Prenatal exposure to environmental insults and enhanced risk of developing Schizophrenia and Autism Spectrum Disorder: Focus on biological pathways and epigenetic mechanisms
Publication date: Available online 4 July 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Nadia Cattane, Juliet Richetto, Annamaria CattaneoaAbstractWhen considering neurodevelopmental disorders (NDDs), Schizophrenia (SZ) and Autism Spectrum Disorder (ASD) are considered to be among the most severe in term of prevalence, morbidity and impact on the society.Similar features and overlapping symptoms have been observed at multiple levels, suggesting common pathophysiological bases. Indeed, recent genome-wide association studies (GWAS) and epidemiological data report shared vulnerability genes and environmental ...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

Editorial Board
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

Editorial: Jeffrey Glennon & Simone Macrì
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

Understanding heterogeneity in conduct disorder: A review of psychophysiological studies
In conclusion, it might be important to redefine CD diagnostic criteria based on physiological heterogeneity to enable the identification of distinct subtypes of CD. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

Psychiatric evaluation of youths with Disruptive Behavior Disorders and psychopathic traits: A critical review of assessment measures
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): Gabriele Masi, Annarita Milone, Paola Brovedani, Simone Pisano, Pietro MuratoriAbstractDisruptive Behavior Disorders (DBDs) are stable and impairing disorders, heterogeneous in presentation, developmental pathways, and treatment needs. Disentangling subtypes according to psychopathological dimensions is helpful for timely diagnoses, precise prognoses and tailored interventions. Psychopathic traits are relevant in subtyping DBDs with severe antisocial and aggressive behaviors. Three psychopathy dimensions have been found: 1) a...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

Mapping the developmental pathways of child conduct problems through the neurobiology of empathy
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): Caroline Moul, David J. Hawes, Mark R. DaddsAbstractThe notion that antisocial behavior reflects failures of empathy has a long history in the clinical literature, yet only recently has evidence emerged to support neuroscientific accounts of empathy and the development of child conduct problems. Much of this evidence has come from research into callous-unemotional traits, which correspond to the affective component of psychopathy and therefore encompass deficits in empathy within a broader cluster of emotional impairments. In...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

Clock genes, ADHD and aggression
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): Floriana Mogavero, Amanda Jager, Jeffrey C. GlennonAbstractAttention deficit/hyperactivity disorder (ADHD) is frequently associated with comorbid aggression and sleep disturbances. The sleep/wake cycle is under the control of the circadian system which is moderated by clock genes. Clock genes can regulate the transcription of monoamine oxidase A, which is involved in the degradation of monoamines. Disturbances in monoamine interaction with clock genes in those with monoamine gene polymorphisms may regulate susceptibility of A...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

Neuro-cognitive system dysfunction and symptom sets: A review of fMRI studies in youth with conduct problems
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): R.J.R. Blair, K. Veroude, J.K. BuitelaarAbstractIn this paper, we review fMRI work on neuro-cognitive systems that are considered to be dysfunctional in individuals with conduct problems (i.e., individuals with Conduct Disorder (CD), Oppositional Defiant Disorder (ODD) or antisocial behavior without formal clinical diagnosis). These are: empathy, the acute threat response, reinforcement-based decision-making, response inhibition and the Default Mode Network. Evidence regarding the Default Mode Network is somewhat inconsistent...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

Genetic influences on conduct disorder
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): Jessica E. Salvatore, Danielle M. DickAbstractConduct disorder (CD) is a moderately heritable psychiatric disorder of childhood and adolescence characterized by aggression toward people and animals, destruction of property, deceitfulness or theft, and serious violation of rules. Genome-wide scans using linkage and association methods have identified a number of suggestive genomic regions that are pending replication. A small number of candidate genes (e.g., GABRA2, MAOA, SLC6A4, AVPR1A) are associated with CD related phenotyp...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

Can laboratory animals violate behavioural norms? Towards a preclinical model of conduct disorder
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): Simone Macrì, Francesca Zoratto, Flavia Chiarotti, Giovanni LaviolaAbstractConduct disorder (CD), a disturbance characterised by excess rates of aggression – often associated with callousness, lack of empathy and shallow/deficient affect – is extremely prevalent (2–10%) in the juvenile population. CD symptoms are quantitative rather than qualitative in nature whereby, rather than exhibiting abnormal behaviours, CD patients indulge in normal behaviours at abnormal rates. Although genetic and environmen...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

Preclinical models of conduct disorder – principles and pharmacologic perspectives
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): Jozsef HallerAbstractThe translational value of preclinical research was recently enhanced by abnormal aggression models, which focus on deviant behaviors induced by the exposure of rodents to etiological factors of aggression-related psychopathologies. Prompted by similar trials in other psychiatric disorders, here we investigate models of abnormal aggression from the perspective of DSM5 criteria. After proposing principles based on which analogies can be established between psychopathology symptoms and rodent behavioral dys...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

Towards an animal model of callousness
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): Julen Hernandez-Lallement, Marijn van Wingerden, Tobias KalenscherAbstractCallous-unemotional traits – the insensitivity to other’s welfare and well-being – are characterized by a lack of empathy. They are characteristic of psychopathy and can be found in other anti-social disorders, such as conduct disorder. Because of the increasing prevalence of anti-social disorders and the rising societal costs of violence and aggression, it is of great importance to elucidate the psychological and physiological mechani...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

Behavioral and mechanistic insight into rodent empathy
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): Sivaani Sivaselvachandran, Erinn L. Acland, Salsabil Abdallah, Loren J. MartinAbstractEmpathy is a psychological construct that allows individuals to understand and share the emotions of others. The ability to share emotional states relies on basic social mechanisms, such as mimicry and emotional contagion, which are considered building blocks for empathy. Mimicking another’s emotional or physical state is essential for successful social interactions and is found in a number of animal species. For the current review we ...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

The link between aberrant hypothalamic–pituitary–adrenal axis activity during development and the emergence of aggression—Animal studies
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): Sophie E. Walker, Aurélie Papilloud, Damien Huzard, Carmen SandiAbstractAggressive behavior is not uniform, including proactive and reactive forms of aggression. Aberrant functioning of the hypothalamic–pituitary–adrenal (HPA) axis is frequently associated with abnormal aggression. Here, we review the rodent literature in order to assess whether developmental abnormalities in the HPA axis can be causally linked with the emergence of abnormal aggression. We examine studies that involve genetic models and lif...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

Association of trauma, Posttraumatic Stress Disorder and Conduct Disorder: A systematic review and meta-analysis
ConclusionsStudies focusing on the association of trauma, PTSD and CD are still relatively rare. Possible comorbidity models are discussed considering psychological and biological risk factors in a comprehensive model. The high rate of PTSD in CD may be due to shared risk factors; furthermore, CD might increase the risk for comorbid PTSD due to CD inherent risk taking behavior. To study pathways of risk, especially longitudinal studies are necessary. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

Antisocial behaviour and psychopathy: Uncovering the externalizing link in the P3 modulation
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): Rita Pasion, Carina Fernandes, Mariana R. Pereira, Fernando BarbosaAbstractIn 2009, Gao and Raine's meta-analysis analysed P3 modulation over the antisocial spectrum. However, some questions remained open regarding the P3 modulation patterns across impulsive and violent manifestations of antisocial behaviour, phenotypic components of psychopathy, and P3 components. A systematic review of 36 studies was conducted (N = 3514) to extend previous results and to address these unresolved questions. A clear link between dec...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

The impact of chronic stress during adolescence on the development of aggressive behavior: A systematic review on the role of the dopaminergic system in rodents
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): Jorim J Tielbeek, Zeineb Al-Itejawi, Josjan Zijlmans, Tinca JC Polderman, Joshua W Buckholtz, Arne PopmaAbstractPathological aggression, frequently observed in psychiatric patients and criminal subjects, poses a major burden on the health care and criminal justice system, necessitating better aetiological models to inform targets for prevention and intervention. Emerging evidence suggests that adverse experiences during development can cause long-lasting brain alterations associated with maladaptive behaviors, such as aggress...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

Aggressive behavior in transgenic animal models: A systematic review
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): Amanda Jager, Dorien A. Maas, Kim Fricke, Rob B. de Vries, Geert Poelmans, Jeffrey C. GlennonAbstractAggressive behavior is often core or comorbid to psychiatric and neurodegenerative disorders. Transgenic animal models are commonly used to study the neurobiological mechanisms underlying aggressive phenotypes and have led to new insights into aggression. This systematic review critically evaluates the available literature on transgenic animal models tested for aggression with the resident-intruder test. By combining the avail...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

The pharmacological treatment of aggression in children and adolescents with conduct disorder. Do callous—unemotional traits modulate the efficacy of medication?
ConclusionConsidering heterogeneity of the disorder, more proof-of-concept clinical studies are needed to define effects of medication and role of CU traits. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

Gene x environment interactions in conduct disorder: Implications for future treatments
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): Nathalie E. Holz, Katrin Zohsel, Manfred Laucht, Tobias Banaschewski, Sarah Hohmann, Daniel BrandeisAbstractConduct disorder (CD) causes high financial and social costs, not only in affected families but across society, with only moderately effective treatments so far. There is consensus that CD is likely caused by the convergence of many different factors, including genetic and adverse environmental factors. There is ample evidence of gene-environment interactions in the etiology of CD on a behavioral level regarding genetic...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

Classification and treatment of antisocial individuals: From behavior to biocognition
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): I.A. Brazil, J.D.M. van Dongen, J.H.R. Maes, R.B. Mars, A.R. Baskin-SommersAbstractAntisocial behavior is a heterogeneous construct that can be divided into subtypes, such as antisocial personality and psychopathy. The adverse consequences of antisocial behavior produce great burden for the perpetrators, victims, family members, and for society at-large. The pervasiveness of antisocial behavior highlights the importance of precisely characterizing subtypes of antisocial individuals and identifying specific factors that are et...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

Childhood aggression: A synthesis of reviews and meta-analyses to reveal patterns and opportunities for prevention and intervention strategies
This study provides a synthesis of meta-analyses and systematic reviews on non-pharmacological treatments for childhood aggression. Treatments referred to universal prevention, selective prevention, indicated prevention, or intervention (Mrazek and Haggerty, 1994). Seventy-two meta-analyses and systematic reviews met the inclusion criteria. We describe their characteristics, effect sizes across types of treatments, and the effects of various moderators. For universal and selective prevention, effects were mostly absent or small; for indicated prevention and interventions, effects were mostly small or medium. Only two moder...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

Common social cognitive impairments do not mean common causes: A commentary on Cotter et al. (2018)
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): David Dodell-Feder, Laura T. GermineAbstractMany clinical conditions, ranging from psychiatric to neurodegenerative illnesses, are associated with impairments in the processes by which we perceive, interpret, and respond to social information; a suite of abilities known as social cognition. Through a systematic review of meta-analyses, Cotter et al. (2018) present a compelling view of social cognitive deficits as a core phenotype of many clinical conditions. However, we caution against one potential interpretation of their...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

Prostheses as extensions of the body: Progress and challenges
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): Maria Niedernhuber, Damiano G. Barone, Bigna LenggenhagerAbstractRecent years have seen a surge of interest in the incorporation of artificial limbs. This research promises to provide individuals with sensorimotor disorders such as amputations with prostheses which feel like their own body part. While neuroscience made a leap towards uncovering the basic neurocognitive mechanisms of bodily self-consciousness, the development of incorporated prosthetic limbs still faces substantial challenges in basic neuroscience and in cl...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

A review of brain insulin signaling in mood disorders: From biomarker to clinical target
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): Thanh Thanh L. Nguyen, Lily C. Chan, Kristin Borreginne, Rajas P. Kale, Chunling Hu, Susannah J. TyeAbstractPatients with mood disorders are at increased risk for metabolic dysfunction. Co-occurrence of the two conditions is typically associated with a more severe disease course and poorer treatment outcomes. The specific pathophysiological mechanisms underlying this bidirectional relationship between mood and metabolic dysfunction remains poorly understood. However, it is likely that impairment of metabolic processes with...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

Attention deficit/hyperactivity-disorder and obesity: A review and model of current hypotheses explaining their comorbidity
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): Tomasz Hanć, Samuele CorteseAbstractAvailable meta-analyses point to a significant association between attention-deficit/hyperactivity disorder (ADHD) and obesity. The possible mechanisms underlying this relationship are unclear. Here, we overview the studies aimed at identifying the factors contributing to the comorbidity between ADHD and obesity, including genetic factors, fetal programming, executive dysfunctions, psychosocial stress, factors directly related to energy balance, and sleep patterns alterations. The bulk ...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

TPH2 polymorphisms across the spectrum of psychiatric morbidity: A systematic review and meta-analysis
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): Koen Willem Ottenhof, Mari Sild, Mélissa Luce Lévesque, Henricus Gerardus Ruhé, Linda BooijAbstractTryptophan hydroxylase 2 (TPH2) is the rate-limiting enzyme in brain serotonin synthesis. The TPH2 gene has frequently been investigated in relation to psychiatric morbidity. The aim of the present review is to integrate results from association studies between TPH2 single nucleotide polymorphisms (SNPs) and various psychiatric disorders, which we furthermore quantified with meta-analysis.We reviewed 166 ...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

An update on contextual fear memory mechanisms: Transition between Amygdala and Hippocampus
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): Nicholas Chaaya, Andrew R. Battle, Luke R. JohnsonAbstractContext is an ever-present combination of discrete environmental elements capable of influencing many psychological processes. When context is associated with an aversive stimulus, a permanent contextual fear memory is formed. Context is hypothesized to greatly influence the treatability of various fear-based pathologies, in particular, post-traumatic stress disorder (PTSD). In order to understand how contextual fear memories are encoded and impact underlying fear p...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

Current perspectives on the cerebellum and reading development
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): Travis A. Alvarez, Julie A. FiezAbstractThe dominant neural models of typical and atypical reading focus on the cerebral cortex. However, Nicolson et al. (2001) proposed a model, the cerebellar deficit hypothesis, in which the cerebellum plays an important role in reading. To evaluate the evidence in support of this model, we qualitatively review the current literature and employ meta-analytic tools examining patterns of functional connectivity between the cerebellum and the cerebral reading network. We find evidence for a...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

A new outlook on cholinergic interneurons in Parkinson’s disease and L-DOPA-induced dyskinesia
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): Melissa M. Conti, Nicole Chambers, Christopher BishopAbstractTraditionally, dopamine (DA) and acetylcholine (ACh) striatal systems were considered antagonistic and imbalances or aberrant signaling between these neurotransmitter systems could be detrimental to basal ganglia activity and pursuant motor function, such as in Parkinson’s disease (PD) and L-DOPA-induced dyskinesia (LID). Herein, we discuss the involvement of cholinergic interneurons (ChIs) in striatally-mediated movement in a healthy, parkinsonian, and dys...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

Antenatal ultrasound value in risk calculation for Autism Spectrum Disorder: A systematic review to support future research
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): Francesca Fulceri, Andrea Guzzetta, Argyro Athanasiadou, Laura Iaconianni, Maria Luisa ScattoniAbstractThere is a growing research interest on the antenatal features of children with neurodevelopmental disorders. Indeed, it has been proved that the neurodevelopment is, at least partly, affected by processes occurring in fetal life and that the early neurodevelopmental disorders identification is essential to optimize long-term outcomes.This systematic review aims to summarize findings on antenatal ultrasound data, which ar...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

The relationship between diffusion tensor imaging findings and cognitive outcomes following adult traumatic brain injury: A meta-analysis
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): E.J. Wallace, J.L. Mathias, L. WardAbstractCognitive impairments are common following a traumatic brain injury (TBI) and frequently result from white matter (WM) damage. This damage can be quantified using diffusion tensor imaging (DTI), which measures the directionality (fractional anisotropy: FA) and amount (mean diffusivity/apparent diffusion coefficient: MD/ADC) of water diffusion in WM, with high FA and low MD/ADC thought to indicate greater WM integrity. However, the relationship between DTI and cognitive outcomes is...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

The cingulum bundle: Anatomy, function, and dysfunction
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): Emma J. Bubb, Claudia Metzler-Baddeley, John P. AggletonAbstractThe cingulum bundle is a prominent white matter tract that interconnects frontal, parietal, and medial temporal sites, while also linking subcortical nuclei to the cingulate gyrus. Despite its apparent continuity, the cingulum’s composition continually changes as fibres join and leave the bundle. To help understand its complex structure, this review begins with detailed, comparative descriptions of the multiple connections comprising the cingulum bundle....
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

Mechanisms of cortisol – Substance use development associations: Hypothesis generation through gene enrichment analysis
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): Kristine Marceau, Emily A. AbelAbstractThere are many theories about the mechanisms of associations between hypothalamic-pituitary-adrenal (HPA) function (indexed by cortisol) and substance use. However, the potential for genes that contribute to both HPA function and substance use to confound the association (e.g., genetic confounding) has largely been ignored. We explore the potential role of genetics in cortisol-substance use associations, build a conceptual framework placing theories and mechanisms for how cortisol and...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

Understanding individual variability in symptoms and recovery following mTBI: A role for TMS-EEG?
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): Hannah L. Coyle, Jennie Ponsford, Kate E. HoyAbstractThe pathophysiology associated with mild traumatic brain injury (mTBI) includes neurometabolic and cytoskeletal changes that have been shown to impair structural and functional connectivity. Evidence that persistent neuropsychological impairments post injury are linked to structural and functional connectivity changes is increasing. However, to date the relationship between connectivity changes, heterogeneity of persistent symptoms and recovery post mTBI has been poorly ...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

The neural circuitry of restricted repetitive behavior: Magnetic resonance imaging in neurodevelopmental disorders and animal models
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): B.J. Wilkes, M.H. LewisAbstractRestricted, repetitive behaviors (RRBs) are patterns of behavior that exhibit little variation in form and have no obvious function. RRBs although transdiagonstic are a particularly prominent feature of certain neurodevelopmental disorders, yet relatively little is known about the neural circuitry of RRBs. Past work in this area has focused on isolated brain regions and neurotransmitter systems, but implementing a neural circuit approach has the potential to greatly improve understanding of R...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

Neuroimaging perspectives on fetal motor behavior
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): Tayyib T.A. Hayat, Mary A. RutherfordAbstractWe are entering a new era of understanding human development with the ability to perform studies at the earliest time points possible. There is a substantial body of evidence to support the concept that early motor behaviour originates from supraspinal motor centres, reflects neurological integrity, and that altered patterns of behaviour precede clinical manifestation of disease. Cine Magnetic Resonance Imaging (cineMRI) has established its value as a novel method to visualise m...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

Ventral anterior cingulate cortex and social decision-making
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): Patricia L. Lockwood, Marco K. WittmannAbstractStudies in the field of social neuroscience have recently made use of computational models of decision-making to provide new insights into how we learn about the self and others during social interactions. Importantly, these studies have increasingly drawn attention to brain areas outside of classical cortical "social brain" regions that may be critical for social processing. In particular, two portions of the ventral anterior cingulate cortex (vACC), subgenual anter...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

Feeling bad or feeling good, does emotion affect your consumption of food? A meta-analysis of the experimental evidence
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): Catharine Evers, Alexandra Dingemans, Astrid F. Junghans, Anja BoevéAbstractWhether emotions affect eating, and in whom, has remained unclear. This meta-analysis assessed the effect of emotions on eating in both healthy and eating disordered individuals. Fifty-six experimental studies investigating the causal effect of emotions on eating behavior were selected including 3670 participants. Separate meta-analyses (random models) were performed for negative and positive emotions. Among healthy people the moderating imp...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

Cognitive benefits of angiotensin IV and angiotensin-(1–7): A systematic review of experimental studies
ConclusionStudies of cognitive impairment show salutary effects of acute administration of Ang IV and its analogs, as well as AT4R activation. Brain RAS peptides appear most effective administered intracerebroventricularly, close to the time of learning acquisition or retention testing. Ang-(1–7) shows anti-dementia qualities. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

Early life stress, air pollution, inflammation, and disease: An integrative review and immunologic model of social-environmental adversity and lifespan health
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): Hector A. Olvera Alvarez, Laura D. Kubzansky, Matthew J. Campen, George M. SlavichAbstractSocially disadvantaged individuals are at greater risk for simultaneously being exposed to adverse social and environmental conditions. Although the mechanisms underlying joint effects remain unclear, one hypothesis is that toxic social and environmental exposures have synergistic effects on inflammatory processes that underlie the development of chronic diseases, including cardiovascular disease, diabetes, depression, and certain typ...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

Episodic and working memory function in Primary Progressive Aphasia: A meta-analysis
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): Willem S. Eikelboom, Nikki Janssen, Lize C. Jiskoot, Esther van den Berg, Ardi Roelofs, Roy P.C. KesselsAbstractObjectiveThe distinction between Primary Progressive Aphasia (PPA) variants remains challenging for clinicians, especially for the non-fluent (nfv-PPA) and the logopenic variants (lv-PPA). Previous research suggests that memory tests might aid this differentiation. This meta-analysis compares memory function among PPA variants.MethodEffects sizes were extracted from 41 studies (N = 849). Random-effects models...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

Understanding sources of adult age differences in task switching: Evidence from behavioral and ERP studies
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): Patrick D. Gajewski, Nicola K. Ferdinand, Jutta Kray, Michael FalkensteinAbstractThe task-switching paradigm is a valid tool to measure age-related changes in executive functions. It allows identifying the most vulnerable cognitive control processes affected by aging. This review provides an overview about the current evidence on behavioral and electrophysiological signatures of adult age differences in task switching with a focus on age-related changes in ERP correlates of three task-processing phases: (1) advanced task p...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

Early human brain development: Starring the subplate
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): Mijna Hadders-AlgraAbstractThis review summarizes early human brain development on the basis of neuroanatomical data and functional connectomics. It indicates that the most significant changes in the brain occur during the second half of gestation and the first three months post-term, in particular in the cortical subplate and cerebellum. As the transient subplate pairs a high rate of intricate developmental changes and interactions with clear functional activity, two phases of development are distinguished: a) the transie...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

Efficacy and acceptability of non-invasive brain stimulation for the treatment of adult unipolar and bipolar depression: A systematic review and meta-analysis of randomised sham-controlled trials
We examined the efficacy and acceptability of non-invasive brain stimulation in adult unipolar and bipolar depression. Randomised sham-controlled trials of transcranial direct current stimulation (tDCS), transcranial magnetic stimulation (TMS) and theta-burst stimulation (TBS), without co-initiation of another treatment, were included. We analysed effects on response, remission, all-cause discontinuation rates and continuous depression severity measures. Fifty-six studies met our criteria for inclusion (N = 3058, mean age = 44.96 years, 61.73% female). Response rates demonstrated efficacy of high-frequency rTMS ove...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

Longitudinal assessment of chemotherapy-induced changes in brain and cognitive functioning: A systematic review
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): Mingmei Li, Karen CaeyenberghsAbstractIn addition to the burden of a life-threatening diagnosis, cancer patients are struggling with adverse side-effects from cancer treatment. Chemotherapy has been linked to an array of cognitive impairments and alterations in brain structure and function (“chemobrain”). In this review, we summarized the existing evidence that evaluate the changes in cognitive functioning and brain with chemotherapy, as assessed using structural and functional MRI-based techniques in a longitu...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

Meta-analytic evidence for a core problem solving network across multiple representational domains
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): Jessica E. Bartley, Emily R. Boeving, Michael C. Riedel, Katherine L. Bottenhorn, Taylor Salo, Simon B. Eickhoff, Eric Brewe, Matthew T. Sutherland, Angela R. LairdAbstractProblem solving is a complex skill engaging multi-stepped reasoning processes to find unknown solutions. The breadth of real-world contexts requiring problem solving is mirrored by a similarly broad, yet unfocused neuroimaging literature, and the domain-general or context-specific brain networks associated with problem solving are not well understood. To...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

Modulation of glucocorticoids by the serotonin transporter polymorphism: A narrative review
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): T.M. Klein Gunnewiek, J.R. Homberg, T. KoziczAbstractThe biological background and consequences of serotonin transporter polymorphism-glucocorticoid relationship in individual differences in stress reactivity has been a major interest in neuropsychiatry research. Individual differences in glucocorticoid release have long been implicated in vulnerability to stress-related psychopathologies, like depression and anxiety in various species. Yet, it is largely elusive to what extent results from non-human primates and rodents t...
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

The neurobiology of the male sexual refractory period
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): Seizert A. CurtisAbstractDespite having been recognized for many years, the mechanisms governing the male sexual refractory period (post-ejaculatory refractory period, post-ejaculatory interval) remain poorly understood. This review examines the brain and spinal areas putatively involved in this phenomenon to draw a coherent picture from the available data. It is hoped that this will reveal where further research will offer the potential for crucial insights on this topic.Graphical abstract (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research

The role of the anterior insula in social norm compliance and enforcement: Evidence from coordinate-based and functional connectivity meta-analyses
In conclusion, we propose that dAI mediates cognitive processes that generate expectancy for norm compliance, whereas vAI mediates aversive feelings that generate motivation to norm enforcement. The identified functional differentiation of the right AI in the social domain contributes to a better understanding of its role in basic and clinical neuroscience. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - July 5, 2018 Category: Neuroscience Source Type: research