The feeling of anger: from brain networks to linguistic expressions
Publication date: Available online 3 December 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Nelly Alia-Klein, Gabriela Gan, Gadi Gilam, Jessica Bezek, Antonio Bruno, Thomas F. Denson, Talma Hendler, Leroy Lowe, Veronica Mariotti, Maria R. Muscatello, Sara Palumbo, Silvia Pellegrini, Pietro Pietrini, Amelia Rizzo, Edelyn VeronaAbstractThis review of the neuroscience of anger is part of The Human Affectome Project, where we attempt to map anger and its components (i.e., physiological, cognitive, experiential) to the neuroscience literature (i.e., genetic markers, functional imaging of human brain networks) a...
Source: Neuroscience and Biobehavioral Reviews - December 4, 2019 Category: Neuroscience Source Type: research

Therapeutic use of serotoninergic hallucinogens: a review of the evidence and of the biological and psychological mechanisms
Publication date: Available online 3 December 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Rafael Guimarães dos Santos, Jaime Eduardo Cecilio HallakAbstractSerotoninergic hallucinogens include drugs such as lysergic acid diethylamide (LSD), dimethyltryptamine (DMT) and psilocybin. Recent trials with single/few doses of these compounds show that they induce rapid and sustained antidepressive, anxiolytic, and antiaddictive effects. These effects are also observed in religious groups using the DMT-containing brew ayahuasca. The agonist action of these substances on 5-HT2A receptors expressed in fronta...
Source: Neuroscience and Biobehavioral Reviews - December 4, 2019 Category: Neuroscience Source Type: research

Obesity affects brain structure and function- rescue by bariatric surgery?
Publication date: Available online 30 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Minke H.C. Nota, Debby Vreeken, Maximilian Wiesmann, Edo O. Aarts, Eric J. Hazebroek, Amanda J KiliaanAbstractObesity has a major impact on metabolic health thereby negatively affecting brain function and structure, however mechanisms involved are not entirely understood. The increasing prevalence of obesity is accompanied by a growing number of bariatric surgeries (BS). Weight loss after BS appears to improve cognitive function in patients. Therefore, unraveling mechanisms how BS influences brain function may be h...
Source: Neuroscience and Biobehavioral Reviews - December 1, 2019 Category: Neuroscience Source Type: research

Neuropeptides and oligopeptidases in schizophrenia
Publication date: Available online 30 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Benjamín Rodríguez, João Victor Nani, Priscila G.C. Almeida, Eliza Brietzke, Richard S. Lee, Mirian A.F. HayashiAbstractSchizophrenia (SCZ) is a complex psychiatric disorder with severe impact on patient’s livelihood. In the last years, the importance of neuropeptides in SCZ and other CNS disorders has been recognized, mainly due to their ability to modulate the signaling of classical monoaminergic neurotransmitters as dopamine. In addition, a class of enzymes coined as oligopeptidases ar...
Source: Neuroscience and Biobehavioral Reviews - December 1, 2019 Category: Neuroscience Source Type: research

Disease-discordant twin structural MRI studies on affective disorders
Publication date: Available online 29 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): G. Delvecchio, A. Pigoni, I.E. Bauer, J.C. Soares, P. BrambillaAbstractMagnetic resonance imaging (MRI) studies have identified neural structures implicated in the pathophysiology of mood disorders, especially bipolar disorder (BD) and major depressive disorder (MDD). However, the role of genetic and environmental influences on such brain deficits is still unclear. In this context, the present review summarizes the current evidence from structural MRI and Diffusion Tensor Imaging (DTI) studies on twin samples conco...
Source: Neuroscience and Biobehavioral Reviews - November 30, 2019 Category: Neuroscience Source Type: research

Lymnaea stagnalis as model for translational neuroscience research: from pond to bench
Publication date: Available online 28 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): V. Rivi, C. Benatti, C. Colliva, G. Radighieri, N. Brunello, F. Tascedda, J.M.C. BlomAbstractThe purpose of this review is to illustrate how a reductionistic, but sophisticated, approach based on the use of a simple model system such as the pond snail Lymnaea stagnalis (L. stagnalis), might be useful to address fundamental questions in learning and memory. L. stagnalis, as a model, provides an interesting platform to investigate the dialog between the synapse and the nucleus and vice versa during memory and learnin...
Source: Neuroscience and Biobehavioral Reviews - November 30, 2019 Category: Neuroscience Source Type: research

Impairment of sociocognitive functions in patients with brain tumours
Publication date: Available online 28 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Milena Pertz, Annalena Okoniewski, Uwe Schlegel, Patrizia ThomaAbstractThe ability to decode mental states and to come up with effective solutions for interpersonal problems aids successful initiation and maintenance of social interactions and contributes to participation and mental health. Since these abilities of social cognition are challenged in highly demanding situations, such as diagnosis and treatment of a life-threatening illness, this article reviews the literature on emotion recognition, empathy, Theory ...
Source: Neuroscience and Biobehavioral Reviews - November 30, 2019 Category: Neuroscience Source Type: research

The role of chemical transmitters in neuron-glia interaction and pain in sensory ganglion
Publication date: Available online 27 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Yoshizo Matsuka, Shaista Afroz, Junhel C. Dalanon, Takuma Iwasa, Arief Waskitho, Masamitsu OshimaAbstractNeuropathic pain (NP) develops because of damage to the peripheral or central nervous system. It results in the hyperalgesia and allodynia. In the recent years, various researchers have studied the involvement of neuro-immune system in causing persistence of pain. The absence of synaptic contacts in the sensory ganglion makes them distinctive in terms of pain related signalling. In sensory ganglia, the neurotran...
Source: Neuroscience and Biobehavioral Reviews - November 28, 2019 Category: Neuroscience Source Type: research

Aging: therapeutics for a healthy future
Publication date: Available online 26 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Robert Hodgson, Brian K. Kennedy, Eliezer Masliah, Kimberly Scearce-Levie, Barbara Tate, Anjli Venkateswaran, Steven P. BraithwaiteAbstractIncreased healthcare and pharmaceutical understanding has led to the eradication of many childhood, infectious and preventable diseases; however, we are now experiencing the impact of aging disorders as the lifespan increases. These disorders have already become a major burden on society and threaten to become a defining challenge of our generation. Indications such as Alzheimer...
Source: Neuroscience and Biobehavioral Reviews - November 28, 2019 Category: Neuroscience Source Type: research

One cranium, two brains not yet introduced: Distinct but complementary views of the social brain
Publication date: January 2020Source: Neuroscience & Biobehavioral Reviews, Volume 108Author(s): George S. Prounis, Alexander G. OphirAbstractSocial behavior is pervasive across the animal kingdom, and elucidating how the brain enables animals to respond to social contexts is of great interest and profound importance. Our understanding of ‘the social brain’ has been fractured as it has matured. Two drastically different conceptualizations of the social brain have emerged with relatively little awareness of each other. In this review, we briefly recount the history behind the two dominant definitions of a so...
Source: Neuroscience and Biobehavioral Reviews - November 28, 2019 Category: Neuroscience Source Type: research

Substance related disorders are associated with impaired valuation of delayed gratification and feedback processing: A multilevel meta-analysis and meta-regression
In this study we thus performed multilevel linear mixed-effects meta-analyses and meta-regressions to examine the effects of SUDs on the Delay Discounting Task (DD) and on the Iowa Gambling Task (IGT). We found a moderate to large effect for SUD on both, the IGT and DD. While the effect on the DD was generalized to all substance classes, a smaller effect for cannabis-related disorder when compared to other SUDs was found with regard to the IGT. Early onset of substance use and psychiatric comorbidities were associated with stronger effects on the DD. Our findings suggest that feedback processing is more vulnerable to speci...
Source: Neuroscience and Biobehavioral Reviews - November 27, 2019 Category: Neuroscience Source Type: research

Beyond Labeled Lines: A population coding account of the Thermal Grill Illusion
Publication date: Available online 26 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Francesca Fardo, Brianna Beck, Micah Allen, Nanna FinnerupAbstractHeat and pain illusions can be generated by simultaneous cold and warm stimulation on the skin, at temperatures that would normally be perceived as innocuous in isolation (e.g., ‘synthetic heat’ and the ‘thermal grill illusion’). Historically, two key questions have dominated the literature: Which specific pathway conveys the illusory perception of heat and pain? Where specifically does the illusory pain originate in the centr...
Source: Neuroscience and Biobehavioral Reviews - November 27, 2019 Category: Neuroscience Source Type: research

Towards a comparative science of emotion: Affect and consciousness in humans and animals
Publication date: Available online 26 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Elizabeth S. Paul, Shlomi Sher, Marco Tamietto, Piotr Winkielman, Michael T. MendlAbstractThe componential view of human emotion recognises that affective states comprise conscious, behavioural, physiological, neural and cognitive elements. Although many animals display bodily and behavioural changes consistent with the occurrence of affective states similar to those seen in humans, the question of whether and in which species these are accompanied by conscious experiences remains controversial. Finding scientifica...
Source: Neuroscience and Biobehavioral Reviews - November 27, 2019 Category: Neuroscience Source Type: research

Still No Evidence That Exergames Improve Cognitive Ability: A Commentary on Stanmore et al. (2017)
Publication date: Available online 21 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Giovanni Sala, K. Semir Tatlidil, Fernand GobetAbstractA recent meta-analysis (Stanmore et al. Neurosci. Biobehav. Rev. 78:34–43, 2017) claimed that exergames exert medium-size positive effects on people's overall cognitive function. The present article critically tests this claim. We argue that the meta-analysis reported inflated effect sizes mainly for three reasons: (a) some effect sizes were miscalculated; (b) there was an excessive amount of true heterogeneity; and (c) no publication-bias-corrected estim...
Source: Neuroscience and Biobehavioral Reviews - November 22, 2019 Category: Neuroscience Source Type: research

The Neural Circuitry Supporting Successful Spatial Navigation despite Variable Movement Speeds
Publication date: Available online 21 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): William M. Sheeran, Omar J. AhmedAbstractAnts who have successfully navigated the long distance between their foraging spot and their nest dozens of times will drastically overshoot their destination if the size of their legs is doubled by the addition of stilts. This observation reflects a navigational strategy called path integration, a strategy also utilized by mammals. Path integration necessitates that animals keep track of their movement speed and use it to precisely and instantly modify where they think they...
Source: Neuroscience and Biobehavioral Reviews - November 22, 2019 Category: Neuroscience Source Type: research

Editorial Board
Publication date: December 2019Source: Neuroscience & Biobehavioral Reviews, Volume 107Author(s): (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - November 21, 2019 Category: Neuroscience Source Type: research

Editorial
Publication date: December 2019Source: Neuroscience & Biobehavioral Reviews, Volume 107Author(s): (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - November 21, 2019 Category: Neuroscience Source Type: research

Neural Circuits Linking Sleep and Addiction: Animal Models to Understand Why Select Individuals Are More Vulnerable to Substance Use Disorders After Sleep Deprivation
Publication date: Available online 19 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Allison M. Ahrens, Omar J. AhmedAbstractIndividuals differ widely in their drug-craving behaviors. One reason for these differences involves sleep. Sleep disturbances lead to an increased risk of substance use disorders and relapse in only some individuals. While animal studies have examined the impact of sleep on reward circuitry, few have addressed the role of individual differences in the effects of altered sleep. There does, however, exist a rodent model of individual differences in reward-seeking behavior: the...
Source: Neuroscience and Biobehavioral Reviews - November 21, 2019 Category: Neuroscience Source Type: research

Pharmacological manipulations of judgement bias: a systematic review and meta-analysis
Publication date: Available online 17 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Vikki Neville, Shinichi Nakagawa, Josefina Zidar, Elizabeth S. Paul, Malgorzata Lagisz, Melissa Bateson, Hanne Løvlie, Michael MendlAbstractValidated measures of animal affect are crucial to research spanning numerous disciplines. Judgement bias, which assesses decision-making under ambiguity, is a promising measure of animal affect. One way of validating this measure is to administer drugs with affect-altering properties in humans to non-human animals and determine whether the predicted judgement biases are...
Source: Neuroscience and Biobehavioral Reviews - November 18, 2019 Category: Neuroscience Source Type: research

Glutamate receptors in domestication and modern human evolution
Publication date: Available online 16 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Thomas O’Rourke, Cedric BoeckxAbstractThere has been a recent resurgence of interest in the hypothesis that anatomically modern humans and domesticated species have followed convergent evolutionary paths. Here, we review results from domestication and modern-human evolutionary studies in order to evaluate evidence for shared changes to neurotransmission across these species. We compare genomic and, where available, brain-expression differences across 488 neurotransmitter receptor genes in 14 domesticated spec...
Source: Neuroscience and Biobehavioral Reviews - November 18, 2019 Category: Neuroscience Source Type: research

Hippocampal pattern separation of emotional information determining risk or resilience in individuals exposed to childhood trauma: linking exposure to neurodevelopmental alterations and threat anticipation
Publication date: Available online 16 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Aleksandra Lecei, Ruud van WinkelAbstractChildhood adversity increases the risk of developing psychiatric symptoms later in life. However, the neurobiological mechanisms underlying this association are unknown. This paper reviews the current literature regarding structural and functional alterations in the hippocampus and amygdala following childhood adversity, ultimately converging into a model that proposes impaired ‘pattern separation’ as an important underlying mechanism associated with risk or resi...
Source: Neuroscience and Biobehavioral Reviews - November 18, 2019 Category: Neuroscience Source Type: research

One cranium, two brains not yet introduced: Distinct but complimentary views of the social brain
Publication date: Available online 16 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): George S. Prounis, Alexander G. OphirAbstractSocial behavior is pervasive across the animal kingdom, and elucidating how the brain enables animals to respond to social contexts is of great interest and profound importance. Our understanding of ‘the social brain’ has been fractured as it has matured. Two drastically different conceptualizations of the social brain have emerged with relatively little awareness of each other. In this review, we briefly recount the history behind the two dominant definition...
Source: Neuroscience and Biobehavioral Reviews - November 18, 2019 Category: Neuroscience Source Type: research

Rodent medial and lateral orbitofrontal cortices represent unique components of cognitive maps of task space
Publication date: Available online 16 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Laura A. Bradfield, Genevra HartAbstractThe orbitofrontal cortex (OFC) has been proposed to function as a cognitive map of task space: a mental model of the steps involved in a task. This idea has proven popular because it provides a cohesive explanation for a number of disparate findings regarding the OFC’s role in a broad array of tasks. Concurrently, evidence has begun to reveal the functional heterogeneity of OFC subregions, particularly the medial and lateral OFC. How these subregions uniquely contribute...
Source: Neuroscience and Biobehavioral Reviews - November 18, 2019 Category: Neuroscience Source Type: research

A systematic review and meta-analysis of the evidence for unaware fear conditioning
Publication date: Available online 17 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Gaëtan Mertens, Iris M. EngelhardAbstractWhether fear conditioning can take place without contingency awareness is a topic of continuing debate and conflicting findings have been reported in the literature. This systematic review provides a critical assessment of the available evidence. Specifically, a search was conducted to identify articles reporting fear conditioning studies in which the contingency between conditioned stimuli (CS) and the unconditioned stimulus (US) was masked, and in which CS-US continge...
Source: Neuroscience and Biobehavioral Reviews - November 18, 2019 Category: Neuroscience Source Type: research

Know safety, no fear
Publication date: Available online 16 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Susan Sangha, Maria M. Diehl, Hadley C. Bergstrom, Michael R. DrewAbstractEvery day we are bombarded by stimuli that must be assessed for their potential for harm or benefit. Once a stimulus is learned to predict harm, it can elicit fear responses. Such learning can last a lifetime but is not always beneficial for an organism. For an organism to thrive in its environment, it must know when to engage in defensive, avoidance behaviors and when to engage in non-defensive, approach behaviors. Fear should be suppressed ...
Source: Neuroscience and Biobehavioral Reviews - November 17, 2019 Category: Neuroscience Source Type: research

Names and their meanings: A dual-process account of proper-name encoding and retrieval
Publication date: Available online 14 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Thomas O’Rourke, Ruth de Diego BalaguerAbstractThe ability to pick out a unique entity with a proper name is an important component of human language. It has been a primary focus of research in the philosophy of language since the nineteenth century. Brain-based evidence has shed new light on this capacity, and an extensive literature indicates the involvement of distinct fronto-temporal and temporo-occipito-parietal association cortices in proper-name retrieval. However, comparatively few efforts have sought...
Source: Neuroscience and Biobehavioral Reviews - November 15, 2019 Category: Neuroscience Source Type: research

Characterising the structure of cognitive heterogeneity in schizophrenia spectrum disorders. A systematic review and narrative synthesis
Publication date: December 2019Source: Neuroscience & Biobehavioral Reviews, Volume 107Author(s): Sean P. Carruthers, Tamsyn E. Van Rheenen, Caroline Gurvich, Philip J. Sumner, Susan L. RossellAbstractThe aim of the present review was to systematically summarise our current understanding of the structure of the cognitive heterogeneity that exists within schizophrenia spectrum disorder (SSD). Fifty-two relevant studies were identified from January 1980 to March 2019 that investigated cognitive subgroups within SSD. Twenty-five studies employed classification criteria based on current neuropsychological function, 14 st...
Source: Neuroscience and Biobehavioral Reviews - November 15, 2019 Category: Neuroscience Source Type: research

Moral Motivation and the Basal Forebrain
Publication date: Available online 13 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Roland Zahn, Ricardo de Oliveira-Souza, Jorge MollAbstractMoral motivations drive humans to sacrifice selfish needs to serve the needs of others and internalized sociocultural norms. Over the past two decades, several brain regions have been associated with different aspects of moral cognition and behaviour. Only more recently, however, investigations have highlighted the importance of the basal forebrain for moral motivation. This includes the septo-hypothalamic region, implicated in kinship bonding across mammal ...
Source: Neuroscience and Biobehavioral Reviews - November 14, 2019 Category: Neuroscience Source Type: research

Neural correlates of social cognition in populations at risk of psychosis: A systematic review
Publication date: Available online 12 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): P. Kozhuharova, F. Saviola, U. Ettinger, P. AllenAbstractSocial cognition refers to the mental operations governing social interactions. Recent research has highlighted the importance of social cognition in determining functional outcome in patients with schizophrenia and in psychosis risk populations. The aim of this review is to investigate the neural correlates of social cognition in different psychosis risk populations, potentially representing different levels of risk i.e. high schizotypy (SR), familial risk (...
Source: Neuroscience and Biobehavioral Reviews - November 14, 2019 Category: Neuroscience Source Type: research

Neurocognitive consequences of chronic cannabis use: a systematic review and meta-analysis
Publication date: Available online 9 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Pedro Rafael Figueiredo, Serenella Tolomeo, J. Douglas Steele, Alexander BaldacchinoABSTRACTCannabis is currently the most used illicit substance in the world with a global widespread distribution. Although its acute neurocognitive effects on human behaviour have been reported, there is a lack of robust analysis investigating the link, if any, between chronic cannabis use and neurocognitive function. A systematic review of the literature was conducted in order to identify relevant studies published from 2010 to 2019...
Source: Neuroscience and Biobehavioral Reviews - November 11, 2019 Category: Neuroscience Source Type: research

Is autonomic nervous system function atypical in Attention Deficit Hyperactivity Disorder (ADHD)? A systematic review of the evidence
Publication date: Available online 10 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Alessio Bellato, Iti Arora, Chris Hollis, Madeleine J. GroomAbstractAlthough arousal mechanisms have frequently been found to be atypical in ADHD, these findings usually emerged from indirect behavioural measures which give only a limited understanding of arousal dysregulation in this condition. To assess the hypothesis that functioning of the autonomic nervous system (ANS), one component of arousal, is atypical in ADHD, we carried out a systematic review of the literature on 55 studies investigating electro-dermal...
Source: Neuroscience and Biobehavioral Reviews - November 11, 2019 Category: Neuroscience Source Type: research

Opposite-sex and same-sex twin studies of physiological, cognitive and behavioral traits
Publication date: Available online 8 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Linda Juel Ahrenfeldt, Kaare Christensen, Nancy L. Segal, Yoon-Mi HurAbstractA scientific interest in opposite-sex (OS) twins comes from animal studies showing hormone transfer between fetuses in utero. A parallel effect in humans may occur, especially for OS females who may be exposed to androgens, in particular testosterone, from the male co-twin. Conversely, OS males may be exposed to lower levels of prenatal testosterone than do same-sex (SS) males. In this special issue, we reviewed published studies investigat...
Source: Neuroscience and Biobehavioral Reviews - November 9, 2019 Category: Neuroscience Source Type: research

Cardiovascular effects of prenatal stress—Are there implications for cerebrovascular, cognitive and mental health outcome?
Publication date: Available online 7 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Julia J. Müller, Iwa Antonow-Schlorke, Nasim Kroegel, Sven Rupprecht, Florian Rakers, Otto W. Witte, Matthias SchwabAbstractPrenatal stress programs offspring cognitive and mental health outcome. We reviewed whether prenatal stress also programs cardiovascular dysfunction which potentially modulates cerebrovascular, cognitive and mental health disorders. We focused on maternal stress and prenatal glucocorticoid (GC) exposure which have different programming effects. While maternal stress induced cortisol is mos...
Source: Neuroscience and Biobehavioral Reviews - November 9, 2019 Category: Neuroscience Source Type: research

Cumulative evidence for association of parental diabetes mellitus and attention-deficit/hyperactivity disorder
Publication date: Available online 7 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Yan Zeng, Ying Tang, Yan Yue, Wenxing Li, Xia Qiu, Peng Hu, Jun Tang, Huiqing Wang, Xiaoyan Yang, Yi Qu, Dezhi MuAbstractWe conducted a systematic review and meta-analysis to evaluate the association between parental diabetes mellitus and the risk of ADHD in offspring. The PubMed, EMBASE, Cochrane, and Web of Science databases were searched from inception to May 31, 2019. Thirteen observational studies containing 5,052,736 participants were included. Two reviewers independently extracted data and assessed the qualit...
Source: Neuroscience and Biobehavioral Reviews - November 9, 2019 Category: Neuroscience Source Type: research

Obstructive sleep apnea syndrome in adults with Down syndrome: causes and consequences. Is it a "chicken and egg" question?
Publication date: Available online 7 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Léa Dumortier, Véronique-Aurélie BricoutAbstractIndividuals with Down syndrome present many clinical characteristics, such as metabolic, endocrine, anatomic and neurologic dysfunctions, that contribute to the physiopathology of obstructive sleep apnea syndrome (OSAS). As a result, sleep apnea prevalence is significantly greater in population with Down syndrome, and may have critical consequences on health and quality of life, such as cardiovascular risks and obesity.This paper compiles a list of...
Source: Neuroscience and Biobehavioral Reviews - November 9, 2019 Category: Neuroscience Source Type: research

Microglial memory of early life stress and inflammation: susceptibility to neurodegeneration in adulthood
Publication date: Available online 5 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Paula Desplats, Ashley M. Gutierrez, Marta C. Antonelli, Martin G. FraschAbstractWe review evidence supporting the role of early life programming in the susceptibility for adult neurodegenerative diseases while highlighting questions and proposing avenues for future research to advance our understanding of this fundamental process. The key elements of this phenomenon are chronic stress, neuroinflammation triggering microglial polarization, microglial memory and their connection to neurodegeneration. We review the me...
Source: Neuroscience and Biobehavioral Reviews - November 6, 2019 Category: Neuroscience Source Type: research

The Duality of Human Cognition: Operations and Intentionality in Mental Life and Illness
Publication date: Available online 5 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): R. Walter HeinrichsAbstractWhat people think about, the intentional aspect of cognition, is distinguished from its operational aspect, or how proficiently they think. Many psychiatric disorders as well as social problems like racism, are defined largely by specified thought contents, whereas neurological disorders including dementia are defined by low proficiency. Intentionality contrasts with operational cognition in resisting objectification and in being expressed primarily in verbal narratives and subjective self...
Source: Neuroscience and Biobehavioral Reviews - November 6, 2019 Category: Neuroscience Source Type: research

The neurophysiological basis of compassion: An fMRI meta-analysis of compassion and its related neural processes
Publication date: Available online 4 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Jeffrey J. Kim, Ross Cunnington, James N. KirbyAbstractTheoretical and neurophysiological investigations into compassion are burgeoning, yet the putative neural mechanisms which underpin such processes are less well understood. Therefore, we have conducted an Activation-Likelihood Estimate based meta-analysis in order to ascertain the shared neural processes consistently identified as relevant to compassion. Our analysis of sixteen fMRI studies revealed activation across seven broad regions, with the largest peaks l...
Source: Neuroscience and Biobehavioral Reviews - November 5, 2019 Category: Neuroscience Source Type: research

Influence of Cognitive Reserve in Schizophrenia: A Systematic Review
ConclusionOur findings suggest that higher CR delays the clinical diagnosis threshold and severity of the symptoms in patients with schizophrenia. However, effect of singular sociobehavioral measures on clinical expression and benefits of intervention program need further investigation. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - November 3, 2019 Category: Neuroscience Source Type: research

Psychosocial Factors and Perceived Tremor Disability in Essential Tremor
Publication date: Available online 1 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Karthick Thangavelu, Andrew C. Talk, Gavin I. Clark, Nadeeka N.W. DissanayakaAbstractGrowing evidence suggests that patients with essential tremor (ET) show impairment in psychosocial functions and subsequently increasing vulnerability to anxiety. Here we review evidence supporting a positive relationship between self-reported motor disability and psychological symptoms in ET and critically analyze evidence suggesting how psychosocial factors enhance tremor disability in ET. Theories related to motor competency, beh...
Source: Neuroscience and Biobehavioral Reviews - November 2, 2019 Category: Neuroscience Source Type: research

Impact of copy number variation on human neurocognitive deficits and congenital heart defects: a systematic review
Publication date: Available online 1 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Katrina Savory, Susruta Manivannan, Malik Zaben, Orhan Uzun, Yasir Ahmed SyedAbstractCopy number variant (CNV) syndromes are often associated with both neurocognitive deficits (NCDs) and congenital heart defects (CHDs). Children and adults with cardiac developmental defects likely to have NCDs leading to increased risk of hospitalisation and reduce independence. To date, the association between these two phenotypes have not been explored in relation to CNV syndromes. In order to address this question, we systematica...
Source: Neuroscience and Biobehavioral Reviews - November 2, 2019 Category: Neuroscience Source Type: research

A meta-analytic review of prospection deficits in Parkinson’s disease
Publication date: Available online 1 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Sarah P. Coundouris, Gill Terrett, Liisa Laakso, Daniel Schweitzer, Anthony Kneebone, Peter G. Rendell, Julie D. HenryAbstractParkinson’s disease (PD) is one of the most common neurodegenerative disorders, and is associated with prominent motor deficits. However, neurocognitive impairment is also a common clinical feature that can contribute greatly to the overall disease burden. In the current study, a meta-analysis was conducted to gain a clearer understanding of how PD affects one of the most functionally i...
Source: Neuroscience and Biobehavioral Reviews - November 2, 2019 Category: Neuroscience Source Type: research

Evidence for incentive salience sensitization as a pathway to alcohol use disorder
Publication date: Available online 28 October 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Roberto U. Cofresí, Bruce D. Bartholow, Thomas M. PiaseckiAbstractCofresí, R. C., B. D. Bartholow and T. M. Piasecki. Evidence for incentive salience sensitization as a pathway to alcohol use disorder. NEUROSCI BIOBEHAV REV 21(1) XXX-XXX, 1998. – The incentive salience sensitization (ISS) theory of addiction holds that addictive behavior stems from the ability of drugs to progressively sensitize the brain circuitry that mediates attribution of incentive salience (IS) to reward-predictive cues and...
Source: Neuroscience and Biobehavioral Reviews - October 30, 2019 Category: Neuroscience Source Type: research

The sensory-deprived brain as a unique tool to understand brain development and function
Publication date: Available online 28 October 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Emiliano Ricciardi, Davide Bottari, Maurice Ptito, Brigitte Röder, Pietro Pietrini (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - October 30, 2019 Category: Neuroscience Source Type: research

Stress-Induced Plasticity and Functioning of Ventral Tegmental Dopamine Neurons
Publication date: Available online 27 October 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Erik H. Douma, E. Ronald de KloetAbstractThe ventral tegmental area dopamine (VTA-DA) mesolimbic circuit processes emotional, motivational, and social reward associations together with their more demanding cognitive aspects that involve the mesocortical circuitry. Coping with stress increases VTA-DA excitability, but when the stressor becomes chronic the VTA-DA circuit is less active, which may lead to degeneration and local microglial activation. This switch between activation and inhibition of VTA-DA neurons is mo...
Source: Neuroscience and Biobehavioral Reviews - October 28, 2019 Category: Neuroscience Source Type: research

Neuroplasticity in Cerebral Visual Impairment (CVI): Assessing Functional Vision and the Neurophysiological Correlates of Dorsal Stream Dysfunction
Publication date: Available online 23 October 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Christopher R. Bennett, Corinna M. Bauer, Emma S. Bailin, Lotfi B. MerabetAbstractCerebral visual impairment (CVI) results from perinatal injury to visual processing structures and pathways and is the most common individual cause of pediatric visual impairment and blindness in developed countries. While there is mounting evidence demonstrating extensive neuroplastic reorganization in early onset, profound ocular blindness, how the brain reorganizes in the setting of congenital damage to cerebral (i.e. retro-genicula...
Source: Neuroscience and Biobehavioral Reviews - October 24, 2019 Category: Neuroscience Source Type: research

Chronic oxytocin administration as a tool for investigation and treatment: A cross-disciplinary systematic review
Publication date: Available online 21 October 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Marilyn Horta, Kathryn Kaylor, David Feifel, Natalie C. EbnerAbstractOxytocin (OT) subserves various physiological, behavioral, and cognitive processes. This paired with the ability to administer OT with minimal and inconsistent side effects has spurred research to explore its therapeutic potential. Findings from single-dose studies indicate that OT administration may be beneficial, at least under certain circumstances. The state of the field, however, is less clear regarding effects from chronic OT administration, ...
Source: Neuroscience and Biobehavioral Reviews - October 22, 2019 Category: Neuroscience Source Type: research

Revealing the optimal thresholds for movement performance: A systematic review and meta-analysis to benchmark pathological walking behaviour
Publication date: Available online 19 October 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Deepak K. Ravi, Michelle Gwerder, Niklas König Ignasiak, Christian R. Baumann, Mechtild Uhl, Jaap H. van Dieën, William R. Taylor, Navrag B. SinghAbstractIn order to address whether increased levels of movement output variability indicate pathological performance, we systematically reviewed and synthesized meta-analysis data on healthy and pathological motor behavior. After screening up to 24’000 reports from four databases, 85 studies were included containing 2409 patients and 2523 healthy asymptoma...
Source: Neuroscience and Biobehavioral Reviews - October 21, 2019 Category: Neuroscience Source Type: research

Can we ‘seize’ the gut microbiota to treat epilepsy?
Publication date: Available online 15 October 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Carmen De Caro, Luigi Francesco Iannone, Rita Citraro, Pasquale Striano, Giovambattista De Sarro, Andrew Constanti, John F. Cryan, Emilio RussoAbstractThe gut-microbiota, the complex intestinal microbial ecosystem essential to health, is an emerging concept in medicine. Several studies demonstrate a microbiota-gut-brain bidirectional connection via neural, endocrine, metabolic and immune pathways. Accordingly, the gut microbiota has a crucial role in modulating intestinal permeability, to alter local/peripheral immu...
Source: Neuroscience and Biobehavioral Reviews - October 16, 2019 Category: Neuroscience Source Type: research

Structural and functional brain reorganisation due to blindness: the special case of bilateral congenital anophthalmia
We describe the functional reorganisation and associated structural and connectivity changes that occur in the brain of those affected by the condition. By considering animal models of this condition, we investigate the changes that may be occurring on a scale that is not captured by human in vivo imaging techniques. Finally, we lay out a model pathway for taking auditory information to the occipital cortex that may be specific to anophthalmia. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - October 16, 2019 Category: Neuroscience Source Type: research