Tmic-01. molecular and clinical characterization of pd-l1 expression at transcriptional level via 976 samples of brain glioma
CONCLUSION:PD-L1 is upregulated in glioblastoma, and is synergistic with other check point members. Moreover, PD-L1 is significantly associated with T-cell activation and macrophage related immune response and predicts much worse survival for patients, warranting clinical trials of PD1/PD-L1 checkpoint inhibitors for potential glioma treatment. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Wang, Z. Tags: TUMOR MICROENVIRONMENT Source Type: research
Surg-42. "gv/ga sarissa-lancet" an innovative device for the identification of glioma margins
CONCLUSION:The rapid DNA analysis by flow cytometry is a promising, low-cost adjunct for intraoperative glioma excision and should be further investigated. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Vartholomatos, G., Alexiou, G., Voulgaris, S., Kyritsis, A. Tags: SURGICAL THERAPY Source Type: research
Surg-41. "journal bias" in neuro-oncology: an analysis of the surgical high grade glioma literature
CONCLUSIONS:We termed the tendency of certain types of articles to be published in select journals "journal bias" and discuss the implication of this form of bias as it pertains to evidence-based medicine. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Hirshman, B., Jones, L., Tang, J., Ali, M. A., Proudfoot, J., Carley, K., Carter, B., Chen, C. Tags: SURGICAL THERAPY Source Type: research
Surg-40. indications and outcomes of brain tumor surgery in high field intra-operative mri
CONCLUSIONS:High field intra-operative MRI can be routinely incorporated into neurosurgical oncology and combined with electrophysiological stimulation mapping. This combination of optimal image-guidance and physiological guidance can facilitate safe, extensive resection even for challenging tumors in eloquent locations. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Parney, I. F., Planchard, R. Tags: SURGICAL THERAPY Source Type: research
Surg-39. surgical resection of glioblastoma in elderly patients: the potential role of 5-ala fluorescence guidance
Glioblastoma (GBM) is the most common primary brain tumor in adults and commonly occurs in individuals aged 65 years or older. The prognosis of elderly patients with GBM is universally poor: their median survival ranges from 4 to 9 months. The main reason is that older patients are often treated more conservatively than younger; this is a result of reluctance to offer aggressive treatment for fear of postoperative complications. Several series report that the 5-ALA fluorescence-guided resection increases the extension of tumor removal, improving survival. The aim of this study is to evaluate the impact of 5-ALA o...
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Carapella, C., Villani, V. Tags: SURGICAL THERAPY Source Type: research
Surg-38. direct evidence of plasticity within primary motor and sensory cortices via direct electrical stimulation in glioblastoma patients undergoing repeat awake craniotomy
In this study, we examine plasticity within primary sensory (S1) and motor (M1) cortices in glioblastoma patients undergoing repeat intra-operative direct electrical stimulation (DES) under awake conditions.METHODS:This retrospective analysis included five patients with glioblastoma in/near M1/S1 that underwent two awake surgeries, each with DES-based sensory and motor mapping. Inter-surgery interval was 216 ± 41 days. Plasticity was defined as a change in mapping result (gain, loss, or change of function) within M1/S1 at second operation or absence of typical mapping result without a change in the patient&rsqu...
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Gibb, W., Kong, N. Tags: SURGICAL THERAPY Source Type: research
Surg-37. modern postoperative seizure prophylaxis with levetiracetam in over 300 newly diagnosed glioblastoma patients
CONCLUSION:Our large retrospective study of modern seizure prophylaxis with levetiracetam revealed the initial post-operative week to be the most common seizure period regardless of pre-operative seizure status, emphasizing the timeframe during which patients without seizures should be prophylaxed and suggesting consideration for a second agent during this period in patients with preoperative seizures. Furthermore, the neurosurgeon’s discretion to choose which patients without preoperative seizures to give prophylactic levetiracetam to may select high risk patients, the variables of which we will seek to define, shed...
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Jahangiri, A., Flanigan, P. M., Choi, S., Chou, A., Arnush, M., Bruhn, J., Kuang, R., Truong, A., Clarke, J., Chang, E., McDermott, M., Chang, S., Berger, M. S., Aghi, M. Tags: SURGICAL THERAPY Source Type: research
SURG-36. IMPACT OF MULTIMODALITY MONITORING USING DIRECT ELECTRICAL STIMULATION TO DETERMINE CORTICOSPINAL TRACT SHIFT AND INTEGRITY IN THE iMRI suite
Preserving the integrity of the corticospinal tract (CST) while maximizing the extent of tumor resection is one of the key principles of brain tumor surgery to prevent new neurological deficits. The goal of this project was to determine the impact of the use of peri-operative DTI fiber-tracking protocols for localization of the CSTs, in conjunction with intraoperative direct electrical stimulation (DES) on patient neurological outcomes. Fifty-three patients underwent resection of tumors adjacent to the motor gyrus and the underlying CST. Preoperative and postoperative DTI mapping, intraoperative cortical and subcortical di...
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Krivosheya, D., Rao, G., Tummala, S., Kumar, V., Suki, D., Prabhu, S. Tags: SURGICAL THERAPY Source Type: research
Surg-34. improved survival with decreased wait time to surgery in glioblastoma patients presenting with seizure
CONCLUSIONS:Seizure as the only preoperative symptom independently improved survival, however when patients developed additional preoperative symptoms, typically due to delay in surgery, no prognostic benefit was observed. Prompt diagnosis and neurosurgical intervention is warranted in patients with seizures without other preoperative symptoms to preserve their favorable prognosis. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Flanigan, P. M., Jahangiri, A., Kuang, R., Truong, A., Choi, S., Chou, A., McDermott, M. F., Berger, M. S., Aghi, M. Tags: SURGICAL THERAPY Source Type: research
Surg-32. intra-class correlations of laser-treated high grade gliomas
CONCLUSION:The ICC gives a composite of the consistency of measurements made by multiple observers measuring the same quantity. The overall ICC of 0.65 means there is good correlation between observers in our study between measured volumes. When the ICC was examined between the 4 best readers, who were the more senior and experienced observers, the ICC scores were noted to be excellent for all three volumes. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Noh, T., Lee, I. Tags: SURGICAL THERAPY Source Type: research
SURG-31. INTRAOPERATIVE MOLECULAR DIAGNOSIS AND SURGICAL GUIDANCE USING iKNIFE REAL-TIME MASS SPECTROMETRY
CONCLUSIONS:The iKnife represents a system which can accurately and rapidly identify tissue being operated on and easily integrates with the current setup in all operating rooms. The information is collected during routine use of bipolar forceps raising the possibility of controlling tumor resection using the real-time molecular data being obtained. Further multicentre studies are required to investigate patient-patient and machine-machine variability. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Vaqas, B., White, E., Hui-Yu, H., Balog, J., Galea, D., Takats, Z., ONeill, K. Tags: SURGICAL THERAPY Source Type: research
Surg-30. using the neurologic assessment in neuro-oncology (nano) scale as a predictive assessment tool for survival in patients with primary glioblastoma
The neurologic assessment in neuro-oncology (NANO) scale is a standardized metric designed to measure neurologic function in neuro-oncology. Current available neuroradiological evaluation criteria fail to use specific clinical criteria for tumor recurrence. Additionally, existing clinical measures of patient performance such as the Karnofsky Performance Scale (KPS) and the Eastern Cooperative Oncology Group (ECOG) are generalized and do not incorporate specific neurologic performance criteria in assessment of the patient, nor are they used to predict glioma progression. Currently, it is not known whether or not the NANO sc...
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Ung, T., Ney, D., Damek, D., Yousseff, S., Lillehei, K., Ormond, D. Tags: SURGICAL THERAPY Source Type: research
Surg-29. personalizing the decision gross total resection (gtr) in neuro-oncology
CONCLUSION:Our study suggest that surgeons should take tumor histopathology into account when deciding upon the extent of surgical resection of glial tumors and the critical need for real-time intra-operative histologic diagnosis. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Chen, C., Alattar, A., Schupper, A., Brandel, M., Padwal, J., Hirshman, B., Carter, B. Tags: SURGICAL THERAPY Source Type: research
Surg-28. combination of intraoperative mri with electrophysiological monitoring for enhanced brain tumor resection
In this study, 203 patients undergoing craniotomy and tumor resection with iMRI by a single surgeon were followed to determine outcomes. Among these, 124 also underwent electrophysiological mapping of motor (65 of 203), speech (3 of 203) or both (56 of 203). There were no significant differences in age, gender or comorbidities among the participants. Patients undergoing combined motor and speech mapping were less likely to obtain a gross total resection (18% versus 32% of patients undergoing motor mapping only and 42% who received surgery without intraoperative mapping). However, when controlled for tumor location and...
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Planchard, R., Shepherd, D. Tags: SURGICAL THERAPY Source Type: research
Surg-27. stereotactic laser ablation (sla) as treatment for brain metastases that recur after stereotactic radiosurgery: a multi-institutional experience
CONCLUSION:SLA is an effective treatment option for BMs that fail SRS. Ablation of >80% of BMs is associated with decreased risk of disease progression. The efficacy of SLA in this setting may be augmented by adjuvant hypo-fractionated SRS. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Chen, C., Amaan, M., Rennert, R., Carroll, K., Sharma, M., Barnholtz-sloan, J., Myers, C., Barnett, G., Smith, K., Mohammadi, A., Sloan, A. Tags: SURGICAL THERAPY Source Type: research
