The activated synaptic terminals beyond the light illumination range affect the results of optogenetics
Conclusions
The LED-light-evoked response cannot reflect microcircuit of the recorded neuron and the activated neurons within the illumination range accurately. Together, these results confirm that light alone can affect neural activity, but this can be unrelated to the genuine ‘optogenetic effect’. (Source: NeuroReport)
Source: NeuroReport - April 24, 2022 Category: Neurology Tags: Integrative Systems Source Type: research
Loss of GBA in zebrafish leads to dopaminergic neurodegeneration, but overexpression of α-synuclein does not further worsen degeneration
Conclusions
These results indicate that loss of gba function was sufficient to generate a neurodegenerative phenotype in zebrafish regardless of the expression of α-synuclein. (Source: NeuroReport)
Source: NeuroReport - April 24, 2022 Category: Neurology Tags: Degeneration and Repair Source Type: research
Effect of exercise from a very early stage after intracerebral hemorrhage on microglial and macrophage reactivity states in rats
Conclusion
Very early exercise may inhibit the activation of anti-inflammatory-associated macrophages/microglia. (Source: NeuroReport)
Source: NeuroReport - April 24, 2022 Category: Neurology Tags: Degeneration and Repair Source Type: research
Magnetic resonance spectroscopy shows associations between neurometabolite levels and perivascular space volume in Parkinson’s disease: a pilot and feasibility study
Conclusion
These exploratory findings indicate that co-analysis of PVS and MRS is feasible and may help elucidate the cellular and metabolic substrates of glymphatic and inflammatory processes in PD. (Source: NeuroReport)
Source: NeuroReport - April 24, 2022 Category: Neurology Tags: Degeneration and Repair Source Type: research
Extracellular application of the N-methyl-D-aspartate receptor allosteric modulator rapastinel acts remotely to regulate Ca2+ inactivation at an intracellular locus
Conclusion
Extracellular binding of RAP to the NMDAR produces a novel, long-range reduction in affinity of the Ca2+ inactivation site on the NMDAR C-terminus accessible to the intracellular space. This action underlies enhancement in NMDAR-gated conductance elicited by RAP. (Source: NeuroReport)
Source: NeuroReport - April 24, 2022 Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research
Therapeutic effect of anti-HMGB1 antibody in a mouse model of 4-h middle cerebral artery occlusion: comparison with tissue plasminogen activator
Conclusion
These results indicate that αHMGB1 antibody may be therapeutically efficient in the delayed phase of ischemia, where tPA treatment is no longer an eligible option. Treatment with an αHMGB1 antibody may be an effective therapeutic option in patients who exceed the tPA therapeutic time window. (Source: NeuroReport)
Source: NeuroReport - April 24, 2022 Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research
The predictive value of local to remote functional connectivity changes in comitant exotropia patients
Conclusion
Our result highlights that CE patients had abnormal local to remote functional connectivity in the cerebellar network, SMN, DMN, which might indicate the neural mechanism of eye movements and stereo vision dysfunction in CE patients. Moreover, the SVM algorithm reveals ReHo maps as a potential biomarker for predicting clinical outcomes in CE patients. (Source: NeuroReport)
Source: NeuroReport - April 6, 2022 Category: Neurology Tags: Clinical Neuroscience Source Type: research
Swimming exercise reverses chronic unpredictable mild stress–induced depression-like behaviors and alleviates neuroinflammation and collapsing response mediator protein-2–mediated neuroplasticity injury in adult male mice
Conclusion
Our study confirmed that swimming exercise reverses CUMS-induced depressive behaviors, and neuroinflammation and CRMP2-mediated neuroplasticity are involved, which may provide a new insight into the antidepression therapy of exercise. (Source: NeuroReport)
Source: NeuroReport - April 6, 2022 Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research
Galectin-3 ablation does not affect infarct size or inflammatory cytokines after experimental stroke in 24-month-old female mice
Conclusion
In summary, it can be said that the absence of the inflammatory mediator Galectin-3 does not seem to have a strong poststroke effect in aged females. Unfortunately, we could not analyze these mice with immunohistochemistry, which limited our study. (Source: NeuroReport)
Source: NeuroReport - April 6, 2022 Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research
Sevoflurane diminishes neurogenesis and promotes ferroptosis in embryonic prefrontal cortex via inhibiting nuclear factor-erythroid 2–related factor 2 expression
Conclusion
We conclude that Nrf2-related neurogenesis inhibition and ferroptosis are a central mechanism contributing to sevoflurane-induced neurotoxicity in embryonic brain. The results of the present study are the first to demonstrate that ferroptosis and the expression of Nrf2 are involved in sevoflurane-related neurotoxicity in embryonic brain, which provides new vision for consideration in anesthesia-associated neurological abnormalities. (Source: NeuroReport)
Source: NeuroReport - April 6, 2022 Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research
The m6A methyltransferase METTL3 promotes LPS-induced microglia inflammation through TRAF6/NF-κB pathway
Conclusion
METTL3 promotes LPS-induced microglial inflammation by activating the TRAF6-NF-κB pathway. (Source: NeuroReport)
Source: NeuroReport - April 6, 2022 Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research
Dysregulation of bcl-2 enhanced rotenone-induced α-synuclein aggregation associated with autophagic pathways: Erratum
No abstract available (Source: NeuroReport)
Source: NeuroReport - March 17, 2022 Category: Neurology Tags: Erratum Source Type: research
Blue light exposure increases functional connectivity between dorsolateral prefrontal cortex and multiple cortical regions
Objective
Blue light is a powerful environmental stimulus that can produce significant phase shifts in the circadian rhythm of melatonin and sleep propensity as well as acute effects on alertness of neurobehavioral performance. Here, we undertook an expansion and reanalysis of our previously published findings to examine the effect of acute blue light exposure on the strength of resting-state functional connectivity (rsFC) between a previously identified region of the left dorsolateral prefrontal cortex (DLPFC) and 106 cortical and subcortical regions.
Methods
Twenty-nine healthy adults (16 men and 13 women; age...
Source: NeuroReport - March 17, 2022 Category: Neurology Tags: Integrative Systems Source Type: research
Spectral dynamic causal modeling of mindfulness, mind-wandering, and resting-state in the triple network using fMRI
Conclusion
To the best of our knowledge, this is the first study to examine possible differences in effective connectivity patterns among mindfulness, mind-wandering and resting-state using the triple network. We believe that our findings will provide deeper insights into the neural substrates of mindfulness compared to mind-wandering and resting-state. (Source: NeuroReport)
Source: NeuroReport - March 17, 2022 Category: Neurology Tags: Integrative Systems Source Type: research
Dexmedetomidine alleviates the hypoxic-ischemic brain damage via miR-20a-5p/methionine adenosyltransferase 2B axis in rat pups
Conclusion
DEX alleviated HIBD via the miR-20a-5p/MAT2B axis in rats. (Source: NeuroReport)
Source: NeuroReport - March 17, 2022 Category: Neurology Tags: Degeneration and Repair Source Type: research
