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'I feel stronger and younger all the time--perspectives of elderly kidney transplant recipients: thematic synthesis of qualitative research
Conclusions Kidney transplantation was perceived to slow and even reverse the experience of aging among elderly recipients, especially compared with dialysis. However, some were frustrated over persistent limitations after transplant, struggled with the burden of medication side effects and worried about a possible return to dialysis if the transplant failed. Clarifying patient expectations of transplantation, providing support to alleviate the debilitating impacts of immunosuppression and addressing fears about deteriorating health and graft failure may improve satisfaction and outcomes in elderly kidney transplant recipi...
Source: Nephrology Dialysis Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Pinter, J., Hanson, C. S., Craig, J. C., Chapman, J. R., Budde, K., Halleck, F., Tong, A. Tags: Renal Transplantation Source Type: research

Estimated nephron number of the remaining donor kidney: impact on living kidney donor outcomes
Conclusions Low nephron number predisposes donors to inferior remaining eGFR, hypertension and proteinuria. The strong correlation in elderly donors may be attributed to reduced renal functional reserve due to the decline of renal function with age. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Schachtner, T., Reinke, P. Tags: Renal Transplantation Source Type: research

High-urgency kidney transplantation in the Eurotransplant Kidney Allocation System: success or waste of organs? The Eurotransplant 15-year all-centre survey
Conclusions Facing organ shortages, increasing wait times and considerable mortality on dialysis, we question the current policy of HU allocation and propose more restrictive criteria with regard to individuals with vascular complications or repeated retransplantations in order to support patients on the non-HU waiting list with a much better long-term prognosis. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Assfalg, V., Hüser, N., van Meel, M., Haller, B., Rahmel, A., de Boer, J., Matevossian, E., Novotny, A., Knops, N., Weekers, L., Friess, H., Pratschke, J., Függer, R., Janko, O., Rasoul-Rockenschaub, S., Bosmans, J.-L., Broeders, N., Peete Tags: Renal Transplantation Source Type: research

Phosphorus metabolism in peritoneal dialysis- and haemodialysis-treated patients
Conclusions Our data suggest that the time-averaged phosphorus concentrations in patients treated with PD are higher as compared with patients treated with HD. Despite a better preserved renal function, total phosphorus clearance is lower in patients treated with PD. Additional studies are needed to confirm these findings in a population with a different demographic profile and dietary background and to define clinical implications. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Evenepoel, P., Meijers, B. K. I., Bammens, B., Viaene, L., Claes, K., Sprangers, B., Naesens, M., Hoekstra, T., Schlieper, G., Vanderschueren, D., Kuypers, D. Tags: Intra- and Extracorporeal Treatments of Kidney Failure Source Type: research

Mortality trends among Japanese dialysis patients, 1988-2013: a joinpoint regression analysis
Conclusions Significant progress has been made, particularly with regard to the decrease in age-standardized mortality rates. The risk of cardiovascular death has decreased, while the risk of death from infection has remained unchanged for 25 years. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Wakasugi, M., Kazama, J. J., Narita, I. Tags: Intra- and Extracorporeal Treatments of Kidney Failure Source Type: research

Fibroblast growth factor 23 correlates with volume status in haemodialysis patients and is not reduced by haemodialysis
Conclusions FGF-23 was associated with volume status in haemodialysis patients. The strong association with UFV suggests that optimization of volume status, for example by more intensive haemodialysis regimens, may also benefit mineral homeostasis. A single dialysis session did not lower FGF-23 levels. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Humalda, J. K., Riphagen, I. J., Assa, S., Hummel, Y. M., Westerhuis, R., Vervloet, M. G., Voors, A. A., Navis, G., Franssen, C. F. M., de Borst, M. H., on behalf of the NIGRAM Consortium Tags: Intra- and Extracorporeal Treatments of Kidney Failure Source Type: research

PLA2R antibodies, glomerular PLA2R deposits and variations in PLA2R1 and HLA-DQA1 genes in primary membranous nephropathy in South Asians
Conclusion To conclude, anti-PLA2R and enhanced glomerular PLA2R staining are found in more than two-thirds of Indian PMN cases. A reduction in the anti-PLA2R titer correlated with response to therapy. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Ramachandran, R., Kumar, V., Kumar, A., Yadav, A. K., Nada, R., Kumar, H., Kumar, V., Rathi, M., Kohli, H. S., Gupta, K. L., Sakhuja, V., Jha, V. Tags: Chronic Kidney Disease Source Type: research

Use of urine biomarker-derived clusters to predict the risk of chronic kidney disease and all-cause mortality in HIV-infected women
Conclusions For predicting incident CKD in HIV-infected women, clusters developed from three urine-based kidney disease biomarkers were as effective as an eight-marker panel in improving risk discrimination. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Scherzer, R., Lin, H., Abraham, A., Thiessen-Philbrook, H., Parikh, C. R., Bennett, M., Cohen, M. H., Nowicki, M., Gustafson, D. R., Sharma, A., Young, M., Tien, P., Jotwani, V., Shlipak, M. G. Tags: Chronic Kidney Disease Source Type: research

Individual long-term albuminuria exposure during angiotensin receptor blocker therapy is the optimal predictor for renal outcome
Conclusions Following the initial response to ARBs, a large within-patient albuminuria variability is observed. Hence, incorporating multiple albuminuria measurements over time in risk algorithms may be more appropriate to monitor treatment effects and quantify renal risk. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Felix Kröpelin, T., de Zeeuw, D., Holtkamp, F. A., Packham, D. K., L. Heerspink, H. J. Tags: Chronic Kidney Disease Source Type: research

Relationship of proximal tubular injury to chronic kidney disease as assessed by urinary kidney injury molecule-1 in five cohort studies
Conclusion Proximal tubule injury appears to be an integral and measurable element of multiple stages of CKD. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Waikar, S. S., Sabbisetti, V., Ärnlöv, J., Carlsson, A. C., Coresh, J., Feldman, H. I., Foster, M. C., Fufaa, G. D., Helmersson-Karlqvist, J., Hsu, C.-y., Kimmel, P. L., Larsson, A., Liu, Y., Lind, L., Liu, K. D., Mifflin, T. E., Nelson, R Tags: Acute Kidney Injury Source Type: research

Extended versus standard azathioprine maintenance therapy in newly diagnosed proteinase-3 anti-neutrophil cytoplasmic antibody-associated vasculitis patients who remain cytoplasmic anti-neutrophil cytoplasmic antibody-positive after induction of remission: a randomized clinical trial
Conclusions This randomized trial suggests that extended azathioprine maintenance therapy has only a limited effect on the prevention of relapse in patients with PR3-AAV at 4 years after diagnosis. Moreover, positive C-ANCA status at stable remission was not associated with an increased rate of relapse. Trial registration ClinicalTrials.gov NCT 00128895. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Sanders, J.-S. F., de Joode, A. A. E., DeSevaux, R. G., Broekroelofs, J., Voskuyl, A. E., van Paassen, P., Kallenberg, C. G. M., Tervaert, J. W. C., Stegeman, C. A. Tags: Acute Kidney Injury Source Type: research

Metallothioneins and renal ageing
Conclusions Increased expression of MTs in the kidney with ageing might be a protective mechanism against increased oxidative stress, which is closely related to the ageing process. Our findings indicate that MTs are functionally involved in the pathophysiology of ageing-related processes. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Leierer, J., Rudnicki, M., Braniff, S.-J., Perco, P., Koppelstaetter, C., Mühlberger, I., Eder, S., Kerschbaum, J., Schwarzer, C., Schroll, A., Weiss, G., Schneeberger, S., Wagner, S., Königsrainer, A., Böhmig, G. A., Mayer, G. Tags: BASIC SCIENCE Source Type: research

Changes in inflammatory biomarkers after renal revascularization in atherosclerotic renal artery stenosis
Conclusions These divergent patterns of inflammatory signals are consistent with cell cycle arrest (TIMP-2, IGFBP7) and relative protection from acute kidney injury after imaging and stenting. Sustained basal elevation of circulating and renal venous inflammatory biomarkers support ongoing, possibly episodic, renal stress in ARAS that limits toxicity from stent revascularization. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Wang, W., Saad, A., Herrmann, S. M., Eirin Massat, A., McKusick, M. A., Misra, S., Lerman, L. O., Textor, S. C. Tags: BASIC SCIENCE Source Type: research

Glomerular filtration rate decline as a surrogate end point in kidney disease progression trials
Chronic kidney disease (CKD) is strongly associated with increased risks of progression to end-stage kidney disease (ESKD) and mortality. Clinical trials evaluating CKD progression commonly use a composite end point of death, ESKD or serum creatinine doubling. However, due to low event rates, such trials require large sample sizes and long-term follow-up for adequate statistical power. As a result, very few interventions targeting CKD progression have been tested in randomized controlled trials. To overcome this problem, the National Kidney Foundation and Food and Drug Administration conducted a series of analyses to deter...
Source: Nephrology Dialysis Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Badve, S. V., Palmer, S. C., Hawley, C. M., Pascoe, E. M., Strippoli, G. F. M., Johnson, D. W. Tags: REVIEWS - CLINICAL SCIENCE AND OUTCOME RESEARCH IN NEPHROLOGY Source Type: research

Kelch-like 3/Cullin 3 ubiquitin ligase complex and WNK signaling in salt-sensitive hypertension and electrolyte disorder
Pseudohypoaldosteronism type II (PHAII) is a hereditary disease characterized by salt-sensitive hypertension, hyperkalemia and thiazide sensitivity. Mutations in with-no-lysine kinase 1 (WNK1) and WNK4 genes are reported to cause PHAII. Rigorous studies have demonstrated that WNK kinases constitute a signaling cascade with oxidative stress-responsive gene 1 (OSR1), Ste20-related proline-alanine-rich kinase (SPAK) and the solute carrier family 12a (SLC12a) transporter, including thiazide-sensitive NaCl cotransporter. The WNK–OSR1/SPAK-SLC12a signaling cascade is present in the kidneys and vascular smooth muscle cells ...
Source: Nephrology Dialysis Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Sohara, E., Uchida, S. Tags: REVIEWS - CLINICAL SCIENCE AND OUTCOME RESEARCH IN NEPHROLOGY Source Type: research