Nephrology Dialysis Transplantation This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Moderator's view: Treatment of IgA nephropathy--getting comfortable with uncertainty
A Polar Views discussion by Pozzi and Rauen et al. on the interpretation and clinical application of the recently published Supportive Versus Immunosuppressive Therapy of Progressive IgA Nephropathy (STOP-IgAN) trial has elucidated important points concerning potential strengths and weaknesses of this landmark randomized trial. This critical examination of the impact of steroid monotherapy or steroid plus an immunosuppressive (IS) agent compared with ‘supportive’ therapy with inhibitors of the renin–angiotensin system (RAS) has enhanced our appreciation of the importance of rigorous application of titrate...
Source: Nephrology Dialysis Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Glassock, R. J. Tags: POLAR VIEWS IN NEPHROLOGY Source Type: research

Opponent's comments
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Pozzi, C. Tags: POLAR VIEWS IN NEPHROLOGY Source Type: research

Con: STOP immunosuppression in IgA nephropathy
A comprehensive supportive therapy approach constitutes the mainstay treatment of IgA nephropathy (IgAN) patients. In our recent Supportive versus immunosuppressive Therapy Of Progressive IgA Nephropathy (STOP-IgAN) trial, we systematically selected for patients at high risk of a progressive disease course and evaluated the effect of immunosuppression, combined with supportive care, on renal end points in these patients. There was a higher rate of full clinical remission and transient proteinuria reduction in immunosuppressed patients. However, deterioration of renal function (i.e. number of patients with an estimated glom...
Source: Nephrology Dialysis Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Rauen, T., Eitner, F., Fitzner, C., Floege, J. Tags: POLAR VIEWS IN NEPHROLOGY Source Type: research

Opponent's comments
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Rauen, T., Eitner, F., Fitzner, C., Floege, J. Tags: POLAR VIEWS IN NEPHROLOGY Source Type: research

Pro: STOP immunosuppression in IgA nephropathy?
The Kidney Disease: Improving Global Outcomes (KDIGO) guidelines suggest a 6-month course of corticosteroids (CS) for IgA nephropathy (IgAN) patients with persistent proteinuria ≥1 g/day despite 3–6 months of renin–angiotensin system (RAS) blockers and glomerular filtration rate (GFR) >50 mL/min/1.73 m2. In December 2015, Rauen et al. (N Engl J Med 2015; 373: 2225–2236) published an article entitled ‘Intensive supportive care plus immunosuppression in IgA nephropathy’ (STOP-IgAN), which presented results from 379 IgAN patients from 32 nephrology centres in Germany. During a run-in phase ...
Source: Nephrology Dialysis Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Pozzi, C. Tags: POLAR VIEWS IN NEPHROLOGY Source Type: research

Dialysis and pregnancy: no longer the impossible
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Bramham, K. Tags: IN FOCUS Source Type: research

The acute kidney injury e-alert and clinical care bundles: the road to success is always under construction
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Meijers, B., De Moor, B., Van Den Bosch, B. Tags: IN FOCUS Source Type: research

A further genetic cause of thin basement membrane nephropathy
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Savige, J. Tags: IN FOCUS Source Type: research

Effect of resveratrol on progression of polycystic kidney disease: a case of cautious optimism
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Moradi, H., Vaziri, N. D. Tags: IN FOCUS Source Type: research

Announcements
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - September 27, 2016 Category: Urology & Nephrology Tags: Announcements Source Type: research

The mode of sensitization and its influence on allograft outcomes in highly sensitized kidney transplant recipients
Conclusions The mode of sensitization predicts graft survival in highly sensitized kidney transplant recipients (PRA ≥98%). Patients who are highly sensitized from re-transplants have inferior graft survival compared with patients who are highly sensitized from other modes of sensitization. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - September 27, 2016 Category: Urology & Nephrology Authors: Redfield, R. R., Scalea, J. R., Zens, T. J., Mandelbrot, D. A., Leverson, G., Kaufman, D. B., Djamali, A. Tags: Renal Transplantation Source Type: research

Pretransplant angiotensin II type 1-receptor antibodies are a risk factor for earlier detection of de novo HLA donor-specific antibodies
Conclusions The findings suggest that higher levels of pretransplant circulating antibodies against AT1R (>30 U) in kidney graft recipients constitute an independent risk factor for earlier de novo HLA-DSA detection during the posttransplant period. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - September 27, 2016 Category: Urology & Nephrology Authors: Cuevas, E., Arreola-Guerra, J. M., Hernandez-Mendez, E. A., Salcedo, I., Castelan, N., Uribe-Uribe, N. O., Vilatoba, M., Contreras-Saldivar, A. G., Sanchez-Cedillo, A. I., Ramirez, J. B., de Rungs, D., Granados, J., Morales-Buenrostro, L. E., Alberu, J. Tags: Renal Transplantation Source Type: research

Efficacy and safety of antibody induction therapy in the current era of kidney transplantation
Conclusion Induction therapy following kidney transplantation should be targeted to increased-risk transplants. In this analysis, a beneficial effect of antibody induction in normal-risk transplants could not be demonstrated. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - September 27, 2016 Category: Urology & Nephrology Authors: Opelz, G., Unterrainer, C., Süsal, C., Döhler, B. Tags: Renal Transplantation Source Type: research

The influence of renal transplantation on retained microbial-human co-metabolites
Conclusions Colonic microbiota-derived uraemic retention solutes substantially decrease following renal transplantation. The 24-h urinary excretion of these microbial–human co-metabolites is lower when compared with CKD patients, suggesting an independent influence of transplantation on intestinal uptake, a composite of colonic microbial metabolism and intestinal absorption. Renal solute handling may differ between transplant recipients and CKD patients. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - September 27, 2016 Category: Urology & Nephrology Authors: Poesen, R., Evenepoel, P., de Loor, H., Bammens, B., Claes, K., Sprangers, B., Naesens, M., Kuypers, D., Augustijns, P., Meijers, B. Tags: Renal Transplantation Source Type: research

The effects of resistance exercise and oral nutritional supplementation during hemodialysis on indicators of nutritional status and quality of life
Conclusion Oral nutritional supplementation during HD improves NS. The addition of RE during HD does not seem to augment the acute anabolic effects of intradialytic ONS on NS. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - September 27, 2016 Category: Urology & Nephrology Authors: Martin-Alemany, G., Valdez-Ortiz, R., Olvera-Soto, G., Gomez-Guerrero, I., Aguire-Esquivel, G., Cantu-Quintanilla, G., Lopez-Alvarenga, J. C., Miranda-Alatriste, P., Espinosa-Cuevas, A. Tags: Intra- and Extracorporeal Treatments of Kidney Failure Source Type: research