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Erythropoietin Promotes Neural Plasticity and Spatial Memory Recovery in Fimbria-Fornix-Lesioned Rats
Conclusions. This finding supports our working hypothesis that EPO can modulate transient neuroplastic mechanisms triggered by training in lesioned animals. Consequently, we propose that EPO administration can be a useful trophic factor to promote neural restoration when given in combination with training. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - October 20, 2015 Category: Neurology Authors: Almaguer-Melian, W., Merceron-Martinez, D., Pavon-Fuentes, N., Alberti-Amador, E., Leon-Martinez, R., Ledon, N., Delgado Ocana, S., Bergado Rosado, J. A. Tags: Basic Research Articles Source Type: research

Quantifying Real-World Upper-Limb Activity in Nondisabled Adults and Adults With Chronic Stroke
Conclusions. Quantification and visualization of real-world bilateral UL activity can be accomplished using this novel accelerometry-based methodology and complements results obtained from clinical tests of function when assessing recovery of UL activity following neurological injury. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - October 20, 2015 Category: Neurology Authors: Bailey, R. R., Klaesner, J. W., Lang, C. E. Tags: Clinical Research Articles Source Type: research

The HAAPI (Home Arm Assistance Progression Initiative) Trial: A Novel Robotics Delivery Approach in Stroke Rehabilitation
Conclusions. Robotic + HEP and HEP only were both effectively delivered remotely. There was no difference between groups in change in motor function over time. Additional research is necessary to determine the appropriate dosage of HMP and HEP. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - October 20, 2015 Category: Neurology Authors: Wolf, S. L., Sahu, K., Bay, R. C., Buchanan, S., Reiss, A., Linder, S., Rosenfeldt, A., Alberts, J. Tags: Clinical Research Articles Source Type: research

Usability and Workload of Access Technology for People With Severe Motor Impairment: A Comparison of Brain-Computer Interfacing and Eye Tracking
Conclusions. Although BCIs could be potentially useful for people with severe physical disabilities, we showed that the usability of BCIs based on the visual P300 remains inferior to eye tracking. We suggest that future research on visual BCIs should use eye tracking–based control as a comparison to evaluate performance or focus on nonvisual paradigms for persons who have lost gaze control. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - October 20, 2015 Category: Neurology Authors: Pasqualotto, E., Matuz, T., Federici, S., Ruf, C. A., Bartl, M., Olivetti Belardinelli, M., Birbaumer, N., Halder, S. Tags: Clinical Research Articles Source Type: research

Assessing Proprioception: A Systematic Review of Possibilities
Proprioception is a vital aspect of motor control and when degraded or lost can have a profound impact on function in diverse clinical populations. This systematic review aimed to identify clinically related tools to measure proprioceptive acuity, to classify the construct(s) underpinning the tools, and to report on the clinimetric properties of the tools. We searched key databases with the pertinent search terms, and from an initial list of 935 articles, we identified 57 of relevance. These articles described 32 different tools or methods to quantify proprioception. There was wide variation in methods, the joints able to ...
Source: Neurorehabilitation and Neural Repair - October 20, 2015 Category: Neurology Authors: Hillier, S., Immink, M., Thewlis, D. Tags: Clinical Research Articles Source Type: research

Feasibility of Focused Stepping Practice During Inpatient Rehabilitation Poststroke and Potential Contributions to Mobility Outcomes
Conclusion. Providing focused, repeated stepping training was feasible early poststroke during inpatient rehabilitation and was related to mobility outcomes. Further research is required to evaluate the effectiveness of these training strategies on short- or long-term mobility outcomes as compared with conventional interventions. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - October 20, 2015 Category: Neurology Authors: Hornby, T. G., Holleran, C. L., Leddy, A. L., Hennessy, P., Leech, K. A., Connolly, M., Moore, J. L., Straube, D., Lovell, L., Roth, E. Tags: Clinical Research Articles Source Type: research

Long-Term Follow-up to a Randomized Controlled Trial Comparing Peroneal Nerve Functional Electrical Stimulation to an Ankle Foot Orthosis for Patients With Chronic Stroke
Conclusions. At 12 months, both FES and AFOs continue to demonstrate equivalent gains in gait speed. Results suggest that long-term FES use may lead to additional improvements in walking endurance and functional ambulation; further research is needed to confirm these findings. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - October 20, 2015 Category: Neurology Authors: Bethoux, F., Rogers, H. L., Nolan, K. J., Abrams, G. M., Annaswamy, T., Brandstater, M., Browne, B., Burnfield, J. M., Feng, W., Freed, M. J., Geis, C., Greenberg, J., Gudesblatt, M., Ikramuddin, F., Jayaraman, A., Kautz, S. A., Lutsep, H. L., Madhavan, S Tags: Clinical Research Articles Source Type: research

Visual Priming Enhances the Effects of Nonspatial Cognitive Rehabilitation Training on Spatial Learning After Experimental Traumatic Brain Injury
Previous work demonstrates that spatial (explicit) and nonspatial (implicit) elements of place learning in the Morris water maze (MWM) task can be dissociated and examined in the context of experimental traumatic brain injury (TBI). Providing nonspatial cognitive training (CT) after injury can improve place learning compared with untrained controls. In the present study, we hypothesized that brief exposure to extra-maze cues, in conjunction with CT, may further improve MWM performance and extra-maze cue utilization compared with CT alone. Adult male Sprague-Dawley rats (n = 66) received controlled cortical impact (CCI) inj...
Source: Neurorehabilitation and Neural Repair - September 23, 2015 Category: Neurology Authors: Edwards, C. M., Kumar, K., Koesarie, K., Brough, E., Ritter, A. C., Brayer, S. W., Thiels, E., Skidmore, E. R., Wagner, A. K. Tags: Basic Research Article Source Type: research

The Association of Grip Strength With Severity and Duration of Parkinson's: A Cross-Sectional Study
Conclusions. This is the first demonstration that increasing severity of Parkinson’s was associated with weaker grip after adjustment for known influences on muscle strength. Participants’ age, gender, and body size also had a significant impact on strength. Adjustment of reported values for all these factors is essential to allow accurate reporting of grip strength values in intervention trials and comparison between different groups. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - September 23, 2015 Category: Neurology Authors: Roberts, H. C., Syddall, H. E., Butchart, J. W., Stack, E. L., Cooper, C., Sayer, A. A. Tags: Clinical Research Articles Source Type: research

Lighten Up: Specific Postural Instructions Affect Axial Rigidity and Step Initiation in Patients With Parkinson's Disease
Conclusion. Mindful movement approaches such as AT may benefit balance and mobility in subjects with PD by acutely facilitating increased upright postural alignment while decreasing rigidity. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - September 23, 2015 Category: Neurology Authors: Cohen, R. G., Gurfinkel, V. S., Kwak, E., Warden, A. C., Horak, F. B. Tags: Clinical Research Articles Source Type: research

Toward Inclusive Trial Protocols in Heterogeneous Neurological Disorders: Prediction-Based Stratification of Participants With Incomplete Cervical Spinal Cord Injury
Conclusion. The application of conditional inference trees is feasible for iSCI participants and provides easily implementable, prediction-based decision rules for inclusion and stratification. This algorithm could be utilized to model various trial endpoints and outcome thresholds. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - September 23, 2015 Category: Neurology Authors: Tanadini, L. G., Hothorn, T., Jones, L. A. T., Lammertse, D. P., Abel, R., Maier, D., Rupp, R., Weidner, N., Curt, A., Steeves, J. D. Tags: Clinical Research Articles Source Type: research

Corticopontocerebellar Connectivity Disruption in Congenital Hemiplegia
Conclusions. Disruption of structural cerebrocerebellar connectivity is present in patients with congenital unilateral brain injury and might be related to impaired hand function in bimanual skills, with potential implication in tailoring early intervention strategies. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - September 23, 2015 Category: Neurology Authors: Fiori, S., Pannek, K., Pasquariello, R., Ware, R. S., Cioni, G., Rose, S. E., Boyd, R. N., Guzzetta, A. Tags: Clinical Research Articles Source Type: research

Use of Accelerometer-Based Feedback of Walking Activity for Appraising Progress With Walking-Related Goals in Inpatient Stroke Rehabilitation: A Randomized Controlled Trial
Conclusion. Feedback did not increase the amount of walking completed by individuals with stroke. However, there was a significant increase in cadence, indicating that intensity of daily walking was greater for those who received feedback than the control group. Additionally, more intense daily walking activity appeared to translate to greater improvements in walking speed. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - September 23, 2015 Category: Neurology Authors: Mansfield, A., Wong, J. S., Bryce, J., Brunton, K., Inness, E. L., Knorr, S., Jones, S., Taati, B., McIlroy, W. E. Tags: Clinical Research Articles Source Type: research

Modulation of Perception or Emotion? A Scoping Review of Tinnitus Neuromodulation Using Transcranial Direct Current Stimulation
Conclusions. tDCS is an effective research tool for transient tinnitus neuromodulation. However, efforts should be invested in designing clinical trials using local and multiple sites of stimulation, optimized parameters, and objective outcome measures before it can be translated in to a clinical tool for tinnitus management. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - September 23, 2015 Category: Neurology Authors: Shekhawat, G. S., Stinear, C. M., Searchfield, G. D. Tags: Clinical Research Articles Source Type: research

The Effects of Highly Challenging Balance Training in Elderly With Parkinson's Disease: A Randomized Controlled Trial
Conclusions. The HiBalance program significantly benefited balance and gait abilities when compared with usual care and showed promising transfer effects to everyday living. Long-term follow-up assessments will further explore these effects. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - September 23, 2015 Category: Neurology Authors: Conradsson, D., Lofgren, N., Nero, H., Hagstromer, M., Stahle, A., Lokk, J., Franzen, E. Tags: Clinical Research Articles Source Type: research