Sleep architecture and the risk of incident dementia in the community
Conclusions: Despite contemporary interest in slow-wave sleep and dementia pathology, our findings implicate REM sleep mechanisms as predictors of clinical dementia. (Source: Neurology)
Source: Neurology - September 18, 2017 Category: Neurology Authors: Pase, M. P., Himali, J. J., Grima, N. A., Beiser, A. S., Satizabal, C. L., Aparicio, H. J., Thomas, R. J., Gottlieb, D. J., Auerbach, S. H., Seshadri, S. Tags: All Sleep Disorders, All Cognitive Disorders/Dementia, Alzheimer's disease, Cognitive aging, Cohort studies ARTICLE Source Type: research

Erenumab (AMG 334) in episodic migraine: Interim analysis of an ongoing open-label study
Conclusions: One-year efficacy, supported by functional improvements and favorable safety and tolerability profiles, supports further investigation of erenumab as a preventive treatment in patients with EM. Clinicaltrials.gov identifier: NCT01952574. Classification of evidence: This study provides Class IV evidence that for patients with episodic migraine, erenumab reduces long-term MMD and improves headache-related disability and migraine-specific quality of life. (Source: Neurology)
Source: Neurology - September 18, 2017 Category: Neurology Authors: Ashina, M., Dodick, D., Goadsby, P. J., Reuter, U., Silberstein, S., Zhang, F., Gage, J. R., Cheng, S., Mikol, D. D., Lenz, R. A. Tags: Migraine, All Clinical trials, Class IV ARTICLE Source Type: research

Stenting for symptomatic vertebral artery stenosis: The Vertebral Artery Ischaemia Stenting Trial
Conclusions: Stenting in extracranial stenosis appears safe with low complication rates. Large phase 3 trials are required to determine whether stenting reduces stroke risk. ISRCTN.com identifier: ISRCTN95212240. Classification of evidence: This study provides Class I evidence that for patients with symptomatic vertebral stenosis, angioplasty with stenting does not reduce the risk of stroke. However, the study lacked the precision to exclude a benefit from stenting. (Source: Neurology)
Source: Neurology - September 18, 2017 Category: Neurology Authors: Markus, H. S., Larsson, S. C., Kuker, W., Schulz, U. G., Ford, I., Rothwell, P. M., Clifton, A., For the VIST Investigators Tags: Stroke prevention, All Cerebrovascular disease/Stroke, Clinical trials Randomized controlled (CONSORT agreement) ARTICLE Source Type: research

Incidence and management of seizures after ischemic stroke: Systematic review and meta-analysis
Conclusions: The burden of stroke-related seizures and epilepsy due to ischemic stroke is substantial. Further studies are required to determine risk factors for epilepsy following ischemic stroke and optimal secondary prevention. (Source: Neurology)
Source: Neurology - September 18, 2017 Category: Neurology Authors: Wang, J. Z., Vyas, M. V., Saposnik, G., Burneo, J. G. Tags: All Cerebrovascular disease/Stroke, Incidence studies, All Epilepsy/Seizures ARTICLE Source Type: research

Genetic epilepsy with febrile seizures plus: Refining the spectrum
Conclusion: As 37/409 (9%) affected individuals have focal epilepsies, we suggest that GEFS+ be renamed genetic epilepsy with febrile seizures plus rather than generalized epilepsy with febrile seizures plus. The phenotypic overlap between GEFS+ and the classic generalized epilepsies is considerably greater than first thought. The clinical and molecular data suggest that the 2 major groups of generalized epilepsies share genetic determinants. (Source: Neurology)
Source: Neurology - September 18, 2017 Category: Neurology Authors: Zhang, Y.-H., Burgess, R., Malone, J. P., Glubb, G. C., Helbig, K. L., Vadlamudi, L., Kivity, S., Afawi, Z., Bleasel, A., Grattan-Smith, P., Grinton, B. E., Bellows, S. T., Vears, D. F., Damiano, J. A., Goldberg-Stern, H., Korczyn, A. D., Dibbens, L. M., Tags: All Genetics ARTICLE Source Type: research