Neuroergonomics of car driving: A critical meta-analysis of neuroimaging data on the human brain behind the wheel
Publication date: Available online 25 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Jordan Navarro, François Osiurak, Emanuelle ReynaudAbstractCar driving, an everyday life activity, has been under the scope of investigation for long. Neurosciences and psychology have contributed to better understand the human processes engaged while driving, to such an extent that a meta-analysis of all available fMRI data is now possible to extract the most relevant information. Using the Activation Likelihood Estimation method, we therefore conducted such a meta-analysis on 9 studies, representing 27 neur...
Source: Neuroscience and Biobehavioral Reviews - October 26, 2018 Category: Neuroscience Source Type: research

A systematic review of Drosophila short-term-memory genetics: Meta-analysis reveals robust reproducibility
Publication date: December 2018Source: Neuroscience & Biobehavioral Reviews, Volume 95Author(s): Tayfun Tumkaya, Stanislav Ott, Adam Claridge-ChangAbstractGeneticists use olfactory conditioning in Drosophila to identify learning genes; however, little is known about how these genes are integrated into short-term memory (STM) pathways. Here, we investigated the hypothesis that the STM evidence base is weak. We performed systematic review and meta-analysis of the field. Using metrics to quantify variation between discovery articles and follow-up studies, we found that seven genes were both highly replicated, and highly r...
Source: Neuroscience and Biobehavioral Reviews - October 26, 2018 Category: Neuroscience Source Type: research

Overlaps and distinctions between attention deficit/hyperactivity disorder and autism spectrum disorder in young adulthood: Systematic review and guiding framework for EEG research
Publication date: Available online 24 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Alex Lau-Zhu, Anne Fritz, Gráinne McLoughlinAbstractAttention deficit/hyperactivity disorders (ADHD) and autism spectrum disorders (ASD) frequently co-occur. However, we know little about the neural basis of the overlaps and distinctions between these disorders, particularly in young adulthood – a critical time window for brain plasticity across executive and socioemotional domains. Here, we systematically review 75 articles investigating ADHD and ASD in young adult samples (mean ages 16 to 26) using co...
Source: Neuroscience and Biobehavioral Reviews - October 25, 2018 Category: Neuroscience Source Type: research

Hypothalamic-pituitary-adrenal axis and autonomic nervous system reactivity in children prenatally exposed to maternal depression: A systematic review of prospective studies
Publication date: Available online 23 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Laura S. Bleker, Lotte van Dammen, Mariska M.G. Leeflang, Jacqueline Limpens, Tessa J. Roseboom, Susanne R. de RooijAbstractDepression is a common condition affecting up to 20% of all pregnant women, and is associated with subsequent developmental and behavioral problems in children, such as conduct disorder and ADHD. One proposed mechanism underlying these associations is modification of the fetal hypothalamic pituitary adrenal (HPA)-axis and the autonomic nervous system (ANS), resulting in altered responses to str...
Source: Neuroscience and Biobehavioral Reviews - October 24, 2018 Category: Neuroscience Source Type: research

The hidden side of Parkinson’s disease: studying pain, anxiety and depression in animal models
Publication date: Available online 23 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Fanny Faivre, Anil Joshi, Erwan Bezard, Michel BarrotABSTRACTParkinson’s disease is a neurodegenerative disease leading to the loss of midbrain dopamine neurons. It is well known and characterized by motor symptoms that are secondary to the loss of dopamine innervation, but it is also accompanied by a range of various non-motor symptoms, including pain and psychiatric disorders such as anxiety and depression. These non-motor symptoms usually appear at early stages of the disease, sometimes even before the firs...
Source: Neuroscience and Biobehavioral Reviews - October 24, 2018 Category: Neuroscience Source Type: research

Cognitive training: a new avenue in gambling disorder management?
Discussion and perspectivesStudies assessing cognitive training in gambling disorder are being conducted and first results should be upcoming. Methodological challenges have been identified. Several candidate target cognitive functions of training programs are being investigated, relying on the most documented impairments in gambling disorder, inhibition, reward sensitivity and decision making. Gambling-specific or neutral environments are to be distinguished clearly and do not rely on similar assumptions, i.e. general vulnerability or vulnerability expressed only in the specific context of gambling. Proper control groups ...
Source: Neuroscience and Biobehavioral Reviews - October 23, 2018 Category: Neuroscience Source Type: research

Motion adaptation and attention: A critical review and meta-analysis
Publication date: Available online 22 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Laura Bartlett, Erich W. Graf, Nicholas Hedger, Wendy J. AdamsAbstractThe motion aftereffect (MAE) provides a behavioural probe into the mechanisms underlying motion perception, and has been used to study the effects of attention on motion processing. Visual attention can enhance detection and discrimination of selected visual signals. However, the relationship between attention and motion processing remains contentious: not all studies find that attention increases MAEs. Our meta-analysis reveals several factors th...
Source: Neuroscience and Biobehavioral Reviews - October 23, 2018 Category: Neuroscience Source Type: research

Facets of impulsivity and alcohol use: What role do emotions play?
Publication date: Available online 19 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Aleksandra M. Herman, Theodora DukaAbstractAlcohol misuse is a major public concern. Impulsivity has been recognised as a significant risk factor predisposing for the initiation of alcohol use, continuation and excessive alcohol use. Evidence suggests that impulsivity is also a result of both acute alcohol intoxication and long-term alcohol abuse. The multifaceted character of impulsivity and the various ways of assessing it in humans and animal models, hampers the full understanding of how impulsivity relates to al...
Source: Neuroscience and Biobehavioral Reviews - October 20, 2018 Category: Neuroscience Source Type: research

Using rodents to model abnormal sensitivity to feedback in depression
Publication date: Available online 19 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Rafal Rygula, Karolina Noworyta-Sokolowska, Robert Drozd, Anna KozubAbstractDepressive disorder accounts for a substantial proportion of psychiatric problems across the globe and has a devastating impact on quality of life and occupational function. Psychological models of depression emphasize the causal role of cognitive distortions in this disease, and cognitive problems have been included in the diagnostic criteria for depressive episodes. Here, we focus on recent progress in preclinical modelling of aberrations ...
Source: Neuroscience and Biobehavioral Reviews - October 20, 2018 Category: Neuroscience Source Type: research

Role of pharmacokinetic and pharmacodynamic parameters in neuroadaptations induced by drugs of abuse, with a focus on opioids and psychostimulants
Publication date: Available online 16 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Nicolas Marie, Corinne Canestrelli, Florence NobleAbstractThe purpose of this review is to illustrate the importance of pharmacodynamic and pharmacokinetic factors in the complexity of the behavioral and neurochemical adaptations that occur following chronic treatments with drugs of abuse, with a focus on opioids and psychostimulants. As these neuroadaptations are thought to contribute to the pathogenesis and persistence of addiction, it is important to well understand how they can be modulated. The experimental res...
Source: Neuroscience and Biobehavioral Reviews - October 17, 2018 Category: Neuroscience Source Type: research

A large-scale integrative analysis of GWAS and common meQTLs across whole life course identifies genes, pathways and tissue/cell types for three major psychiatric disorders
Publication date: Available online 16 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Yan Zhao, Xiao Liang, Feng Zhu, Yan Wen, Jiawen Xu, Jian Yang, Miao Ding, Bolun Cheng, Mei Ma, Lu Zhang, Shiqiang Cheng, Cuiyan Wu, Sen Wang, Xi Wang, Yujie Ning, Xiong Guo, Feng ZhangAbstractAttention deficit hyperactivity disorder (ADHD), bipolar disorder (BP) and schizophrenia (SCZ) are complex psychiatric disorders. We conducted a large-scale integrative analysis of genome-wide association studies (GWAS) and life course consistent methylation quantitative trait loci (meQTLs) datasets. The GWAS data of ADHD (incl...
Source: Neuroscience and Biobehavioral Reviews - October 17, 2018 Category: Neuroscience Source Type: research

Hugs and kisses – the role of motor preferences and emotional lateralization for hemispheric asymmetries in human social touch
Publication date: Available online 16 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Sebastian Ocklenburg, Julian Packheiser, Judith Schmitz, Noemi Rook, Onur Güntürkün, Jutta Peterburs, Gina M GrimshawAbstractSocial touch is an important aspect of human social interaction - across all cultures, humans engage in kissing, cradling and embracing. These behaviors are necessarily asymmetric, but the factors that determine their lateralization are not well-understood. Because the hands are often involved in social touch, motor preferences may give rise to asymmetric behavior. However, soci...
Source: Neuroscience and Biobehavioral Reviews - October 17, 2018 Category: Neuroscience Source Type: research

Cortisol and alpha-amylase assessment in psychotherapeutic intervention studies: A systematic review
Publication date: Available online 11 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Sebastian Laufer, Sinha Engel, Christine Knaevelsrud, Sarah SchumacherAbstractDysregulations of the hypothalamus-pituitary-adrenal (HPA) axis and the autonomic nervous system (ANS) as parts of the stress response system have been associated with development and maintenance of various mental disorders. It has been suggested that these alterations might normalize in the course of psychotherapy. We conducted a comprehensive review of psychotherapeutic intervention effects on HPA axis and ANS regulation in adult samples...
Source: Neuroscience and Biobehavioral Reviews - October 12, 2018 Category: Neuroscience Source Type: research

Neural substrates of Internally-Based and Externally-Cued Timing: an activation likelihood estimation (ALE) meta-analysis of fMRI studies
Publication date: Available online 11 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Alice Teghil, Maddalena Boccia, Fabrizia D’Antonio, Antonella Di Vita, Carlo de Lena, Cecilia GuarigliaAbstractA dynamic interplay exists between Internally-Based (IBT) and Externally-Cued (ECT) time processing. While IBT processes support the self-generation of context-independent temporal representations, ECT mechanisms allow constructing temporal representations primarily derived from the structure of the sensory environment. We performed an activation likelihood estimation (ALE) meta-analysis on 177 fMRI e...
Source: Neuroscience and Biobehavioral Reviews - October 12, 2018 Category: Neuroscience Source Type: research

Disturbances of sleep quality, timing and structure and their relationship with other neuropsychiatric symptoms in Alzheimer’s disease and schizophrenia: insights from studies in patient populations and animal models
Publication date: Available online 9 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Raphaelle Winsky-Sommerer, Paula de Oliveira, Sally Loomis, Keith Wafford, Derk-Jan Dijk, Gary GilmourAbstractThe high prevalence of sleep disturbance in neurodegenerative and psychiatric conditions is often interpreted as evidence for both sleep’s sensitivity to and causal involvement in brain pathology. Nevertheless, how and which aspects of sleep contribute to brain function remains largely unknown. This review provides a critical evaluation of clinical and animal literature describing sleep and circadian di...
Source: Neuroscience and Biobehavioral Reviews - October 11, 2018 Category: Neuroscience Source Type: research

Commentary on: E. H. Toomarian and E. M. Hubbard (2018), On the genesis of spatial-numerical associations: Evolutionary and cultural factors co-construct the mental number line
Publication date: Available online 9 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Samuel Shaki, Martin H. Fischer (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - October 9, 2018 Category: Neuroscience Source Type: research

Animal models in addiction research: A dimensional approach
Publication date: Available online 8 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Steven J. Lamontagne, Mary C. OlmsteadAbstractDrug addiction affects approximately 10% of the population and these numbers are rising. Treatment and prevention of addiction are impeded by current diagnostic systems, such as DSM-5, which are based on outcomes rather than processes. Here, we review the importance of adopting a dimensional framework, specifically the Research Domain Criteria (RDoC), to identify protective and vulnerability mechanisms in addiction. We discuss how preclinical researchers should work withi...
Source: Neuroscience and Biobehavioral Reviews - October 8, 2018 Category: Neuroscience Source Type: research

A regulatory view on novel methodologies and context of use of biomarkers
Publication date: Available online 24 September 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): M.B. Tome, M.T. Isaac (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - October 7, 2018 Category: Neuroscience Source Type: research

The aversive brain system of teleosts: Implications for neuroscience and biological psychiatry
Publication date: Available online 6 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Rhayra Xavier do Carmo Silva, Monica Gomes Lima-Maximino, Caio MaximinoAbstractDefensive behavior is a function of specific survival circuits, the “aversive brain system”, that are thought to be conserved across vertebrates, and involve threat detection and the organization of defensive responses to reduce or eliminate threat. In mammals, these circuits involve amygdalar and hypothalamic subnuclei and midbrain circuits. The increased interest in teleost fishes as model organisms in neuroscience created a ...
Source: Neuroscience and Biobehavioral Reviews - October 7, 2018 Category: Neuroscience Source Type: research

Editorial Board
Publication date: November 2018Source: Neuroscience & Biobehavioral Reviews, Volume 94Author(s): (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - October 7, 2018 Category: Neuroscience Source Type: research

“A regulatory view on novel methodologies and context of use of biomarkers”
Publication date: Available online 24 September 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): M.B. Tome, M.T. Isaac (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - October 4, 2018 Category: Neuroscience Source Type: research

The role of the hippocampal theta rhythm in non-spatial discrimination and associative learning task
Publication date: Available online 25 September 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Yuya Sakimoto, Shogo SakataAbstractThe configural association theory and the conflict resolution model propose that hippocampal function is involved in learning negative patterning tasks (A+, B+, AB− ). The first theory suggests a critical role of the hippocampus in the formation of configural representations of compound stimuli, in which stimuli A and B are presented simultaneously. The second theory hypothesizes that the hippocampus is important for inhibiting the response to a stimulus that is in conflict...
Source: Neuroscience and Biobehavioral Reviews - October 4, 2018 Category: Neuroscience Source Type: research

Metabolism and adult neurogenesis: towards an understanding of the role of lipocalin-2 and iron-related oxidative stress
Publication date: Available online 26 September 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Ana Catarina Ferreira, Nuno Sousa, João M. Bessa, João Carlos Sousa, Fernanda MarquesAbstractThe process of generating new functional neurons in the adult mammalian brain occurs from the local neural stem and progenitor cells and requires tight control of the progenitor cell’s activity. Several signaling pathways and intrinsic/extrinsic factors have been well studied over the last years, but recent attention has been given to the critical role of cellular metabolism in determining the functiona...
Source: Neuroscience and Biobehavioral Reviews - October 4, 2018 Category: Neuroscience Source Type: research

Insights from perceptual, sensory, and motor functioning in autism and cerebellar primary disturbances: Are there reliable markers for these disorders?
Publication date: Available online 27 September 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Luca Casartelli, Marco Riva, Laura Villa, Renato BorgattiAbstractThe contribution of cerebellar circuitry alterations in the pathophysiology of Autism Spectrum Disorder (ASD) has been widely investigated in the last decades. Yet, experimental studies on neurocognitive markers of ASD have not been attentively compared with similar studies in patients with cerebellar primary disturbances (e.g., malformations, agenesis, degeneration, etc). Addressing this neglected issue could be useful to underline unexpected areas ...
Source: Neuroscience and Biobehavioral Reviews - October 4, 2018 Category: Neuroscience Source Type: research

Systematic review of co-occurring OCD and TD: evidence for a tic-related OCD subtype?
ConclusionsSeveral specific features are reliable associated with co-occurring OCD + TD. The field lacks methodological sound studies. The review found evidence against and in favor for different hypotheses regarding the nature of comorbidity of OCD and TD. This could indicate the existence of a stepwise model of co-morbidity, or could be an artefact of the low methodological quality of studies. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - October 4, 2018 Category: Neuroscience Source Type: research

G protein-coupled receptor heteromers are key players in substance use disorder
We report changes at the molecular and cellular levels that establish specific functional impact and highlight behavioral outcome in preclinical models. Finally, we briefly discuss selective targeting of native heteromers as an innovative therapeutic option. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - October 4, 2018 Category: Neuroscience Source Type: research

Social Touch During Development: Long-Term Effects on Brain and Behavior
Publication date: Available online 29 September 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): K.L. Bales, L.R. Witczak, T.C. Simmons, L.E. Savidge, E.S. Rothwell, F.D. Rogers, R.A. Manning, M.J. Heise, M. Englund, R. Arias del RazoAbstractIn this paper, our goal is to explore what is known about the role of social touch during development. We first address the neural substrates of social touch and the role of tactile experience in neural development. We discuss natural variation in early exposure to social touch, followed by a discussion on experimental manipulations of social touch during development and ...
Source: Neuroscience and Biobehavioral Reviews - October 4, 2018 Category: Neuroscience Source Type: research

Healthy play, better coping: The importance of play for the development of children in health and disease
Publication date: Available online 29 September 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Sanne L. Nijhof, Christiaan H. Vinkers, Stefan M. van Geelen, Sasja N. Duijff, E.J. Marijke Achterberg, Janjaap van der Net, Remco C. Veltkamp, Martha A. Grootenhuis, Elise M. van de Putte, Manon H.J. Hillegers, Anneke W. van der Brug, Corette J. Wierenga, Manon J.N.L. Benders, Rutger C.M.E. Engels, C. Kors van der Ent, Louk J.M.J. Vanderschuren, Heidi M.B. LesscherAbstractPlay is of vital importance for the healthy development of children. From a developmental perspective, play offers ample physical, emotional, c...
Source: Neuroscience and Biobehavioral Reviews - October 4, 2018 Category: Neuroscience Source Type: research

Meta-analyses of the neural mechanisms and predictors of response to psychotherapy in depression and anxiety
Publication date: Available online 29 September 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Lindsey Marwood, Toby Wise, Adam M. Perkins, Anthony J. CleareAbstractUnderstanding the neural mechanisms underlying psychological therapy could aid understanding of recovery processes and help target treatments. The dual-process model hypothesises that psychological therapy is associated with increased emotional-regulation in prefrontal brain regions and decreased implicit emotional-reactivity in limbic regions; however, research has yielded inconsistent findings. Meta-analyses of brain activity changes accompany...
Source: Neuroscience and Biobehavioral Reviews - October 4, 2018 Category: Neuroscience Source Type: research

Audiovisual Multisensory Integration in Individuals with Autism Spectrum Disorder: A Systematic Review and Meta-Analysis
Publication date: Available online 1 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Jacob I. Feldman, Kacie Dunham, Margaret Cassidy, Mark T. Wallace, Yupeng Liu, Tiffany G. WoynaroskiAbstractAn ever-growing literature has aimed to determine how individuals with autism spectrum disorder (ASD) differ from their typically developing (TD) peers on measures of multisensory integration (MSI) and to ascertain the degree to which differences in MSI are associated with the broad range of symptoms associated with ASD. Findings, however, have been highly variable across the studies carried out to date. The pr...
Source: Neuroscience and Biobehavioral Reviews - October 4, 2018 Category: Neuroscience Source Type: research

The Effects of Exercise on Cognition and Gait in Parkinson’s disease: A Scoping Review
Publication date: Available online 3 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Brittany Intzandt, Eric N. Beck, Carolina R.A. SilveiraAbstractCognitive and gait deficits are two debilitating symptoms that occur in Parkinson’s disease (PD). Importantly, a relationship between cognitive and gait deficits exists in PD, suggesting reliance on cognition is increased to compensate for gait deficits and/or deterioration of cognition and gait may share common mechanisms. Rehabilitation strategies targeting one factor could lead to the improvement of the other, presenting a unique opportunity to t...
Source: Neuroscience and Biobehavioral Reviews - October 4, 2018 Category: Neuroscience Source Type: research

Neuromodulation for substance addiction in human subjects: A review
Publication date: December 2018Source: Neuroscience & Biobehavioral Reviews, Volume 95Author(s): Ausaf Bari, Jasmine DeCisare, Diana Babayan, Mariama Runcie, Hiro Sparks, Bayard WilsonAbstractSubstance abuse is one of the most prevalent and costly health problems in the world today. Standard medical therapy is often not curative, and relapse is common. Research over the past several decades on the neural underpinnings of addiction has implicated a network of structures within the brain shown to be altered in patients with substance abuse. The field of neuromodulation aims to utilize this knowledge to treat dysfunctiona...
Source: Neuroscience and Biobehavioral Reviews - October 4, 2018 Category: Neuroscience Source Type: research

Social brain, social dysfunction and social withdrawal
Publication date: Available online 20 September 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Stefano Porcelli, Nic Van Der Wee, Steven van der Werff, Moji Aghajani, Jeffrey C. Glennon, Sabrina van Heukelum, Floriana Mogavero, Antonio Lobo, Francisco Javier Olivera, Elena Lobo, Mar Posadas, Juergen Dukart, Rouba Kozak, Estibaliz Arce, Arfan Ikram, Jacob Vorstman, Amy Bilderbeck, Ilja Saris, Martien J. Kas, Alessandro SerrettiAbstractThe human social brain is complex. Current knowledge fails to define the neurobiological processes underlying social behaviour involving the (patho-) physiological mechanisms t...
Source: Neuroscience and Biobehavioral Reviews - September 21, 2018 Category: Neuroscience Source Type: research

Intranasal Oxytocin and OXTR Genotype Effects on Resting State Functional Connectivity: A Systematic Review
DiscussionIN-OT appears to modulate resting state functional connectivity in a manner similar to its effects on task fMRI, consistent with hypothesized models of IN-OT. However, conclusions are limited by the narrow range of neuroanatomical seed regions, and methodological and experimental design heterogeneity. Future studies should take into account individual differences. Findings may provide insight into mechanisms through which IN-OT impacts human behavior. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - September 21, 2018 Category: Neuroscience Source Type: research

Dopamine and opioid systems adaptation in alcoholism revisited: Convergent evidence from positron emission tomography and postmortem studies
Publication date: Available online 19 September 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Anita C. Hansson, Gerhard Gründer, Natalie Hirth, Hamid R. Noori, Rainer Spanagel, Wolfgang H. SommerAbstractA major hypothesis in the addiction field suggests deficits in dopamine signaling during abstinence as a driving mechanism for the relapsing course of the disorder. Paradoxically, blockade of mu-opioid receptors (MORs) intended to suppress dopamine release and alcohol reward is a widely used treatment for preventing relapse in alcohol use disorder (AUD). To elucidate this apparent discrepancy, we syste...
Source: Neuroscience and Biobehavioral Reviews - September 21, 2018 Category: Neuroscience Source Type: research

Motor dysfunction as research domain across bipolar, obsessive-compulsive and neurodevelopmental disorders
Publication date: Available online 17 September 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Dusan Hirjak, Andreas Meyer-Lindenberg, Stefan Fritze, Fabio Sambataro, Katharina M. Kubera, Robert C. WolfAbstractAlthough genuine motor abnormalities (GMA) are frequently found in schizophrenia, they are also considered as an intrinsic feature of bipolar, obsessive-compulsive, and neurodevelopmental disorders with early onset such as autism, ADHD, and Tourette syndrome. Such transnosological observations strongly suggest a common neural pathophysiology. This systematic review highlights the evidence on GMA and t...
Source: Neuroscience and Biobehavioral Reviews - September 18, 2018 Category: Neuroscience Source Type: research

Neural coding: A single neuron’s perspective
Publication date: Available online 15 September 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Alireza Azarfar, Niccoló Calcini, Chao Huang, Fleur Zeldenrust, Tansu CelikelAbstractWhat any sensory neuron knows about the world is one of the cardinal questions in Neuroscience. Information from the sensory periphery travels across synaptically coupled neurons as each neuron encodes information by varying the rate and timing of its action potentials (spikes). Spatiotemporally correlated changes in this spiking regimen across neuronal populations are the neural basis of sensory representations. In the som...
Source: Neuroscience and Biobehavioral Reviews - September 17, 2018 Category: Neuroscience Source Type: research

Addiction and Stress: An Allostatic View
Publication date: Available online 15 September 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): George F. Koob, Jay SchulkinAbstractAllostasis, or stability through change, has most often been linked with challenges to homeostasis, in which repeated challenges or stressors produce sufficient allostatic load to generate an allostatic state that can ultimately lead to a disease state. The present review argues that the impact of stress on drug addiction fits with an allostatic model and represents a challenge to brain circuit regulatory mechanisms that underlie the emotional state of the animal. The central th...
Source: Neuroscience and Biobehavioral Reviews - September 17, 2018 Category: Neuroscience Source Type: research

New synthetic opioids: Part of a new addiction landscape
Publication date: Available online 12 September 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Laurent Karila, Maude Marillier, Boris Chaumette, Joel Billieux, Franchitto Nicolas, Benyamina AmineAbstractSynthetic opioids (SO) are a major risk for public health across the world. These drugs can be divided into 2 categories, pharmaceutical and non-pharmaceutical fentanyls. A new generation of SO has emerged on the drug market since 2010. North America is currently facing an opioid epidemic of morbi-mortality, caused by over-prescription of opioids, illegally diverted prescribed medicines, the increasing use o...
Source: Neuroscience and Biobehavioral Reviews - September 12, 2018 Category: Neuroscience Source Type: research

Biomarker correlates of psychotherapy outcomes in borderline personality disorder: A systematic review
Publication date: Available online 9 September 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Ely M. Marceau, Denise Meuldijk, Michelle L. Townsend, Nadia Solowij, Brin F.S. GrenyerAbstractStudies of neurobiological mechanisms in borderline personality disorder (BPD) have increased our understanding of the pathophysiology of its development and course. Less is known about how psychotherapy may influence these neurobiological factors, and also whether biomarkers may predict psychotherapy outcomes. We conducted a systematic review using PRISMA guidelines. Fourteen studies providing data from 467 participants ...
Source: Neuroscience and Biobehavioral Reviews - September 10, 2018 Category: Neuroscience Source Type: research

Neuroepigenetics and addictive behaviors: where do we stand?
Publication date: Available online 8 September 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): David de Sa Nogueira, Karine Merienne, Katia BefortAbstractSubstance use disorders involve long-term changes in the brain that lead to compulsive drug seeking, craving, and a high probability of relapse. Recent findings have highlighted the role of epigenetic regulations in controlling chromatin access and regulation of gene expression following exposure to drugs of abuse. In the present review, we focus on data investigating genome-wide epigenetic modifications in the brain of addicted patients or in rodent models...
Source: Neuroscience and Biobehavioral Reviews - September 9, 2018 Category: Neuroscience Source Type: research

Adolescence as a neurobiological critical period for the development of higher-order cognition
Publication date: Available online 7 September 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Bart Larsen, Beatriz LunaAbstractThe transition from adolescence to adulthood is characterized by improvements in higher-order cognitive abilities and corresponding refinements of the structure and function of the brain regions that support them. Whereas the neurobiological mechanisms that govern early development of sensory systems are well-understood, the mechanisms that drive developmental plasticity of association cortices, such as prefrontal cortex (PFC), during adolescence remain to be explained. In this revi...
Source: Neuroscience and Biobehavioral Reviews - September 8, 2018 Category: Neuroscience Source Type: research

Effects of early life stress on biochemical indicators of the dopaminergic system: a 3 level meta-analysis of rodent studies
Publication date: Available online 7 September 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): V. Bonapersona, M. Joëls, R.A. SarabdjitsinghAbstractAdverse early life events are a well-established risk factor for the precipitation of behavioral disorders characterized by anomalies in the dopaminergic system, such as schizophrenia and addiction. The correlation between early life conditions and the dopaminergic system has been causally investigated in more than 90 rodent publications. Here, we tested the validity of the hypothesis that early life stress (ELS) alters dopamine signaling by performing an ex...
Source: Neuroscience and Biobehavioral Reviews - September 8, 2018 Category: Neuroscience Source Type: research

The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation
Publication date: Available online 7 September 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Larissa N. Dooley, Kate R. Kuhlman, Theodore F. Robles, Naomi I. Eisenberger, Michelle G. Craske, Julienne E. BowerAbstractA wealth of evidence has implicated inflammation in the development of depression. Yet, the heterogeneous nature of depression has impeded efforts to understand, prevent, and treat the disease. The purpose of this integrative review is to summarize the connections between inflammation and established core features of depression that exhibit more homogeneity than the syndrome itself: exaggerated...
Source: Neuroscience and Biobehavioral Reviews - September 8, 2018 Category: Neuroscience Source Type: research

Electrophysiological Assessment Methodology of Sensory Processing Dysfunction in Schizophrenia and Dementia of the Alzheimer Type
This article describes aspects of a research project whose aim is to delineate the neurobiology that may underlie Social Withdrawal in Alzheimer’s disease, Schizophrenia and Major Depression. This is a European-funded IMI 2 project, identified as PRISM (Psychiatric Ratings using Intermediate Stratified Markers). This paper focuses specifically on the selected electrophysiological paradigms chosen based on a comprehensive review of all relevant literature and practical constraints. The choice of the electrophysiological biomarkers were fundamentality based their metrics and capacity to discriminate between populations...
Source: Neuroscience and Biobehavioral Reviews - September 7, 2018 Category: Neuroscience Source Type: research

Targeting the gut microbiota to influence brain development and function in early life
Publication date: Available online 6 September 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Shugui Wang, Louise Harvey, Rocio Martin, Eline M. van der Beek, Jan Knol, John Cryan, Ingrid B. RenesAbstractIn the first 2 – 3 years of life, the gut microbiota of infants quickly becomes diverse and rich. Disruptions in the evolving gut microbiota during this critical developmental period can impact brain development. Communication between the microbiota, gut and brain is driven by hormonal and neural regulation, as well as immune and metabolic pathways, however, our understanding of how the parallel devel...
Source: Neuroscience and Biobehavioral Reviews - September 7, 2018 Category: Neuroscience Source Type: research

Growing out of attention deficit hyperactivity disorder: insights from the ‘remitted’ brain
Publication date: Available online 5 September 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Gustavo Sudre, Aman Mangalmurti, Philip ShawAbstractWe consider developmental and cognitive models to explain why some children ‘grow out’ of attention deficit hyperactivity disorder (ADHD) by adulthood. The first model views remission as a convergence towards more typical brain function and structure. In support, some studies find that adult remitters are indistinguishable from those who were never affected in the neural substrates of 'top-down' mechanisms of cognitive control, some 'bottom-up' process...
Source: Neuroscience and Biobehavioral Reviews - September 6, 2018 Category: Neuroscience Source Type: research

Cognitive-motor interference during gait in patients with multiple sclerosis: a mixed methods systematic review
ConclusionsCMI should be assessed in MS with a standardised dual task such as the Verbal Fluency task while walking, with measurements of the double support time and the effect on the cognitive task. The clinical usefulness of CMI in the assessment of patients with MS is discussed. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - September 4, 2018 Category: Neuroscience Source Type: research

Non-pharmacological factors that determine drug use and addiction
Publication date: Available online 1 September 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Serge H. Ahmed, Aldo Badiani, Klaus A. Miczek, Christian P. MüllerAbstractBased on their pharmacological properties, psychoactive drugs are supposed to take control of the natural reward system to finally drive compulsory drug seeking and consumption. However, psychoactive drugs are not used in an arbitrary way as pure pharmacological reinforcement would suggest, but rather in a highly specific manner depending on non-pharmacological factors. While pharmacological effects of psychoactive drugs are well studied...
Source: Neuroscience and Biobehavioral Reviews - September 3, 2018 Category: Neuroscience Source Type: research

Glucocorticoid receptor gene (NR3C1) DNA methylation in association with trauma, psychopathology, transcript expression, or genotypic variation: A systematic review
Publication date: Available online 31 August 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Oliver J. Watkeys, Kyle Kremerskothen, Yann Quidé, Janice M. Fullerton, Melissa J. GreenAbstractThe glucocorticoid receptor gene (NR3C1) is a critical component of the stress response system. Cytosine methylation of NR3C1 has been repeatedly associated with trauma and mental disorders, including major depression, post-traumatic stress disorder, anxiety, and personality disorders, suggesting that NR3C1 methylation may play a role in stress-related psychopathology. We systematically reviewed 55 studies examining...
Source: Neuroscience and Biobehavioral Reviews - September 1, 2018 Category: Neuroscience Source Type: research