The cholinergic anti ‐inflammatory pathway revisited
Neurogastroenterology&Motility,Volume 30, Issue 3, March 2018. (Source: Neurogastroenterology and Motility)
Source: Neurogastroenterology and Motility - February 22, 2018 Category: Gastroenterology Source Type: research
Cover Image
Neurogastroenterology&Motility,Volume 30, Issue 3, March 2018. (Source: Neurogastroenterology and Motility)
Source: Neurogastroenterology and Motility - February 22, 2018 Category: Gastroenterology Source Type: research
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Neurogastroenterology&Motility,Volume 30, Issue 3, March 2018. (Source: Neurogastroenterology and Motility)
Source: Neurogastroenterology and Motility - February 22, 2018 Category: Gastroenterology Source Type: research
The cholinergic anti ‐inflammatory pathway revisited
Abstract
Inflammatory bowel disease negatively affects the quality of life of millions of patients around the world. Although the precise etiology of the disease remains elusive, aberrant immune system activation is an underlying cause. As such, therapies that selectively inhibit immune cell activation without broad immunosuppression are desired. Inhibition of immune cell activation preventing pro‐inflammatory cytokine production through neural stimulation has emerged as one such treatment. These therapeutics are based on the discovery of the cholinergic anti‐inflammatory pathway, a reflex arc that induces efferent vag...
Source: Neurogastroenterology and Motility - February 22, 2018 Category: Gastroenterology Authors: K. Murray, C. Reardon Tags: MINI ‐REVIEW Source Type: research
Issue Information
(Source: Neurogastroenterology and Motility)
Source: Neurogastroenterology and Motility - February 22, 2018 Category: Gastroenterology Tags: ISSUE INFORMATION Source Type: research
Cover Image
The cover image, by K.‐S. Ng et al., is based on the Original Article Quantification and neurochemical coding of the myenteric plexus in humans: No regional variation between the distal colon and rectum, DOI: 10.1111/nmo.13193. (Source: Neurogastroenterology and Motility)
Source: Neurogastroenterology and Motility - February 22, 2018 Category: Gastroenterology Authors: K. ‐S. Ng, N. A. Montes‐Adrian, D. A. Mahns, M. A. Gladman Tags: COVER IMAGE Source Type: research
Cardiovascular safety of prokinetic agents: A focus on drug ‐induced arrhythmias
Neurogastroenterology&Motility, EarlyView. (Source: Neurogastroenterology and Motility)
Source: Neurogastroenterology and Motility - February 14, 2018 Category: Gastroenterology Source Type: research
bis ‐(p‐hydroxyphenyl)‐pyridyl‐2‐methane (BHPM)—the active metabolite of the laxatives bisacodyl and sodium picosulfate—enhances contractility and secretion in human intestine in vitro
Neurogastroenterology&Motility, EarlyView. (Source: Neurogastroenterology and Motility)
Source: Neurogastroenterology and Motility - February 14, 2018 Category: Gastroenterology Source Type: research
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Neurogastroenterology&Motility, Ahead of Print. (Source: Neurogastroenterology and Motility)
Source: Neurogastroenterology and Motility - February 14, 2018 Category: Gastroenterology Source Type: research
bis ‐(p‐hydroxyphenyl)‐pyridyl‐2‐methane (BHPM)—the active metabolite of the laxatives bisacodyl and sodium picosulfate—enhances contractility and secretion in human intestine in vitro
Conclusions and InterferencesBHPM enhanced mucosal secretion and muscle contractility. Results suggested that the laxative effect of BHPM was a consequence of the increase in muscle tone as well as an increased K+ secretion when acting luminally and a nerve‐driven Cl− and HCO3− secretion once acting basolaterally after absorption.
We identified the action of bis‐(p‐hydroxyphenyl)‐pyridyl‐2‐methane (BHPM), the active metabolite of the laxatives bisacodyl and sodium picosulfate, in human intestinal samples.
BHPM increased muscle tone in small and large intestine. It enhanced K+ secretion when acting lumin...
Source: Neurogastroenterology and Motility - February 14, 2018 Category: Gastroenterology Authors: D. Krueger, I. E. Demir, G. O. Ceyhan, F. Zeller, M. Schemann Tags: ORIGINAL ARTICLE Source Type: research
The effect of arabinoxylooligosaccharides on upper gastroduodenal motility and hunger ratings in humans
Neurogastroenterology&Motility, EarlyView. (Source: Neurogastroenterology and Motility)
Source: Neurogastroenterology and Motility - February 13, 2018 Category: Gastroenterology Source Type: research
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Neurogastroenterology&Motility, Ahead of Print. (Source: Neurogastroenterology and Motility)
Source: Neurogastroenterology and Motility - February 13, 2018 Category: Gastroenterology Source Type: research
