Amygdala where art thou?
Publication date: Available online 7 June 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Miquel A. Fullana, Anton Albajes-Eizagirre, Carles Soriano-Mas, Bram Vervliet, Narcís Cardoner, Olívia Benet, Joaquim Radua, Ben J. Harrison (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Clinical use of semantic space models in psychiatry and neurology: A systematic review and meta-analysis
Publication date: Available online 8 June 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): J.N. de Boer, A.E. Voppel, M.J.H. Begemann, H.G. Schnack, F. Wijnen, I.E.C. SommerAbstractVerbal communication disorders are a hallmark of many neurological and psychiatric illnesses. Recent developments in computational analysis provide objective characterizations of these language abnormalities. We conducted a meta-analysis assessing semantic space models as a diagnostic or prognostic tool in psychiatric or neurological disorders. Diagnostic test accuracy analyses revealed reasonable sensitivity and specificity and hi...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

From controlled to compulsive drug-taking: The role of the habenula in addiction
Publication date: Available online 21 June 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Victor Mathis, Paul J. KennyAbstractAddiction is now recognized as a neurobiological and cognitive brain disorder and is generally viewed as a switch from recreational or voluntary to compulsive substance use despite aversive consequences. The habenula, composed of medial (MHb) and lateral (LHb) domains, has been implicated in regulating behavioral flexibility and anxiety-related behaviors and is considered a core component of the brain “anti-reward” system. These functions position the habenula to influenc...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Why cognitive event-related potentials (ERPs) should have a role in the management of alcohol disorders
Publication date: Available online 21 June 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Salvatore Campanella, Elisa Schroder, Hendrik Kajosch, Xavier Noel, Charles KornreichAbstractAlcohol dependence is currently one of the most serious public health problems. Indeed, 3–8% of all deaths worldwide are attributable to effects of alcohol consumption. Although the first step in alcohol dependence treatment is straightforward, the main problem for clinicians lies with the prevention of relapse, as 40–70% of patients who only undergo psychosocial therapy resume alcohol use within a year following tr...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Role of Kynurenine Pathway and its Metabolites in Mood Disorders: A Systematic Review and Meta-Analysis of Clinical Studies
Publication date: Available online 22 June 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Danilo Arnone, Smita Saraykar, Haitham Salem, Antonio L. Teixeira, Robert Dantzer, Sudhakar SelvarajABSTRACTActivation of the kynurenine pathway is one of the described mechanisms by which inflammation can induce depression. It involves multiple pathways including interference with the bioavailability of tryptophan central to the synthesis of the neurotransmitter serotonin.In this systematic review, we examine the relationship between kynurenine metabolites (kynurenine, kynurenic acid, tryptophan, quinolinic acid, the ...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Overview of the clinical implementation of a study exploring social withdrawal in patients with schizophrenia and Alzheimer’s disease
Publication date: Available online 22 June 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Amy C. Bilderbeck, Brenda W.J.H. Penninx, Celso Arango, Nic van der Wee, René Kahn, Inge Winter-van Rossum, Anja Hayen, Martien J. Kas, Anke Post, Gerard R. DawsonABSTRACTTrans-diagnostic, domain- or symptom-focused approaches have been heralded as advancing psychiatric research, but relatively few clinical research programmes have been undertaken to leverage their potential. In this manuscript we describe the approach and protocol for an exploratory study, PRISM (Psychiatric Ratings using Intermediate Stratifie...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Executive Dysfunction in Parkinson’s Disease: A Meta-Analysis on the Wisconsin Card Sorting Test Literature
Publication date: Available online 23 June 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Florian Lange, Carolin Brückner, Aylin Knebel, Caroline Seer, Bruno KoppAbstractExecutive dysfunctions are a frequently described non-motor symptom in patients with Parkinson’s disease (PD). However, the nature, extent, variability, and determinants of executive dysfunctions in PD are still poorly understood. To improve the characterization of executive dysfunctions in PD, we conducted a meta-analysis of the studies administering the Wisconsin Card Sorting Test (WCST) to patients with PD and healthy controls...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Strategies for integrated analysis in imaging genetics studies
Publication date: Available online 23 June 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Natàlia Vilor-Tejedor, Silvia Alemany, Alejandro Cáceres, Mariona Bustamante, Jesús Pujol, Jordi Sunyer, Juan R. GonzálezAbstractImaging Genetics (IG) integrates neuroimaging and genomic data from the same individual, deepening our knowledge of the biological mechanisms behind neurodevelopmental domains and neurological disorders. Although the literature on IG has exponentially grown over the past years, the majority of studies have mainly analyzed associations between candidate brain region...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Working definitions, subjective and objective assessments and experimental paradigms in a study exploring social withdrawal in schizophrenia and Alzheimer’s disease
Publication date: Available online 24 June 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Nic. J.A. van der Wee, Amy C. Bilderbeck, Maria Cabello, Jose L. Ayuso-Mateos, Ilya M.J. Saris, Erik J. Giltay, Brenda WJH. Penninx, Celso Arango, Anke Post, Stefano PorcelliAbstractSocial withdrawal is one of the first and common signs of early social dysfunction in a number of important neuropsychiatric disorders, likely because of the enormous amount and complexity of brain processes required to initiate and maintain social relationships (Adolphs, 2009). The Psychiatric Ratings using Intermediate Stratified Markers ...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Neuropeptide modulation of addiction: Focus on galanin
Publication date: Available online 24 June 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Shannyn G. Genders, Karlene J. Scheller, Elvan DjoumaAbstractAddiction is a chronic, relapsing disorder characterised by the use of a substance or act to the point of compulsion. There are a number of medical treatments available for the intervention of these disorders, however, the effectiveness of current therapeutics is far from adequate. Neuropeptides are known to modulate addictive behaviours and may provide new therapeutic targets for the treatment of substance abuse. Accumulating evidence has suggested galanin a...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

A systematic review and meta-analysis of structural magnetic resonance imaging studies investigating cognitive and social activity levels in older adults
Publication date: Available online 27 June 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): M. Anatürk, N. Demnitz, K.P. Ebmeier, C.E. SextonAbstractPopulation aging has prompted considerable interest in identifying modifiable factors that may help protect the brain and its functions. Collectively, epidemiological studies show that leisure activities with high mental and social demands are linked with better cognition in old age. The extent to which socio-intellectual activities relate to the brain’s structure is, however, not yet fully understood. This systematic review and meta-analysis summarize...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Purinergic modulation of glutamate transmission: An expanding role in stress-linked neuropathology
Publication date: Available online 28 June 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): J. Mayhew, B.A. Graham, K. Biber, M. Nilsson, F.R. WalkerAbstractChronic stress has been extensively linked to disturbances in glutamatergic signalling. Emerging from this field of research is a considerable number of studies identifying the ability of purines at the pre-, post-, and peri-synaptic levels to tune glutamatergic neurotransmission. While the evidence describing purinergic control of glutamate has continued to grow, there has been relatively little attention given to how chronic stress modulates purinergic ...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

It's time: A commentary on fear extinction in the human brain using fMRI
Publication date: Available online 30 June 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Jayne Morriss, Shannon Hoare, Carien M. van ReekumAbstractThe recent meta-analysis by Fullana et al. (2018) is both timely and significant, providing a vital milestone towards understanding the neural networks involved in threat extinction in humans. Fullana et al. (2018) examined both threat extinction and recall separately using sophisticated meta-analytic methods based on raw contrast maps. Importantly, the meta-analysis highlighted a lack of consistent activation across studies for key neural “players” ...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Prenatal exposure to environmental insults and enhanced risk of developing Schizophrenia and Autism Spectrum Disorder: Focus on biological pathways and epigenetic mechanisms
Publication date: Available online 4 July 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Nadia Cattane, Juliet Richetto, Annamaria CattaneoaAbstractWhen considering neurodevelopmental disorders (NDDs), Schizophrenia (SZ) and Autism Spectrum Disorder (ASD) are considered to be among the most severe in term of prevalence, morbidity and impact on the society.Similar features and overlapping symptoms have been observed at multiple levels, suggesting common pathophysiological bases. Indeed, recent genome-wide association studies (GWAS) and epidemiological data report shared vulnerability genes and environmental ...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Food intake and addictive-like eating behaviors: time to think about the circadian clock(s)
Publication date: Available online 7 July 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Jorge MendozaAbstractCompulsive feeding has been considered as an addicted-like behavior with similarities to drug addiction. Food intake is brain controlled involving a balance between metabolic and hedonic pathways that modulate respectively how much and what is eaten. Pathological conditions such as compulsive feeding or an eating addiction can interfere with this balance and obesity may develop. Daily feeding times are also centrally controlled by the circadian clock in the suprachiasmatic nucleus. Disruptions of th...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Editorial Board
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Editorial: Jeffrey Glennon & Simone Macrì
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Understanding heterogeneity in conduct disorder: A review of psychophysiological studies
In conclusion, it might be important to redefine CD diagnostic criteria based on physiological heterogeneity to enable the identification of distinct subtypes of CD. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Psychiatric evaluation of youths with Disruptive Behavior Disorders and psychopathic traits: A critical review of assessment measures
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): Gabriele Masi, Annarita Milone, Paola Brovedani, Simone Pisano, Pietro MuratoriAbstractDisruptive Behavior Disorders (DBDs) are stable and impairing disorders, heterogeneous in presentation, developmental pathways, and treatment needs. Disentangling subtypes according to psychopathological dimensions is helpful for timely diagnoses, precise prognoses and tailored interventions. Psychopathic traits are relevant in subtyping DBDs with severe antisocial and aggressive behaviors. Three psychopathy dimensions have been found: 1) a...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Mapping the developmental pathways of child conduct problems through the neurobiology of empathy
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): Caroline Moul, David J. Hawes, Mark R. DaddsAbstractThe notion that antisocial behavior reflects failures of empathy has a long history in the clinical literature, yet only recently has evidence emerged to support neuroscientific accounts of empathy and the development of child conduct problems. Much of this evidence has come from research into callous-unemotional traits, which correspond to the affective component of psychopathy and therefore encompass deficits in empathy within a broader cluster of emotional impairments. In...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Clock genes, ADHD and aggression
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): Floriana Mogavero, Amanda Jager, Jeffrey C. GlennonAbstractAttention deficit/hyperactivity disorder (ADHD) is frequently associated with comorbid aggression and sleep disturbances. The sleep/wake cycle is under the control of the circadian system which is moderated by clock genes. Clock genes can regulate the transcription of monoamine oxidase A, which is involved in the degradation of monoamines. Disturbances in monoamine interaction with clock genes in those with monoamine gene polymorphisms may regulate susceptibility of A...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Neuro-cognitive system dysfunction and symptom sets: A review of fMRI studies in youth with conduct problems
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): R.J.R. Blair, K. Veroude, J.K. BuitelaarAbstractIn this paper, we review fMRI work on neuro-cognitive systems that are considered to be dysfunctional in individuals with conduct problems (i.e., individuals with Conduct Disorder (CD), Oppositional Defiant Disorder (ODD) or antisocial behavior without formal clinical diagnosis). These are: empathy, the acute threat response, reinforcement-based decision-making, response inhibition and the Default Mode Network. Evidence regarding the Default Mode Network is somewhat inconsistent...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Genetic influences on conduct disorder
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): Jessica E. Salvatore, Danielle M. DickAbstractConduct disorder (CD) is a moderately heritable psychiatric disorder of childhood and adolescence characterized by aggression toward people and animals, destruction of property, deceitfulness or theft, and serious violation of rules. Genome-wide scans using linkage and association methods have identified a number of suggestive genomic regions that are pending replication. A small number of candidate genes (e.g., GABRA2, MAOA, SLC6A4, AVPR1A) are associated with CD related phenotyp...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Can laboratory animals violate behavioural norms? Towards a preclinical model of conduct disorder
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): Simone Macrì, Francesca Zoratto, Flavia Chiarotti, Giovanni LaviolaAbstractConduct disorder (CD), a disturbance characterised by excess rates of aggression – often associated with callousness, lack of empathy and shallow/deficient affect – is extremely prevalent (2–10%) in the juvenile population. CD symptoms are quantitative rather than qualitative in nature whereby, rather than exhibiting abnormal behaviours, CD patients indulge in normal behaviours at abnormal rates. Although genetic and environmen...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Preclinical models of conduct disorder – principles and pharmacologic perspectives
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): Jozsef HallerAbstractThe translational value of preclinical research was recently enhanced by abnormal aggression models, which focus on deviant behaviors induced by the exposure of rodents to etiological factors of aggression-related psychopathologies. Prompted by similar trials in other psychiatric disorders, here we investigate models of abnormal aggression from the perspective of DSM5 criteria. After proposing principles based on which analogies can be established between psychopathology symptoms and rodent behavioral dys...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Towards an animal model of callousness
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): Julen Hernandez-Lallement, Marijn van Wingerden, Tobias KalenscherAbstractCallous-unemotional traits – the insensitivity to other’s welfare and well-being – are characterized by a lack of empathy. They are characteristic of psychopathy and can be found in other anti-social disorders, such as conduct disorder. Because of the increasing prevalence of anti-social disorders and the rising societal costs of violence and aggression, it is of great importance to elucidate the psychological and physiological mechani...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Behavioral and mechanistic insight into rodent empathy
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): Sivaani Sivaselvachandran, Erinn L. Acland, Salsabil Abdallah, Loren J. MartinAbstractEmpathy is a psychological construct that allows individuals to understand and share the emotions of others. The ability to share emotional states relies on basic social mechanisms, such as mimicry and emotional contagion, which are considered building blocks for empathy. Mimicking another’s emotional or physical state is essential for successful social interactions and is found in a number of animal species. For the current review we ...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

The link between aberrant hypothalamic–pituitary–adrenal axis activity during development and the emergence of aggression—Animal studies
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): Sophie E. Walker, Aurélie Papilloud, Damien Huzard, Carmen SandiAbstractAggressive behavior is not uniform, including proactive and reactive forms of aggression. Aberrant functioning of the hypothalamic–pituitary–adrenal (HPA) axis is frequently associated with abnormal aggression. Here, we review the rodent literature in order to assess whether developmental abnormalities in the HPA axis can be causally linked with the emergence of abnormal aggression. We examine studies that involve genetic models and lif...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Association of trauma, Posttraumatic Stress Disorder and Conduct Disorder: A systematic review and meta-analysis
ConclusionsStudies focusing on the association of trauma, PTSD and CD are still relatively rare. Possible comorbidity models are discussed considering psychological and biological risk factors in a comprehensive model. The high rate of PTSD in CD may be due to shared risk factors; furthermore, CD might increase the risk for comorbid PTSD due to CD inherent risk taking behavior. To study pathways of risk, especially longitudinal studies are necessary. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Antisocial behaviour and psychopathy: Uncovering the externalizing link in the P3 modulation
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): Rita Pasion, Carina Fernandes, Mariana R. Pereira, Fernando BarbosaAbstractIn 2009, Gao and Raine's meta-analysis analysed P3 modulation over the antisocial spectrum. However, some questions remained open regarding the P3 modulation patterns across impulsive and violent manifestations of antisocial behaviour, phenotypic components of psychopathy, and P3 components. A systematic review of 36 studies was conducted (N = 3514) to extend previous results and to address these unresolved questions. A clear link between dec...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

The impact of chronic stress during adolescence on the development of aggressive behavior: A systematic review on the role of the dopaminergic system in rodents
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): Jorim J Tielbeek, Zeineb Al-Itejawi, Josjan Zijlmans, Tinca JC Polderman, Joshua W Buckholtz, Arne PopmaAbstractPathological aggression, frequently observed in psychiatric patients and criminal subjects, poses a major burden on the health care and criminal justice system, necessitating better aetiological models to inform targets for prevention and intervention. Emerging evidence suggests that adverse experiences during development can cause long-lasting brain alterations associated with maladaptive behaviors, such as aggress...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Aggressive behavior in transgenic animal models: A systematic review
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): Amanda Jager, Dorien A. Maas, Kim Fricke, Rob B. de Vries, Geert Poelmans, Jeffrey C. GlennonAbstractAggressive behavior is often core or comorbid to psychiatric and neurodegenerative disorders. Transgenic animal models are commonly used to study the neurobiological mechanisms underlying aggressive phenotypes and have led to new insights into aggression. This systematic review critically evaluates the available literature on transgenic animal models tested for aggression with the resident-intruder test. By combining the avail...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

The pharmacological treatment of aggression in children and adolescents with conduct disorder. Do callous—unemotional traits modulate the efficacy of medication?
ConclusionConsidering heterogeneity of the disorder, more proof-of-concept clinical studies are needed to define effects of medication and role of CU traits. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Gene x environment interactions in conduct disorder: Implications for future treatments
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): Nathalie E. Holz, Katrin Zohsel, Manfred Laucht, Tobias Banaschewski, Sarah Hohmann, Daniel BrandeisAbstractConduct disorder (CD) causes high financial and social costs, not only in affected families but across society, with only moderately effective treatments so far. There is consensus that CD is likely caused by the convergence of many different factors, including genetic and adverse environmental factors. There is ample evidence of gene-environment interactions in the etiology of CD on a behavioral level regarding genetic...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Classification and treatment of antisocial individuals: From behavior to biocognition
Publication date: August 2018Source: Neuroscience & Biobehavioral Reviews, Volume 91Author(s): I.A. Brazil, J.D.M. van Dongen, J.H.R. Maes, R.B. Mars, A.R. Baskin-SommersAbstractAntisocial behavior is a heterogeneous construct that can be divided into subtypes, such as antisocial personality and psychopathy. The adverse consequences of antisocial behavior produce great burden for the perpetrators, victims, family members, and for society at-large. The pervasiveness of antisocial behavior highlights the importance of precisely characterizing subtypes of antisocial individuals and identifying specific factors that are et...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Childhood aggression: A synthesis of reviews and meta-analyses to reveal patterns and opportunities for prevention and intervention strategies
This study provides a synthesis of meta-analyses and systematic reviews on non-pharmacological treatments for childhood aggression. Treatments referred to universal prevention, selective prevention, indicated prevention, or intervention (Mrazek and Haggerty, 1994). Seventy-two meta-analyses and systematic reviews met the inclusion criteria. We describe their characteristics, effect sizes across types of treatments, and the effects of various moderators. For universal and selective prevention, effects were mostly absent or small; for indicated prevention and interventions, effects were mostly small or medium. Only two moder...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Common social cognitive impairments do not mean common causes: A commentary on Cotter et al. (2018)
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): David Dodell-Feder, Laura T. GermineAbstractMany clinical conditions, ranging from psychiatric to neurodegenerative illnesses, are associated with impairments in the processes by which we perceive, interpret, and respond to social information; a suite of abilities known as social cognition. Through a systematic review of meta-analyses, Cotter et al. (2018) present a compelling view of social cognitive deficits as a core phenotype of many clinical conditions. However, we caution against one potential interpretation of their...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Prostheses as extensions of the body: Progress and challenges
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): Maria Niedernhuber, Damiano G. Barone, Bigna LenggenhagerAbstractRecent years have seen a surge of interest in the incorporation of artificial limbs. This research promises to provide individuals with sensorimotor disorders such as amputations with prostheses which feel like their own body part. While neuroscience made a leap towards uncovering the basic neurocognitive mechanisms of bodily self-consciousness, the development of incorporated prosthetic limbs still faces substantial challenges in basic neuroscience and in cl...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

A review of brain insulin signaling in mood disorders: From biomarker to clinical target
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): Thanh Thanh L. Nguyen, Lily C. Chan, Kristin Borreginne, Rajas P. Kale, Chunling Hu, Susannah J. TyeAbstractPatients with mood disorders are at increased risk for metabolic dysfunction. Co-occurrence of the two conditions is typically associated with a more severe disease course and poorer treatment outcomes. The specific pathophysiological mechanisms underlying this bidirectional relationship between mood and metabolic dysfunction remains poorly understood. However, it is likely that impairment of metabolic processes with...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Attention deficit/hyperactivity-disorder and obesity: A review and model of current hypotheses explaining their comorbidity
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): Tomasz Hanć, Samuele CorteseAbstractAvailable meta-analyses point to a significant association between attention-deficit/hyperactivity disorder (ADHD) and obesity. The possible mechanisms underlying this relationship are unclear. Here, we overview the studies aimed at identifying the factors contributing to the comorbidity between ADHD and obesity, including genetic factors, fetal programming, executive dysfunctions, psychosocial stress, factors directly related to energy balance, and sleep patterns alterations. The bulk ...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

TPH2 polymorphisms across the spectrum of psychiatric morbidity: A systematic review and meta-analysis
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): Koen Willem Ottenhof, Mari Sild, Mélissa Luce Lévesque, Henricus Gerardus Ruhé, Linda BooijAbstractTryptophan hydroxylase 2 (TPH2) is the rate-limiting enzyme in brain serotonin synthesis. The TPH2 gene has frequently been investigated in relation to psychiatric morbidity. The aim of the present review is to integrate results from association studies between TPH2 single nucleotide polymorphisms (SNPs) and various psychiatric disorders, which we furthermore quantified with meta-analysis.We reviewed 166 ...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

An update on contextual fear memory mechanisms: Transition between Amygdala and Hippocampus
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): Nicholas Chaaya, Andrew R. Battle, Luke R. JohnsonAbstractContext is an ever-present combination of discrete environmental elements capable of influencing many psychological processes. When context is associated with an aversive stimulus, a permanent contextual fear memory is formed. Context is hypothesized to greatly influence the treatability of various fear-based pathologies, in particular, post-traumatic stress disorder (PTSD). In order to understand how contextual fear memories are encoded and impact underlying fear p...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Current perspectives on the cerebellum and reading development
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): Travis A. Alvarez, Julie A. FiezAbstractThe dominant neural models of typical and atypical reading focus on the cerebral cortex. However, Nicolson et al. (2001) proposed a model, the cerebellar deficit hypothesis, in which the cerebellum plays an important role in reading. To evaluate the evidence in support of this model, we qualitatively review the current literature and employ meta-analytic tools examining patterns of functional connectivity between the cerebellum and the cerebral reading network. We find evidence for a...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

A new outlook on cholinergic interneurons in Parkinson’s disease and L-DOPA-induced dyskinesia
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): Melissa M. Conti, Nicole Chambers, Christopher BishopAbstractTraditionally, dopamine (DA) and acetylcholine (ACh) striatal systems were considered antagonistic and imbalances or aberrant signaling between these neurotransmitter systems could be detrimental to basal ganglia activity and pursuant motor function, such as in Parkinson’s disease (PD) and L-DOPA-induced dyskinesia (LID). Herein, we discuss the involvement of cholinergic interneurons (ChIs) in striatally-mediated movement in a healthy, parkinsonian, and dys...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Antenatal ultrasound value in risk calculation for Autism Spectrum Disorder: A systematic review to support future research
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): Francesca Fulceri, Andrea Guzzetta, Argyro Athanasiadou, Laura Iaconianni, Maria Luisa ScattoniAbstractThere is a growing research interest on the antenatal features of children with neurodevelopmental disorders. Indeed, it has been proved that the neurodevelopment is, at least partly, affected by processes occurring in fetal life and that the early neurodevelopmental disorders identification is essential to optimize long-term outcomes.This systematic review aims to summarize findings on antenatal ultrasound data, which ar...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

The relationship between diffusion tensor imaging findings and cognitive outcomes following adult traumatic brain injury: A meta-analysis
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): E.J. Wallace, J.L. Mathias, L. WardAbstractCognitive impairments are common following a traumatic brain injury (TBI) and frequently result from white matter (WM) damage. This damage can be quantified using diffusion tensor imaging (DTI), which measures the directionality (fractional anisotropy: FA) and amount (mean diffusivity/apparent diffusion coefficient: MD/ADC) of water diffusion in WM, with high FA and low MD/ADC thought to indicate greater WM integrity. However, the relationship between DTI and cognitive outcomes is...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

The cingulum bundle: Anatomy, function, and dysfunction
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): Emma J. Bubb, Claudia Metzler-Baddeley, John P. AggletonAbstractThe cingulum bundle is a prominent white matter tract that interconnects frontal, parietal, and medial temporal sites, while also linking subcortical nuclei to the cingulate gyrus. Despite its apparent continuity, the cingulum’s composition continually changes as fibres join and leave the bundle. To help understand its complex structure, this review begins with detailed, comparative descriptions of the multiple connections comprising the cingulum bundle....
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Mechanisms of cortisol – Substance use development associations: Hypothesis generation through gene enrichment analysis
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): Kristine Marceau, Emily A. AbelAbstractThere are many theories about the mechanisms of associations between hypothalamic-pituitary-adrenal (HPA) function (indexed by cortisol) and substance use. However, the potential for genes that contribute to both HPA function and substance use to confound the association (e.g., genetic confounding) has largely been ignored. We explore the potential role of genetics in cortisol-substance use associations, build a conceptual framework placing theories and mechanisms for how cortisol and...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Understanding individual variability in symptoms and recovery following mTBI: A role for TMS-EEG?
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): Hannah L. Coyle, Jennie Ponsford, Kate E. HoyAbstractThe pathophysiology associated with mild traumatic brain injury (mTBI) includes neurometabolic and cytoskeletal changes that have been shown to impair structural and functional connectivity. Evidence that persistent neuropsychological impairments post injury are linked to structural and functional connectivity changes is increasing. However, to date the relationship between connectivity changes, heterogeneity of persistent symptoms and recovery post mTBI has been poorly ...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

The neural circuitry of restricted repetitive behavior: Magnetic resonance imaging in neurodevelopmental disorders and animal models
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): B.J. Wilkes, M.H. LewisAbstractRestricted, repetitive behaviors (RRBs) are patterns of behavior that exhibit little variation in form and have no obvious function. RRBs although transdiagonstic are a particularly prominent feature of certain neurodevelopmental disorders, yet relatively little is known about the neural circuitry of RRBs. Past work in this area has focused on isolated brain regions and neurotransmitter systems, but implementing a neural circuit approach has the potential to greatly improve understanding of R...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research