Diabetes ‐induced colonic slow transit mediated by the up‐regulation of PDGFRα+ cells/SK3 in streptozotocin‐induced diabetic mice
Conclusions and InferencesThese results suggest that the purinergic neurotransmitters/P2Y1/SK3 signaling pathway is up‐regulated in the diabetic colons, thereby mediating diabetes‐induced colonic slow transit.
This article investigates the contributions of PDGFRα+ cells to diabetes‐induced colonic slow transit in streptozotocin‐induced diabetic mice. The colonic smooth muscles were more sensitive to apamin (the SK3 antagonist) in STZ‐treated mice, indicating that the functionally up‐regulated SK3 channels exerted more inhibitory effects on the colonic motility. (Source: Neurogastroenterology and Motility)
Source: Neurogastroenterology and Motility - March 9, 2018 Category: Gastroenterology Authors: N. ‐N. Song, H.‐L. Lu, C. Lu, L. Tong, S.‐Q. Huang, X. Huang, J. Chen, Y.‐C. Kim, W.‐X. Xu Tags: ORIGINAL ARTICLE Source Type: research
Pressure exposure and catheter impingement affect the recorded pressure in the Manoscan 360 ™ system
Conclusions and InferencesIn addition to the known effects of temperature, both sustained pressure exposure and catheter impingement significantly affect the recorded pressure and the magnitude of the PD observed at the end of the recording. These effects can be substantial enough to result in erroneous manometric diagnoses.
The accuracy of pressure measurements by Manoscan system is affected by development of pressure drift (PD) throughout the recording. Application of sustained pressure significantly increased PD, and catheter impingement produced remarkable increases in the recorded pressure as well as PD. In addition ...
Source: Neurogastroenterology and Motility - March 9, 2018 Category: Gastroenterology Authors: A. Babaei, A. Szabo, S. D. Yorio, B. T. Massey Tags: ORIGINAL ARTICLE Source Type: research
Rikkunshito simultaneously improves dyspepsia correlated with anxiety in patients with functional dyspepsia: A randomized clinical trial (the DREAM study)
Neurogastroenterology&Motility, EarlyView. (Source: Neurogastroenterology and Motility)
Source: Neurogastroenterology and Motility - March 2, 2018 Category: Gastroenterology Source Type: research
Normal values for assessment of anal sphincter morphology, anorectal motion, and pelvic organ prolapse with MRI in healthy women
Neurogastroenterology&Motility, EarlyView. (Source: Neurogastroenterology and Motility)
Source: Neurogastroenterology and Motility - March 2, 2018 Category: Gastroenterology Source Type: research
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Neurogastroenterology&Motility, Ahead of Print. (Source: Neurogastroenterology and Motility)
Source: Neurogastroenterology and Motility - March 2, 2018 Category: Gastroenterology Source Type: research
Normal values for assessment of anal sphincter morphology, anorectal motion, and pelvic organ prolapse with MRI in healthy women
ConclusionsIn addition to age, BMI and parity also affect anorectal motion in asymptomatic women. These findings provide age‐adjusted normal values for rectoanal anatomy and pelvic floor motion.
Compared to age, BMI and parity have lesser effects on anorectal motion in asymptomatic women. These findings provide age‐adjusted normal values for rectoanal anatomy and pelvic floor motion. (Source: Neurogastroenterology and Motility)
Source: Neurogastroenterology and Motility - March 2, 2018 Category: Gastroenterology Authors: P. Tirumanisetty, D. Prichard, J. G. Fletcher, S. Chakraborty, A. R. Zinsmeister, A. E. Bharucha Tags: ORIGINAL ARTICLE Source Type: research
Intra ‐operative high‐resolution mapping of slow wave propagation in the human jejunum: Feasibility and initial results
Neurogastroenterology&Motility, EarlyView. (Source: Neurogastroenterology and Motility)
Source: Neurogastroenterology and Motility - March 1, 2018 Category: Gastroenterology Source Type: research
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Neurogastroenterology&Motility, Ahead of Print. (Source: Neurogastroenterology and Motility)
Source: Neurogastroenterology and Motility - March 1, 2018 Category: Gastroenterology Source Type: research
Walker ‐256 tumor alters morphology of intestinal myenteric plexus in rats
Conclusions and InferencesThis study showed that the Walker‐256 tumor induced alterations in the morphology of nitrergic and cholinergic neurons in the myenteric plexus and decreased the upper GI transit with the presence of multiple constrictions in the colon. Therefore, these alterations can interfere on neurotransmission and can be related to the intestinal motility alterations observed in tumor‐bearing rats.
Gastrointestinal dysmotility is common in patients with cancer, and there are a few studies about the myenteric plexus in the presence of anatomically remote tumors. This study showed that the Walker‐256 tum...
Source: Neurogastroenterology and Motility - March 1, 2018 Category: Gastroenterology Authors: P. Marega, E. A. Liberti, J. J. S. Freitas, K. S. Kietzer Tags: ORIGINAL ARTICLE Source Type: research
Mylohyoid motor evoked potentials can effectively predict persistent dysphagia 3 months poststroke
Conclusions and InferencesMH‐MEP was well‐correlated with dysphagia severity assessed by VFSS. The rMT ratio and amplitude ratio of MH‐MEP can effectively predict persistent dysphagia 3 months poststroke.
The purpose of this study was to investigate the association between MH‐MEP and swallowing function and determine the value of MH‐MEP for predicting aspiration three months post‐stroke. MH‐MEP was well correlated with dysphagia severity assessed by VFSS. The MH‐MEP can effectively predict persistent dysphagia 3 months post‐stroke. (Source: Neurogastroenterology and Motility)
Source: Neurogastroenterology and Motility - March 1, 2018 Category: Gastroenterology Authors: K. M. Lee, M. C. Joo, Y. M. Yu, M. ‐S. Kim Tags: ORIGINAL ARTICLE Source Type: research
Systematic review: Disease ‐specific instruments to assess gastrointestinal symptoms in functional dyspepsia
Abstract
BackgroundFunctional dyspepsia (FD) is a common functional gastrointestinal disorder with incompletely understood pathophysiology and heterogeneous symptom presentation. Assessment of treatment efficacy in FD is a methodological challenge as response to treatment must be assessed primarily by measuring subjective symptoms. Therefore, the use of patient‐reported outcome measures (PROMs) is recommended by regulatory authorities to assess gastrointestinal symptoms in clinical trials for FD. In the last decades, a multitude of outcome measures has been developed. However, currently no PROM has been approved by the r...
Source: Neurogastroenterology and Motility - March 1, 2018 Category: Gastroenterology Authors: F. G. M. Smeets, A. A. M. Masclee, J. M. Conchillo, D. Keszthelyi Tags: REVIEW ARTICLE Source Type: research
Rikkunshito simultaneously improves dyspepsia correlated with anxiety in patients with functional dyspepsia: A randomized clinical trial (the DREAM study)
Conclusion & inferencesRikkunshito may be beneficial for FD patients to simultaneously treat gastrointestinal and psychological symptoms.
In the RCT conducted for Helicobacter pylori‐negative FD patients, rikkunshito significantly relieved dyspeptic symptoms compared to placebo possibly via improvement for physiological dysfunction based on the changes in PAGI‐SYM scores. Attenuation of anxiety correlated with improvement of dyspeptic symptoms such as postprandial fullness/early satiety. Rikkunshito exhibits relevant pharmacological actions throughout the brain‐gut axis and improves dyspeptic symptoms mediated b...
Source: Neurogastroenterology and Motility - March 1, 2018 Category: Gastroenterology Authors: K. Tominaga, Y. Sakata, H. Kusunoki, T. Odaka, K. Sakurai, O. Kawamura, A. Nagahara, T. Takeuchi, Y. Fujikawa, T. Oshima, M. Kato, T. Furuta, K. Murakami, T. Chiba, H. Miwa, Y. Kinoshita, K. Higuchi, M. Kusano, R. Iwakiri, K. Fujimoto, J. F. Tack, T. Arak Tags: ORIGINAL ARTICLE Source Type: research
Intra ‐operative high‐resolution mapping of slow wave propagation in the human jejunum: Feasibility and initial results
Conclusions & InferencesThis study introduces HR mapping of human intestinal slow waves, and provides first descriptions of intestinal pacemaker sites and velocity anisotropy. Future translation to other intestinal regions, disease states, and postsurgical dysmotility holds potential for improving the basic and clinical understanding of small intestine pathophysiology.
This study evaluated the feasibility of high‐resolution (HR) slow wave mapping in the human small intestine, including defining spatiotemporal propagation patterns. Slow wave frequency, amplitude, downstroke width, and anisotropic velocity profile wer...
Source: Neurogastroenterology and Motility - March 1, 2018 Category: Gastroenterology Authors: T. R. Angeli, G. O'Grady, R. Vather, I. P. Bissett, L. K. Cheng Tags: ORIGINAL ARTICLE Source Type: research
Electro ‐acupuncture at ST37 and ST25 induce different effects on colonic motility via the enteric nervous system by affecting excitatory and inhibitory neurons
Conclusions and InferencesElectro‐acupuncture at specific acupoints can improve intestinal motility in constipation by altering the ENS and differentially affecting excitatory and inhibitory neurons, restoring the coordination between contraction and relaxation muscles, and working in concert with the central nervous system and peripheral neural pathways.
EA stimulation at either ST 37 or ST 25 relieves the symptoms of constipation, but has different effects in the proximal colon. ST 37 alters both excitatory and inhibitory enteric neurons, while ST 25 only influences inhibitory neurons. (Source: Neurogastroenterology and Motility)
Source: Neurogastroenterology and Motility - February 28, 2018 Category: Gastroenterology Authors: C. Liang, K. ‐Y. Wang, M.‐R. Gong, Q. Li, Z. Yu, B. Xu Tags: ORIGINAL ARTICLE Source Type: research
