Dopamine D1 and D3 receptor polypharmacology as a potential treatment approach for substance use disorder
Publication date: Available online 22 March 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): Ewa Galaj, Scott Ewing, Robert Ranaldi In the search for efficacious pharmacotherapies to treat cocaine addiction much attention has been given to agents targeting dopamine D1 or D3 receptors because of the involvement of these receptors in drug-related behaviors. D1-like and D3 receptor partial agonists and antagonists have been shown to reduce drug reward, reinstatement of drug seeking and conditioned place preference (CPP) in rodents and non-human primates. However, translation of these encouraging results to...
Source: Neuroscience and Biobehavioral Reviews - March 23, 2018 Category: Neuroscience Source Type: research

Working memory training mostly engages general-purpose large-scale networks for learning
Publication date: Available online 21 March 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): Juha Salmi, Lars Nyberg, Matti Laine The present meta-analytic study examined brain activation changes following working memory (WM) training, a form of cognitive training that has attracted considerable interest. Comparisons with perceptual-motor (PM) learning revealed that WM training engages domain-general large-scale networks for learning encompassing the dorsal attention and salience networks, sensory areas, and striatum. Also the dynamics of the training-induced brain activation changes within these networ...
Source: Neuroscience and Biobehavioral Reviews - March 22, 2018 Category: Neuroscience Source Type: research

Joggin ’ the Noggin: Towards a Physiological Understanding of Exercise-Induced Cognitive Benefits
Publication date: Available online 20 March 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): Nikolas J. Stimpson, Glen Davison, Amir-Homayoun Javadi This narrative review examines literature pertaining to possible physiological explanations for observed cognitive benefits stemming from improvements to cardiovascular fitness following chronic aerobic exercise. Studies regarding exercise and cardiovascular fitness, angiogenesis, neuroinflammation in relation to IGF-1 signalling, regulation of neurotrophins, neurogenesis and plasticity, cognitive training, are briefly described. We propose that current evi...
Source: Neuroscience and Biobehavioral Reviews - March 21, 2018 Category: Neuroscience Source Type: research

Sensory aspects of Tourette syndrome
This article focuses on the rapidly expanding literature on the clinical and neurobiological aspects of the premonitory urge and multimodal hypersensitivity in patients with TS, with particular attention to pathophysiological mechanisms and possible treatment implications. These findings suggest that TS is a neurobehavioural condition characterised by intrinsic perceptual abnormalities involving the insula and sensorimotor areas, in addition to basal ganglia dysfunction. Further research will clarify the role of sensory symptoms in TS, as well as the effects of external sensory input on underlying motor abnormalities. (Sou...
Source: Neuroscience and Biobehavioral Reviews - March 19, 2018 Category: Neuroscience Source Type: research

Interindividual Variability in Neurobehavioral Response to Sleep Loss: A Comprehensive Review
Publication date: Available online 18 March 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): Olga Tkachenko, David F. Dinges Stable trait-like responding is well established for neurobehavioral performance measures across repeated exposures to total sleep deprivation and partial chronic sleep restriction. These observed phenotypes are task-dependent, suggesting that there are distinct cognitive profiles of responding with differential vulnerability to sleep loss within the same individual. Numerous factors have been investigated as potential markers of phenotypic vulnerability to the effects of sleep lo...
Source: Neuroscience and Biobehavioral Reviews - March 19, 2018 Category: Neuroscience Source Type: research

Residual effects of cannabis use in adolescent and adult brains — A meta-analysis of fMRI studies
Publication date: May 2018 Source:Neuroscience & Biobehavioral Reviews, Volume 88 Author(s): Grace Blest-Hopley, Vincent Giampietro, Sagnik Bhattacharyya While numerous studies have investigated the residual effects of cannabis use on human brain function, results of these studies have been inconsistent. Using meta-analytic approaches we summarize the effects of prolonged cannabis exposure on human brain function as measured using task-based functional MRI (fMRI) across studies employing a range of cognitive activation tasks comparing regular cannabis users with non-users. Separate meta-analyses were carried out f...
Source: Neuroscience and Biobehavioral Reviews - March 17, 2018 Category: Neuroscience Source Type: research

The role of associative fear and avoidance learning in anxiety disorders: Gaps and directions for future research
Publication date: Available online 14 March 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): Andre Pittig, Michael Treanor, Richard T. LeBeau, Michelle G. Craske Anxiety disorders are the most common mental disorders, and are often chronic and disabling. Although exposure-based treatments are effective, a substantial number of individuals fail to fully remit or experience a return of symptoms after treatment. Understanding the critical processes underlying the development and treatment of anxiety disorders will help identify individuals at risk and optimize treatments. Aversive associative learning offe...
Source: Neuroscience and Biobehavioral Reviews - March 15, 2018 Category: Neuroscience Source Type: research

Non-pharmacological modulation of cerebral white matter organization: a systematic review of non-psychiatric and psychiatric studies
Conclusions Non-pharmacological interventions can induce changes in WM. DWI is a relevant correlate of e.g. cognitive training in prospective, long-term RCTs of psychiatric patients. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - March 15, 2018 Category: Neuroscience Source Type: research

Chronobiological regulation of psychosocial and physiological outcomes in multiple sclerosis
Publication date: Available online 13 March 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): Elisea De Somma, Rajiv W. Jain, Kelvin W.C. Poon, Kaitlyn A. Tresidder, Julia P. Segal, Nader Ghasemlou There is mounting scientific evidence showing the importance of innate biological rhythms on disease onset and progression. Perhaps the most important of these is the circadian rhythm, a cycle of oscillations lasting approximately 24 hours. Recent work has shown that circadian rhythms are intrinsically linked to the immune system in a bidirectional fashion, and disruption of these cycles can contribute to ch...
Source: Neuroscience and Biobehavioral Reviews - March 14, 2018 Category: Neuroscience Source Type: research

Neural Effects of Mindfulness-Based Interventions on Patients with Major Depressive Disorder: A Systematic Review
Publication date: Available online 13 March 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): Philippe Vignaud, Clément Donde, Thouraya Sadki, Emmanuel Poulet, Jérôme Brunelin Growing evidence has suggested that mindfulness-based interventions (MBIs) could have beneficial effects on the acute phase of depression and on the prevention of depressive relapse or recurrence. Despite growing clinical interest, the effects of MBIs on brain functioning in patients with MDD remain unclear. The aim of this systematic review was to assess the changes in brain functioning associated with MBIs in ...
Source: Neuroscience and Biobehavioral Reviews - March 14, 2018 Category: Neuroscience Source Type: research

Pleasure: the missing link in the regulation of sleep
This report aims first, to fill the gap: sleep, like food, water and sex, is a primary reinforcer. The levels of extracellular mesolimbic dopamine show circadian oscillations and mark the “wanting” for pro-homeostatic stimuli. Further, the dopamine levels decrease during waking and are replenished during sleep, in opposition to sleep propensity. The wanting of sleep, therefore, may explain the homeostatic and circadian regulation of sleep. Accordingly, sleep onset occurs when the displeasure of excessive waking is maximal, coinciding with the minimal levels of mesolimbic dopamine. Reciprocally, sleep ends after...
Source: Neuroscience and Biobehavioral Reviews - March 14, 2018 Category: Neuroscience Source Type: research

Applications of the Morris water maze in translational traumatic brain injury research
Publication date: Available online 13 March 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): Laura B. Tucker, Alexander G. Velosky, Joseph T. McCabe Acquired traumatic brain injury (TBI) is frequently accompanied by persistent cognitive symptoms, including executive function disruptions and memory deficits. The Morris Water Maze (MWM) is the most widely-employed laboratory behavioral test for assessing cognitive deficits in rodents after experimental TBI. Numerous protocols exist for performing the test, which has shown great robustness in detecting learning and memory deficits in rodents after inflicti...
Source: Neuroscience and Biobehavioral Reviews - March 14, 2018 Category: Neuroscience Source Type: research

Recent Insights into Antidepressant Therapy: Distinct Pathways and Potential Common Mechanisms in the Treatment of Depressive Syndromes
Publication date: Available online 14 March 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): Dietrich van Calker, Tsvetan Serchov, Claus Normann, Knut Biber There is an urgent, unmet clinical need for faster and more efficient antidepressant drugs with higher response rates. In animal models of depression it was shown in the last few years that inhibition of three signaling molecules (BDNF, p11 and Homer1a) prevents efficacy of antidepressant therapy. These data not only show the crucial role of these factors for the treatment of depression, but may also point towards a better understanding of the molec...
Source: Neuroscience and Biobehavioral Reviews - March 14, 2018 Category: Neuroscience Source Type: research

Curiosity in old age: A possible key to achieving adaptive aging
Publication date: Available online 12 March 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): Michiko Sakaki, Ayano Yagi, Kou Murayama Curiosity is a fundamental part of human motivation that supports a variety of human intellectual behaviors ranging from early learning in children to scientific discovery. However, there has been little attention paid to the role of curiosity in aging populations. By bringing together broad but sparse neuroscientific and psychological literature on curiosity and related concepts (e.g., novelty seeking in older adults), we propose that curiosity, although it declines with...
Source: Neuroscience and Biobehavioral Reviews - March 13, 2018 Category: Neuroscience Source Type: research

A Critical Review of Brain and Cognitive Reserve in Huntington ’s Disease
Publication date: Available online 11 March 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): Maria V. Soloveva, Sharna D. Jamadar, Govinda Poudel, Nellie Georgiou-Karistianis The ‘reserve’ hypothesis posits that the brain undergoes structural and functional reorganisation to actively cope with brain damage or disease. Consistent with passive and active components of ‘reserve’, the brain moderates its biological substrates (brain reserve) and differentially changes the level of neural activity in tasks-specific networks and/or by recruiting additional non-task related brain region...
Source: Neuroscience and Biobehavioral Reviews - March 12, 2018 Category: Neuroscience Source Type: research

Rewiring the connectome: evidence and effects
Publication date: Available online 11 March 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): Sophie H. Bennett, Alastair J. Kirby, Gerald T. Finnerty Neuronal connections form the physical basis for communication in the brain. Recently, there has been much interest in mapping the “connectome” to understand how brain structure gives rise to brain function, and ultimately, to behaviour. These attempts to map the connectome have largely assumed that connections are stable once formed. Recent studies, however, indicate that connections in mammalian brains may undergo rewiring during learning and...
Source: Neuroscience and Biobehavioral Reviews - March 12, 2018 Category: Neuroscience Source Type: research

Residual effects of cannabis use in adolescent and adult brains – a meta-analysis of fMRI studies
Publication date: Available online 10 March 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): Grace Blest-Hopley, Vincent Giampietro, Sagnik Bhattacharyya While numerous studies have investigated the residual effects of cannabis use on human brain function, results of these studies have been inconsistent. Using meta-analytic approaches we summarize the effects of prolonged cannabis exposure on human brain function as measured using task-based functional MRI (fMRI) across studies employing a range of cognitive activation tasks comparing regular cannabis users with non-users. Separate meta-analyses were ca...
Source: Neuroscience and Biobehavioral Reviews - March 10, 2018 Category: Neuroscience Source Type: research

Do mothers sound good? A systematic review of the effects of maternal voice exposure on preterm infants ’ development
Publication date: Available online 10 March 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): Livio Provenzi, Sara Broso, Rosario Montirosso Preterm infants are hospitalized in the Neonatal Intensive Care Unit (NICU) and are precociously separated from their mothers. Although developmental care interventions are meant to facilitate mother-infant bonding, physical contact is not always possible. Maternal voice exposure has been proposed as a way to foster maternal closeness and support postnatal bonding. Here we present a systematic review on maternal voice effects on preterm infants’ development. L...
Source: Neuroscience and Biobehavioral Reviews - March 10, 2018 Category: Neuroscience Source Type: research

Fear extinction in the human brain: a meta-analysis of fMRI studies in healthy participants
We present the results of a set of meta-analyses of human fear extinction studies in healthy participants, conducted with functional magnetic resonance imaging (fMRI) and reporting whole-brain results. Meta-analyses of fear extinction learning primarily implicate consistent activation of brain regions linked to threat appraisal and experience, including the dorsal anterior cingulate and anterior insular cortices. An overlapping anatomical result was obtained from the meta-analysis of extinction recall studies, except when studies directly compared an extinguished threat stimulus to an unextinguished threat stimulus (instea...
Source: Neuroscience and Biobehavioral Reviews - March 10, 2018 Category: Neuroscience Source Type: research

The Pharmacology of Amphetamine and Methylphenidate: Relevance to the Neurobiology of Attention-Deficit/Hyperactivity Disorder and Other Psychiatric Comorbidities
Publication date: Available online 8 February 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): Stephen V. Faraone Psychostimulants, including amphetamines and methylphenidate, are first-line pharmacotherapies for individuals with attention-deficit/hyperactivity disorder (ADHD). This review aims to educate physicians regarding differences in pharmacology and mechanisms of action between amphetamine and methylphenidate, thus enhancing physician understanding of psychostimulants and their use in managing individuals with ADHD who may have comorbid psychiatric conditions. A systematic literature review of P...
Source: Neuroscience and Biobehavioral Reviews - March 9, 2018 Category: Neuroscience Source Type: research

Factors influencing spatial frequency extraction in faces: A review
Publication date: Available online 9 March 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): Coline Jeantet, Stéphanie Caharel, Raymund Schwan, Joëlle Lighezzolo-Alnot, Vincent Laprevote JEANTET, C., Caharel, S., Schwan, R., Lighezzolo-Alnot, J., and Laprevote, V. Factors influencing spatial frequencies extraction in faces: a review. NEUROSCI BIOBEHAV REV XX(X) XXX-XXX, 2017. Spatial frequency is an elementary aspect of visual perception. Moreover, faces elicit distinct responses by the human visual system when compared to other visual objects. This review examines the factors influencing spa...
Source: Neuroscience and Biobehavioral Reviews - March 9, 2018 Category: Neuroscience Source Type: research

From Feedback Loop Transitions to Biomarkers in the Psycho-Immune-Neuroendocrine Network: Detecting the Critical Transition from Health to Major Depression
Conclusions Progression from health to disease is driven by FLTs in the PINE network, which is likely to undergo changes characteristic of system instability. Biomarkers of system instability may effectively predict the critical transition to MDD. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - March 8, 2018 Category: Neuroscience Source Type: research

The role of the cerebellum in multiple sclerosis —150 years after Charcot
Publication date: Available online 23 February 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): Katrin Parmar, Christine Stadelmann, Maria A. Rocca, Dawn Langdon, Egidio D'Angelo, Marcus D’Souza, Jessica Burggraaff, Christiane Wegner, Jaume Sastre-Garriga, Alonso Barrantes-Freer, Jonas Dorn, Bernard M.J. Uitdehaag, Xavier Montalban, Jens Wuerfel, Christian Enzinger, Alex Rovira, Mar Tintore, Massimo Filippi, Ludwig Kappos, Till Sprenger Despite its functional importance and well known clinical impact in Multiple Sclerosis (MS), the cerebellum has only received significant attention over the past f...
Source: Neuroscience and Biobehavioral Reviews - March 6, 2018 Category: Neuroscience Source Type: research

Sleep in adults with ADHD: Systematic review and meta-analysis of subjective and objective studies
Publication date: Available online 2 March 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): Amparo Díaz-Román, Raziya Mitchell, Samuele Cortese Sleep alterations associated with adulthood ADHD are poorly understood. Here, we conducted the first meta-analysis of sleep studies in adults with ADHD. Based on a pre-registered protocol (PROSPERO-CRD42017065407), we searched Pubmed, Ovid and Web of Knowledge databases through August 3rd, 2017, with no language or publication type restrictions, and contacted study authors for unpublished data/information. From a pool of 8812 references, we retaine...
Source: Neuroscience and Biobehavioral Reviews - March 3, 2018 Category: Neuroscience Source Type: research

Multisensory cortical processing and dysfunction across the neuropsychiatric spectrum
Publication date: Available online 26 February 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): Betty E. Hornix, Robbert Havekes, Martien J.H. Kas Sensory processing is affected in multiple neuropsychiatric disorders like schizophrenia and autism spectrum disorders. Genetic and environmental factors guide the formation and fine-tuning of brain circuitry necessary to receive, organize, and respond to sensory input in order to behave in a meaningful and consistent manner. During certain developmental stages the brain is sensitive to intrinsic and external factors. For example, disturbed expression levels ...
Source: Neuroscience and Biobehavioral Reviews - February 26, 2018 Category: Neuroscience Source Type: research

The Role of the Cerebellum in Multiple Sclerosis – 150 years after Charcot
Publication date: Available online 23 February 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): Katrin Parmar, Christine Stadelmann, Maria A. Rocca, Dawn Langdon, Egidio D'Angelo, Marcus D’Souza, Jessica Burggraaff, Christiane Wegner, Jaume Sastre-Garriga, Alonso Barrantes-Freer, Jonas Dorn, Bernard M.J. Uitdehaag, Xavier Montalban, Jens Wuerfel, Christian Enzinger, Alex Rovira, Mar Tintore, Massimo Filippi, Ludwig Kappos, Till Sprenger Despite its functional importance and well known clinical impact in Multiple Sclerosis (MS), the cerebellum has only received significant attention over the past f...
Source: Neuroscience and Biobehavioral Reviews - February 24, 2018 Category: Neuroscience Source Type: research

Fairness, fast and slow: A review of dual process models of fairness
Publication date: Available online 24 February 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): Bjørn G. Hallsson, Hartwig R. Siebner, Oliver J. Hulme Fairness, the notion that people deserve or have rights to certain resources or kinds of treatment, is a fundamental dimension of moral cognition. Drawing on recent evidence from economics, psychology, and neuroscience, we ask whether self-interest is always intuitive, requiring self-control to override with reasoning-based fairness concerns, or whether fairness itself can be intuitive. While we find strong support for rejecting the notion that sel...
Source: Neuroscience and Biobehavioral Reviews - February 24, 2018 Category: Neuroscience Source Type: research

Subliminal (Latent) Processing of Pain and its Evolution to Conscious Awareness
Publication date: Available online 21 February 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): David Borsook, Andrew M. Youssef, Nadia Barakat, Christine B. Sieberg, Igor Elman By unconscious or covert processing of pain we refer to nascent interactions that affect the eventual deliverance of pain awareness. Thus, internal processes (viz., repeated nociceptive events, inflammatory kindling, reorganization of brain networks, genetic) or external processes (viz., environment, socioeconomic levels, modulation of epigenetic status) contribute to enhancing or inhibiting the presentation of pain awareness. H...
Source: Neuroscience and Biobehavioral Reviews - February 21, 2018 Category: Neuroscience Source Type: research

Assessment of Intradimensional/Extradimensional Attentional Set-Shifting in Rats
Publication date: Available online 21 February 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): David S. Tait, Eric M. Bowman, Lorenz S. Neuwirth, Verity J. Brown The rat intradimensional/extradimensional (ID/ED) task, first described by Birrell and Brown 18 years ago, has become the predominant means by which attentional set-shifting is investigated in rodents: the use of rats in the task has been described in over 135 publications by researchers from nearly 90 universities and pharmaceutical companies. There is variation in the protocols used by different groups, including differences in apparatus, st...
Source: Neuroscience and Biobehavioral Reviews - February 21, 2018 Category: Neuroscience Source Type: research

Reactivity to interpersonal stress in patients with eating disorders: A systematic review and meta-analysis of studies using an experimental paradigm
Publication date: April 2018 Source:Neuroscience & Biobehavioral Reviews, Volume 87 Author(s): Alessio Maria Monteleone, Janet Treasure, Carol Kan, Valentina Cardi Reactivity to interpersonal stress in patients with eating disorders: A systematic review and meta-analysis of studies using an experimental paradigm. NEUROSCI BIOBEHAV REV XXX-XXX, 2018.- Social difficulties have been implicated in the development and maintenance of eating disorder symptoms. The aim of this work was to conduct a systematic review and meta-analysis of experimental studies testing patientsö reactivity to interpersonal stress, compar...
Source: Neuroscience and Biobehavioral Reviews - February 20, 2018 Category: Neuroscience Source Type: research

Meta-analysis and systematic review of the literature characterizing auditory mismatch negativity in individuals with autism
Publication date: April 2018 Source:Neuroscience & Biobehavioral Reviews, Volume 87 Author(s): Sophie Schwartz, Barbara Shinn-Cunningham, Helen Tager-Flusberg A number of past studies have used mismatch negativity (MMN) to identify auditory processing deficits in individuals with autism spectrum disorder (ASD). Our meta-analysis compared MMN responses for individuals with ASD and typically developing controls (TD). We analyzed 67 experiments across 22 publications that employed passive, auditory-based MMN paradigms with ASD and TD participants. Most studies lacked design characteristics that would lead to an accur...
Source: Neuroscience and Biobehavioral Reviews - February 20, 2018 Category: Neuroscience Source Type: research

Motor dysfunction as research domain in the period preceding manifest schizophrenia: A systematic review
Publication date: April 2018 Source:Neuroscience & Biobehavioral Reviews, Volume 87 Author(s): Dusan Hirjak, Andreas Meyer-Lindenberg, Katharina M. Kubera, Philipp A. Thomann, Robert C. Wolf Schizophrenia is a severe behavioral syndrome of neurodevelopmental nature marked by primary or genuine motor abnormalities (GMA), which refer to spontaneous and medication-independent motor phenomena. Since motor dysfunction thus might be a consequence of events occurring during early childhood and adolescence, GMA can be detected in the period preceding manifest schizophrenia. However, the question whether motor system dysfu...
Source: Neuroscience and Biobehavioral Reviews - February 20, 2018 Category: Neuroscience Source Type: research

NGF-dependent neurons and neurobiology of emotions and feelings: Lessons from congenital insensitivity to pain with anhidrosis
Publication date: April 2018 Source:Neuroscience & Biobehavioral Reviews, Volume 87 Author(s): Yasuhiro Indo NGF is a well-studied neurotrophic factor, and TrkA is a receptor tyrosine kinase for NGF. The NGF–TrkA system supports the survival and maintenance of NGF-dependent neurons during development. Congenital insensitivity to pain with anhidrosis (CIPA) is an autosomal recessive genetic disorder due to loss-of-function mutations in the NTRK1 gene encoding TrkA. Individuals with CIPA lack NGF-dependent neurons, including NGF-dependent primary afferents and sympathetic postganglionic neurons, in otherwise i...
Source: Neuroscience and Biobehavioral Reviews - February 20, 2018 Category: Neuroscience Source Type: research

Moderate effects of noninvasive brain stimulation of the frontal cortex for improving negative symptoms in schizophrenia: meta-analysis of controlled trials
Conclusions The available evidence indicates that noninvasive prefrontal neurostimulation can improve negative symptoms. This finding suggests a causal role for the lateral frontal cortex in self-initiated goal-directed behavior. The evidence is stronger for rTMS than for tDCS, although this may be due to the small number of studies as yet with tDCS. More research is needed to establish moderator variables that may affect response to neurostimulation and to optimize treatment parameters in order to achieve stable and durable (and thus clinically relevant) effects. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - February 19, 2018 Category: Neuroscience Source Type: research

Blood biomarkers in paediatric mild traumatic brain injury: a systematic review
Conclusion GFAP appears to be a promising blood biomarker for the prognosis and monitoring of mTBI, whereas UCH-L1 appears more promising at mTBI diagnosis. Despite this, the overall heterogeneity in assessed biomarkers, study design and measurement tools has made drawing specific conclusions challenging. Future research will require more uniform study design and methodological approaches to allow for the comparison, corroboration and validation of blood biomarkers within the context of paediatric mTBI. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - February 17, 2018 Category: Neuroscience Source Type: research

Predicting neurodevelopmental outcome in preterm born infants using auditory event-related potentials: A systematic review
Publication date: Available online 17 February 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): Antoinette Depoorter, Julia Früh, Katharina Herrmann, Davide Zanchi, Peter Weber Prematurity is a known risk factor for later cognitive deficits. At present there are neither behavioral nor neurological tests available to detect those preterm infants who would benefit most from early interventions. Neurophysiologic methods, and more specifically, auditory event-related potentials (AERPs) are convenient tools to investigate early cognitive functioning. However, the capability of AERPs as a prognostic fact...
Source: Neuroscience and Biobehavioral Reviews - February 17, 2018 Category: Neuroscience Source Type: research

Phosphodiesterase inhibition and modulation of corticostriatal and hippocampal circuits: Clinical overview and translational considerations
Publication date: Available online 15 February 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): P.R.A. Heckman, A. Blokland, E.P.P. Bollen, J. Prickaerts The corticostriatal and hippocampal circuits contribute to the neurobiological underpinnings of several neuropsychiatric disorders, including Alzheimer’s disease, Parkinson’s disease and schizophrenia. Based on biological function, these circuits can be clustered into motor circuits, associative/cognitive circuits and limbic circuits. Together, dysfunctions in these circuits produce the wide range of symptoms observed in related neuropsychi...
Source: Neuroscience and Biobehavioral Reviews - February 15, 2018 Category: Neuroscience Source Type: research

Serotonergic psychedelics and personality: a systematic review of contemporary research
Publication date: Available online 13 February 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): José Carlos Bouso, Rafael G. dos Santos, Miguel Ángel Alcázar-Córcoles, Jaime E.C. Hallak Serotonergic psychedelics act as agonists at cortical 5-HT2A receptors and seem to induce personality changes. We conducted a systematic review of studies assessing the effects of these drugs on personality. Papers published from 1985 to 2016 were included from PubMed, LILACS, and SciELO databases. Three hundred and sixty-nine studies were identified, and 18 were included. Specific personality...
Source: Neuroscience and Biobehavioral Reviews - February 14, 2018 Category: Neuroscience Source Type: research

Are sleep disturbances causally linked to the presence and severity of psychotic-like, dissociative and hypomanic experiences in non-clinical populations? A Systematic Review
Publication date: Available online 13 February 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): Jack Barton, Simon D. Kyle, Filippo Varese, Steven H. Jones, Gillian Haddock The present review aimed to 1) identify what sleep disturbances co-occur alongside psychotic-like, dissociative and hypomanic experiences; 2) assess the strength of potential associations between the severity of sleep disturbances and of the experiences studied; and 3) appraise evidence for a causal link. MedLine and PsycInfo were searched and 44 studies were deemed eligible. Results showed that insomnia was associated with all indiv...
Source: Neuroscience and Biobehavioral Reviews - February 14, 2018 Category: Neuroscience Source Type: research

ATP-activated P2X7 receptor in the pathophysiology of mood disorders and as an emerging target for the development of novel antidepressant therapeutics
Publication date: Available online 14 February 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): Linyu Wei, Sharifah A Syed Mortadza, Jing Yan, Libin Zhang, Lu Wang, Yaling Yin, Chaokun Li, Sylvie Chalon, Patrick Emond, Catherine Belzung, Dongliang Li, Chengbiao Lu, Sebastien Roger, Lin-Hua Jiang Mood disorders are a group of psychiatric conditions that represent leading global disease burdens. Increasing evidence from clinical and preclinical studies supports that innate immune system dysfunction plays an important part in the pathophysiology of mood disorders. P2X7 receptor, belonging to the ligand-gat...
Source: Neuroscience and Biobehavioral Reviews - February 14, 2018 Category: Neuroscience Source Type: research

Cognitive and Neuromodulation Strategies for Unhealthy Eating and Obesity: Systematic Review and Discussion of Neurocognitive Mechanisms
Publication date: Available online 9 February 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): Laura Forcano, Fernanda Mata, Rafael de la Torre, Antonio Verdejo-Garcia We systematically reviewed research on cognitive training and neuromodulation interventions for reducing food craving/intake, unhealthy diet and weight, and discussed their mechanisms of action. We reviewed 50 studies involving six cognitive trainings: Approach and Attentional Bias Modification, Implementation Intentions, Response Inhibition, Episodic Future Thinking and Working Memory; and four neuromodulation approaches: Transcranial Ma...
Source: Neuroscience and Biobehavioral Reviews - February 9, 2018 Category: Neuroscience Source Type: research

Frontoparietal areas link impairments of large-scale intrinsic brain networks with aberrant fronto-striatal interactions in OCD: a meta-analysis of resting-state functional connectivity
Publication date: Available online 3 February 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): Deniz A. Gürsel, Mihai Avram, Christian Sorg, Felix Brandl, Kathrin Koch Neuroimaging studies report evidence for two distinct pathophysiological models of obsessive-compulsive disorder (OCD): disrupted fronto-striatal circuits and impaired large-scale fronto-parietal-limbic intrinsic brain networks, defined by functionally connected (FC) infra-slow oscillations in ongoing brain activity. To synthesize this literature and overcome inconsistencies, we conducted a coordinate-based meta-analysis of 18 whole-...
Source: Neuroscience and Biobehavioral Reviews - February 4, 2018 Category: Neuroscience Source Type: research

Examining the effectiveness of acetylcholinesterase inhibitors and stimulant-based medications for cognitive dysfunction in multiple sclerosis: A systematic review and meta-analysis
Publication date: March 2018 Source:Neuroscience & Biobehavioral Reviews, Volume 86 Author(s): Jack Cotter, Nils Muhlert, Anahita Talwar, Kiri Granger We sought to examine the effectiveness of acetylcholinesterase inhibitors (AChEIs) and stimulant-based medications for improving cognitive performance in patients with multiple sclerosis (MS). An electronic database search was conducted on 25th March 2017. Eligible studies were double-blind, randomised, placebo-controlled trials that examined the efficacy of compounds that act primarily as AChEIs or stimulants (administered daily for ≥1 week) on cognitive outcome...
Source: Neuroscience and Biobehavioral Reviews - February 3, 2018 Category: Neuroscience Source Type: research

A meta-analytical review of brain activity associated with intertemporal decisions: Evidence for an anterior-posterior tangibility axis
Publication date: March 2018 Source:Neuroscience & Biobehavioral Reviews, Volume 86 Author(s): Benjamin J. Smith, John R. Monterosso, Cheryl J. Wakslak, Antoine Bechara, Stephen J. Read In temporal discounting experiments, subjects are repeatedly presented with option sets in which they must choose between receiving a small amount of money sooner (SmallerSooner) or a larger amount of money at a more distant point in time (LargerLater). Although over 50 temporal discounting experiments using fMRI are described in literature, there has not been a meta-analysis identifying regions activated when subjects choose Small...
Source: Neuroscience and Biobehavioral Reviews - February 3, 2018 Category: Neuroscience Source Type: research

Metabolic/inflammatory/vascular comorbidity in psychiatric disorders; soluble epoxide hydrolase (sEH) as a possible new target
Publication date: Available online 2 February 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): W. Swardfager, M. Hennebelle, D. Yu, B.D. Hammock, A.J. Levitt, K. Hashimoto, A.Y. Taha The common and severe psychiatric disorders, including major depressive disorder (MDD) and bipolar disorder (BD), are associated with inflammation, oxidative stress and changes in lipid metabolism. Those pathways are implicated in the premature development of vascular and metabolic comorbidities, which account for considerable morbidity and mortality, including increased dementia risk. During endoplasmic reticulum stress, t...
Source: Neuroscience and Biobehavioral Reviews - February 2, 2018 Category: Neuroscience Source Type: research

High anxiety trait: A vulnerable phenotype for stress-induced depression
Publication date: Available online 2 February 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): Meltem Weger, Carmen Sandi A great deal of research aims to identify risk factors related to individual vulnerability to develop stress-induced psychopathologies. Here, we summarize evidence that point at anxiety trait as a significant contributor to inter-individual differences in stress-vulnerability. Specifically, we underscore high anxiety trait as a key vulnerability phenotype. Highly anxious individuals show both behavioral alterations and cognitive deficits, along with more reactive physiological stress...
Source: Neuroscience and Biobehavioral Reviews - February 2, 2018 Category: Neuroscience Source Type: research

The infant brain in the social world: moving toward interactive social neuroscience with functional near-infrared spectroscopy
Publication date: Available online 31 January 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): Nicole M. McDonald, Katherine L. Perdue Typically developing infants rapidly acquire a sophisticated array of social skills within the first year of life. These social skills are largely learned within the context of day-to-day interactions with caregivers. While social neuroscience has made great gains in our knowledge of the underlying neural circuitry of social cognition and behavior, much of this work has focused on experiments that sacrifice ecological validity for experimental control. Functional near-in...
Source: Neuroscience and Biobehavioral Reviews - February 1, 2018 Category: Neuroscience Source Type: research

The Vicious Cycle of Itch and Anxiety
Publication date: Available online 31 January 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): Kristen M. Sanders, Tasuku Akiyama Chronic itch is associated with increased stress, anxiety, and other mood disorders. In turn, stress and anxiety exacerbate itch, leading to a vicious cycle that affects patient behavior (scratching) and worsens disease prognosis and quality of life. This cycle persists across chronic itch conditions of different etiologies and even to some extent in healthy individuals, suggesting that the final common pathway for itch processing (the central nervous system) plays a major ro...
Source: Neuroscience and Biobehavioral Reviews - February 1, 2018 Category: Neuroscience Source Type: research

The Neurobiological Basis of Sleep: Insights from Drosophila
Publication date: Available online 31 January 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): Sarah Ly, Allan I. Pack, Nirinjini Naidoo Sleep is a biological enigma that has raised numerous questions about the inner workings of the brain. The fundamental question of why our nervous systems have evolved to require sleep remains a topic of ongoing scientific deliberation. This question is largely being addressed by research using animal models of sleep. Drosophila melanogaster, also known as the common fruit fly, exhibits a sleep state that shares common features with many other species. Drosophila sleep...
Source: Neuroscience and Biobehavioral Reviews - February 1, 2018 Category: Neuroscience Source Type: research

Reprint of Reframing autism as a behavioral syndrome and not a specific mental disorder: Perspectives from a literature review
Publication date: Available online 31 January 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): S. Tordjman, D. Cohen, N. Coulon, G.M. Anderson, M. Botbol, P.L. Roubertoux Clinical and molecular genetics have advanced current knowledge on genetic disorders associated with autism. A review of diverse genetic disorders associated with autism is presented and for the first time discussed extensively with regard to possible common underlying mechanisms leading to a similar cognitive-behavioral phenotype of autism. The possible role of interactions between genetic and environmental factors, including epigenet...
Source: Neuroscience and Biobehavioral Reviews - February 1, 2018 Category: Neuroscience Source Type: research