanda SpitoniAbstractThe unmyelinated C-tactile afferents system holds a hedonic function in touch experiences, shaping social functioning in the so-called affective touch hypothesis. Despite the fact that females are recognized as more sensitive to discriminative aspects of touch and respond more positively to touch than men, sex differences in the perception of affective touch have not been extensively investigated. We aimed to fill this gap by meta-analyzing existing...
Source: Neuroscience and Biobehavioral Reviews - October 13, 2019 Category: Neuroscience Source Type: research

General anesthetic neurotoxicity in the young: Mechanism and prevention
Publication date: Available online 10 October 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Chao Ji, Qiang Ni, Wurong Chen, Zeyong Yang, Daqing MaAbstractGeneral anesthesia (GA) is usually considered to safely induce a reversible unconscious state allowing surgery to be performed without pain. A growing number of studies, in particular pre-clinical studies, however, demonstrate that general anesthetics can cause neuronal death and even long-term neurological deficits. Herein, we report our literature review and meta-analysis data of the neurological outcomes after anesthesia in the young. We also review av...
Source: Neuroscience and Biobehavioral Reviews - October 12, 2019 Category: Neuroscience Source Type: research

Neural bases of Impulse Control Disorders in Parkinson’s disease: a systematic review and an ALE meta-analysis
In conclusion, the present study strongly supported that ICD in PD are related to a dysfunction of limbic divisions of the striatum and of the prefrontal cortex and provided a neurofunctional basis for devising potential therapeutic interventions. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - October 5, 2019 Category: Neuroscience Source Type: research

Physical activity and depression: Towards understanding the antidepressant mechanisms of physical activity
Publication date: Available online 2 October 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Aaron Kandola, Garcia Ashdown-Franks, Joshua Hendrikse, Catherine M. Sabiston, Brendon StubbsAbstractPhysical activity can treat and prevent depressive symptoms, but its antidepressant mechanisms are yet to be established. In this review, we comprehensively assess key biological and psychosocial mechanisms through which physical activity exerts antidepressant effects, with a particular focus on exercise.Exercise, a subset of physical activity, influences a range of biological and psychosocial processes also implicate...
Source: Neuroscience and Biobehavioral Reviews - October 3, 2019 Category: Neuroscience Source Type: research

Interpersonal difficulties in obesity: A systematic review and meta-analysis to inform a rejection sensitivity-based model
Publication date: Available online 1 October 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Gaia Albano, Katie Rowlands, Luigi Baciadonna, Gianluca Lo Coco, Valentina CardiAbstractObesity is associated with difficulties due to stigma and loneliness. These impact negatively on individuals’ quality of life and behaviour change efforts. Increased sensitivity to others’ negative feedback might play a role in the maintenance of these difficulties and could be addressed in psychological interventions. We conducted a systematic review of interpersonal difficulties in individuals with obesity, across th...
Source: Neuroscience and Biobehavioral Reviews - October 2, 2019 Category: Neuroscience Source Type: research

How does cannabidiol (CBD) influence the acute effects of delta-9-tetrahydrocannabinol (THC) in humans? A systematic review
Publication date: Available online 30 September 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Abigail M. Freeman, Katherine Petrilli, Rachel Lees, Chandni Hindocha, Claire Mokrysz, H. Valerie Curran, Rob Saunders, Tom P. FreemanAbstractThe recent liberalisation of cannabis regulation has increased public and scientific debate about its potential benefits and risks. A key focus has been the extent to which cannabidiol (CBD) might influence the acute effects of delta-9-tetrahydrocannabinol (THC), but this has never been reviewed systematically. In this systematic review of how CBD influences the acute effect...
Source: Neuroscience and Biobehavioral Reviews - October 2, 2019 Category: Neuroscience Source Type: research

Mechanisms of action of the ketogenic diet in depression
Publication date: Available online 27 September 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Adam Włodarczyk, Wiesław Jerzy Cubała (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - September 28, 2019 Category: Neuroscience Source Type: research

The Capacity for Acute Exercise to Modulate Emotional Memories: A Review of Findings and Mechanisms
Publication date: Available online 25 September 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Dharani Keyan, Richard A. BryantAbstractAnxiety disorders, such as posttraumatic stress disorder, are underpinned by fear learning mechanisms. This review outlines how acute bouts of exercise can moderate fear memory acquisition, consolidation, and extinction. These fear memory mechanisms are central to the development and treatment of anxiety disorders. We propose that the documented effects of acute exercise directly impact key neurobiological processes implicated in fear memory modulation. Central to the relati...
Source: Neuroscience and Biobehavioral Reviews - September 26, 2019 Category: Neuroscience Source Type: research

Causal connection between Dissociation and Ongoing Interpersonal Violence: A systematic review
ConclusionThere is growing evidence for dissociation as a cause of interpersonal violence. However, the available evidence is still limited, and our review rather reveals an important research gap. Future longitudinal and experimental studies aimed at clarifying the role of dissociation in the context of violence should take into account the theoretical and empirical complexity around the concept of dissociation. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - September 26, 2019 Category: Neuroscience Source Type: research

An Introductory Guide to Conducting the Trier Social Stress Test
Publication date: Available online 24 September 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Izelle Labuschagne, Caitlin Grace, Peter Rendell, Gill Terrett, Markus HeinrichsAbstractThe Trier Social Stress Test (TSST) is a reliable biopsychological tool to examine the effects of acute stress on psychological and physiological functioning in humans. While the TSST reliably increases hypothalamic-pituitary-adrenal axis activation, amongst other biomarkers, through a combination of social evaluative threat and uncontrollability, the original protocol is limited in methodological detail that has impacted its r...
Source: Neuroscience and Biobehavioral Reviews - September 26, 2019 Category: Neuroscience Source Type: research

Circuits for social learning: A unified model and application to Autism Spectrum Disorder
Publication date: Available online 24 September 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Marilena M. DeMayo, Larry J. Young, Ian B. Hickie, Yun Ju C. Song, Adam J. GuastellaAbstractEarly life social experiences shape neural pathways in infants to develop lifelong social skills. This review presents the first unified circuit-based model of social learning that can be applied to early life social development, drawing together unique human developmental milestones, sensitive learning periods, and behavioral and neural scaffolds. Circuit domains for social learning are identified governing Activation, Int...
Source: Neuroscience and Biobehavioral Reviews - September 26, 2019 Category: Neuroscience Source Type: research

Editorial Board
Publication date: November 2019Source: Neuroscience & Biobehavioral Reviews, Volume 106Author(s): (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - September 26, 2019 Category: Neuroscience Source Type: research

Digging through the roots of addiction: Understanding the causes that underlie the insidious problem of substance use disorders (SUDs)
Publication date: November 2019Source: Neuroscience & Biobehavioral Reviews, Volume 106Author(s): Amie L. Severino, Christopher J. EvansAbstractThis issue features a selection of articles that explore mechanisms of processes that contribute to behaviors that are associated with addiction. We have identified selected articles which focus on the mechanisms underlying maladaptive consumption and affective dysregulation. In addition to the articles within this issue, we highlight the necessity of inclusive study design and acknowledgement of individual drug vulnerabilities. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - September 26, 2019 Category: Neuroscience Source Type: research

Characterising the structure of cognitive hetereogenity in schizophrenia spectrum disorder: A systematic review and narrative synthesis
Publication date: December 2019Source: Neuroscience & Biobehavioral Reviews, Volume 107Author(s): Sean P. Carruthers, Tamsyn E. Van Rheenen, Caroline Gurvich, Philip J. Sumner, Susan L. RossellAbstractThe aim of the present review was to systematically summarise our current understanding of the structure of the cognitive heterogeneity that exists within schizophrenia spectrum disorder (SSD). Fifty-two relevant studies were identified from January 1980 to March 2019 that investigated cognitive subgroups within SSD. Twenty-five studies employed classification criteria based on current neuropsychological function, 14 st...
Source: Neuroscience and Biobehavioral Reviews - September 26, 2019 Category: Neuroscience Source Type: research

A comparative approach to affect and cooperation
Publication date: Available online 23 September 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Jorg J.M. Massen, Friederike Behrens, Jordan S. Martin, Martina Stocker, Sarah F. BrosnanABSTRACTA central premise of the science of comparative affect is that we can best learn about the causes and consequences of affect by comparing affective phenomena across a variety of species, including humans. We take as a given that affect is widely shared across animals, but a key challenge is to accurately represent each species' affective experience. A common approach in the comparative study of behavior and cognition i...
Source: Neuroscience and Biobehavioral Reviews - September 25, 2019 Category: Neuroscience Source Type: research

Emotional Bias varies with Stimulus type, Arousal and Task setting: Meta-analytic evidences
Publication date: Available online 23 September 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Jiajin Yuan, Yu Tian, Xiting Huang, Huiyong Fan, Xuemei WeiAbstractEmotional bias, which describes human’s asymmetric processing of emotional stimuli, consists of negativity bias (Increased response to negative over positive stimuli) and positivity offset (the reversed phenomenon). Previous studies suggest that stimulus arousal (high/low), stimulus type (scenic/verbal), cultural background (Eastern/Western), and task setting (explicit/implicit) may modulate emotional bias, but with inconclusive findings. To ...
Source: Neuroscience and Biobehavioral Reviews - September 25, 2019 Category: Neuroscience Source Type: research

Multi-Outcome Meta-Analysis (MOMA) of Cognitive Remediation in Schizophrenia: revisiting the relevance of human coaching and elucidating interplay between multiple outcomes
Publication date: Available online 23 September 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Lana Kambeitz-Ilankovic, Linda T. Betz, Clara Dominke, Shalaila S. Haas, Karuna Subramaniam, Melisa Fisher, Sophia Vinogradov, Nikolaos Koutsouleris, Joseph KambeitzAbstractCognitive remediation (CR) is nowadays mainly administered in a computerized fashion, yet frequently supplemented by human guidance. The effects of CR on cognitive, functional and clinical outcomes are consistently reported, yet the response is heterogeneous. In order to resolve this heterogeneity, we employed a multi-outcome meta-analytic appr...
Source: Neuroscience and Biobehavioral Reviews - September 25, 2019 Category: Neuroscience Source Type: research

The relation between anxious personality traits and fear generalization in healthy subjects: A systematic review and meta-analysis
Publication date: Available online 23 September 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Milou S.C. Sep, Anna Steenmeijer, Mitzy KennisAbstractBackgroundAnxious personality characteristics form a risk factor for anxiety disorders. A proposed mechanistic pathway is that anxious personality could lead to greater vulnerability by increasing fear generalization. Here, we investigate if there is evidence for this relationship before the onset of pathological anxiety, with a meta-analysis in healthy subjects.MethodsOur search (anxious personality & fear generalization) was performed in PubMed, PsychInfo...
Source: Neuroscience and Biobehavioral Reviews - September 25, 2019 Category: Neuroscience Source Type: research

How to assess and manage cognitive impairment induced by treatments of non-central nervous system cancer
Publication date: Available online 22 September 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Marie Lange, Hélène Castel, Johan Le Fel, Laure Tron, Didier Maillet, Myriam Bernaudin, Omar Touzani, Joy Perrier, Mathieu Boone, Idlir Licaj, Bénédicte Giffard, Martine Dubois, Olivier Rigal, Thomas Durand, Catherine Belin, Damien Ricard, Rozenn Le Gal, Véronique Pancré, Isabelle Hardy-Léger, Florence JolyAbstractA number of neurotoxicity associated with oncological treatments has been reported in non-central nervous system cancers.An expert group presents the stat...
Source: Neuroscience and Biobehavioral Reviews - September 23, 2019 Category: Neuroscience Source Type: research

A potential role for microglia in stress- and drug-induced plasticity in the nucleus accumbens: A mechanism for stress-induced vulnerability to substance use disorder
Publication date: Available online 21 September 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Anna G. McGrath, Lisa A. BriandAbstractStress is an important risk factor for the development of substance use disorder (SUD). Exposure to both stress and drugs abuse lead to changes in synaptic plasticity and stress-induced alterations in synaptic plasticity may contribute to later vulnerability to SUD. Recent developmental neuroscience studies have identified microglia as regulators of synaptic plasticity. As both stress and drugs of abuse lead to microglial activation, we propose this as a potential mechanism u...
Source: Neuroscience and Biobehavioral Reviews - September 22, 2019 Category: Neuroscience Source Type: research

A Novel Neurobehavioral Framework of the Effects of Positive Early Postnatal Experience on Incentive and Consummatory Reward Sensitivity
Publication date: Available online 20 September 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Fu YuAbstractEarly postnatal experience has a profound influence on the development of organisms. In this integration, we provide a novel framework of the neurobehavioral pathways through which positive early postnatal experience acts to enhance adult reward sensitivity. The heterogeneity of the construct of reward and the underlying neurotransmitter systems (i.e., dopamine in incentive reward, opioids in consummatory reward, and oxytocin in orienting the reward systems to social cues) are first described as a mea...
Source: Neuroscience and Biobehavioral Reviews - September 21, 2019 Category: Neuroscience Source Type: research

Neurological and psychiatric adverse effects of long-term methylphenidate treatment in ADHD: A map of the current evidence
Publication date: Available online 20 September 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Helga Krinzinger, Charlotte L Hall, Madeleine J Groom, Mohammed T Ansari, Tobias Banaschewski, Jan K Buitelaar, Sara Carucci, David Coghill, Marina Danckaerts, Ralf W Dittmann, Bruno Falissard, Peter Garas, Sarah K Inglis, Hanna Kovshoff, Puja Kochhar, Suzanne McCarthy, Peter Nagy, Antje Neubert, Samantha Roberts, Kapil SayalAbstractMethylphenidate (MPH), the most common medication for children with Attention Deficit/Hyperactivity Disorder (ADHD) in many countries, is often prescribed for long periods of time. Any...
Source: Neuroscience and Biobehavioral Reviews - September 21, 2019 Category: Neuroscience Source Type: research

Impaired Hippocampus-Dependent Associative Learning as a Mechanism Underlying PTSD: A Meta-Analysis
Publication date: Available online 20 September 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Hilary K. Lambert, Katie A. McLaughlinAbstractSmaller hippocampal volume is associated with increased risk for PTSD following trauma, but the hippocampal functions involved remain unknown. We propose a conceptual model that identifies broad impairment in hippocampus-dependent associative learning as a vulnerability factor for PTSD. Associative learning of foreground cues and background context is required to form an integrated representation of an event. People with poor associative learning may have difficulty re...
Source: Neuroscience and Biobehavioral Reviews - September 21, 2019 Category: Neuroscience Source Type: research

Shared pathways for neuroprogression and somatoprogression in neuropsychiatric disorders
Publication date: Available online 20 September 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Gerwyn Morris, Basant K. Puri, Adam J. Walker, Michael Maes, Andre F. Carvalho, Ken Walder, Michael BerkAbstractActivated immune-inflammatory, oxidative and nitrosative stress (IO&NS) pathways and consequent mitochondrial aberrations are involved in the pathophysiology of psychiatric disorders including major depression, bipolar disorder and schizophrenia. They offer independent and shared contributions to pathways underpinning medical comorbidities including insulin resistance, metabolic syndrome, obesity and...
Source: Neuroscience and Biobehavioral Reviews - September 21, 2019 Category: Neuroscience Source Type: research

Neural architecture of the vertebrate brain: implications for the interaction between emotion and cognition
Publication date: Available online 18 September 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Luiz Pessoa, Loreta Medina, Patrick R. Hof, Ester DesfilisAbstractCognition is considered a hallmark of the primate brain that requires a high degree of signal integration, such as achieved in the prefrontal cortex. Moreover, it is often assumed that cognitive capabilities imply “superior” computational mechanisms compared to those involved in emotion or motivation. In contrast to these ideas, we review data on the neural architecture across vertebrates that support the concept that association and int...
Source: Neuroscience and Biobehavioral Reviews - September 20, 2019 Category: Neuroscience Source Type: research

Contributions of the basal ganglia to action sequence learning and performance
Publication date: Available online 18 September 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Eric GarrAbstractAnimals engage in intricately woven and choreographed action sequences that are constructed from trial-and-error learning. The mechanisms by which the brain links together individual actions which are later recalled as fluid chains of behavior are not fully understood, but there is broad consensus that the basal ganglia play a crucial role in this process. This paper presents a comprehensive review of the role of the basal ganglia in action sequencing, with a focus on whether the computational fra...
Source: Neuroscience and Biobehavioral Reviews - September 20, 2019 Category: Neuroscience Source Type: research

The epigenome of twins as a perfect laboratory for studying behavioural traits
Publication date: Available online 16 September 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Qihua TanAbstractThe debate upon the relative importance of nature vs nurture in the development of human behaviour can be traced back to ancient times. Traditional epidemiology and genetic epidemiology have confirmed the association of environmental and genetic factors with behavioural traits. Current genomic studies are identifying genetic variants associated with various behavioural traits. However, exploring the relationship of abundant environmental factors with the complex epigenome that mediates human behav...
Source: Neuroscience and Biobehavioral Reviews - September 17, 2019 Category: Neuroscience Source Type: research

Opioid addiction and the cerebellum
Publication date: Available online 14 September 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Josep Moreno-RiusAbstractOpioid addiction has reached the epidemic status in the United States in recent years. A multitude of factors have contributed to an alarming increase in misuse and health issues related to these drugs. Although medications exist to treat some aspects of opioid addiction since long ago, relapse and fatality rates remain very high despite their long-term availability. Therefore, more research devoted to better understanding its neural substrates is needed to aid developing new treatment opt...
Source: Neuroscience and Biobehavioral Reviews - September 15, 2019 Category: Neuroscience Source Type: research

Affective symptoms and AT(N) biomarkers in mild cognitive impairment and Alzheimer’s disease: a systematic literature review
DISCUSSIONWhereas some AD biomarkers showed to be associated with affective symptoms in AD, most evidence was inconsistent. This is likely due to differences in study design or heterogeneity in affective symptoms. Directions for future research are given. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - September 14, 2019 Category: Neuroscience Source Type: research

The Effects of Developmental Alcohol Exposure on the Neurobiology of Spatial Processing
Publication date: Available online 14 September 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Ryan E. Harvey, Laura E. Berkowitz, Derek A. Hamilton, Benjamin J. ClarkAbstractThe consumption of alcohol during gestation is detrimental to the developing central nervous system. One functional outcome of this exposure is impaired spatial processing, defined as sensing and integrating information pertaining to spatial navigation and spatial memory. The hippocampus, entorhinal cortex, and anterior thalamus are brain regions implicated in spatial processing and are highly susceptible to the effects of developmenta...
Source: Neuroscience and Biobehavioral Reviews - September 14, 2019 Category: Neuroscience Source Type: research

Review of Animal Models of Bipolar Disorder that Alter Ion Regulation
ConclusionAnimal models that disrupt ion regulation are more inclined to model both mania and depression; and are thus the most promising models available. However, other models are important for demonstrating mechanisms in important pathophysiologic aspect of bipolar disorder. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - September 14, 2019 Category: Neuroscience Source Type: research

Making translation work: Harmonizing cross-species methodology in the behavioural neuroscience of Pavlovian fear conditioning
Publication date: Available online 12 September 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Jan Haaker, Stephen Maren, Marta Andreatta, Christian J. Merz, Jan Richter, S. Helene Richter, Shira Meir Drexler, Maren D. Lange, Kay Jüngling, Frauke Nees, Thomas Seidenbecher, Miquel A. Fullana, Carsten T. Wotjak, Tina B. LonsdorfAbstractTranslational neuroscience bridges insights from specific mechanisms in rodents to complex functions in humans and is key to advance our general understanding of central nervous function. A prime example of translational research is the study of cross-species mechanisms th...
Source: Neuroscience and Biobehavioral Reviews - September 14, 2019 Category: Neuroscience Source Type: research

Changing handedness: what can we learn from preference shift studies?
Publication date: Available online 12 September 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Alexandre Jehan Marcori, Pedro Henrique Martins Monteiro, Victor Hugo Alves OkazakiAbstractMARCORI, A.J., P.H.M. Monteiro, and V.H.A. Okazaki. Changing handedness: what can we learn from preference shift studies? - Handedness is a dynamic and complex aspect of human behavior. Changing it through practice, either willingly or obliged by some reason, requires a considerable amount of effort. Analyzing studies that presented handedness shifts may expand our comprehension of this phenomenon, since knowing how to chang...
Source: Neuroscience and Biobehavioral Reviews - September 14, 2019 Category: Neuroscience Source Type: research

Risk factors for posttraumatic stress disorder: an umbrella review of systematic reviews and meta-analyses
Publication date: Available online 11 September 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Miquel Tortella-Feliu, Miquel A. Fullana, Ana Pérez-Vigil, Xavier Torres, Jacobo Chamorro, Sergio A. Littarelli, Aleix Solanes, Valentina Ramella-Cravaro, Ana Vilar, José A. González-Parra, Raül Andero, Prof Abraham Reichenberg, Prof David Mataix-Cols, Eduard Vieta, Paolo Fusar-Poli, Prof John P.A. Ioannidis, Prof Murray B. Stein, Joaquim Radua, Lorena Fernández de la CruzAbstractApproximately one third of individuals who experience a severe traumatic event will develop posttraumat...
Source: Neuroscience and Biobehavioral Reviews - September 12, 2019 Category: Neuroscience Source Type: research

Neurocomputational mechanisms underlying emotional awareness: insights afforded by deep active inference and their potential clinical relevance
Publication date: Available online 10 September 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Ryan Smith, Richard D. Lane, Thomas Parr, Karl J. FristonAbstractEmotional awareness (EA) is recognized as clinically relevant to the vulnerability to, and maintenance of, psychiatric disorders. However, the neurocomputational processes that underwrite individual variations remain unclear. In this paper, we describe a deep (active) inference model that reproduces the cognitive-emotional processes and self-report behaviors associated with EA. We then present simulations to illustrate (seven) distinct mechanisms tha...
Source: Neuroscience and Biobehavioral Reviews - September 12, 2019 Category: Neuroscience Source Type: research

The maternal brain: Neural responses to infants in mothers with and without mood disorder
Publication date: Available online 10 September 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Anne J. Bjertrup, Nellie K. Friis, Kamilla W. MiskowiakAbstractMothers’ sensitive responses to their infants have evolutionary importance and are likely hardwired into the maternal brain. Mood disorders are associated with aberrant neural processing of emotion in regions overlapping with ‘maternal sensitivity networks’ and this could compromise maternal processing of infant signals. This systematic review aimed to integrate findings from studies of neural responses to infant stimuli in healthy mo...
Source: Neuroscience and Biobehavioral Reviews - September 12, 2019 Category: Neuroscience Source Type: research

Do Women Expose Themselves to more Health-Related Risks in Certain Phases of the Menstrual Cycle? A Meta-analytic Review
Publication date: Available online 9 September 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Jordane Boudesseul, Kelly A. Gildersleeve, Martie G. Haselton, Laurent BègueAbstractResearchers have increasingly examined the menstrual cycle as a potential source of day-to-day variation in women’s cognitions, motivations, and behavior. Within this literature, several lines of research have examined the impact of the menstrual cycle on women’s engagement in activities that could negatively affect their health (alcohol and tobacco consumption, sexual behavior, risk recognition). However, finding...
Source: Neuroscience and Biobehavioral Reviews - September 10, 2019 Category: Neuroscience Source Type: research

Prominence of delta oscillatory rhythms in the motor cortex and their relevance for auditory and speech perception
We describe the functional coupling between delta and beta oscillations in the motor cortex during spontaneous and planned motor acts. In an active sensing framework, perception is strongly shaped by motor activity, in particular in the delta band, which imposes temporal constraints on the sampling of sensory information. By encoding temporal contextual information, delta oscillations modulate auditory processing and impact behavioral outcomes. Finally, we consider the contribution of motor delta oscillations in the perceptual analysis of speech signals, providing a contextual temporal frame to optimize the parsing and pro...
Source: Neuroscience and Biobehavioral Reviews - September 10, 2019 Category: Neuroscience Source Type: research

The study of active avoidance: A platform for discussion
Publication date: Available online 8 September 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Maria M. Diehl, Christian Bravo-Rivera, Gregory J. QuirkAbstractTraditional active avoidance tasks have advanced the field of aversive learning and memory for decades and are useful for studying simple avoidance responses in isolation; however, these tasks have limited clinical relevance because they fail to model key features of clinical avoidance. In contrast, platform-mediated avoidance (PMA) more closely resembles clinical avoidance because the response i) is associated with an unambiguous safe location, ii) is...
Source: Neuroscience and Biobehavioral Reviews - September 9, 2019 Category: Neuroscience Source Type: research

Conserved features of anterior cingulate networks support observational learning across species
Publication date: Available online 8 September 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Anthony Burgos-Robles, Katalin M. Gothard, Marie H. Monfils, Alexei Morozov, Aleksandra VicenticAbstractThe ability to observe, interpret, and learn behaviors and emotions from conspecifics is crucial for survival, as it bypasses direct experience to avoid potential dangers and maximize rewards and benefits. The anterior cingulate cortex (ACC) and its extended neural connections are emerging as important networks for the detection, encoding, and interpretation of social signals during observational learning. Eviden...
Source: Neuroscience and Biobehavioral Reviews - September 9, 2019 Category: Neuroscience Source Type: research

Characterising the structure of cognitive heterogeneity in schizophrenia spectrum disorders—A systematic review and narrative synthesis
Publication date: Available online 7 September 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Sean P. Carruthers, Caroline Gurvich, Philip J. Sumner, Tamsyn E. Van Rheenen, Susan L. RossellAbstractThe aim of the present review was to systematically summarise our current understanding of the structure of the cognitive heterogeneity that exists within schizophrenia spectrum disorder (SSD). Fifty-two relevant studies were identified from January 1980 to March 2019 that investigated cognitive subgroups within SSD. Twenty-five studies employed classification criteria based on current neuropsychological function,...
Source: Neuroscience and Biobehavioral Reviews - September 9, 2019 Category: Neuroscience Source Type: research

A neural-vascular complex of age-related changes in the human brain: Anatomy, physiology, and implications for neurocognitive aging
Publication date: Available online 6 September 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Dema Abdelkarim, Yuguang Zhao, Monroe P. Turner, Dinesh K. Sivakolundu, Hanzhang Lu, Bart RypmaAbstractTheories of neurocognitive aging rely heavily on functional magnetic resonance imaging (fMRI) to test hypotheses regarding the brain basis of age-differences in cognition. This technique is based on the blood-oxygen level dependent signal (BOLD) that arises from the coordinated neural-vascular coupling that leads to increased blood flow following an increase in neural activity. Here we review the literature and cu...
Source: Neuroscience and Biobehavioral Reviews - September 7, 2019 Category: Neuroscience Source Type: research