What we can learn from a genetic rodent model about autism
Publication date: Available online 27 December 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Dorit Möhrle, Marta Fernández, Olga Peñagarikano, Andreas Frick, Brian Allman, Susanne SchmidAbstractAutism spectrum disorders (ASD) are complex neurodevelopmental disorders that are caused by genetic and/or environmental impacts, often probably by the interaction of both. They are characterised by deficits in social communication and interaction and by restricted and repetitive behaviours and interests from early childhood on, causing significant impairment. While it is clear that no animal mode...
Source: Neuroscience and Biobehavioral Reviews - December 29, 2019 Category: Neuroscience Source Type: research

The need to incorporate aged animals into the preclinical modeling of neurological conditions
Publication date: Available online 23 December 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Mujun Sun, Stuart J. McDonald, Rhys D. Brady, Lyndsey Collins-Praino, Glenn R. Yamakawa, Mastura Monif, Terence J. O’Brien, Geoff Cloud, Christopher G. Sobey, Richelle Mychasiuk, David J. Loane, Sandy R. ShultzAbstractNeurological conditions such as traumatic brain injury, stroke, Parkinson’s disease, epilepsy, multiple sclerosis, and Alzheimer’s disease are serious clinical problems that affect millions of people worldwide. The majority of clinical trials for these common conditions have failed, ...
Source: Neuroscience and Biobehavioral Reviews - December 25, 2019 Category: Neuroscience Source Type: research

Are the roots of human economic systems shared with non-human primates?
Publication date: Available online 23 December 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Elsa Addessi, Sacha Bourgeois-GirondeAbstractWe review and analyze evidence for an evolutionary rooting of human economic behaviors and organization in non-human primates. Rather than focusing on the direct application of economic models that a priori account for animal decision behavior, we adopt an inductive definition of economic behavior in terms of the contribution of individual cognitive capacities to the provision of resources within an exchange structure. We spell out to what extent non-human primates&rsquo...
Source: Neuroscience and Biobehavioral Reviews - December 25, 2019 Category: Neuroscience Source Type: research

Endometriosis and Pain in the Adolescent- Striking Early to Limit Suffering: A Narrative Review
Publication date: Available online 17 December 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Christine B. Sieberg, Claire E. Lunde, David BorsookAbstractEndometriosis, a condition in which uterine tissue grows outside the uterus, is a debilitating disease, affecting millions of women and costing the United States approximately $78 billion annually in pain- related disability. It is also the leading cause of chronic pelvic pain (CPP), which is often unresponsive to existing treatments. Adolescent women with the disease are at particular risk as there are often significant diagnostic delays, which in turn ca...
Source: Neuroscience and Biobehavioral Reviews - December 19, 2019 Category: Neuroscience Source Type: research

Effects of acute caffeine consumption following sleep loss on cognitive, physical, occupational and driving performance: A systematic review and meta-analysis
Publication date: Available online 16 December 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Christopher Irwin, Saman Khalesi, Ben Desbrow, Danielle McCartneyAbstractCaffeine is widely used to counteract the effects of sleep loss. This systematic review and meta-analysis examined the impact of acute caffeine consumption on cognitive, physical, occupational and driving performance in sleep deprived/restricted individuals. 45 publications providing 327 effect estimates (EEs) were included in the review. Caffeine improved response time (44 EEs; g = 0.86; 95% CI: 0.53-0.83) and accuracy (27 EEs; ...
Source: Neuroscience and Biobehavioral Reviews - December 17, 2019 Category: Neuroscience Source Type: research

Neuropathic pain after spinal cord injury and physical exercise in animal models: a systematic review and meta-analysis
Publication date: Available online 16 December 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Juliete Palandi, Franciane Bobinski, Gabriela Martins de Oliveira, Jocemar IlhaAbstractThe aim of this systematic review was to summarize the effects of physical exercise on neuropathic pain (NP) in animal models of SCI. The search was conducted in Medline and Science Direct to identify experimental pre-clinical studies involving animal models of SCI, physical exercise as an intervention and the assessment of NP. Fifteen articles met the eligibility criteria. The review shows that in studies of NP involving animal ...
Source: Neuroscience and Biobehavioral Reviews - December 17, 2019 Category: Neuroscience Source Type: research

Health risk behaviours and allostatic load: A systematic review
This study examines the contribution of HRB and their effects on multisystem biological risk associated with morbidity and early mortality. We systematically reviewed the literature to assess the links between HRB and AL. Twenty-six eligible human studies were included in our assessment of the current literature investigating the association of different HRB that included overeating/obesity, alcohol, smoking, drug use, physical inactivity and sleep impairments in relation to AL. We found that 50% of obesity and substance abuse, 75% of sleep and 62.5% of combined HRB studies showed a significant association with AL. Lifesty...
Source: Neuroscience and Biobehavioral Reviews - December 16, 2019 Category: Neuroscience Source Type: research

Learning to lose control: A process-based account of behavioral addiction
Publication date: Available online 14 December 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): José C. Perales, Daniel L. King, Juan F. Navas, Adriano Schimmenti, Guillaume Sescousse, Vladan Starcevic, Ruth J. van Holst, Joël BillieuxAbstractLearning psycho(bio)logy has developed a solid corpus of evidence and theory regarding behavior control modes. The present article briefly reviews that literature and its influence on recent models in which the transition from goal-directed to compulsive behavior is identified as the main process underlying substance use disorders.This literature is also rele...
Source: Neuroscience and Biobehavioral Reviews - December 16, 2019 Category: Neuroscience Source Type: research

Memory and neuromodulation: a perspective of DNA methylation
Publication date: Available online 14 December 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Chi Him Poon, Lee Wei LimAbstractNeuromodulation techniques have shown promising efficacy on memory function and understanding the epigenetic mechanisms contributing to these processes would shed light on the molecular outcomes essential for cognition. In this review, we highlight some epigenetic mechanisms underlying neuromodulation and regulatory effects of neuronal activity-induced DNA methylation on genes that are highly involved in memory formation. Next, we examine the evidence to support DNA methyltransferas...
Source: Neuroscience and Biobehavioral Reviews - December 16, 2019 Category: Neuroscience Source Type: research

Why do we move to the beat? A multi-scale approach, from physical principles to brain dynamics
Publication date: Available online 14 December 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Loïc Damm, Déborah Varoqui, Valérie Cochen De Cock, Simone Dalla Bella, Benoît BardyAbstractHumans’ ability to synchronize movement with auditory rhythms relies on motor networks, such as cortical areas, basal ganglia and the cerebellum, which also participate in rhythm perception and movement production. Current research has provided insights into the dependence of this action-perception coupling upon the entrainment of neuronal activity by external rhythms. At a physical level, adva...
Source: Neuroscience and Biobehavioral Reviews - December 16, 2019 Category: Neuroscience Source Type: research

Dance and Parkinson’s: A review and exploration of the role of cognitive representations of action
Publication date: Available online 14 December 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Judith Bek, Aline I. Arakaki, Adam Lawrence, Matthew Sullivan, Gayathri Ganapathy, Ellen PoliakoffAbstractParkinson’s disease (PD) is a neurodegenerative disease causing both sensorimotor and non-motor impairments, and there is a clear need for non-medical approaches to improve quality of life. Dance is an increasingly popular activity among people with PD, which demonstrates potential therapeutic benefits. However, findings to date have been inconsistent, and little is known about the mechanisms underlying b...
Source: Neuroscience and Biobehavioral Reviews - December 16, 2019 Category: Neuroscience Source Type: research

A neuroscientist’s guide to transgenic mice and other genetic tools
Publication date: Available online 13 December 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Shaghayegh Navabpour, Janine L. Kwapis, Timothy J. JaromeAbstractThe past decade has produced an explosion in the number and variety of genetic tools available to neuroscientists, resulting in an unprecedented ability to precisely manipulate the genome and epigenome in behaving animals. However, no single resource exists that describes all of the tools available to neuroscientists. Here, we review the genetic, transgenic, and viral techniques that are currently available to probe the complex relationship between ge...
Source: Neuroscience and Biobehavioral Reviews - December 14, 2019 Category: Neuroscience Source Type: research

Twin studies of brain structure and cognition in schizophrenia
Publication date: Available online 13 December 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Bianca Besteher, Paolo Brambilla, Igor NenadićAbstractTwin studies in schizophrenia have been crucial in establishing estimates for the heritability and thus providing evidence for a genetic component in this disorder. Recent years have seen the application of the twin study paradigm to both putative intermediate phenotypes and biomarkers of disease as well as a diversification of its use in schizophrenia research. This review addressed studies of brain structure (T1 morphometry) and cognition in schizophrenia usi...
Source: Neuroscience and Biobehavioral Reviews - December 14, 2019 Category: Neuroscience Source Type: research

Transcriptional and Epigenetic Changes of Brain Derived Neurotrophic Factor Following Prenatal Stress: A Systematic Review of Animal Studies
Publication date: Available online 12 December 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Negin Badihian, Seyede Shahrbanoo Daniali, Roya KelishadiAbstractGestational period plays critical role in neuropsychological development. One of the genes that undergoes changes by prenatal stress (PNS) exposure, is the gene coding brain derived neurotrophic factor (BDNF). Studies have reported different patterns of change following PNS in BDNF, which emphasizes the complexity of the issue. In this review, systematic search of PubMed, Scopus, Web of Science and Cochrane CENTRAL databases was performed. Primary sea...
Source: Neuroscience and Biobehavioral Reviews - December 13, 2019 Category: Neuroscience Source Type: research

Bilingual language processing: A meta-analysis of functional neuroimaging studies
Publication date: Available online 12 December 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Simone Sulpizio, Nicola Del Maschio, Davide Fedeli, Jubin AbutalebiAbstractNotwithstanding rising interest, a coherent picture of the brain’s representation of two languages has not yet been achieved. In the present meta-analysis we analysed a large number of functional neuroimaging studies focusing on language processing in bilinguals. We used activation likelihood estimation (ALE) to enucleate activation areas involved in bilingual processing and control of different types of linguistic knowledge – le...
Source: Neuroscience and Biobehavioral Reviews - December 13, 2019 Category: Neuroscience Source Type: research

Neurochemical profiles in hereditary ataxias: A meta-analysis of Magnetic Resonance Spectroscopy studies
Publication date: Available online 12 December 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Janna Krahe, Ferdinand Binkofski, Jörg B. Schulz, Kathrin Reetz, Sandro RomanzettiAbstractMagnetic resonance spectroscopy (MRS) is applied to investigate the neurochemical profiles of degenerative hereditary ataxias. This meta-analysis provides a quantitative review and reappraisal of MRS findings in spinocerebellar ataxias (SCA) and Friedreich ataxia (FA) available to date. From each study, changes in N-acetyl aspartate (NAA), choline-containing compounds (Cho) and myo-Inositol (mI) ratios to total creatine (...
Source: Neuroscience and Biobehavioral Reviews - December 13, 2019 Category: Neuroscience Source Type: research

The nature and nurture of ADHD and its comorbidities: a narrative review on twin studies
Publication date: Available online 12 December 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Naomi Tistarelli, Corrado Fagnani, Miriam Troianiello, Maria Antonietta Stazi, Walter AdrianiAbstractAttention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children worldwide, and also the recognition of its persistence into adulthood is increasing. While ADHD in childhood is highly heritable and mostly driven by familial factors, during adulthood it appears to show a lower heritability, even if there is not total agreement on this yet. This disorder often co-occurs with many oth...
Source: Neuroscience and Biobehavioral Reviews - December 13, 2019 Category: Neuroscience Source Type: research

Neural correlates of emotion-attention interactions: From perception, learning, and memory to social cognition, individual differences, and training interventions
Publication date: January 2020Source: Neuroscience & Biobehavioral Reviews, Volume 108Author(s): Florin Dolcos, Yuta Katsumi, Matthew Moore, Nick Berggren, Beatrice de Gelder, Nazanin Derakshan, Alfons O. Hamm, Ernst H.W. Koster, Cecile D. Ladouceur, Hadas Okon-Singer, Alan J. Pegna, Thalia Richter, Susanne Schweizer, Jan Van den Stock, Carlos Ventura-Bort, Mathias Weymar, Sanda DolcosAbstractDue to their ability to capture attention, emotional stimuli tend to benefit from enhanced perceptual processing, which can be helpful when such stimuli are task-relevant but hindering when they are task-irrelevant. Altered emotio...
Source: Neuroscience and Biobehavioral Reviews - December 13, 2019 Category: Neuroscience Source Type: research

Factors influencing the success of exposure therapy for specific phobia: A systematic review
Publication date: Available online 9 December 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Joscha Böhnlein, Luisa Altegoer, Nina Kristin Muck, Kati Roesmann, Ronny Redlich, Udo Dannlowski, Elisabeth J. LeehrABSTRACTAlthough Exposure Therapy (ET) is the first-line treatment of Specific Phobia (SP), there is no clear consensus on which factors influence its success, and thus on how to conduct it most efficiently. This review summarizes the current state of research regarding this topic. N = 111 studies were in accordance with our eligibility criteria: participants had at least symptoms of...
Source: Neuroscience and Biobehavioral Reviews - December 10, 2019 Category: Neuroscience Source Type: research

The connection between microbiome and schizophrenia
This article aims to describe and understand the developmental relationships between intestinal microbiota and the risk of developing schizophrenia. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - December 10, 2019 Category: Neuroscience Source Type: research

Are Candidate Neurocognitive Endophenotypes of OCD Present in Paediatric Patients? A Systematic Review
Publication date: Available online 9 December 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Aleya A. Marzuki, Ana Maria Frota Lisboa Pereira de Souza, Barbara J. Sahakian, Trevor W. RobbinsAbstractTo-date it has been difficult to ascertain the exact cognitive profile of childhood OCD as studies report variable results. Adult OCD research lately utilises the endophenotype approach; studying cognitive traits that are present in both patients and their unaffected first-degree relatives, and are thought to lie closer to the genotype than the full-blown disorder. By observing whether candidate endopenotypes of ...
Source: Neuroscience and Biobehavioral Reviews - December 10, 2019 Category: Neuroscience Source Type: research

Opioid receptor modulation of neural circuits in depression: What can be learned from preclinical data?
This article highlights how the opioid system potently modulates mesolimbic circuitry underlying motivation and reward processing, limbic circuitry underlying fear and anxiety responses, cortical and hippocampal circuitry underlying a variety of cognitive functions, as well as broad functional and structural plasticity mechanisms. Ultimately, a more thorough understanding of how the opioid system modulates these core functional domains may lead to novel treatment strategies and molecular targets in the treatment of MDD. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - December 10, 2019 Category: Neuroscience Source Type: research

Neuropharmacological modulation of the aberrant bodily self through psychedelics
Publication date: Available online 6 December 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Jasmine T. Ho, Katrin H. Preller, Bigna LenggenhagerAbstractAs a continual source of sensory input and fundamental component of self-referential processing, the body holds an integral modulatory role in cognition. In a healthy state, predictive coding of multisensory integration promotes the construction of a coherent self. However, several psychiatric disorders comprise aberrant perceptions of the bodily self that are purported to involve discrepancies in the integration and updating of multisensory systems. Change...
Source: Neuroscience and Biobehavioral Reviews - December 7, 2019 Category: Neuroscience Source Type: research

Effectiveness of language training and non-invasive brain stimulation on oral and written naming performance in Primary Progressive Aphasia: A meta-analysis and systematic review
Publication date: Available online 4 December 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Maria Cotelli, Rosa Manenti, Clarissa Ferrari, Elena Gobbi, Ambra Macis, Stefano F. CappaAbstractThe aim of this systematic review and meta-analysis is to examine the efficacy of language training, alone or in combination with non-invasive brain stimulation techniques, designed to improve oral and written naming abilities in Primary Progressive Aphasia (PPA), and to investigate whether gains can be maintained over time and generalize to untrained items. An electronic database search was conducted up to 31st of May 2...
Source: Neuroscience and Biobehavioral Reviews - December 6, 2019 Category: Neuroscience Source Type: research

Long-term memory consolidation or reconsolidation impairment induces amnesia with key characteristics that are similar to key learning characteristics
Publication date: Available online 4 December 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): V.P. Nikitin, S.V. Solntseva, S.A. Kozyrev, P.V. NikitinAbstractAccording to a common perspective, amnesia is a passive consequence of memory consolidation or reconsolidation impairment. The results of our own study, as well as literature data, allowed us to offer an interpretation of amnesia. Amnesia is an active process whose key characteristics are similar to those of other long-term plastic rearrangements of the brain, including learning processes. In accordance with this hypothesis, the review considers the dat...
Source: Neuroscience and Biobehavioral Reviews - December 6, 2019 Category: Neuroscience Source Type: research

Corrigendum to “Nutritional interventions and cognitive-related outcomes in patients with late-life cognitive disorders: A systematic review” Neurosci. Biobehav. Rev. 95 (2018) 480–498
Publication date: Available online 5 December 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Vincenzo Solfrizzi, Pasquale Agosti, Madia Lozupone, Carlo Custodero, Andrea Schilardi, Vincenzo Valiani, Andrea Santamato, Rodolfo Sardone, Vittorio Dibello, Luca Di Lena, Roberta Stallone, Maurizio Ranieri, Antonello Bellomo, Antonio Greco, Antonio Daniele, Davide Seripa, Carlo Sabbà, Giancarlo Logroscino, Francesco Panza (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - December 6, 2019 Category: Neuroscience Source Type: research

The feeling of anger: from brain networks to linguistic expressions
Publication date: Available online 3 December 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Nelly Alia-Klein, Gabriela Gan, Gadi Gilam, Jessica Bezek, Antonio Bruno, Thomas F. Denson, Talma Hendler, Leroy Lowe, Veronica Mariotti, Maria R. Muscatello, Sara Palumbo, Silvia Pellegrini, Pietro Pietrini, Amelia Rizzo, Edelyn VeronaAbstractThis review of the neuroscience of anger is part of The Human Affectome Project, where we attempt to map anger and its components (i.e., physiological, cognitive, experiential) to the neuroscience literature (i.e., genetic markers, functional imaging of human brain networks) a...
Source: Neuroscience and Biobehavioral Reviews - December 4, 2019 Category: Neuroscience Source Type: research

Therapeutic use of serotoninergic hallucinogens: a review of the evidence and of the biological and psychological mechanisms
Publication date: Available online 3 December 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Rafael Guimarães dos Santos, Jaime Eduardo Cecilio HallakAbstractSerotoninergic hallucinogens include drugs such as lysergic acid diethylamide (LSD), dimethyltryptamine (DMT) and psilocybin. Recent trials with single/few doses of these compounds show that they induce rapid and sustained antidepressive, anxiolytic, and antiaddictive effects. These effects are also observed in religious groups using the DMT-containing brew ayahuasca. The agonist action of these substances on 5-HT2A receptors expressed in fronta...
Source: Neuroscience and Biobehavioral Reviews - December 4, 2019 Category: Neuroscience Source Type: research

Obesity affects brain structure and function- rescue by bariatric surgery?
Publication date: Available online 30 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Minke H.C. Nota, Debby Vreeken, Maximilian Wiesmann, Edo O. Aarts, Eric J. Hazebroek, Amanda J KiliaanAbstractObesity has a major impact on metabolic health thereby negatively affecting brain function and structure, however mechanisms involved are not entirely understood. The increasing prevalence of obesity is accompanied by a growing number of bariatric surgeries (BS). Weight loss after BS appears to improve cognitive function in patients. Therefore, unraveling mechanisms how BS influences brain function may be h...
Source: Neuroscience and Biobehavioral Reviews - December 1, 2019 Category: Neuroscience Source Type: research

Neuropeptides and oligopeptidases in schizophrenia
Publication date: Available online 30 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Benjamín Rodríguez, João Victor Nani, Priscila G.C. Almeida, Eliza Brietzke, Richard S. Lee, Mirian A.F. HayashiAbstractSchizophrenia (SCZ) is a complex psychiatric disorder with severe impact on patient’s livelihood. In the last years, the importance of neuropeptides in SCZ and other CNS disorders has been recognized, mainly due to their ability to modulate the signaling of classical monoaminergic neurotransmitters as dopamine. In addition, a class of enzymes coined as oligopeptidases ar...
Source: Neuroscience and Biobehavioral Reviews - December 1, 2019 Category: Neuroscience Source Type: research

Disease-discordant twin structural MRI studies on affective disorders
Publication date: Available online 29 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): G. Delvecchio, A. Pigoni, I.E. Bauer, J.C. Soares, P. BrambillaAbstractMagnetic resonance imaging (MRI) studies have identified neural structures implicated in the pathophysiology of mood disorders, especially bipolar disorder (BD) and major depressive disorder (MDD). However, the role of genetic and environmental influences on such brain deficits is still unclear. In this context, the present review summarizes the current evidence from structural MRI and Diffusion Tensor Imaging (DTI) studies on twin samples conco...
Source: Neuroscience and Biobehavioral Reviews - November 30, 2019 Category: Neuroscience Source Type: research

Lymnaea stagnalis as model for translational neuroscience research: from pond to bench
Publication date: Available online 28 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): V. Rivi, C. Benatti, C. Colliva, G. Radighieri, N. Brunello, F. Tascedda, J.M.C. BlomAbstractThe purpose of this review is to illustrate how a reductionistic, but sophisticated, approach based on the use of a simple model system such as the pond snail Lymnaea stagnalis (L. stagnalis), might be useful to address fundamental questions in learning and memory. L. stagnalis, as a model, provides an interesting platform to investigate the dialog between the synapse and the nucleus and vice versa during memory and learnin...
Source: Neuroscience and Biobehavioral Reviews - November 30, 2019 Category: Neuroscience Source Type: research

Impairment of sociocognitive functions in patients with brain tumours
Publication date: Available online 28 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Milena Pertz, Annalena Okoniewski, Uwe Schlegel, Patrizia ThomaAbstractThe ability to decode mental states and to come up with effective solutions for interpersonal problems aids successful initiation and maintenance of social interactions and contributes to participation and mental health. Since these abilities of social cognition are challenged in highly demanding situations, such as diagnosis and treatment of a life-threatening illness, this article reviews the literature on emotion recognition, empathy, Theory ...
Source: Neuroscience and Biobehavioral Reviews - November 30, 2019 Category: Neuroscience Source Type: research

The role of chemical transmitters in neuron-glia interaction and pain in sensory ganglion
Publication date: Available online 27 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Yoshizo Matsuka, Shaista Afroz, Junhel C. Dalanon, Takuma Iwasa, Arief Waskitho, Masamitsu OshimaAbstractNeuropathic pain (NP) develops because of damage to the peripheral or central nervous system. It results in the hyperalgesia and allodynia. In the recent years, various researchers have studied the involvement of neuro-immune system in causing persistence of pain. The absence of synaptic contacts in the sensory ganglion makes them distinctive in terms of pain related signalling. In sensory ganglia, the neurotran...
Source: Neuroscience and Biobehavioral Reviews - November 28, 2019 Category: Neuroscience Source Type: research

Aging: therapeutics for a healthy future
Publication date: Available online 26 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Robert Hodgson, Brian K. Kennedy, Eliezer Masliah, Kimberly Scearce-Levie, Barbara Tate, Anjli Venkateswaran, Steven P. BraithwaiteAbstractIncreased healthcare and pharmaceutical understanding has led to the eradication of many childhood, infectious and preventable diseases; however, we are now experiencing the impact of aging disorders as the lifespan increases. These disorders have already become a major burden on society and threaten to become a defining challenge of our generation. Indications such as Alzheimer...
Source: Neuroscience and Biobehavioral Reviews - November 28, 2019 Category: Neuroscience Source Type: research

One cranium, two brains not yet introduced: Distinct but complementary views of the social brain
Publication date: January 2020Source: Neuroscience & Biobehavioral Reviews, Volume 108Author(s): George S. Prounis, Alexander G. OphirAbstractSocial behavior is pervasive across the animal kingdom, and elucidating how the brain enables animals to respond to social contexts is of great interest and profound importance. Our understanding of ‘the social brain’ has been fractured as it has matured. Two drastically different conceptualizations of the social brain have emerged with relatively little awareness of each other. In this review, we briefly recount the history behind the two dominant definitions of a so...
Source: Neuroscience and Biobehavioral Reviews - November 28, 2019 Category: Neuroscience Source Type: research

Substance related disorders are associated with impaired valuation of delayed gratification and feedback processing: A multilevel meta-analysis and meta-regression
In this study we thus performed multilevel linear mixed-effects meta-analyses and meta-regressions to examine the effects of SUDs on the Delay Discounting Task (DD) and on the Iowa Gambling Task (IGT). We found a moderate to large effect for SUD on both, the IGT and DD. While the effect on the DD was generalized to all substance classes, a smaller effect for cannabis-related disorder when compared to other SUDs was found with regard to the IGT. Early onset of substance use and psychiatric comorbidities were associated with stronger effects on the DD. Our findings suggest that feedback processing is more vulnerable to speci...
Source: Neuroscience and Biobehavioral Reviews - November 27, 2019 Category: Neuroscience Source Type: research

Beyond Labeled Lines: A population coding account of the Thermal Grill Illusion
Publication date: Available online 26 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Francesca Fardo, Brianna Beck, Micah Allen, Nanna FinnerupAbstractHeat and pain illusions can be generated by simultaneous cold and warm stimulation on the skin, at temperatures that would normally be perceived as innocuous in isolation (e.g., ‘synthetic heat’ and the ‘thermal grill illusion’). Historically, two key questions have dominated the literature: Which specific pathway conveys the illusory perception of heat and pain? Where specifically does the illusory pain originate in the centr...
Source: Neuroscience and Biobehavioral Reviews - November 27, 2019 Category: Neuroscience Source Type: research

Towards a comparative science of emotion: Affect and consciousness in humans and animals
Publication date: Available online 26 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Elizabeth S. Paul, Shlomi Sher, Marco Tamietto, Piotr Winkielman, Michael T. MendlAbstractThe componential view of human emotion recognises that affective states comprise conscious, behavioural, physiological, neural and cognitive elements. Although many animals display bodily and behavioural changes consistent with the occurrence of affective states similar to those seen in humans, the question of whether and in which species these are accompanied by conscious experiences remains controversial. Finding scientifica...
Source: Neuroscience and Biobehavioral Reviews - November 27, 2019 Category: Neuroscience Source Type: research

Still No Evidence That Exergames Improve Cognitive Ability: A Commentary on Stanmore et al. (2017)
Publication date: Available online 21 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Giovanni Sala, K. Semir Tatlidil, Fernand GobetAbstractA recent meta-analysis (Stanmore et al. Neurosci. Biobehav. Rev. 78:34–43, 2017) claimed that exergames exert medium-size positive effects on people's overall cognitive function. The present article critically tests this claim. We argue that the meta-analysis reported inflated effect sizes mainly for three reasons: (a) some effect sizes were miscalculated; (b) there was an excessive amount of true heterogeneity; and (c) no publication-bias-corrected estim...
Source: Neuroscience and Biobehavioral Reviews - November 22, 2019 Category: Neuroscience Source Type: research

The Neural Circuitry Supporting Successful Spatial Navigation despite Variable Movement Speeds
Publication date: Available online 21 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): William M. Sheeran, Omar J. AhmedAbstractAnts who have successfully navigated the long distance between their foraging spot and their nest dozens of times will drastically overshoot their destination if the size of their legs is doubled by the addition of stilts. This observation reflects a navigational strategy called path integration, a strategy also utilized by mammals. Path integration necessitates that animals keep track of their movement speed and use it to precisely and instantly modify where they think they...
Source: Neuroscience and Biobehavioral Reviews - November 22, 2019 Category: Neuroscience Source Type: research

Editorial Board
Publication date: December 2019Source: Neuroscience & Biobehavioral Reviews, Volume 107Author(s): (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - November 21, 2019 Category: Neuroscience Source Type: research

Editorial
Publication date: December 2019Source: Neuroscience & Biobehavioral Reviews, Volume 107Author(s): (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - November 21, 2019 Category: Neuroscience Source Type: research

Neural Circuits Linking Sleep and Addiction: Animal Models to Understand Why Select Individuals Are More Vulnerable to Substance Use Disorders After Sleep Deprivation
Publication date: Available online 19 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Allison M. Ahrens, Omar J. AhmedAbstractIndividuals differ widely in their drug-craving behaviors. One reason for these differences involves sleep. Sleep disturbances lead to an increased risk of substance use disorders and relapse in only some individuals. While animal studies have examined the impact of sleep on reward circuitry, few have addressed the role of individual differences in the effects of altered sleep. There does, however, exist a rodent model of individual differences in reward-seeking behavior: the...
Source: Neuroscience and Biobehavioral Reviews - November 21, 2019 Category: Neuroscience Source Type: research

Pharmacological manipulations of judgement bias: a systematic review and meta-analysis
Publication date: Available online 17 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Vikki Neville, Shinichi Nakagawa, Josefina Zidar, Elizabeth S. Paul, Malgorzata Lagisz, Melissa Bateson, Hanne Løvlie, Michael MendlAbstractValidated measures of animal affect are crucial to research spanning numerous disciplines. Judgement bias, which assesses decision-making under ambiguity, is a promising measure of animal affect. One way of validating this measure is to administer drugs with affect-altering properties in humans to non-human animals and determine whether the predicted judgement biases are...
Source: Neuroscience and Biobehavioral Reviews - November 18, 2019 Category: Neuroscience Source Type: research

Glutamate receptors in domestication and modern human evolution
Publication date: Available online 16 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Thomas O’Rourke, Cedric BoeckxAbstractThere has been a recent resurgence of interest in the hypothesis that anatomically modern humans and domesticated species have followed convergent evolutionary paths. Here, we review results from domestication and modern-human evolutionary studies in order to evaluate evidence for shared changes to neurotransmission across these species. We compare genomic and, where available, brain-expression differences across 488 neurotransmitter receptor genes in 14 domesticated spec...
Source: Neuroscience and Biobehavioral Reviews - November 18, 2019 Category: Neuroscience Source Type: research

Hippocampal pattern separation of emotional information determining risk or resilience in individuals exposed to childhood trauma: linking exposure to neurodevelopmental alterations and threat anticipation
Publication date: Available online 16 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Aleksandra Lecei, Ruud van WinkelAbstractChildhood adversity increases the risk of developing psychiatric symptoms later in life. However, the neurobiological mechanisms underlying this association are unknown. This paper reviews the current literature regarding structural and functional alterations in the hippocampus and amygdala following childhood adversity, ultimately converging into a model that proposes impaired ‘pattern separation’ as an important underlying mechanism associated with risk or resi...
Source: Neuroscience and Biobehavioral Reviews - November 18, 2019 Category: Neuroscience Source Type: research

One cranium, two brains not yet introduced: Distinct but complimentary views of the social brain
Publication date: Available online 16 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): George S. Prounis, Alexander G. OphirAbstractSocial behavior is pervasive across the animal kingdom, and elucidating how the brain enables animals to respond to social contexts is of great interest and profound importance. Our understanding of ‘the social brain’ has been fractured as it has matured. Two drastically different conceptualizations of the social brain have emerged with relatively little awareness of each other. In this review, we briefly recount the history behind the two dominant definition...
Source: Neuroscience and Biobehavioral Reviews - November 18, 2019 Category: Neuroscience Source Type: research

Rodent medial and lateral orbitofrontal cortices represent unique components of cognitive maps of task space
Publication date: Available online 16 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Laura A. Bradfield, Genevra HartAbstractThe orbitofrontal cortex (OFC) has been proposed to function as a cognitive map of task space: a mental model of the steps involved in a task. This idea has proven popular because it provides a cohesive explanation for a number of disparate findings regarding the OFC’s role in a broad array of tasks. Concurrently, evidence has begun to reveal the functional heterogeneity of OFC subregions, particularly the medial and lateral OFC. How these subregions uniquely contribute...
Source: Neuroscience and Biobehavioral Reviews - November 18, 2019 Category: Neuroscience Source Type: research

A systematic review and meta-analysis of the evidence for unaware fear conditioning
Publication date: Available online 17 November 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Gaëtan Mertens, Iris M. EngelhardAbstractWhether fear conditioning can take place without contingency awareness is a topic of continuing debate and conflicting findings have been reported in the literature. This systematic review provides a critical assessment of the available evidence. Specifically, a search was conducted to identify articles reporting fear conditioning studies in which the contingency between conditioned stimuli (CS) and the unconditioned stimulus (US) was masked, and in which CS-US continge...
Source: Neuroscience and Biobehavioral Reviews - November 18, 2019 Category: Neuroscience Source Type: research