Characterizing vulnerable brain areas and circuits in mouse models of autism: Towards understanding pathogenesis and new therapeutic approaches
Publication date: Available online 22 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Kelvin Hui, Yuta Katayama, Keiichi I. Nakayama, Jun Nomura, Takeshi SakuraiAbstractRecent human genetics studies have identified many genetic variants that may be responsible for autism spectrum disorder (ASD). ASD mouse models with genetic modifications mimicking these rare genetic variants have provided invaluable mechanistic insights into the disruption of various biological processes and brain areas/circuitry affected in ASD patients. In this review, we begin by reviewing several mouse models for ASD-associated...
Source: Neuroscience and Biobehavioral Reviews - November 23, 2018 Category: Neuroscience Source Type: research

Polymorphisms in genes related to the hypothalamic-pituitary-adrenal axis and antidepressant response – systematic review
ConclusionsReplication studies and additional investigations exploring gene x environment and drug x environment interactions are necessary before pharmacological treatments may be adjusted based on a patient’s genetic profile. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - November 21, 2018 Category: Neuroscience Source Type: research

Corrigendumto “Transcranial magnetic stimulation in basic and clinical neuroscience: A comprehensive review of fundamental principles and novel insights” [Neurosci. Biobehav. Rev. 83 (2017) 381–404]
Publication date: Available online 19 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Antoni Valero-Cabré, Julià L. Amengual, Chloé Stengel, Alvaro Pascual-Leone, Olivier A. Coubard (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - November 21, 2018 Category: Neuroscience Source Type: research

Systems Biology and Gene Networks in Alzheimer's Disease
Publication date: Available online 20 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Zuo-Teng Wang, Chen-Chen Tan, Lan Tan, Jin-Tai YuAbstractGene mining has been a fruitful approach in the study of Alzheimer’s disease (AD). As a new starting point for studying AD, genetic and genomic investigations consistently strive to discover causative variants that are related to disease pathophysiology. Currently, genetic and genomic approaches have identified numerous loci. However, the elaboration of AD mechanism lagged behind gene discovery. The extensive use of parallel, high-throughput, next-gener...
Source: Neuroscience and Biobehavioral Reviews - November 21, 2018 Category: Neuroscience Source Type: research

Neuroimaging of chronic MDMA (“ecstasy”) effects: A meta-analysis
Publication date: January 2019Source: Neuroscience & Biobehavioral Reviews, Volume 96Author(s): Felix Müller, Raphael Brändle, Matthias E. Liechti, Stefan BorgwardtAbstractIn this meta-analysis, we aimed to assess the evidence from neuroimaging studies for chronic alterations in the brains of MDMA users. The databases PubMed, Embase, and Web of Science were searched for studies published from inception to August 24, 2018, without any language restriction. Sixteen independent studies comprising 356 MDMA users and 311 controls were included. Of these, five studies investigated frontal and occipital N-acetylaspa...
Source: Neuroscience and Biobehavioral Reviews - November 19, 2018 Category: Neuroscience Source Type: research

Anxious brain networks: a coordinate-based activation likelihood estimation meta-analysis of resting-state functional connectivity studies in anxiety
Publication date: Available online 17 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Jie Xu, Nicholas T. Van Dam, Chunliang Feng, Yuejia Luo, Hui Ai, Ruolei Gu, Pengfei XuAbstractAnxiety and anxiety disorders are associated with specific alterations to functional brain networks, including intra-networks and inter-networks. Given the heterogeneity within anxiety disorders and inconsistencies in functional network differences across studies, identifying common patterns of altered brain networks in anxiety is imperative. Here, we conducted an activation likelihood estimation meta-analysis of resting-s...
Source: Neuroscience and Biobehavioral Reviews - November 17, 2018 Category: Neuroscience Source Type: research

Neuroimaging of chronic MDMA (“ecstasy”) effects: A meta-analysis of the literature
Publication date: Available online 12 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Felix Müller, Raphael Brändle, Matthias E. Liechti, Stefan BorgwardtAbstractIn this meta-analysis, we aimed to assess the evidence from neuroimaging studies for chronic alterations in the brains of MDMA users. The databases PubMed, Embase, and Web of Science were searched for studies published from inception to August 24, 2018, without any language restriction. Sixteen independent studies comprising 356 MDMA users and 311 controls were included. Of these, five studies investigated frontal and occipital N-...
Source: Neuroscience and Biobehavioral Reviews - November 14, 2018 Category: Neuroscience Source Type: research

Emotional control, reappraised
Publication date: Available online 6 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Saskia B.J. Koch, Rogier B. Mars, Ivan Toni, Karin RoelofsAbstractWe are frequently challenged with situations requiring the control of our emotions, often under substantial time-pressure and rapidly changing contextual demands. Coping with those demands requires the ability to flexibly and rapidly switch between different emotional control strategies. However, this ability has been largely neglected by current neurocognitive models on emotional control. Drawing on the decision-making literature, we propose that rap...
Source: Neuroscience and Biobehavioral Reviews - November 7, 2018 Category: Neuroscience Source Type: research

Attachment style: the neurobiological substrate, interaction with genetics and role in neurodevelopmental disorders risk pathways
Publication date: Available online 6 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Linda A. Antonucci, Paolo Taurisano, Gabrielle Coppola, Rosalinda CassibbaAbstractLiterature has suggested that attachment insecurity has been previously associated with subsequent onset of several psychiatric conditions characterized by emotion dysregulation. Nevertheless, only few studies have investigated the neurobiological basis of attachment style and whether attachment insecurity may share a common neurobiological substrate with neurodevelopmental disorders. In this narrative contribution, we aimed to review ...
Source: Neuroscience and Biobehavioral Reviews - November 7, 2018 Category: Neuroscience Source Type: research

Empathy is not in our genes
Publication date: Available online 3 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Cecilia HeyesAbstractIn academic and public life empathy is seen as a fundamental force of morality – a psychological phenomenon, rooted in biology, with profound effects in law, policy, and international relations. But the roots of empathy are not as firm as we like to think. The matching mechanism that distinguishes empathy from compassion, envy, schadenfreude, and sadism is a product of learning. Here I present a dual system model that distinguishes Empathy1, an automatic process that catches the feelings o...
Source: Neuroscience and Biobehavioral Reviews - November 4, 2018 Category: Neuroscience Source Type: research

Relating constructs of attention and working memory to social withdrawal in Alzheimer’s disease and schizophrenia: issues regarding paradigm selection
Publication date: Available online 3 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Gary Gilmour, Stefano Porcelli, Valérie Bertaina-Anglade, Estibaliz Arce, Juergen Dukart, Anja Hayen, Antonio Lobo, Raul Lopez Anton, Emilio Merlo Pich, Darrel J. Pemberton, Martha N. Havenith, Jeffrey Glennon, Brian Harel, Gerard Dawson, Hugh Marston, Rouba Kozak, Alessandro SerrettiAbstractCentral nervous system diseases are not currently diagnosed based on knowledge of biological mechanisms underlying their symptoms. Greater understanding may be offered through an agnostic approach to traditional disease c...
Source: Neuroscience and Biobehavioral Reviews - November 4, 2018 Category: Neuroscience Source Type: research

Motor output, neural states and auditory perception
Publication date: Available online 2 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Daniel Reznik, Roy MukamelAbstractBehavior is a complex product of interactions between sensory influx arising from the environment and the neural state of the organism. Therefore, identical sensory input can elicit different behavioral responses in different contexts. Research in recent years has demonstrated that perception is modulated when an organism is engaged in active behavior – suggesting that neural activity in motor pathways is one factor governing the neural state of networks engaged in sensory pro...
Source: Neuroscience and Biobehavioral Reviews - November 3, 2018 Category: Neuroscience Source Type: research

Oral Anticoagulants and Risk of Dementia: A Systematic Review and Meta-analysis of Observational Studies and Randomized Controlled Trials
Publication date: Available online 2 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Pajaree Mongkhon, Abdallah Y. Naser, Laura Fanning, Gary Tse, Wallis C.Y. Lau, Ian C.K. Wong, Chuenjid KongkaewAbstractAtrial fibrillation (AF) is a documented risk factor for dementia. However, it is unclear whether oral anticoagulant (OAC) treatment can reduce the development of dementia or cognitive impairment. We conducted a systematic review and meta-analysis of the association between OAC use and subsequent dementia development in AF patients by searching databases from their inception to February 2018 without...
Source: Neuroscience and Biobehavioral Reviews - November 3, 2018 Category: Neuroscience Source Type: research

Fatigue and its management in the workplace
Publication date: Available online 2 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): John A. Caldwell, J. Lynn Caldwell, Lauren A. Thompson, Harris R. LiebermanAbstractFatigue, or workplace sleepiness, is a consequence of modern industrial society. It is a complex biological phenomenon that occurs as a function of time awake, time-of-day, workload, health, and off-duty lifestyle. Fatigue is a function of two major biological factors – the homeostatic drive for sleep and circadian rhythm of sleepiness. The greatest cause of fatigue is insufficient or disrupted sleep. Excessive sleepiness in the...
Source: Neuroscience and Biobehavioral Reviews - November 3, 2018 Category: Neuroscience Source Type: research

Review of interventions for the management of anxiety symptoms in children with ASD
ConclusionsVarious methods for coping with anxiety in children with ASD have been applied,including pharmacotherapy, psychosocial andCBT interventions, parent education and school-based programs. A combination of approachesshould be selected,based onassessment of each child's particular characteristics. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - November 3, 2018 Category: Neuroscience Source Type: research

Nutritional Interventions and Cognitive-related Outcomes in Patients with Late-life Cognitive Disorders: A Systematic Review
Publication date: Available online 3 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Vincenzo Solfrizzi, Pasquale Agosti, Madia Lozupone, Carlo Custodero, Andrea Schilardi, Vincenzo Valiani, Andrea Santamato, Rodolfo Sardone, Vittorio Dibello, Luca Di Lena, Roberta Stallone, Maurizio Ranieri, Antonello Bellomo, Antonio Greco, Antonio Daniele, Davide Seripa, Carlo Sabbà, Giancarlo Logroscino, Francesco PanzaAbstractThere have been a large number of observational studies on the impact of nutrition on neuroprotection, however, there was a lack of evidence from randomized clinical trials (RCTs). ...
Source: Neuroscience and Biobehavioral Reviews - November 3, 2018 Category: Neuroscience Source Type: research

Regular cannabis use is associated with altered activation of central executive and default mode networks even after prolonged abstinence in adolescent users: results from a complementary meta-analysis
Publication date: Available online 3 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Grace Blest-Hopley, Vincent Giampietro, Sagnik BhattacharyyaAbstractWhether the effects of cannabis use on brain function persist or recover following abstinence remains unclear. Therefore, using meta-analytic techniques, we examined whether functional alterations measured using fMRI persist in cannabis users abstinent for over 25 days (or 600 hours) as evidence suggests that the effects on cognitive performance no longer persist beyond this period. Systematic literature search identified 20 studies, of which...
Source: Neuroscience and Biobehavioral Reviews - November 3, 2018 Category: Neuroscience Source Type: research

Aetiology of Eating Behaviours: a possible mechanism to understand obesity development in early childhood
Publication date: Available online 1 November 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Nikki Boswell, Rebecca Byrne, Peter S.W. DaviesAbstractChildhood obesity is an issue of public health concern that is understood to emerge due to disequilibrium in energy homeostasis. This commentary explores literature regarding neuro-biological mechanisms of energy homeostasis and the relationship between subjective measures of children’s eating behaviours and objective measures of appetite, in order to better understand the aetiology of childhood obesity. Early life influences, such as in utero exposure, br...
Source: Neuroscience and Biobehavioral Reviews - November 2, 2018 Category: Neuroscience Source Type: research

Neural mechanisms of emotion regulation and their role in endocrine and immune functioning: A review with implications for treatment of affective disorders
Publication date: Available online 29 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Richard B. Lopez, Bryan T. Denny, Christopher P. FagundesAbstractIn the past century, medical progress has helped increase life expectancy and improve health outcomes more generally. Despite this progress, psychiatric disorders—especially affective disorders including depressive and anxiety disorders—are quite common and have been linked to dysfunction in endocrine and immune systems. In this review, we discuss neurobiological correlates of emotion regulation strategies and their effects on mental and ph...
Source: Neuroscience and Biobehavioral Reviews - October 30, 2018 Category: Neuroscience Source Type: research

Fear as a Translational Mechanism in the Psychopathology of Anorexia Nervosa
Publication date: Available online 28 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Stuart B. Murray, Michael Strober, Michelle G. Craske, Scott Griffiths, Cheri A. Levinson, Irina A. StrigoAbstractAnorexia nervosa (AN) is an often chronic and potentially lethal psychiatric disorder, for which the precise etiology remains elusive. While current treatment outcomes are modest at best, it is thought that the identification of translational mechanisms driving the psychopathology of AN will assist in the development and optimization of novel treatments. AN is a disorder characterized by fear and avoidan...
Source: Neuroscience and Biobehavioral Reviews - October 29, 2018 Category: Neuroscience Source Type: research

Biological preparedness and resistance to extinction of skin conductance responses conditioned to fear relevant animal pictures: A systematic review
Publication date: Available online 28 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Fredrik Åhs, Jörgen Rosén, Granit Kastrati, Mats Fredrikson, Thomas Agren, Johan N. LundströmAbstractPreparedness theory is one of the most influential ideas in explaining the origin of specific phobias. The theory proposes that fear conditioning is selective to animals that have posed a threat to survival throughout human evolution, and that acquired fear memories to such threats are resistant to extinction. We reviewed fear conditioning studies testing whether autonomic responses conditioned...
Source: Neuroscience and Biobehavioral Reviews - October 29, 2018 Category: Neuroscience Source Type: research

A REVIEW OF psychiatric conceptions of mental and behavioural disorders in PRADER-WILLI SYNDROME
We present a review of psychiatric associations with comorbid mental and behavioural disorders affecting people with Prader-Willi syndrome (PWS). This literature review suggests that some assumptions about psychiatric associations of PWS behaviours are unjustified (eg skin picking as OCD) and that genetic aetiology should be considered when making associations between PWS mental and behavioural disorders and psychiatric disorders in the general populationThe literature review also demonstrates the limitations of the studies in terms of small numbers, non-representativeness, and lack of replication. (Source: Neuroscience an...
Source: Neuroscience and Biobehavioral Reviews - October 29, 2018 Category: Neuroscience Source Type: research

Carbachol-Induced Theta-Like Oscillations in the Rodent Brain Limbic System: Underlying Mechanisms and Significance
Publication date: Available online 28 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Maxime Lévesque, Massimo AvoliAbstractTheta oscillations (4-12 Hz) represent one of the most prominent physiological oscillatory activity in the mammalian EEG. They are observed in several areas of the hippocampus and in parahippocampal structures. Theta oscillations play important roles in modulating synaptic plasticity during memory and learning; moreover, they are dependent on septal cholinergic inputs. Theta oscillations can be reproduced in vitro in several regions of the temporal lobe in the abse...
Source: Neuroscience and Biobehavioral Reviews - October 29, 2018 Category: Neuroscience Source Type: research

Estrogenic Regulation of Social Behavior and Sexually Dimorphic Brain Formation
Publication date: Available online 27 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Sonoko Ogawa, Shinji Tsukahara, Elena Choleris, Nandini VasudevanAbstractIt has long been known that the estrogen, 17β-estradiol (17β-E), plays a central role for female reproductive physiology and behavior. Numerous studies have established the neurochemical and molecular basis of estrogenic induction of female sexual behavior, i.e., lordosis, in animal models. In addition, 17β-E also regulates male-type sexual and aggressive behavior. In males, testosterone secreted from the testes is irreversibly a...
Source: Neuroscience and Biobehavioral Reviews - October 27, 2018 Category: Neuroscience Source Type: research

Neuroergonomics of car driving: A critical meta-analysis of neuroimaging data on the human brain behind the wheel
Publication date: Available online 25 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Jordan Navarro, François Osiurak, Emanuelle ReynaudAbstractCar driving, an everyday life activity, has been under the scope of investigation for long. Neurosciences and psychology have contributed to better understand the human processes engaged while driving, to such an extent that a meta-analysis of all available fMRI data is now possible to extract the most relevant information. Using the Activation Likelihood Estimation method, we therefore conducted such a meta-analysis on 9 studies, representing 27 neur...
Source: Neuroscience and Biobehavioral Reviews - October 26, 2018 Category: Neuroscience Source Type: research

A systematic review of Drosophila short-term-memory genetics: Meta-analysis reveals robust reproducibility
Publication date: December 2018Source: Neuroscience & Biobehavioral Reviews, Volume 95Author(s): Tayfun Tumkaya, Stanislav Ott, Adam Claridge-ChangAbstractGeneticists use olfactory conditioning in Drosophila to identify learning genes; however, little is known about how these genes are integrated into short-term memory (STM) pathways. Here, we investigated the hypothesis that the STM evidence base is weak. We performed systematic review and meta-analysis of the field. Using metrics to quantify variation between discovery articles and follow-up studies, we found that seven genes were both highly replicated, and highly r...
Source: Neuroscience and Biobehavioral Reviews - October 26, 2018 Category: Neuroscience Source Type: research

Overlaps and distinctions between attention deficit/hyperactivity disorder and autism spectrum disorder in young adulthood: Systematic review and guiding framework for EEG research
Publication date: Available online 24 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Alex Lau-Zhu, Anne Fritz, Gráinne McLoughlinAbstractAttention deficit/hyperactivity disorders (ADHD) and autism spectrum disorders (ASD) frequently co-occur. However, we know little about the neural basis of the overlaps and distinctions between these disorders, particularly in young adulthood – a critical time window for brain plasticity across executive and socioemotional domains. Here, we systematically review 75 articles investigating ADHD and ASD in young adult samples (mean ages 16 to 26) using co...
Source: Neuroscience and Biobehavioral Reviews - October 25, 2018 Category: Neuroscience Source Type: research

Hypothalamic-pituitary-adrenal axis and autonomic nervous system reactivity in children prenatally exposed to maternal depression: A systematic review of prospective studies
Publication date: Available online 23 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Laura S. Bleker, Lotte van Dammen, Mariska M.G. Leeflang, Jacqueline Limpens, Tessa J. Roseboom, Susanne R. de RooijAbstractDepression is a common condition affecting up to 20% of all pregnant women, and is associated with subsequent developmental and behavioral problems in children, such as conduct disorder and ADHD. One proposed mechanism underlying these associations is modification of the fetal hypothalamic pituitary adrenal (HPA)-axis and the autonomic nervous system (ANS), resulting in altered responses to str...
Source: Neuroscience and Biobehavioral Reviews - October 24, 2018 Category: Neuroscience Source Type: research

The hidden side of Parkinson’s disease: studying pain, anxiety and depression in animal models
Publication date: Available online 23 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Fanny Faivre, Anil Joshi, Erwan Bezard, Michel BarrotABSTRACTParkinson’s disease is a neurodegenerative disease leading to the loss of midbrain dopamine neurons. It is well known and characterized by motor symptoms that are secondary to the loss of dopamine innervation, but it is also accompanied by a range of various non-motor symptoms, including pain and psychiatric disorders such as anxiety and depression. These non-motor symptoms usually appear at early stages of the disease, sometimes even before the firs...
Source: Neuroscience and Biobehavioral Reviews - October 24, 2018 Category: Neuroscience Source Type: research

Cognitive training: a new avenue in gambling disorder management?
Discussion and perspectivesStudies assessing cognitive training in gambling disorder are being conducted and first results should be upcoming. Methodological challenges have been identified. Several candidate target cognitive functions of training programs are being investigated, relying on the most documented impairments in gambling disorder, inhibition, reward sensitivity and decision making. Gambling-specific or neutral environments are to be distinguished clearly and do not rely on similar assumptions, i.e. general vulnerability or vulnerability expressed only in the specific context of gambling. Proper control groups ...
Source: Neuroscience and Biobehavioral Reviews - October 23, 2018 Category: Neuroscience Source Type: research

Motion adaptation and attention: A critical review and meta-analysis
Publication date: Available online 22 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Laura Bartlett, Erich W. Graf, Nicholas Hedger, Wendy J. AdamsAbstractThe motion aftereffect (MAE) provides a behavioural probe into the mechanisms underlying motion perception, and has been used to study the effects of attention on motion processing. Visual attention can enhance detection and discrimination of selected visual signals. However, the relationship between attention and motion processing remains contentious: not all studies find that attention increases MAEs. Our meta-analysis reveals several factors th...
Source: Neuroscience and Biobehavioral Reviews - October 23, 2018 Category: Neuroscience Source Type: research

Facets of impulsivity and alcohol use: What role do emotions play?
Publication date: Available online 19 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Aleksandra M. Herman, Theodora DukaAbstractAlcohol misuse is a major public concern. Impulsivity has been recognised as a significant risk factor predisposing for the initiation of alcohol use, continuation and excessive alcohol use. Evidence suggests that impulsivity is also a result of both acute alcohol intoxication and long-term alcohol abuse. The multifaceted character of impulsivity and the various ways of assessing it in humans and animal models, hampers the full understanding of how impulsivity relates to al...
Source: Neuroscience and Biobehavioral Reviews - October 20, 2018 Category: Neuroscience Source Type: research

Using rodents to model abnormal sensitivity to feedback in depression
Publication date: Available online 19 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Rafal Rygula, Karolina Noworyta-Sokolowska, Robert Drozd, Anna KozubAbstractDepressive disorder accounts for a substantial proportion of psychiatric problems across the globe and has a devastating impact on quality of life and occupational function. Psychological models of depression emphasize the causal role of cognitive distortions in this disease, and cognitive problems have been included in the diagnostic criteria for depressive episodes. Here, we focus on recent progress in preclinical modelling of aberrations ...
Source: Neuroscience and Biobehavioral Reviews - October 20, 2018 Category: Neuroscience Source Type: research

Role of pharmacokinetic and pharmacodynamic parameters in neuroadaptations induced by drugs of abuse, with a focus on opioids and psychostimulants
Publication date: Available online 16 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Nicolas Marie, Corinne Canestrelli, Florence NobleAbstractThe purpose of this review is to illustrate the importance of pharmacodynamic and pharmacokinetic factors in the complexity of the behavioral and neurochemical adaptations that occur following chronic treatments with drugs of abuse, with a focus on opioids and psychostimulants. As these neuroadaptations are thought to contribute to the pathogenesis and persistence of addiction, it is important to well understand how they can be modulated. The experimental res...
Source: Neuroscience and Biobehavioral Reviews - October 17, 2018 Category: Neuroscience Source Type: research

A large-scale integrative analysis of GWAS and common meQTLs across whole life course identifies genes, pathways and tissue/cell types for three major psychiatric disorders
Publication date: Available online 16 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Yan Zhao, Xiao Liang, Feng Zhu, Yan Wen, Jiawen Xu, Jian Yang, Miao Ding, Bolun Cheng, Mei Ma, Lu Zhang, Shiqiang Cheng, Cuiyan Wu, Sen Wang, Xi Wang, Yujie Ning, Xiong Guo, Feng ZhangAbstractAttention deficit hyperactivity disorder (ADHD), bipolar disorder (BP) and schizophrenia (SCZ) are complex psychiatric disorders. We conducted a large-scale integrative analysis of genome-wide association studies (GWAS) and life course consistent methylation quantitative trait loci (meQTLs) datasets. The GWAS data of ADHD (incl...
Source: Neuroscience and Biobehavioral Reviews - October 17, 2018 Category: Neuroscience Source Type: research

Hugs and kisses – the role of motor preferences and emotional lateralization for hemispheric asymmetries in human social touch
Publication date: Available online 16 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Sebastian Ocklenburg, Julian Packheiser, Judith Schmitz, Noemi Rook, Onur Güntürkün, Jutta Peterburs, Gina M GrimshawAbstractSocial touch is an important aspect of human social interaction - across all cultures, humans engage in kissing, cradling and embracing. These behaviors are necessarily asymmetric, but the factors that determine their lateralization are not well-understood. Because the hands are often involved in social touch, motor preferences may give rise to asymmetric behavior. However, soci...
Source: Neuroscience and Biobehavioral Reviews - October 17, 2018 Category: Neuroscience Source Type: research

Cortisol and alpha-amylase assessment in psychotherapeutic intervention studies: A systematic review
Publication date: Available online 11 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Sebastian Laufer, Sinha Engel, Christine Knaevelsrud, Sarah SchumacherAbstractDysregulations of the hypothalamus-pituitary-adrenal (HPA) axis and the autonomic nervous system (ANS) as parts of the stress response system have been associated with development and maintenance of various mental disorders. It has been suggested that these alterations might normalize in the course of psychotherapy. We conducted a comprehensive review of psychotherapeutic intervention effects on HPA axis and ANS regulation in adult samples...
Source: Neuroscience and Biobehavioral Reviews - October 12, 2018 Category: Neuroscience Source Type: research

Neural substrates of Internally-Based and Externally-Cued Timing: an activation likelihood estimation (ALE) meta-analysis of fMRI studies
Publication date: Available online 11 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Alice Teghil, Maddalena Boccia, Fabrizia D’Antonio, Antonella Di Vita, Carlo de Lena, Cecilia GuarigliaAbstractA dynamic interplay exists between Internally-Based (IBT) and Externally-Cued (ECT) time processing. While IBT processes support the self-generation of context-independent temporal representations, ECT mechanisms allow constructing temporal representations primarily derived from the structure of the sensory environment. We performed an activation likelihood estimation (ALE) meta-analysis on 177 fMRI e...
Source: Neuroscience and Biobehavioral Reviews - October 12, 2018 Category: Neuroscience Source Type: research

Disturbances of sleep quality, timing and structure and their relationship with other neuropsychiatric symptoms in Alzheimer’s disease and schizophrenia: insights from studies in patient populations and animal models
Publication date: Available online 9 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Raphaelle Winsky-Sommerer, Paula de Oliveira, Sally Loomis, Keith Wafford, Derk-Jan Dijk, Gary GilmourAbstractThe high prevalence of sleep disturbance in neurodegenerative and psychiatric conditions is often interpreted as evidence for both sleep’s sensitivity to and causal involvement in brain pathology. Nevertheless, how and which aspects of sleep contribute to brain function remains largely unknown. This review provides a critical evaluation of clinical and animal literature describing sleep and circadian di...
Source: Neuroscience and Biobehavioral Reviews - October 11, 2018 Category: Neuroscience Source Type: research

Commentary on: E. H. Toomarian and E. M. Hubbard (2018), On the genesis of spatial-numerical associations: Evolutionary and cultural factors co-construct the mental number line
Publication date: Available online 9 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Samuel Shaki, Martin H. Fischer (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - October 9, 2018 Category: Neuroscience Source Type: research

Animal models in addiction research: A dimensional approach
Publication date: Available online 8 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Steven J. Lamontagne, Mary C. OlmsteadAbstractDrug addiction affects approximately 10% of the population and these numbers are rising. Treatment and prevention of addiction are impeded by current diagnostic systems, such as DSM-5, which are based on outcomes rather than processes. Here, we review the importance of adopting a dimensional framework, specifically the Research Domain Criteria (RDoC), to identify protective and vulnerability mechanisms in addiction. We discuss how preclinical researchers should work withi...
Source: Neuroscience and Biobehavioral Reviews - October 8, 2018 Category: Neuroscience Source Type: research

A regulatory view on novel methodologies and context of use of biomarkers
Publication date: Available online 24 September 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): M.B. Tome, M.T. Isaac (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - October 7, 2018 Category: Neuroscience Source Type: research

The aversive brain system of teleosts: Implications for neuroscience and biological psychiatry
Publication date: Available online 6 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Rhayra Xavier do Carmo Silva, Monica Gomes Lima-Maximino, Caio MaximinoAbstractDefensive behavior is a function of specific survival circuits, the “aversive brain system”, that are thought to be conserved across vertebrates, and involve threat detection and the organization of defensive responses to reduce or eliminate threat. In mammals, these circuits involve amygdalar and hypothalamic subnuclei and midbrain circuits. The increased interest in teleost fishes as model organisms in neuroscience created a ...
Source: Neuroscience and Biobehavioral Reviews - October 7, 2018 Category: Neuroscience Source Type: research

Editorial Board
Publication date: November 2018Source: Neuroscience & Biobehavioral Reviews, Volume 94Author(s): (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - October 7, 2018 Category: Neuroscience Source Type: research

“A regulatory view on novel methodologies and context of use of biomarkers”
Publication date: Available online 24 September 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): M.B. Tome, M.T. Isaac (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - October 4, 2018 Category: Neuroscience Source Type: research

The role of the hippocampal theta rhythm in non-spatial discrimination and associative learning task
Publication date: Available online 25 September 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Yuya Sakimoto, Shogo SakataAbstractThe configural association theory and the conflict resolution model propose that hippocampal function is involved in learning negative patterning tasks (A+, B+, AB− ). The first theory suggests a critical role of the hippocampus in the formation of configural representations of compound stimuli, in which stimuli A and B are presented simultaneously. The second theory hypothesizes that the hippocampus is important for inhibiting the response to a stimulus that is in conflict...
Source: Neuroscience and Biobehavioral Reviews - October 4, 2018 Category: Neuroscience Source Type: research

Metabolism and adult neurogenesis: towards an understanding of the role of lipocalin-2 and iron-related oxidative stress
Publication date: Available online 26 September 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Ana Catarina Ferreira, Nuno Sousa, João M. Bessa, João Carlos Sousa, Fernanda MarquesAbstractThe process of generating new functional neurons in the adult mammalian brain occurs from the local neural stem and progenitor cells and requires tight control of the progenitor cell’s activity. Several signaling pathways and intrinsic/extrinsic factors have been well studied over the last years, but recent attention has been given to the critical role of cellular metabolism in determining the functiona...
Source: Neuroscience and Biobehavioral Reviews - October 4, 2018 Category: Neuroscience Source Type: research

Insights from perceptual, sensory, and motor functioning in autism and cerebellar primary disturbances: Are there reliable markers for these disorders?
Publication date: Available online 27 September 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Luca Casartelli, Marco Riva, Laura Villa, Renato BorgattiAbstractThe contribution of cerebellar circuitry alterations in the pathophysiology of Autism Spectrum Disorder (ASD) has been widely investigated in the last decades. Yet, experimental studies on neurocognitive markers of ASD have not been attentively compared with similar studies in patients with cerebellar primary disturbances (e.g., malformations, agenesis, degeneration, etc). Addressing this neglected issue could be useful to underline unexpected areas ...
Source: Neuroscience and Biobehavioral Reviews - October 4, 2018 Category: Neuroscience Source Type: research

Systematic review of co-occurring OCD and TD: evidence for a tic-related OCD subtype?
ConclusionsSeveral specific features are reliable associated with co-occurring OCD + TD. The field lacks methodological sound studies. The review found evidence against and in favor for different hypotheses regarding the nature of comorbidity of OCD and TD. This could indicate the existence of a stepwise model of co-morbidity, or could be an artefact of the low methodological quality of studies. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - October 4, 2018 Category: Neuroscience Source Type: research

G protein-coupled receptor heteromers are key players in substance use disorder
We report changes at the molecular and cellular levels that establish specific functional impact and highlight behavioral outcome in preclinical models. Finally, we briefly discuss selective targeting of native heteromers as an innovative therapeutic option. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - October 4, 2018 Category: Neuroscience Source Type: research