Altered spontaneous brain activity in patients with asthma: a resting-state functional MRI study using regional homogeneity analysis
Conclusion
Patients with asthma have different functional changes in different brain regions, mainly including the cerebellum, frontal lobe, temporal lobe, and occipital lobe, which provides important pieces of evidence to support the role of brain networks in the pathophysiology of asthma and offers an entirely new target for potential therapeutic intervention in asthma. (Source: NeuroReport)
Source: NeuroReport - November 18, 2021 Category: Neurology Tags: Clinical Neuroscience Source Type: research
Two rTMS sessions per week: a practical approach for treating major depressive disorder
Conclusion
This study contributes to demonstrating that rTMS with a more practical schedule of two sessions/week is an effective antidepressant treatment that could be considered the first choice for managing symptoms of depression. (Source: NeuroReport)
Source: NeuroReport - November 5, 2021 Category: Neurology Tags: Clinical Neuroscience Source Type: research
Increased endogenous reactive oxygen species normalizes proliferation defects of Bmi1 heterozygous knockout neural stem cells
Conclusion
These results suggest that Bmi1+/−-NSCs exhibit normal proliferation and self-renewal due to a slight increase in ROS, but are more vulnerable to changes in redox status. (Source: NeuroReport)
Source: NeuroReport - November 5, 2021 Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research
Neuroprotective effect of paeoniflorin in the mouse model of Parkinson’s disease through α-synuclein/protein kinase C δ subtype signaling pathway
Conclusions
Thus, our results showed that paeoniflorin exerts its neuroprotective effect by regulating the α-synuclein/PKC-δ signaling pathway to reduce neuronal apoptosis. (Source: NeuroReport)
Source: NeuroReport - November 5, 2021 Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research
The upregulation of Nur77 decreases ketamine-induced hippocampal neurons toxicity in rats
Ketamine is clinically used as a narcotic. However, ketamine has certain deficits and produces toxicity to neurons. As a member of the NR4A receptor subfamily, Nur77 decreases neurodegenerative disorders. The study aims to investigate the effects of upregulated Nur77 on ketamine-induced rat hippocampal neurons damage and the active mechanism. Neurons were obtained from rat hippocampal and identified by immunofluorescence assays. The treatment groups contained ketamine group, Nur77 group, ketamine + Nur77 group and ketamine + L-cam group. Neurons apoptosis and reactive oxygen species (ROS) were determined by a related kit u...
Source: NeuroReport - November 5, 2021 Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research
NBTI attenuates neuroinflammation and apoptosis partly by ENT1/NLRP3/Bcl2 pathway after subarachnoid hemorrhage in rats
Conclusions
NBTI relieved SAH-induced EBI partly through ENT1/NLRP3/Bcl2 pathway. (Source: NeuroReport)
Source: NeuroReport - November 5, 2021 Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research
Downregulation of lncRNA GAS5 prevents mitochondrial apoptosis and hypoxic-ischemic brain damage in neonatal rats through the microRNA-128-3p/Bax/Akt/GSK-3β axis
Conclusion
Downregulation of lncRNA GAS5 prevents mitochondrial apoptosis in neonatal HIBD rats by regulating the miR-128-3p/Bax/Akt/GSK-3β axis. (Source: NeuroReport)
Source: NeuroReport - November 5, 2021 Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research
Unitization congruence moderates the effect of unitization on associative recognition: evidence from event-related potentials
Conclusions
These results indicated that UC can moderate the effect of unitization on associative recognition by increasing familiarity and recollection and revealed the need to match the level of unitization of materials arrangements in future studies. (Source: NeuroReport)
Source: NeuroReport - November 5, 2021 Category: Neurology Tags: Integrative Systems Source Type: research
O-GlcNAcase inhibitor has protective effects in intracerebral hemorrhage by suppressing the inflammatory response
Conclusions
O-GlcNAcylation played an important role in suppressing the inflammatory response, enhancing the BBB integrity and reducing edema after ICH. (Source: NeuroReport)
Source: NeuroReport - November 5, 2021 Category: Neurology Tags: Integrative Systems Source Type: research
Sevoflurane modulation of tetrodotoxin-resistant Na+ channels in small-sized dorsal root ganglion neurons of rats
Conclusions
The present results suggest that the inhibition of persistent INa and the modulation of the voltage dependence and inactivation might be, at least in part, responsible for the analgesic effects elicited by sevoflurane. (Source: NeuroReport)
Source: NeuroReport - November 5, 2021 Category: Neurology Tags: Integrative Systems Source Type: research
Mice heterozygous for the Serpinb6a null mutation show deficits in central auditory function after acoustic trauma
Objectives
Complete deficiency of the serine protease inhibitor gene, SERPINB6, is responsible for autosomal-recessive, nonsyndromic sensorineural hearing loss in humans. A mouse model of this deafness gene identifies Serpinb6a expression in the neurosensory epithelium and fibrocytes of the cochlea. Homozygous Serpinb6a mutant mice display an exaggerated hearing loss after exposure to moderate acoustic trauma. It is unknown if and how heterozygous Serpinb6a mice show increased vulnerability to acoustic trauma.
Methods
We exposed Serpinb6a+/− and Serpinb6a+/+ mice to acoustic trauma and measured their hearing f...
Source: NeuroReport - October 7, 2021 Category: Neurology Tags: Integrative Systems Source Type: research
Sex differences in the aging brain? A voxel-based morphometry analysis of the hippocampus and the amygdala
Conclusion
These findings support the extensive series of studies suggesting that sex differences in brain volume are likely related to the confounding effect of head size. While continued effort is allocated to identify sex-related biomarkers, increasing evidence suggests that sexual dimorphism in the hippocampus or the amygdala does not appear to be the primary candidates for precision medicine to identify sex-related biomarkers that index potential vulnerabilities. (Source: NeuroReport)
Source: NeuroReport - October 7, 2021 Category: Neurology Tags: Degeneration and Repair Source Type: research
Cerebral arterial fenestration associated with stroke and other cerebrovascular diseases
In this study, we aimed to investigate the imaging characteristics of cerebral fenestrations, the clinical characteristics of fenestrations complicated with cerebrovascular diseases, and the correlation between fenestrations and cerebrovascular diseases.
Methods
We reviewed the magnetic resonance imaging and computed tomography (CT) imaging findings of patients with cerebrovascular fenestrations in the Third Affiliated Hospital of Soochow University from January 2016 to December 2020, mainly focused on the shape and location of fenestrations. According to the location of fenestrated arteries, patients were divided i...
Source: NeuroReport - October 7, 2021 Category: Neurology Tags: Clinical Neuroscience Source Type: research
LncRNA ITSN1-2 knockdown inhibits OGD/R-induced inflammation and apoptosis in mouse hippocampal neurons via sponging miR-195-5p
Conclusion
Lnc ITSN1-2 knockdown suppressed the inflammation and apoptosis in OGD/R-induced HT22 cells by regulating the miR-195-5p-mediated MAPK pathways. (Source: NeuroReport)
Source: NeuroReport - October 7, 2021 Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research
Effect of combination therapy with neural stem cell transplantation and teramethylpyrazine in rats following acute spinal cord injury
This study was to explore the effects of teramethylpyrazine (TMP) administered in conjunction with neural stem cell transplantation on motor function, pathological lesions and the Janus kinase (JAK)2/signal transducer and activator of transcription 3 signal transduction pathway in rats following acute spinal cord injury (SCI).
Methods
Female Sprague–Dawley rats were randomly divided into sham, model, neural stem cells (NSCs) and NSCs+TMP groups. Motor function was evaluated using the Basso, Beattie, Bresnahan scale. Spinal cord neuropathies and neuron apoptosis were observed by HE and TUNEL staining. The brain-der...
Source: NeuroReport - October 7, 2021 Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research
