Letter re: Burnout, career satisfaction, and well-being among US neurologists in 2016
From a recent workforce survey, Busis et al.1 reported that 63% of neurologists in clinical practice had at least one symptom of burnout. Burnout and percentage of clinical practice time were associated with decreased professional satisfaction. However, meaningful work and job autonomy were associated with increased satisfaction. (Source: Neurology)
Source: Neurology - October 9, 2017 Category: Neurology Authors: Bagot, K. L., Cadilhac, D. A., Kim, J., Vu, M., Bladin, C. F. Tags: WRITECLICK & amp;reg; EDITOR ' S CHOICE Source Type: research

Editors' Note
: In a survey of US American Academy of Neurology member neurologists who had finished training, Busis et al. found that approximately 60% had at least one symptom of burnout. Burnout was strongly associated with decreased career satisfaction, while meaningful work and job autonomy were associated with increased satisfaction. (Source: Neurology)
Source: Neurology - October 9, 2017 Category: Neurology Authors: Karam, C., Galetta, S. Tags: WRITECLICK & amp;reg; EDITOR ' S CHOICE Source Type: research

TIPIC syndrome
A 31-year-old woman presented with left acute cervical pain. Cervical imaging showed a large pericarotid infiltration (figure 1). A diagnosis of transient perivascular inflammation of the carotid artery (TIPIC) syndrome was made. The patient received steroids with full clinical recovery 12 days after onset. The follow-up ultrasound showed striking decrease of the perivascular infiltration, confirming the diagnosis (figure 2). (Source: Neurology)
Source: Neurology - October 9, 2017 Category: Neurology Authors: Lecler, A., Obadia, M., Sadik, J.-C. Tags: Secondary headache disorders, MRI, Ultrasound, Other cerebrovascular disease/ Stroke NEUROIMAGES Source Type: research

Job negotiation
There are many who will find this poem Difficult to understand. And many who, thank God, Will not. (Source: Neurology)
Source: Neurology - October 9, 2017 Category: Neurology Authors: Schor, N. F. Tags: Administration REFLECTIONS: NEUROLOGY AND THE HUMANITIES Source Type: research

Swallowing-induced displacement of the carotid artery as a risk of stroke: Flip-flop phenomenon
A 70-year-old man without cerebrovascular risk factors was admitted to our hospital with amaurosis fugax of the right eye. Diffusion MRI showed an acute asymptomatic brain infarct in the right frontal lobe cortex, and carotid duplex ultrasound revealed movement of the right internal carotid artery (ICA), with a hypoechoic plaque at its origin, in contact with the hyoid bone during head rotation and swallowing (figure). (Source: Neurology)
Source: Neurology - October 9, 2017 Category: Neurology Authors: Kinoshita, N., Saito, K., Tanaka, T., Kajimoto, K., Yamagami, H., Morita, Y., Ihara, M., Nagatsuka, K. Tags: MRI, Ultrasound, Infarction CLINICAL/SCIENTIFIC NOTES Source Type: research

Sex differences in the prevalence of genetic mutations in FTD and ALS: A meta-analysis
Conclusions: Higher female prevalence of C9orf72 hexanucleotide repeat expansions in ALS and GRN mutations in FTD suggest that sex-related risk factors might moderate C9orf72 and GRN-mediated phenotypic expression. (Source: Neurology)
Source: Neurology - October 9, 2017 Category: Neurology Authors: Curtis, A. F., Masellis, M., Hsiung, G.-Y. R., Moineddin, R., Zhang, K., Au, B., Millett, G., Mackenzie, I., Rogaeva, E., Tierney, M. C. Tags: All Clinical Neurology, Amyotrophic lateral sclerosis, Frontotemporal dementia, Gene expression studies, All epidemiology VIEWS & amp;amp; REVIEWS Source Type: research

Giuliano Vanghetti and the innovation of "cineplastic operations"
Conclusions: Vanghetti was the first to accurately perform and describe cineplastic operations for patients following an upper arm amputation. He considered the neurologic implications of the problem and, perhaps in an effort to provide more appropriate proprioceptive feedback, he intuitively applied the prostheses so that they were functionally activated by the muscles of the proximal stump. (Source: Neurology)
Source: Neurology - October 9, 2017 Category: Neurology Authors: Tropea, P., Mazzoni, A., Micera, S., Corbo, M. Tags: Quality of life, Clinical neurology history, Other trauma, Motor Control HISTORICAL NEUROLOGY Source Type: research

Quality improvement in neurology: Stroke and Stroke Rehabilitation Quality Measurement Set update
Stroke is the fifth leading cause of death in the United States and the second leading cause of disability worldwide.1,2 "On average, every 40 seconds, someone in the United States has a stroke, and someone dies of one approximately every 4 minutes."3 Each year, nearly 800,000 people experience stroke, with up to 185,000 experiencing recurrent stroke events.3 Strokes occur at any age, and risk increases with age.4 Nearly half of older stroke survivors experience moderate to severe disability.5 (Source: Neurology)
Source: Neurology - October 9, 2017 Category: Neurology Authors: Latorre, J. G. S., Flanagan, S., Phipps, M. S., Shenoy, A. M., Bennett, A., Seidenwurm, D. Tags: All Imaging, All Cerebrovascular disease/Stroke, All Rehabilitation, All Practice Management SPECIAL ARTICLE Source Type: research

REM sleep behavior disorder is related to enteric neuropathology in Parkinson disease
Conclusions: Patients with PD and RBD have a greater frequency of synuclein pathology in the enteric nervous system, suggesting that RBD is associated with widespread synuclein neuropathology. (Source: Neurology)
Source: Neurology - October 9, 2017 Category: Neurology Authors: Leclair-Visonneau, L., Clairembault, T., Coron, E., Le Dily, S., Vavasseur, F., Dalichampt, M., Pereon, Y., Neunlist, M., Derkinderen, P. Tags: Parkinson's disease/Parkinsonism, Parasomnias ARTICLE Source Type: research

Optical coherence tomography identifies outer retina thinning in frontotemporal degeneration
Conclusions: FTD is associated with outer retina thinning, and this thinning correlates with disease severity. (Source: Neurology)
Source: Neurology - October 9, 2017 Category: Neurology Authors: Kim, B. J., Irwin, D. J., Song, D., Daniel, E., Leveque, J. D., Raquib, A. R., Pan, W., Ying, G.-S., Aleman, T. S., Dunaief, J. L., Grossman, M. Tags: Progressive supranuclear palsy, Retina, Frontotemporal dementia ARTICLE Source Type: research

Cognitive trajectories over 4 years among HIV-infected women with optimal viral suppression
Conclusions: Cognitive difficulties remain among HIV+ women despite persistent viral suppression. In some instances, VS women are worse than NVS women, reinforcing the need for novel adjunctive therapies to attenuate cognitive problems. (Source: Neurology)
Source: Neurology - October 9, 2017 Category: Neurology Authors: Rubin, L. H., Maki, P. M., Springer, G., Benning, L., Anastos, K., Gustafson, D., Villacres, M. C., Jiang, X., Adimora, A. A., Waldrop-Valverde, D., Vance, D. E., Bolivar, H., Alden, C., Martin, E. M., Valcour, V. G., For the Women's Interagency HIV Study Tags: HIV, Neuropsychological assessment, HIV dementia, Assessment of cognitive disorders/dementia ARTICLE Source Type: research

Reversibility of the effects of natalizumab on peripheral immune cell dynamics in MS patients
Conclusions: Natalizumab's effects on peripheral immune cells and pharmacodynamic markers were reversible, with changes starting 8 weeks post last natalizumab dose; levels returned to those observed/expected in untreated patients 16 weeks post last dose. This reversibility differentiates natalizumab from MS treatments that require longer reconstitution times. Characterization of the time course of natalizumab's biological effects may help clinicians make treatment sequencing decisions. Classification of evidence: This study provides Class III evidence that the pharmacodynamic markers of natalizumab are reversed 16 weeks a...
Source: Neurology - October 9, 2017 Category: Neurology Authors: Plavina, T., Muralidharan, K. K., Kuesters, G., Mikol, D., Evans, K., Subramanyam, M., Nestorov, I., Chen, Y., Dong, Q., Ho, P.-R., Amarante, D., Adams, A., De Seze, J., Fox, R., Gold, R., Jeffery, D., Kappos, L., Montalban, X., Weinstock-Guttman, B., Har Tags: All Demyelinating disease (CNS), Multiple sclerosis ARTICLE Source Type: research

25-Hydroxyvitamin D deficiency and risk of MS among women in the Finnish Maternity Cohort
Conclusions: These results directly support vitamin D deficiency as a risk factor for MS and strengthen the rationale for broad public health interventions to improve vitamin D levels. (Source: Neurology)
Source: Neurology - October 9, 2017 Category: Neurology Authors: Munger, K. L., Hongell, K., Aivo, J., Soilu-Hänninen, M., Surcel, H.-M., Ascherio, A. Tags: Multiple sclerosis, Risk factors in epidemiology ARTICLE Source Type: research

Nonlinear temporal dynamics of cerebral small vessel disease: The RUN DMC study
Conclusions: SVD progression is nonlinear, accelerating over time, and a highly dynamic process, with progression interrupted by reduction in some, in a population that on average shows progression. (Source: Neurology)
Source: Neurology - October 9, 2017 Category: Neurology Authors: van Leijsen, E. M. C., van Uden, I. W. M., Ghafoorian, M., Bergkamp, M. I., Lohner, V., Kooijmans, E. C. M., van der Holst, H. M., Tuladhar, A. M., Norris, D. G., van Dijk, E. J., Rutten-Jacobs, L. C. A., Platel, B., Klijn, C. J. M., de Leeuw, F.-E. Tags: MRI, All Cerebrovascular disease/Stroke, Cohort studies, Risk factors in epidemiology ARTICLE Source Type: research

Outcome after stroke thrombolysis in patients >80 years treated within 3 hours vs >3-4.5 hours
Conclusions: In this observational study, unselected patients >80 years of age treated with IVT after 3 hours vs earlier had a slightly higher rate of SICH and similar unadjusted functional outcome but poorer adjusted outcome. The absolute difference between the treatment groups is small, and elderly patients should not be denied IVT in the later time window solely because of age without other contraindications. (Source: Neurology)
Source: Neurology - October 9, 2017 Category: Neurology Authors: Ahmed, N., Lees, K. R., Ringleb, P. A., Bladin, C., Collas, D., Toni, D., Ford, G. A., And the SITS Investigators Tags: All Cerebrovascular disease/Stroke ARTICLE Source Type: research