Neuropathology and Applied Neurobiology 
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Neuropathology and Applied Neurobiology, Ahead of Print. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - June 1, 2017 Category: Neurology Source Type: research
Evolving concepts of chronic traumatic encephalopathy as a neuropathological entity
This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - June 1, 2017 Category: Neurology Authors: Helen Ling, James W Neal, Tamas Revesz Tags: Invited Review Source Type: research
Cholinesterases in Normal and Alzheimer's Disease Primary Olfactory Gyrus
ConclusionsAChE and BChE activities in normal POG recapitulated their distributions in other cortical regions. Greater abundance of BChE‐associated, in comparison to AChE‐associated, AD pathology in the POG suggests preferential involvement of BChE in olfactory dysfunction in AD.This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - June 1, 2017 Category: Neurology Authors: Hayam Hamodat, Meghan K. Cash, John D. Fisk, Sultan Darvesh Tags: Original Article Source Type: research
Aggregation and phosphorylation of α‐synuclein with proteinase K‐resistance in focal α‐synucleinopathy predominantly localized to the cardiac sympathetic nervous system
This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - June 1, 2017 Category: Neurology Authors: Nei Fukasawa, Takahiro Fukuda, Masato Nagaoka, Tohru Harada, Hiroyuki Takahashi, Masahiro Ikegami Tags: Scientific Correspondence Source Type: research
Marinesco Bodies and Substantia Nigra Neuron Density in Parkinson's Disease
ConclusionsWhile findings confirm that MB frequency is low in PD, declines in MB frequency continue with PD duration. The extent to which MB have a distinct relationship with PD warrants clarification. Further studies of MB could be important in understanding PD processes.This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - June 1, 2017 Category: Neurology Authors: Robert D. Abbott, James S. Nelson, G. Webster Ross, Jane H. Uyehara ‐Lock, Caroline M. Tanner, Kamal H. Masaki, Lenore J. Launer, Lon R. White, Helen Petrovitch Tags: Original Article Source Type: research
Unusual neuropathological features and increased brain aluminium in a resident of Camelford, UK
This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - June 1, 2017 Category: Neurology Authors: Andrew King, Claire Troakes, Miren Aizpurua, Ambreen Mirza, Angela Hodges, Safa Al ‐Sarraj, Christopher Exley Tags: Scientific Correspondence Source Type: research
Prognostic value of MGMT protein expression in glioblastoma excluding non ‐tumour cells from the analysis
ConclusionOur data indicate that MGMT protein expression in tumour cells has an independent prognostic significance. Exclusion of non‐tumour cells contributed to a more exact analysis of tumour‐specific MGMT protein expression. This should be incorporated in future studies evaluating MGMT status before potential integration into clinical practice.This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - June 1, 2017 Category: Neurology Authors: Rikke H. Dahlrot, Joseph Dowsett, Sigurd Fosmark, Annika Malmstr öm, Roger Henriksson, Henning Boldt, Karin Stricker, Mia D. Sørensen, Hans S. Poulsen, Malgorzata Lysiak, Peter Söderkvist, Johan Rosell, Steinbjørn Hansen, Bjarne W. Kristensen Tags: Original Article Source Type: research
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Neuropathology and Applied Neurobiology, Ahead of Print. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - May 29, 2017 Category: Neurology Source Type: research
Age ‐associated changes in the blood‐brain barrier: comparative studies in human and mouse
ConclusionsThis study demonstrates BBB dysfunction in normal brain ageing, both in human and mouse cohorts. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - May 29, 2017 Category: Neurology Authors: E. F. Goodall, C. Wang, J. E. Simpson, D. J. Baker, D. R. Drew, P. R. Heath, M. J. Saffrey, I. A. Romero, S. B. Wharton Tags: Original Article Source Type: research
HCV RNA genomic sequences and HCV ‐E2 glycoprotein in sural nerve biopsies from hcv‐infected patients with peripheral neuropathy
ConclusionsThese results indicate that nerve vascular HCV RNA/E2 deposits associated to perivascular inflammatory infiltrates were similar in chronically HCV‐infected patients, regardless of cryoglobulin occurrence. Given the failure to demonstrate HCV productive infection in the examined sural nerve biopsies, nerve damage is likely to result from virus‐triggered immune‐mediated mechanisms.This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - May 25, 2017 Category: Neurology Authors: Sabino Russi, Domenico Sansonno, Salvatore Monaco, Sara Mariotto, Sergio Ferrari, Fabio Pavone, Gianfranco Lauletta, Franco Dammacco Tags: Original Article Source Type: research
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Neuropathology and Applied Neurobiology, Ahead of Print. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - May 25, 2017 Category: Neurology Source Type: research
The physiological phosphorylation of tau is critically changed in fetal brains of individuals with Down syndrome
DiscussionOur observations suggest functional tau disturbance in DS brains during development, rather than axonal loss. This supports the role of tau as a further important player in the pathophysiology of cognitive impairment in DS and related AD. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - May 25, 2017 Category: Neurology Authors: I. Milenkovic, J. Jarc, E. Dassler, E. Aronica, A. Iyer, H. Adle ‐Biassette, A. Scharrer, T. Reischer, J. A. Hainfellner, G. G. Kovacs Tags: Original Article Source Type: research
Brain endothelial cell expression of SPARCL ‐1 is specific to chronic multiple sclerosis lesions and is regulated by inflammatory mediators in vitro
ConclusionsConflicting results of SPARCL‐1's differential expression in CSF of 3 independent cohorts of RRMS and SPMS patients precludes its use as biomarker for disease progression. The expression of SPARCL‐1 by BEC in chronic MS lesions together with its regulation by inflammatory mediators in vitro suggest a role for SPARCL‐1 in MS neuropathology, possibly at the brain vascular level.This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - May 24, 2017 Category: Neurology Authors: C Bridel, M J A Koel ‐Simmelink, L Peferoen, C Derada Troletti, S Durieux, R Gorter, E Nutma, P Gami, E Iacobeus, L Brundin, J Kuhle, H Vrenken, J Killestein, S R Piersma, T V Pham, H E De Vries, S Amor, C R Jimenez, C E Teunissen Tags: Original Article Source Type: research
Review: Astrocytes in Alzheimer's disease and other age ‐associated dementias: a supporting player with a central role
Astrocytes have essential roles in the central nervous system and are also implicated in the pathogenesis of neurodegenerative disease. Forming non‐overlapping domains, astrocytes are highly complex cells. Immunohistochemistry to a variety of proteins can be used to study astrocytes in tissue, labelling different cellular components and sub‐populations, including glial fibrillary acidic protein, ALDH1L1, CD44, NDRG2 and amino acid transporters, but none of these labels the entire astrocyte population. Increasing heterogeneity is recognized in the astrocyte population, a complexity that is relevant both to their normal ...
Source: Neuropathology and Applied Neurobiology - May 22, 2017 Category: Neurology Authors: C. J. Garwood, L. E. Ratcliffe, J. E. Simpson, P. R. Heath, P. G. Ince, S. B. Wharton Tags: Review Source Type: research
In This Issue
(Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - May 22, 2017 Category: Neurology Tags: In This Issue Source Type: research
