Neuropathology and Applied Neurobiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Vascular dementia: clinicopathologic and genetic considerations
This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - December 1, 2017 Category: Neurology Authors: Harry V. Vinters, Chris Zarow, Ewa Borys, Jeffrey D. Whitman, Spencer Tung, William G. Ellis, Ling Zheng, Helena C. Chui Tags: Invited Review Source Type: research

Epothilone D accelerates disease progression in the SOD1G93A mouse model of Amyotrophic Lateral Sclerosis
ConclusionsThe results suggest that EpoD accelerates disease progression in the SOD1G93A mouse model of ALS, and highlights that the pathophysiological involvement of microtubules in ALS is an evolving and underappreciated phenomenon.This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - December 1, 2017 Category: Neurology Authors: Jayden A. Clark, Catherine A. Blizzard, Monique C. Breslin, Elise J. Yeaman, Ka M. Lee, Jyoti A. Chuckowree, Tracey C. Dickson Tags: Original Article Source Type: research

Somatic mutations in neurodegeneration
This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - December 1, 2017 Category: Neurology Authors: Melissa Leija ‐Salazar, Charlotte Lucie Piette, Christos Proukakis Tags: Invited Review Source Type: research

New Perspectives in Epilepsy Neuropathology
This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - December 1, 2017 Category: Neurology Authors: Maria Thom Tags: Annual Review Issue ‐ Review Source Type: research

mTOR pathway, focal cortical dysplasia and epilepsy
This article will review the current and still evolving genetic advances in the elucidation of the molecular basis of FCD. Activating somatic mutations in the MTOR gene are to date the most frequent mutations found in FCD brain specimens. This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - December 1, 2017 Category: Neurology Authors: Elise Marsan, St éphanie Baulac Tags: Invited Review Source Type: research

Regional pattern of microgliosis in sporadic Creutzfeldt ‐Jakob disease in relation to phenotypic variants and disease progression
ConclusionsMicroglial activation is an early event in sCJD pathogenesis and is strongly influenced by prion strain, PRNP codon 129 genotype and disease duration. Microglial lesion profiling, by highlighting strain‐specific properties of prions, contributes to prion strain characterization and classification of human prion diseases, and represents a valid support to molecular and histopathologic typing.This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - December 1, 2017 Category: Neurology Authors: Alessia Franceschini, Rosaria Strammiello, Sabina Capellari, Armin Giese, Piero Parchi Tags: Original Article Source Type: research

Aberrant accumulation of ErbB4 in progressive supranuclear palsy
ConclusionsOur present results suggest that NRG1/ErbB4 signalling could be an important event in the pathogenesis of PSPThis article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - December 1, 2017 Category: Neurology Authors: Aya Murakami, Masataka Nakamura, Satoshi Kaneko, Wen ‐Lang Lin, Dennis W. Dickson, Hirofumi Kusaka Tags: Original Article Source Type: research

Molecular characteristics of long ‐term epilepsy‐associated tumours (LEATs) and mechanisms for tumour‐related epilepsy (TRE)
This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - December 1, 2017 Category: Neurology Authors: Thomas J Stone, Rachel Rowell, Bodiabaduge Ashan Prasanna Jayasekera, Mark O Cunningham, Thomas S Jacques Tags: Annual Review Issue ‐ Review Source Type: research

Neurodegenerative processes in temporal lobe epilepsy with hippocampal sclerosis: Clinical, pathological and neuroimaging evidence
This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - December 1, 2017 Category: Neurology Authors: X. Y Tai, B Bernhardt, M Thom, P Thompson, S Baxendale, M Koepp, N Bernasconi Tags: Annual Review Issue ‐ Review Source Type: research

Value of magnetic resonance imaging for evaluating muscle inflammation: insights from a new mouse model of myositis
This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - December 1, 2017 Category: Neurology Authors: Gwladys Bourdenet, Benjamin Dubourg, Lionel Nicol, Paul Mulder, J érémie Martinet, Yves Allenbach, Christian Boitard, Olivier Boyer Tags: Scientific Correspondence Source Type: research

Multiple neuronal pathologies are common in young patients with pathologically proven Frontotemporal lobar degeneration
ConclusionsIn summary, the present study reports for the first time that age is not a major risk factor for multiple neuronal pathologies in FTLD. These findings have significant implications for the development of protein‐specific biomarkers and treatments for FTLD, and underscore the need for further research to identify the disease factors involved in driving multiple neuronal pathologies in FTLD.This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - December 1, 2017 Category: Neurology Authors: Rachel H Tan, Yue Yang, Glenda M Halliday Tags: Original Article Source Type: research

Aicardi ‐Goutières‐Syndrome with muscle involvement in early infancy
This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - December 1, 2017 Category: Neurology Authors: Nikolaus Deigendesch, Susanne Moralez ‐Gonzalez, Bernhard Weschke, Hans‐Hilmar Goebel, Markus Schuelke, Werner Stenzel Tags: Scientific Correspondence Source Type: research

Whole ‐exome sequencing of the BDR cohort: Evidence to support the role of the PILRA gene in Alzheimer's disease
ConclusionsIn addition, polygenic risk scores (PRS) were able to distinguish between cases and controls with 83.8% accuracy using 3,268 variants, sex, age at death and APOE ε4 and ε2 status as predictors.This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - November 28, 2017 Category: Neurology Authors: Tulsi Patel, Keeley J. Brookes, James Turton, Sultan Chaudhury, Tamar Guetta ‐Baranes, Rita Guerreiro, Jose Bras, Dena Hernandez, Andrew Singleton, Paul T. Francis, John Hardy, Kevin Morgan Tags: Original Article Source Type: research

The past, present and future challenges in epilepsy related and sudden deaths and biobanking
This article reviews how pathologists and healthcare professionals have approached ERD, current practices, logistical problems and areas to improve and harmonize. The main neuropathology, cardiac and genetic findings in SUDEP are outlined, providing a framework for best practices, integration of clinical, pathologic and molecular genetic investigations in SUDEP, and ultimately prevention. This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - November 27, 2017 Category: Neurology Authors: Maria Thom, Maura Boldrini, Elizabeth Bundock, Mary N. Sheppard, Orrin Devinsky Tags: Annual Review Issue ‐ Review Source Type: research

Myoblots: dystrophin quantification by in ‐cell western assay for a streamlined development of Duchenne muscular dystrophy (DMD) treatments
Neuropathology and Applied Neurobiology, EarlyView. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - November 27, 2017 Category: Neurology Source Type: research