Growing out of attention deficit hyperactivity disorder: insights from the ‘remitted’ brain
Publication date: Available online 5 September 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Gustavo Sudre, Aman Mangalmurti, Philip ShawAbstractWe consider developmental and cognitive models to explain why some children ‘grow out’ of attention deficit hyperactivity disorder (ADHD) by adulthood. The first model views remission as a convergence towards more typical brain function and structure. In support, some studies find that adult remitters are indistinguishable from those who were never affected in the neural substrates of 'top-down' mechanisms of cognitive control, some 'bottom-up' process...
Source: Neuroscience and Biobehavioral Reviews - September 6, 2018 Category: Neuroscience Source Type: research

Cognitive-motor interference during gait in patients with multiple sclerosis: a mixed methods systematic review
ConclusionsCMI should be assessed in MS with a standardised dual task such as the Verbal Fluency task while walking, with measurements of the double support time and the effect on the cognitive task. The clinical usefulness of CMI in the assessment of patients with MS is discussed. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - September 4, 2018 Category: Neuroscience Source Type: research

Non-pharmacological factors that determine drug use and addiction
Publication date: Available online 1 September 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Serge H. Ahmed, Aldo Badiani, Klaus A. Miczek, Christian P. MüllerAbstractBased on their pharmacological properties, psychoactive drugs are supposed to take control of the natural reward system to finally drive compulsory drug seeking and consumption. However, psychoactive drugs are not used in an arbitrary way as pure pharmacological reinforcement would suggest, but rather in a highly specific manner depending on non-pharmacological factors. While pharmacological effects of psychoactive drugs are well studied...
Source: Neuroscience and Biobehavioral Reviews - September 3, 2018 Category: Neuroscience Source Type: research

Glucocorticoid receptor gene (NR3C1) DNA methylation in association with trauma, psychopathology, transcript expression, or genotypic variation: A systematic review
Publication date: Available online 31 August 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Oliver J. Watkeys, Kyle Kremerskothen, Yann Quidé, Janice M. Fullerton, Melissa J. GreenAbstractThe glucocorticoid receptor gene (NR3C1) is a critical component of the stress response system. Cytosine methylation of NR3C1 has been repeatedly associated with trauma and mental disorders, including major depression, post-traumatic stress disorder, anxiety, and personality disorders, suggesting that NR3C1 methylation may play a role in stress-related psychopathology. We systematically reviewed 55 studies examining...
Source: Neuroscience and Biobehavioral Reviews - September 1, 2018 Category: Neuroscience Source Type: research

The impact of early life stress on the central oxytocin system and susceptibility for drug addiction: applicability of oxytocin as a pharmacotherapy
Publication date: Available online 30 August 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Sarah J. Baracz, Nicholas A. Everett, Jennifer L. CornishAbstractEarly life trauma is strongly associated with an increased vulnerability to abuse illicit drugs and the impairment of neural development. This includes alterations to the development of the oxytocin system, which plays a pivotal role in the regulation of social behaviours and emotion. Dysregulation of this important system also contributes to increased susceptibility to develop drug addiction. In this review, we provide an overview of the animal models ...
Source: Neuroscience and Biobehavioral Reviews - August 31, 2018 Category: Neuroscience Source Type: research

Intelligence and Uncertainty: Implications of Hierarchical Predictive Processing for the Neuroscience of Cognitive Ability
Publication date: Available online 25 August 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Matthew J. EulerAbstractHierarchical predictive processing (PP) has recently emerged as a candidate theoretical paradigm for neurobehavioral research. To date, PP has found support through its success in offering compelling explanations for a number of perceptual, cognitive, and psychiatric phenomena, as well as from accumulating neurophysiological evidence. However, its implications for understanding intelligence and its neural basis have received relatively little attention. The present review outlines the key tene...
Source: Neuroscience and Biobehavioral Reviews - August 26, 2018 Category: Neuroscience Source Type: research

Amygdala and oxytocin functioning as keys to understanding and treating autism: Commentary on an RDoC based approach
Publication date: Available online 24 August 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Katrin Preckel, Philipp KanskeAbstractThe recent review by Hennessey, Andari and Rainnie (2018) utilizes the proposed Research Domain Criteria (RDoC) to classify amygdala functions and relate them to autism symptomatology. This approach has the potential to challenge the overarching autism diagnosis by furthering our knowledge of the mechanisms giving rise to autism psychopathology and generate novel treatment options. The purpose of this commentary is to provide additional information on a number of points raised in...
Source: Neuroscience and Biobehavioral Reviews - August 25, 2018 Category: Neuroscience Source Type: research

Low on Energy? An energy supply-demand perspective on stress and depression
Publication date: Available online 23 August 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Leif Østergaard, Martin Balslev Jørgensen, Gitte Moos KnudsenAbstractAre energy demands too high, or our energy resources either too low or inappropriately prioritized, as we develop stress and/or depression? We review evidence of dysregulated cellular energy homeostasis and energy depletion in stress and depression, identifying factors that might limit energy substrate availability. Resetting of cellular energy-sensors, splanchnic hypoxia, and catecholamine effects on blood viscosity emerge as mechanis...
Source: Neuroscience and Biobehavioral Reviews - August 24, 2018 Category: Neuroscience Source Type: research

A Systematic Review of Task-Based Functional Neuroimaging Studies Investigating Language, Semantic and Executive Processes in Thought Disorder
Publication date: Available online 22 August 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Philip J. Sumner, Imogen H. Bell, Susan L. RossellAbstractThe aim of the current systematic review was to synthesise the research that has investigated thought disorder (TD) using task-based functional neuroimaging techniques to target executive, language, or semantic functions. Thirty-seven pertinent studies were identified from January 1990 to August 2016. Functional correlates of TD included the superior and middle temporal, fusiform, and inferior frontal gyri bilaterally, as well as the left and right cingulate c...
Source: Neuroscience and Biobehavioral Reviews - August 24, 2018 Category: Neuroscience Source Type: research

Meta-Analysis of Cognitive Ability Differences by Apolipoprotein E Genotype in Young Humans
Publication date: Available online 17 August 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Gali H. Weissberger, Daniel A. Nation, Caroline P. Nguyen, Mark W. Bondi, S. Duke HanAbstractThe apolipoprotein (APOE) ε4 allele has been proposed as an example of an antagonistic pleiotropy gene, conferring a beneficial effect on cognition in early life and a detrimental impact on cognition during later years. However, findings on the cognitive associations of the ε4 allele in younger persons are mixed. This PRISMA conforming study aimed to investigate APOE genotype (e4/non-e4) associations across se...
Source: Neuroscience and Biobehavioral Reviews - August 18, 2018 Category: Neuroscience Source Type: research

Balancing between the two: are freezing of gait and postural instability in Parkinson’s disease connected?
Publication date: Available online 17 August 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): E.M.J. Bekkers, B.W. Dijkstra, E. Heremans, S.M.P. Verschueren, B.R. Bloem, A. NieuwboerABSTRACTPostural instability and freezing of gait (FoG) are key features of Parkinson’s disease (PD) closely related to falls. Growing evidence suggests that co-existing postural deficits could influence the occurrence and severity of FoG. To date, the exact nature of this interrelationship remains largely unknown. We analyzed the complex interaction between postural instability and gait disturbance by comparing the findings...
Source: Neuroscience and Biobehavioral Reviews - August 17, 2018 Category: Neuroscience Source Type: research

“Pure apathy” and cognitive dysfunctions in Parkinson’s disease: A meta-analytic study
Publication date: Available online 13 August 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Alfonsina D’Iorio, Gianpaolo Maggi, Carmine Vitale, Luigi Trojano, Gabriella SantangeloAbstractParkinson’s Disease (PD) is characterized by motor and non-motor symptoms such as cognitive deficit and behavioural disturbances. Apathy seems to be related to cognitive impairment, but some studies failed to confirm the relationship due to different methodological procedures across studies. A meta-analysis on 8 studies was performed to explore the cognitive correlates of apathy without depression and dementia (...
Source: Neuroscience and Biobehavioral Reviews - August 14, 2018 Category: Neuroscience Source Type: research

The PRISM Project: Social Withdrawal from an RDoC Perspective
Publication date: Available online 11 August 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Bruce N. CuthbertAbstractThe PRISM (Psychiatric Ratings using Intermediate Stratified Markers) project was funded under the auspices of the European Union Innovative Medicine Initiative (EU-IMI) to explore quantitative approaches to the biological and behavioral aspects of neuropsychiatric disorders. PRISM focuses specifically on social withdrawal, although its principles are applicable to a wide range of disorders. This commentary explores some of the major aspects of the PRISM design from the perspective of the Res...
Source: Neuroscience and Biobehavioral Reviews - August 11, 2018 Category: Neuroscience Source Type: research

Editorial Board
Publication date: October 2018Source: Neuroscience & Biobehavioral Reviews, Volume 93Author(s): (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - August 10, 2018 Category: Neuroscience Source Type: research

Advanced Biomarkers of Pediatric Mild Traumatic Brain Injury: Progress and Perils
Publication date: Available online 9 August 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Andrew R. Mayer, Mayank Kaushal, Andrew B. Dodd, Faith M. Hanlon, Nicholas A. Shaff, Rebekah Mannix, Christina L. Master, John J. Leddy, David Stephenson, Christopher J. Wertz, Elizabeth M. Suelzer, Kristy B. Arbogast, Timothy B. MeierAbstractThere is growing public concern about neurodegenerative changes (e.g., Chronic Traumatic Encephalopathy) that may occur chronically following clinically apparent and clinically silent (i.e., subconcussive blows) pediatric mild traumatic brain injury (pmTBI). However, there are cu...
Source: Neuroscience and Biobehavioral Reviews - August 10, 2018 Category: Neuroscience Source Type: research

Neural Correlates of Action: Comparing Meta-Analyses of Imagery, Observation, and Execution
Publication date: Available online 9 August 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Robert M. Hardwick, Svenja Caspers, Simon B Eickhoff, Stephan P SwinnenAbstractSeveral models propose Motor Imagery, Action Observation, and Movement Execution recruit the same brain regions. There is, however, no quantitative synthesis of the literature that directly compares their respective networks. Here we summarized data from neuroimaging experiments examining Motor Imagery (303 experiments, 4,902 participants), Action Observation (595 experiments, 11,032 participants), and related control tasks involving Moveme...
Source: Neuroscience and Biobehavioral Reviews - August 10, 2018 Category: Neuroscience Source Type: research

Adhering to best practice guidelines in outcomes measurement
Publication date: Available online 4 August 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): David Morley, Crispin Jenkinson (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - August 5, 2018 Category: Neuroscience Source Type: research

Cerebral correlates of Imitation of Intransitive Gestures: An Integrative Review of Neuroimaging Data and Brain Lesion Studies
Publication date: Available online 4 August 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Mathieu Lesourd, François Osiurak, Josselin Baumard, Angela Bartolo, Tim Vanbellingen, Emanuelle ReynaudAbstractThe aim of the present review is to investigate the cerebral correlates, more particularly the role of the parietal lobe, when imitating intransitive gestures, a task highly sensitive to apraxic errors. By providing an integrative review of functional imaging and brain lesion studies, we focused our attention on the meaning of gestures (meaningful and meaningless) and the body parts (finger and hand)....
Source: Neuroscience and Biobehavioral Reviews - August 5, 2018 Category: Neuroscience Source Type: research

Editorial Board
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - August 3, 2018 Category: Neuroscience Source Type: research

Systematic review of Drosophila short-term-memory genetics: Meta-analysis reveals robust reproducibility
Publication date: Available online 2 August 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Tayfun Tumkaya, Stanislav Ott, Adam Claridge-ChangAbstractGeneticists use olfactory conditioning in Drosophila to identify learning genes; however, little is known about how these genes are integrated into short-term memory (STM) pathways. Here, we investigated the hypothesis that the STM evidence base is weak. We performed systematic review and meta-analysis of the field. Using metrics to quantify variation between discovery articles and follow-up studies, we found that seven genes were both highly replicated, and hi...
Source: Neuroscience and Biobehavioral Reviews - August 3, 2018 Category: Neuroscience Source Type: research

Ketogenic diet as a metabolic therapy for mood disorders: evidence and developments
Publication date: Available online 31 July 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Elisa Brietzke, Rodrigo B. Mansur, Mehala Subramaniapillai, Vicent Balanzá Martinez, Maj Vinberg, Ana González-Pinto, Joshua D. Rosenblat, Roger Ho, Roger S. McIntyreABSTRACTDespite significant advances in pharmacological and non-pharmacological treatments, mood disorders remain a significant source of mental capital loss, with high rates of treatment resistance, requiring a coordinated effort in investigation and development of efficient, tolerable and accessible novel interventions. Ketogenic diet (KD) ...
Source: Neuroscience and Biobehavioral Reviews - August 1, 2018 Category: Neuroscience Source Type: research

Mind wandering perspective on attention-deficit/hyperactivity disorder
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): Natali S. Bozhilova, Giorgia Michelini, Jonna Kuntsi, Philip AshersonAbstractAttention-Deficit/Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder associated with a range of mental health, neurocognitive and functional problems. Although the diagnosis is based on descriptions of behaviour, individuals with ADHD characteristically describe excessive spontaneous mind wandering (MW). MW in individuals with ADHD reflects constant mental activity which lacks topic stability and content consistency. Based on th...
Source: Neuroscience and Biobehavioral Reviews - July 31, 2018 Category: Neuroscience Source Type: research

Hungry Brains: A Meta-Analytical Review of Brain Activation Imaging Studies On Food Perception and Appetite in Obese Individuals
Publication date: Available online 30 July 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): F. Devoto, L. Zapparoli, R. Bonandrini, M. Berlingeri, A. Ferrulli, L. Luzi, G. Banfi, E. PaulesuAbstractThe dysregulation of food intake in chronic obesity has been explained by different theories. To assess their explanatory power, we meta-analyzed 22 brain-activation imaging studies. We found that obese individuals exhibit hyper-responsivity of the brain regions involved in taste and reward for food-related stimuli. Consistent with a Reward Surfeit Hypothesis, obese individuals exhibit a ventral striatum hyper-respo...
Source: Neuroscience and Biobehavioral Reviews - July 31, 2018 Category: Neuroscience Source Type: research

The Role of Epigenetic Modifications in Neurodevelopmental Disorders: A Systematic Review
Publication date: Available online 29 July 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Lorenza Dall’Aglio, Taulant Muka, Charlotte A.M. Cecil, Wichor M. Bramer, Michael M.P.J. Verbiest, Jana Nano, Andrea Cortes Hidalgo, Oscar H. Franco, Henning TiemeierAbstractEpigenetic processes have been suggested as key mechanisms in the etiology of neurodevelopmental disorders. This systematic review summarizes the current evidence for an association between epigenetics and Autism Spectrum Disorder (ASD) and Attention/Deficit-Hyperactivity Disorder (ADHD). Six databases were searched until the 24th of October ...
Source: Neuroscience and Biobehavioral Reviews - July 30, 2018 Category: Neuroscience Source Type: research

Functional neuroanatomy of peripheral inflammatory physiology: A meta-analysis of human neuroimaging studies
Publication date: Available online 29 July 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Thomas E. Kraynak, Anna L. Marsland, Tor D. Wager, Peter J. GianarosAbstractCommunication between the brain and peripheral mediators of systemic inflammation is implicated in numerous psychological, behavioral, and physiological processes. Functional neuroimaging studies have identified brain regions that associate with peripheral inflammation in humans, yet there are open questions about the consistency, specificity, and network characteristics of these findings. The present systematic review provides a meta-analysis ...
Source: Neuroscience and Biobehavioral Reviews - July 30, 2018 Category: Neuroscience Source Type: research

Cannabis use and the development of tolerance: a systematic review of human evidence
Publication date: Available online 26 July 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Marco Colizzi, Sagnik BhattacharyyaAbstractPrevious studies have reported conflicting results in terms of acute effects of cannabis in man. Independently of other factors, such discrepancy may be attributable to the different cannabis use history of study volunteers. It is thought that regular cannabis users may develop tolerance to the effects of acute cannabis administration. Here we systematically review all studies examining the effects of single or repeated cannabinoid administration in man as a function of previo...
Source: Neuroscience and Biobehavioral Reviews - July 27, 2018 Category: Neuroscience Source Type: research

Where in the serotonergic system does it go wrong? Unravelling the route by which the serotonergic system affects feather pecking in chickens
Publication date: Available online 25 July 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Elske N. de Haas, Jerine A.J. van der EijkAbstractA deficient serotonergic system is associated with psychopathological behaviors in various species, among which, feather pecking (FP) in chickens. Deficiency in the serotonergic system can predispose birds to develop FP, while the serotonergic system has shown to be affected in birds that feather peck. Serotonin (5-HT) can further influence dopamine (DA) activity. Lines with high FP tendency generally have low central 5-HT and DA turnovers at a young age, but high turno...
Source: Neuroscience and Biobehavioral Reviews - July 26, 2018 Category: Neuroscience Source Type: research

Vision dominates audition in adults but not children: A meta-analysis of the Colavita effect
Publication date: Available online 23 July 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Rebecca J. Hirst, Lucy Cragg, Harriet A. AllenAbstractThe Colavita effect occurs when participants respond only to the visual element of an audio-visual stimulus. This visual dominance effect is proposed to arise from asymmetric facilitation and inhibition between modalities. It has also been proposed that, unlike adults, children appear predisposed to auditory information. We provide the first quantitative synthesis of studies exploring the Colavita effect, combining data from 70 experiments across 14 studies. A mixed...
Source: Neuroscience and Biobehavioral Reviews - July 24, 2018 Category: Neuroscience Source Type: research

Behavioral Tagging: Plausible involvement of PKMζ, Arc and role of neurotransmitter receptor systems
Publication date: Available online 20 July 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Shruti Vishnoi, Mehar Naseem, Sheikh Raisuddin, Suhel ParvezAbstractThere are many evidences in support of Behavioral Tagging hypothesis that relies on the setting of a learning tag and the synthesis of plasticity related proteins (PRPs). It explains that how a learning tag produced as a result of weak training can be paired up with PRPs that arrive as a result of novelty and consequently lead to long lasting memories. In the following review we have focused on possible involvement of PKMζ, Arc as PRPs and neurotr...
Source: Neuroscience and Biobehavioral Reviews - July 21, 2018 Category: Neuroscience Source Type: research

Mind wandering perspective on ADHD
Publication date: Available online 20 July 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Natali Bozhilova, Giorgia Michelini, Jonna Kuntsi, Philip AshersonAbstractAttention-Deficit/Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder associated with a range of mental health, neurocognitive and functional problems. Although the diagnosis is based on descriptions of behaviour, individuals with ADHD characteristically describe excessive spontaneous mind wandering (MW). MW in individuals with ADHD reflects constant mental activity which lacks topic stability and content consistency. Based on t...
Source: Neuroscience and Biobehavioral Reviews - July 21, 2018 Category: Neuroscience Source Type: research

A touch-scaffolded model of human prosociality
Publication date: September 2018Source: Neuroscience & Biobehavioral Reviews, Volume 92Author(s): Jinlong Su, Yanjie SuAbstractFor centuries, scholars have been puzzled by the distinct human prosociality. A variety of explanations have been proposed to unveil the mystery of it and nearly all these explanations have focused on the role of complex cognitive processes. In this paper, we propose a novel hypothesis that human prosociality is touch-scaffolded. We argue that early tactile stimulation such as maternal touch serves as the basic component that enables the emergence of nascent human prosociality. During this proc...
Source: Neuroscience and Biobehavioral Reviews - July 20, 2018 Category: Neuroscience Source Type: research

Environmental stressors and alcoholism development: focus on molecular targets and their epigenetic regulation
Publication date: Available online 11 July 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Mariangela Pucci, Maria Vittoria Micioni Di Bonaventura, Aranza Wille-Bille, Macarena Soledad Fernández, Mauro Maccarrone, Ricardo Marcos Pautassi, Carlo Cifani, Claudio D’AddarioAbstractAlcohol exposure and stressful events in life can induce long-lasting changes in physiology, behavior and gene expression patterns, eventually facilitating the development of psychiatric diseases like alcohol use disorders (AUD). Epigenetic mechanisms have been recently proposed to play a role in the cellular actions of al...
Source: Neuroscience and Biobehavioral Reviews - July 12, 2018 Category: Neuroscience Source Type: research

Modulation of the endocannabinoid system by sex hormones: Implications for Posttraumatic Stress Disorder
Publication date: Available online 11 July 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Luke John Ney, Allison Matthews, Raimondo Bruno, Kim Louise FelminghamAbstractThe endocannabinoid system is an increasingly recognised pharmacological target for treating stress and anxiety disorders, including post-traumatic stress disorder (PTSD). Recent preclinical developments have implicated the endocannabinoid system in stress responses, emotional memories and fear extinction, all critical to PTSD aetiology. However, preclinical research in endocannabinoid biology has neglected the influential role of sex hormone...
Source: Neuroscience and Biobehavioral Reviews - July 12, 2018 Category: Neuroscience Source Type: research

Investigating the influence of social support on experimental pain and related physiological arousal: A systematic review and meta-analysis
In this study, a meta-analysis was conducted to characterise these effects. A total of 2416 studies were identified in a systematic search, among which 21 were eligible for the quantitative review. The mere presence of another person was not sufficient to modulate pain perception. However, stranger presence was identified to decrease pain-related arousal (SMD = -0.31), and the presence of a significant other increased facial expression of pain (SMD = 0.21). We further found verbal support to decrease pain (SMD = -0.69) and arousal (SMD = -0.99), and we demonstrated moderate to large analgesic effects of intimate relati...
Source: Neuroscience and Biobehavioral Reviews - July 11, 2018 Category: Neuroscience Source Type: research

Coordinate based meta-analysis does not show grey matter atrophy in narcolepsy
Publication date: Available online 5 November 2016Source: Neuroscience & Biobehavioral ReviewsAuthor(s): C.R. Tench, Radu Tanasescu, W.J. Cottam, C.S. Constantinescu, D.P. Auer (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Transfer of maternal psychosocial stress to the fetus
Publication date: Available online 22 February 2017Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Florian Rakers, Sven Rupprecht, Michelle Dreiling, Christoph Bergmeier, Otto W. Witte, Matthias SchwabAbstractPsychosocial maternal stress experienced during different vulnerable periods throughout gestation is thought to increase the individual’s risk to develop neuropsychiatric, cardiovascular and metabolic disease in later life. Cortisol has generally been identified as the major mediator of maternal stress transfer to the fetus. Its lipophilic nature allows a trans-placental passage and thus excessive mat...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Prenatal stress and epigenetics
Publication date: Available online 18 May 2017Source: Neuroscience & Biobehavioral ReviewsAuthor(s): L. Cao-Lei, S.R. de Rooij, S. King, S.G. Matthews, G.A.S. Metz, T.J. Roseboom, M. SzyfAbstractIn utero exposure to environmental stress in both animals and humans could result in long-term epigenome alterations which further lead to consequences for adaptation and development in the offspring. Epigenetics, especially DNA methylation, is considered one of the most widely studied and well-characterized mechanisms involved in the long-lasting effects of in utero stress exposure. In this review, we outlined evidence from an...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Experience-induced transgenerational (re-)programming of neuronal structure and functions: Impact of stress prior and during pregnancy
Publication date: Available online 29 May 2017Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Katharina Braun, Jörg Bock, Tamar Wainstock, Emmanuel Matas, Inna Gaisler-Salomon, Jörg Fegert, Ute Ziegenhain, Menahem SegalAbstractThis review focuses on the inter- and transgenerational effects of stress experience prior to and during gestation. We provide an overview of findings from studies in humans as well as in animal models on brain structural and physiological functions and on the development of cognitive and executive functions. We also discuss the concept of stress-induced (re-)programming in more ...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Prenatal developmental origins of behavior and mental health: The influence of maternal stress in pregnancy
Publication date: Available online 28 July 2017Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Bea R.H. Van den Bergh, Marion I. van den Heuvel, Marius Lahti, Marijke Braeken, Susanne R. de Rooij, Sonja Entringer, Dirk Hoyer, Tessa Roseboom, Katri Räikkönen, Suzanne King, Matthias SchwabAbstractAccumulating research shows that prenatal exposure to maternal stress increases the risk for behavioral and mental health problems later in life. This review systematically analyzes the available human studies to identify harmful stressors, vulnerable periods during pregnancy, specificities in the outcome and bi...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Transgenerational effects of early environmental insults on aging and disease incidence
Publication date: Available online 12 August 2017Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Mirela Ambeskovic, Tessa J. Roseboom, Gerlinde A.S. MetzAbstractAdverse early life experiences are major influences on developmental trajectories with potentially life-long consequences. Prenatal or early postnatal exposure to stress, undernutrition or environmental toxicants may reprogram brain development and increase risk of behavioural and neurological disorders later in life. Not only experience within a single lifetime, but also ancestral experience affects health trajectories and chances of successful aging. T...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Epigenetic regulation of motivated behaviors by histone deacetylase inhibitors
Publication date: Available online 8 October 2017Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Lindsay Elvir, Florian Duclot, Zuoxin Wang, Mohamed KabbajAbstractGrowing evidence has begun to elucidate the contribution of epigenetic mechanisms in the modulation and maintenance of gene expression and behavior. Histone acetylation is one such epigenetic mechanism, which has been shown to profoundly alter gene expression and behaviors. In this review, we begin with an overview of the major epigenetic mechanisms including histones acetylation. We next focus on recent evidence about the influence of environmental st...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Interpretation of published meta-analytical studies affected by implementation errors in the GingerALE software
Publication date: Available online 2 November 2017Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Jane R. Garrison, John Done, Jon S. Simons (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

A quantitative approach to neuropsychiatry: The why and the how
Publication date: Available online 12 December 2017Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Martien J. Kas, Brenda Penninx, Bernd Sommer, Alessandro Serretti, Celso Arango, Hugh MarstonAbstractThe current nosology of neuropsychiatric disorders allows for a pragmatic approach to treatment choice, regulation and clinical research. However, without a biological rationale for these disorders, drug development has stagnated. The recently EU-funded PRISM project aims to develop a quantitative biological approach to the understanding and classification of neuropsychiatric diseases to accelerate the discovery and...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Social withdrawal as psychopathology of mental disorders
Publication date: Available online 27 December 2017Source: Neuroscience & Biobehavioral ReviewsAuthor(s): William T. Carpenter (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Multisensory cortical processing and dysfunction across the neuropsychiatric spectrum
Publication date: Available online 26 February 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Betty E. Hornix, Robbert Havekes, Martien J.H. KasAbstractSensory processing is affected in multiple neuropsychiatric disorders like schizophrenia and autism spectrum disorders. Genetic and environmental factors guide the formation and fine-tuning of brain circuitry necessary to receive, organize, and respond to sensory input in order to behave in a meaningful and consistent manner. During certain developmental stages the brain is sensitive to intrinsic and external factors. For example, disturbed expression levels...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Factors influencing spatial frequency extraction in faces: A review
Publication date: Available online 9 March 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Coline Jeantet, Stéphanie Caharel, Raymund Schwan, Joëlle Lighezzolo-Alnot, Vincent LaprevoteAbstractJEANTET, C., Caharel, S., Schwan, R., Lighezzolo-Alnot, J., and Laprevote, V. Factors influencing spatial frequencies extraction in faces: a review. NEUROSCI BIOBEHAV REV XX(X) XXX-XXX, 2017.Spatial frequency is an elementary aspect of visual perception. Moreover, faces elicit distinct responses by the human visual system when compared to other visual objects. This review examines the factors influencing spa...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Working memory training mostly engages general-purpose large-scale networks for learning
Publication date: Available online 21 March 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Juha Salmi, Lars Nyberg, Matti LaineAbstractThe present meta-analytic study examined brain activation changes following working memory (WM) training, a form of cognitive training that has attracted considerable interest. Comparisons with perceptual-motor (PM) learning revealed that WM training engages domain-general large-scale networks for learning encompassing the dorsal attention and salience networks, sensory areas, and striatum. Also the dynamics of the training-induced brain activation changes within these netwo...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Central fatigue theory and endurance exercise: Toward an interoceptive model
Publication date: Available online 30 March 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Terry McMorris, Martin Barwood, Jo CorbettAbstractWe propose a model of exercise-induced central fatigue based on interoception and motivation. Predictions of the expected sensory feedback are fed forward by the dorsolateral (DL) prefrontal cortex (PFC) to the anterior insula cortex (AIC). During exercise, the AIC receives feedback from lamina Ⅰ lateral spinothalamic and nucleus tractus solitarii medullothalamic pathways. The feedback is compared to the predictions in order to generate a current awareness state, whi...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Animal models of binge drinking, current challenges to improve face validity
Publication date: Available online 5 May 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Jérôme Jeanblanc, Benjamin Rolland, Fabien Gierski, Margaret P. Martinetti, Mickael NaassilaAbstractBinge drinking (BD), i.e., consuming a large amount of alcohol in a short period of time, is an increasing public health issue. Though no clear definition has been adopted worldwide the speed of drinking seems to be a keystone of this behavior. Developing relevant animal models of BD is a priority for gaining a better characterization of the neurobiological and psychobiological mechanisms underlying this dange...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research

Non-invasive biomarkers of fetal brain development reflecting prenatal stress: An integrative multi-scale multi-species perspective on data collection and analysis
Publication date: Available online 30 May 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Martin G. Frasch, Silvia M. Lobmaier, Tamara Stampalija, Paula Desplats, María Eugenia Pallarés, Verónica Pastor, Marcela A. Brocco, Hau-tieng Wu, Jay Schulkin, Christophe L. Herry, Andrew J.E. Seely, Gerlinde A.S. Metz, Yoram Louzoun, Marta C. AntonelliAbstractPrenatal stress (PS) impacts early postnatal behavioural and cognitive development. This process of ‘fetal programming’ is mediated by the effects of the prenatal experience on the developing hypothalamic–pituitary–adr...
Source: Neuroscience and Biobehavioral Reviews - July 10, 2018 Category: Neuroscience Source Type: research