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The Effect of Levodopa on Improvements in Protective Stepping in People With Parkinsons Disease
Conclusions. Individuals with Parkinson’s disease are able to improve protective postural responses through short-term perturbation training, and improvements were more pronounced when on levodopa for some variables. Perturbation training may be more effective if completed while optimally medicated with levodopa. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - September 29, 2016 Category: Neurology Authors: Peterson, D. S., Horak, F. B. Tags: Clinical Research Articles Source Type: research

COMT and ANKK1 Genetics Interact With Depression to Influence Behavior Following Severe TBI: An Initial Assessment
Conclusion. In the context of depression, Val158Met and Taq1a polymorphisms are individually associated with behavioral dysfunction 12 months following severe TBI, with preliminary evidence suggesting cumulative, or perhaps epistatic, effects of COMT and ANKK1 on behavioral dysfunction. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - September 29, 2016 Category: Neurology Authors: Myrga, J. M., Juengst, S. B., Failla, M. D., Conley, Y. P., Arenth, P. M., Grace, A. A., Wagner, A. K. Tags: Clinical Research Articles Source Type: research

Handwriting Impairments in People With Parkinsons Disease and Freezing of Gait
Conclusions. Writing is more severely affected in PD patients with FOG than in those without FOG. These results indicate that deficient movement sequencing and adaptation is a generic problem in patients with FOG. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - September 29, 2016 Category: Neurology Authors: Heremans, E., Nackaerts, E., Broeder, S., Vervoort, G., Swinnen, S. P., Nieuwboer, A. Tags: Clinical Research Articles Source Type: research

Long-Term Exercise Improves Memory Deficits via Restoration of Myelin and Microvessel Damage, and Enhancement of Neurogenesis in the Aged Gerbil Hippocampus After Ischemic Stroke
Conclusions. These results suggest that long-term treadmill exercise after I-R can restore memory function through replacement of multiple damaged structures in the ischemic aged hippocampus. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - September 11, 2016 Category: Neurology Authors: Ahn, J. H., Choi, J. H., Park, J. H., Kim, I. H., Cho, J.-H., Lee, J.-C., Koo, H.-M., Hwangbo, G., Yoo, K.-Y., Lee, C. H., Hwang, I. K., Cho, J. H., Choi, S. Y., Kwon, Y.-G., Kim, Y.-M., Kang, I.-J., Won, M.-H. Tags: Basic Research Article Source Type: research

ApoE and SNAP-25 Polymorphisms Predict the Outcome of Multidimensional Stimulation Therapy Rehabilitation in Alzheimers Disease
Conclusions. Polymorphisms in genes known to modulate neural plasticity might predict the outcome of a multistructured rehabilitation protocol in patients with AD. These data, although needing confirmation on larger case studies, could help optimizing the clinical management of individuals with AD, for example defining a more intensive treatment in those subjects with a lower likelihood of success. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - September 11, 2016 Category: Neurology Authors: Guerini, F. R., Farina, E., Costa, A. S., Baglio, F., Saibene, F. L., Margaritella, N., Calabrese, E., Zanzottera, M., Bolognesi, E., Nemni, R., Clerici, M. Tags: Clinical Research Articles Source Type: research

Performance Variability as a Predictor of Response to Aphasia Treatment
Conclusions. Intraindividual variability may be indicative of potential for improvement on a given task, with more uniform performance suggesting functioning at or near peak potential. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - September 11, 2016 Category: Neurology Authors: Duncan, E. S., Schmah, T., Small, S. L. Tags: Clinical Research Articles Source Type: research

Pharyngeal Electrical Stimulation in Dysphagia Poststroke: A Prospective, Randomized Single-Blinded Interventional Study
Conclusions. Although the direction of observed differences were consistent with PES accelerating swallowing recovery over the first 2 weeks postintervention, suboptimal recruitment prevents definitive conclusions. Our study design experience and outcome data are essential to inform a definitive, multicenter randomized trial. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - September 11, 2016 Category: Neurology Authors: Vasant, D. H., Michou, E., OLeary, N., Vail, A., Mistry, S., Hamdy, S., Greater Manchester Stroke Research Network Tags: Clinical Research Articles Source Type: research

Evaluation of a Physical Activity Intervention for Adults With Brain Impairment: A Controlled Clinical Trial
Conclusion. The 12-week intervention effectively increased adoption of PA in a sample of community-dwelling adults with BI immediately after the intervention but not at follow-up. Future studies should explore strategies to foster maintenance of PA participation. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - September 11, 2016 Category: Neurology Authors: Clanchy, K. M., Tweedy, S. M., Trost, S. G. Tags: Clinical Research Articles Source Type: research

A Critical Evaluation of the Methodological Obstacles to Translating Cell-Based Research Into an Effective Treatment for People With Parkinsons Disease
The remarkable scientific and technological advances in the field of cell research have not been translated into viable restorative therapies for brain disorders. In this article, we examine the best available evidence for the clinical efficacy of reconstructive intracerebral transplantation in people with Parkinson’s disease (PD), with the aim of identifying methodological obstacles to the translation process. The major stumbling block is the fact that the potential contributions of people with neural grafts and the effects of the physical and social environment in which they recover have not been adequately investi...
Source: Neurorehabilitation and Neural Repair - September 11, 2016 Category: Neurology Authors: Polgar, S., Karimi, L., Buultjens, M., Morris, M. E. Tags: Clinical Research Articles Source Type: research

Skilled Bimanual Training Drives Motor Cortex Plasticity in Children With Unilateral Cerebral Palsy
Conclusions. These findings uncover a dichotomy of plasticity: the unstructured practice group improved hand function but did not show changes in motor maps. Skill training is important for driving motor cortex plasticity in children with USCP. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - September 11, 2016 Category: Neurology Authors: Friel, K. M., Kuo, H.-C., Fuller, J., Ferre, C. L., Brandao, M., Carmel, J. B., Bleyenheuft, Y., Gowatsky, J. L., Stanford, A. D., Rowny, S. B., Luber, B., Bassi, B., Murphy, D. L. K., Lisanby, S. H., Gordon, A. M. Tags: Clinical Research Articles Source Type: research

Macrostructural and Microstructural Brain Lesions Relate to Gait Pathology in Children With Cerebral Palsy
Conclusions. These results indicate that the combined influence of multiple brain lesions and their impact on the primary motor deficits might explain a large part of the gait pathology in sCP. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - September 11, 2016 Category: Neurology Authors: Meyns, P., Van Gestel, L., Leunissen, I., De Cock, P., Sunaert, S., Feys, H., Duysens, J., Desloovere, K., Ortibus, E. Tags: Clinical Research Articles Source Type: research

Effects of Unilateral Upper Limb Training in Two Distinct Prognostic Groups Early After Stroke: The EXPLICIT-Stroke Randomized Clinical Trial
Conclusions. Three weeks of early mCIMT is superior to usual care in terms of regaining upper limb capacity in patients with a favorable prognosis; 3 weeks of EMG-NMS in patients with an unfavorable prognosis is not beneficial. Despite meaningful improvements in upper limb capacity, no evidence was found that the time-dependent neurological improvements early poststroke are significantly influenced by either mCIMT or EMG-NMS. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - September 11, 2016 Category: Neurology Authors: Kwakkel, G., Winters, C., van Wegen, E. E. H., Nijland, R. H. M., van Kuijk, A. A. A., Visser-Meily, A., de Groot, J., de Vlugt, E., Arendzen, J. H., Geurts, A. C. H., Meskers, C. G. M., on behalf of the EXPLICIT-Stroke Consortium Tags: Clinical Research Articles Source Type: research

WFNR Franz Gerstenbrand Award Announcement
(Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - September 11, 2016 Category: Neurology Tags: Announcement Source Type: research

Paradoxical Motor Recovery From a First Stroke After Induction of a Second Stroke: Reopening a Postischemic Sensitive Period
Conclusions. New ischemia can reopen a sensitive period of heightened responsiveness to training and mediate full recovery from a previous stroke. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - August 8, 2016 Category: Neurology Authors: Zeiler, S. R., Hubbard, R., Gibson, E. M., Zheng, T., Ng, K., OBrien, R., Krakauer, J. W. Tags: Basic Science Article Source Type: research

Upper Limb Rehabilitation in People With Multiple Sclerosis: A Systematic Review
Conclusions. The results of this systematic review indicated that different types of upper limb rehabilitation strategies can improve upper limb function in PwMS. Further research is necessary to compare directly the effects of different rehabilitation strategies and to investigate the optimal therapy dosage according to the upper limb disability level. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - August 8, 2016 Category: Neurology Authors: Lamers, I., Maris, A., Severijns, D., Dielkens, W., Geurts, S., Van Wijmeersch, B., Feys, P. Tags: Clinical Research Articles Source Type: research