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Variable Intensive Early Walking Poststroke (VIEWS): A Randomized Controlled Trial
Conclusion. Variable intensive stepping training resulted in greater improvements in walking ability than conventional interventions early poststroke. Future studies should evaluate the relative contributions of these training parameters. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - May 4, 2016 Category: Neurology Authors: Hornby, T. G., Holleran, C. L., Hennessy, P. W., Leddy, A. L., Connolly, M., Camardo, J., Woodward, J., Mahtani, G., Lovell, L., Roth, E. J. Tags: Clinical Research Articles Source Type: research

Opposite Effects of Visual Cueing During Writing-Like Movements of Different Amplitudes in Parkinsons Disease
Conclusions. Visual target lines of 1.0 cm improved the writing of sequential loops in contrast to lines spaced at 0.6 cm. These results illustrate that, unlike for gait, visual cueing for fine-motor tasks requires a differentiated approach, taking into account the possible increases of accuracy constraints imposed by cueing. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - May 4, 2016 Category: Neurology Authors: Nackaerts, E., Nieuwboer, A., Broeder, S., Smits-Engelsman, B. C. M., Swinnen, S. P., Vandenberghe, W., Heremans, E. Tags: Clinical Research Articles Source Type: research

Preliminary Associations Between Brain-Derived Neurotrophic Factor, Memory Impairment, Functional Cognition, and Depressive Symptoms Following Severe TBI
Conclusions. Acute BDNF associations with memory recovery may implicate hippocampal damage/degeneration. Comparatively, BDNF associations with PTD status were not as strong as associations with PTD severity. Further investigation may delineate longitudinal BDNF patterns, and BDNF responsive treatments, reflecting mood and cognitive recovery following TBI. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - May 4, 2016 Category: Neurology Authors: Failla, M. D., Juengst, S. B., Arenth, P. M., Wagner, A. K. Tags: Clinical Research Articles Source Type: research

Intensive Rehabilitation Enhances Lymphocyte BDNF-TrkB Signaling in Patients With Parkinsons Disease
Conclusions. The significant correlation between reduced UPDRS scores and the changes in lymphocyte activity suggest that enhanced BDNF-TrkB signaling in lymphocyte and reduced severity of PD symptoms may be related. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - May 4, 2016 Category: Neurology Authors: Fontanesi, C., Kvint, S., Frazzitta, G., Bera, R., Ferrazzoli, D., Di Rocco, A., Rebholz, H., Friedman, E., Pezzoli, G., Quartarone, A., Wang, H.-Y., Ghilardi, M. F. Tags: Clinical Research Articles Source Type: research

No Reduction of Severe Fatigue in Patients With Postpolio Syndrome by Exercise Therapy or Cognitive Behavioral Therapy: Results of an RCT
Conclusions. Our results demonstrate that neither ET nor CBT were superior to UC in reducing fatigue in severely fatigued PPS patients. Further research should investigate explanations for the lack of efficacy of these 2 currently advised approaches in clinical practice, which may provide clues to improving treatment aimed at reducing fatigue in PPS. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - May 4, 2016 Category: Neurology Authors: Koopman, F. S., Voorn, E. L., Beelen, A., Bleijenberg, G., de Visser, M., Brehm, M. A., Nollet, F. Tags: Clinical Research Articles Source Type: research

Prediction of Balance Compensation After Vestibular Schwannoma Surgery
Conclusions. We identified specific preoperative patient and vestibular function characteristics that may predict postoperative balance recovery after VS surgery. Better preoperative characterization of these factors in each patient could inform more personalized presurgical and postsurgical management, leading to a better, more rapid balance recovery, earlier return to normal daily activities and work, improved quality of life, and reduced medical and societal costs. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - May 4, 2016 Category: Neurology Authors: Parietti-Winkler, C., Lion, A., Frere, J., Perrin, P. P., Beurton, R., Gauchard, G. C. Tags: Clinical Research Articles Source Type: research

Rehabilitation Interventions for Improving Social Participation After Stroke: A Systematic Review and Meta-analysis
Conclusions. The included studies provide evidence that rehabilitation interventions may be effective in improving social participation after stroke, especially if exercise is one of the components. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - April 12, 2016 Category: Neurology Authors: Obembe, A. O., Eng, J. J. Tags: Clinical Research Articles Source Type: research

Prevalence of Walking-Related Motor Fatigue in Persons With Multiple Sclerosis: Decline in Walking Distance Induced by the 6-Minute Walk Test
Conclusion. More than one-third of PwMS showed walking-related motor fatigue during the 6MWT, with its prevalence greatest in more disabled persons (up to 51%) and in those with progressive MS phenotype (up to 50%). Identification of walking-related motor fatigue may lead to better-tailored interventions. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - April 12, 2016 Category: Neurology Authors: Leone, C., Severijns, D., Dolezalova, V., Baert, I., Dalgas, U., Romberg, A., Bethoux, F., Gebara, B., Santoyo Medina, C., Maamagi, H., Rasova, K., Maertens de Noordhout, B., Knuts, K., Skjerbaek, A., Jensen, E., Wagner, J. M., Feys, P. Tags: Clinical Research Articles Source Type: research

Impact of Shoulder Abduction Loading on Brain-Machine Interface in Predicting Hand Opening and Closing in Individuals With Chronic Stroke
Conclusions. This study supports the idea that one should consider the effect of shoulder abduction activity when designing BMI classification algorithms for the purpose of restoring hand function in individuals with moderate to severe stroke. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - April 12, 2016 Category: Neurology Authors: Yao, J., Sheaff, C., Carmona, C., Dewald, J. P. A. Tags: Clinical Research Articles Source Type: research

Limb Heaviness: A Perceptual Phenomenon Associated With Poststroke Fatigue?
Poststroke fatigue and limb heaviness are 2 perceptual problems that commonly occur after stroke. Previous work suggests that poststroke fatigue may be related to altered sensorimotor processing whereas limb heaviness is often considered an association of muscle weakness. To address the hypothesis that the perception of limb heaviness may also be a problem of altered sensorimotor control, we investigated whether it was more closely related to poststroke fatigue or muscle weakness. In 69 chronic stroke survivors, we found that those with high perceived limb heaviness (31 individuals) also reported significantly higher level...
Source: Neurorehabilitation and Neural Repair - April 12, 2016 Category: Neurology Authors: Kuppuswamy, A., Clark, E., Rothwell, J., Ward, N. S. Tags: Clinical Research Articles Source Type: research

Intensity, Duration, and Location of High-Definition Transcranial Direct Current Stimulation for Tinnitus Relief
Conclusions. A current intensity of 2 mA for 20-minute duration was the most effective setting used for tinnitus relief. The stimulation of the LTA and DLPFC were equally effective for suppressing tinnitus loudness and annoyance. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - April 12, 2016 Category: Neurology Authors: Shekhawat, G. S., Sundram, F., Bikson, M., Truong, D., De Ridder, D., Stinear, C. M., Welch, D., Searchfield, G. D. Tags: Clinical Research Articles Source Type: research

Primed Physical Therapy Enhances Recovery of Upper Limb Function in Chronic Stroke Patients
Conclusions. Two weeks of iTBS-primed therapy improves upper limb function at the chronic stage of stroke, for at least 1 month postintervention, whereas therapy alone may not be sufficient to alter function. This indicates a potential role for iTBS as an adjuvant to therapy delivered at the chronic stage. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - April 12, 2016 Category: Neurology Authors: Ackerley, S. J., Byblow, W. D., Barber, P. A., MacDonald, H., McIntyre-Robinson, A., Stinear, C. M. Tags: Clinical Research Articles Source Type: research

Neural Substrates of Motor Recovery in Severely Impaired Stroke Patients With Hand Paralysis
We report that interhemispheric inhibition, stronger in the paretic triceps than biceps brachii muscles, significantly correlated with the magnitude of residual impairment (lower Fugl-Meyer scores). In contrast, intracortical inhibition in the paretic biceps brachii, but not in the triceps, correlated positively with motor recovery (Fugl-Meyer scores) and negatively with spasticity (lower Modified Ashworth scores). Our results suggest that interhemispheric inhibition and intracortical inhibition of paretic upper arm muscles relate to motor recovery in different ways. While interhemispheric inhibition may contribute to poor...
Source: Neurorehabilitation and Neural Repair - April 12, 2016 Category: Neurology Authors: Harris-Love, M. L., Chan, E., Dromerick, A. W., Cohen, L. G. Tags: Clinical Research Articles Source Type: research

Passive Hind-Limb Cycling Reduces the Severity of Autonomic Dysreflexia After Experimental Spinal Cord Injury
Conclusion. Passive hind-limb cycling reduces the severity of AD in SCI, and is correlated with changes in primary afferent morphology, but has limited effects on the peripheral vasculature. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - April 12, 2016 Category: Neurology Authors: West, C. R., Crawford, M. A., Laher, I., Ramer, M. S., Krassioukov, A. V. Tags: Clinical Research Articles Source Type: research

Reduced Voluntary Activation During Brief and Sustained Contractions of a Hand Muscle in Secondary-Progressive Multiple Sclerosis Patients
Conclusion. SPMS patients had lower VA than RRMS patients and controls. The importance of voluntary activation for muscle force and fatigability warrants targeted rehabilitation strategies. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - April 12, 2016 Category: Neurology Authors: Wolkorte, R., Heersema, D. J., Zijdewind, I. Tags: Clinical Research Articles Source Type: research